Ursus arctos (brown bear): 113266817 Help Entry 113266817         CDS       T05909                                  Symbol NOS1 Name (RefSeq) nitric oxide synthase, brain   KO K13240   nitric-oxide synthase, brain [EC:1.14.13.39] Organism uah  Ursus arctos (brown bear) Pathway uah00220   Arginine biosynthesis uah00330   Arginine and proline metabolism uah01100   Metabolic pathways uah04020   Calcium signaling pathway uah04081   Hormone signaling uah04145   Phagosome uah04371   Apelin signaling pathway uah04713   Circadian entrainment uah04730   Long-term depression uah04926   Relaxin signaling pathway uah04970   Salivary secretion uah05010   Alzheimer disease uah05014   Amyotrophic lateral sclerosis uah05022   Pathways of neurodegeneration - multiple diseases uah05410   Hypertrophic cardiomyopathy uah05412   Arrhythmogenic right ventricular cardiomyopathy uah05414   Dilated cardiomyopathy uah05416   Viral myocarditis Brite KEGG Orthology (KO) [BR:uah00001]  09100 Metabolism   09105 Amino acid metabolism    00220 Arginine biosynthesis     113266817 (NOS1)    00330 Arginine and proline metabolism     113266817 (NOS1)  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     113266817 (NOS1)    04020 Calcium signaling pathway     113266817 (NOS1)   09133 Signaling molecules and interaction    04081 Hormone signaling     113266817 (NOS1)  09140 Cellular Processes   09141 Transport and catabolism    04145 Phagosome     113266817 (NOS1)  09150 Organismal Systems   09152 Endocrine system    04926 Relaxin signaling pathway     113266817 (NOS1)   09154 Digestive system    04970 Salivary secretion     113266817 (NOS1)   09156 Nervous system    04730 Long-term depression     113266817 (NOS1)   09159 Environmental adaptation    04713 Circadian entrainment     113266817 (NOS1)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     113266817 (NOS1)    05014 Amyotrophic lateral sclerosis     113266817 (NOS1)    05022 Pathways of neurodegeneration - multiple diseases     113266817 (NOS1)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     113266817 (NOS1)    05412 Arrhythmogenic right ventricular cardiomyopathy     113266817 (NOS1)    05414 Dilated cardiomyopathy     113266817 (NOS1)    05416 Viral myocarditis     113266817 (NOS1) Enzymes [BR:uah01000]  1. Oxidoreductases   1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen    1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor     1.14.13.39  nitric-oxide synthase (NADPH)      113266817 (NOS1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  NO_synthase FAD_binding_1 Flavodoxin_1 NAD_binding_1 PDZ PDZ_6 PDZ_2 Motif Other DBs NCBI-GeneID:  113266817 NCBI-ProteinID:  XP_026370361 LinkDB All DBs Position Unknown AA seq 1467 aa AA seqDB search MENQVFSVQQIQPNVISVRLFKRRVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQA GDIILAVNGQPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTI RVTRPLGPATTAVDLSHQSSASKEHTPPVDGAAGPGSGPQHTQDSGREAGSLSNTNSLAP RRPGQDPTKKSAGVAPQDGQNSELLKEIEPVLSLLTSGSKGIHGAGPSKAETKDAEVQVD RGVDGKSHKPLPLGVENDRVFSDLWGKGHVPVVLNNPYSEKEQPPASGKQSPTKNGSPSK CPRFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLPSQQIRRPEDVRTKEQLFP LAKEFIDQYYSSIKRFGSKAHTERLEEVNKEIEATGTYQLKDTELIYGAKHAWRNASRCV GRIQWSKLQVFDARDCTTAHGMFNYICNHIKYATNKGNLRSAITIFPQRTDGKHDFRVWN SQLIRYAGYKQPDGSILGDPANVEFTEICVQQGWKPPRGRFDVLPLLLQANGNDPELFQI PPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVR DYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQTDKVTIVDHHSATE SFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPEPWNTHVW KGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEI FKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVHE ERKYPEPLRFFPRKGPPLPQGDPGVRGLAAARDSQQRSYKVRFNSVSSYSDSHKSSGDGP DLRDNFESAGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCG QEEAFRTWAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTYMAEAPELTQ GLSTVHKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGNQELQYQPGDHLGVFPGNRED LVNALIERLEDAPPVNQLVKVELLEERNTALGVISNWTDEHRLPPCTIFQAFKYYLDITT PPTPLQLQQFASLATSEKEKQRLLVLSRGLQEYEEWKWGKNPTIVEVLEEFPSIQMPSTL LLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRIQADE VVPCFVRGAPSFHLPRNPQVPCILIGPGTGIAPFRSFWQQRQFDIQHKGMSPCPMVLVFG CRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKKYVQDVLQEQLAEPVYRALKEQ GGHIYVCGDVTMAADVLKAIQRIMTQQGKLSAEDAGVFISRLRDDNRYHEDIFGVTLRTY EVTNRLRSESIAFIEESKKDTDEVFSS NT seq 4404 nt NT seq  +upstreamnt  +downstreamnt atggagaatcaggtgttcagtgttcagcagatccaacccaatgtcatttctgtccgcctc ttcaagcgcagggtggggggcctgggcttcctggtgaaagagcgggtgagtaagccaccc gtgatcatctccgacctgatccgagggggcgccgcggagcagagcggcctcatccaggcc ggcgacatcatcctcgccgtcaacggccagcccttggtggacctgagctatgacagtgcc ctggaggtgctcaggggcatcgcctctgagacccacgtggtccttattctgaggggcccc gagggcttcaccactcacctggagaccaccttcaccggggacgggacccccaagaccatc cgggtgacacggcccctgggccccgccaccacagccgtcgatctgtctcaccagtcatcg gccagcaaagagcacacaccgccagtggatggggccgcgggtcctggcagtgggccacag catacccaggacagtgggcgggaagccggctcgctctcgaataccaacagcctggctccc agacgccctggccaggaccctaccaagaaaagtgccggggtggccccccaggacggccag aacagtgaattgctcaaagagatagaacctgtgctgagccttctcaccagtgggagcaaa gggatccatggagcgggaccttccaaggcagagacaaaagatgcggaagtccaggtggac agaggtgtggacggcaagtcccacaaaccgctgcccctgggcgtggagaatgaccgagtc ttcagtgacctgtgggggaagggccatgtgcccgtcgtcctcaacaacccgtattcagag aaggagcagccccctgcctcgggaaaacagtctcccacaaagaatggcagcccctccaag tgcccccgctttcttaaagtcaagaactgggagaccgacgtggttctcaccgacaccctt caccttaagagcacactggaaacgggctgcaccgagcacatctgtatgggctccatcatg ctcccttctcagcaaatacgaaggcctgaagatgtccgcacaaaagaacagctcttccct cttgccaaagagttcattgatcagtactactcgtcaattaaaagatttggctccaaagcc cacacagagaggctggaagaagtcaacaaagagatcgaggccacaggcacctaccagctc aaagacacagagctcatctacggggcgaagcacgcctggcggaatgcctcccgctgcgtt ggcaggatccagtggtccaagctgcaggtgttcgatgcccgagactgcaccacggctcac gggatgttcaactacatctgcaaccacatcaagtacgccaccaacaaagggaacctcagg tctgccatcaccatatttccgcagaggactgacggcaagcatgatttccgagtctggaac tctcagctcatccgctacgccggctacaagcagcctgacggctccatcctaggggaccca gccaatgtggaattcacagagatctgcgtacagcagggctggaaacccccaaggggccgc ttcgatgtcctgccactcctgctccaggccaacggcaacgaccccgagctcttccagatt cctccagagctggtgttggaagtgcccatcagacaccccaagtttgagtggttcaaggat ctgggcctgaagtggtacggcctccccgctgtgtctaatatgctgctggagatcggcggc ctggagttcagcgcctgccccttcagtggctggtacatgggcacagagatcggcgttcgc gactactgtgacaactctcgatacaacatcctggaggaagtggccaagaagatgaacttg gatatgaggaagacatcctccctgtggaaggatcaggcgctggtggaaatcaacattgct gttctctacagcttccagactgacaaagtgaccatcgttgaccaccactctgccaccgag tccttcattaagcacatggagaatgaataccgctgccgggggggctgccccgccgactgg gtgtggatcgtgccccccatgtctggcagcatcaccccggtcttccaccaggagatgctc aactaccggctcaccccctccttcgaataccagcctgagccttggaacacccacgtgtgg aaaggtaccaatgggacccccacaaagcggcgagccatcggcttcaagaagctggcggaa gccgtcaagttttcggccaagctcatggggcaggcaatggccaagagggtcaaggcaacc atcctttatgccacagagacgggcaagtcgcaggcctatgctaaaaccttgtgcgagatc ttcaaacacgcctttgatgccaaggtgatgtccatggaagaatatgacattgtacacctg gaacatgaaactctggtcctggtggttaccagcacttttggcaatggagacccccctgag aatggggagaaattcggctgtgctttgatggaaatgaggcaccccaactccgtgcatgag gaaaggaagtacccggaacccttgcgtttctttccccgtaaagggcctcccctcccccaa ggtgacccaggagtccgtggtctggctgcagcccgtgacagccagcagaggagctacaag gtccgattcaatagcgtttcctcgtattctgactcccataaatcgtcgggcgatgggcca gacctcagagacaactttgagagtgctggacccctggcaaatgtgaggttctctgtgttt ggccttggctcccgtgcttacccgcacttctgtgcctttggacatgctgtggacaccctc ctggaggagctgggaggagagaggatcctgaagatgagggaaggggatgagctgtgtggg caggaagaggctttcaggacctgggccaagaaggtcttcaaggcagcctgtgatgtgttc tgtgtgggagatgacgtcaacatcgagaaggccaacaactccctcatcagcaatgaccgc agctggaagaggaataaattccgcctcacctacatggccgaagctccagaacttacgcaa ggtctgtccactgtccacaaaaagcgggtctcagccgctcgactcctcagccgtcagaac cttcagagccctaaatccagccgatcaaccatcttcgtgcgtctccacaccaacgggaat caggagctccagtaccagcctggggaccacctgggcgtcttcccaggcaaccgcgaggac ctcgtgaacgccctgatcgagcggctggaggacgcacccccggtcaaccagctggtgaag gtggagctgctggaggagcggaacacggctttgggagttatcagtaactggacagatgag caccgcctcccgccctgcaccatcttccaggccttcaagtattacctggacatcaccacg ccgccaacgccactgcagctgcagcagtttgcctccctggccaccagcgagaaagagaag cagcgtctgctggtcctcagcaggggtttgcaggagtacgaggaatggaaatggggcaag aaccccaccatcgtggaggtgctggaggagttcccgtccatccagatgccctccaccctg ctcctgacccagctgtccctgctgcagccccgctactattccatcagctcctccccagac atgtaccctgacgaggtgcacctcaccgtggccatcgtctcctaccgcaccagagatgga gaaggaccaattcaccacggtgtgtgctcctcctggctcaaccggatacaggctgacgaa gtggtcccgtgtttcgtgagaggagcacccagcttccacctgccccgaaatccccaagtg ccctgcatcctcattggcccaggcactggcattgcccctttccgaagcttctggcagcag cggcaatttgatatccaacacaaagggatgagcccctgccccatggtcctggtgttcggg tgccggcaatccaagatagaccacatctacagggaggagacgctccaggccaagaacaag ggggtcttcagagaactgtacacggcctactcccgggagccagacaaaccaaagaagtac gtgcaggacgtcctgcaggagcagctggcagaaccggtgtaccgagccctgaaggagcaa gggggccacatctatgtctgcggggacgtcaccatggccgccgatgtcctcaaagccatc cagcgcatcatgacccagcaggggaaactctcagcagaggatgcgggcgtgttcatcagc aggctgagggatgacaaccggtaccatgaggatattttcggggtcaccctgcgaacatat gaagtgaccaaccgccttagatctgaatccattgccttcattgaggagagcaaaaaagac accgacgaggttttcagctcctaa

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