KEGG   Ursus arctos (brown bear): 113267646
Entry
113267646         CDS       T05909                                 
Symbol
MAPK3
Name
(RefSeq) LOW QUALITY PROTEIN: mitogen-activated protein kinase 3
  KO
K04371  mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
Organism
uah  Ursus arctos (brown bear)
Pathway
uah01521  EGFR tyrosine kinase inhibitor resistance
uah01522  Endocrine resistance
uah01524  Platinum drug resistance
uah04010  MAPK signaling pathway
uah04012  ErbB signaling pathway
uah04014  Ras signaling pathway
uah04015  Rap1 signaling pathway
uah04022  cGMP-PKG signaling pathway
uah04024  cAMP signaling pathway
uah04062  Chemokine signaling pathway
uah04066  HIF-1 signaling pathway
uah04068  FoxO signaling pathway
uah04071  Sphingolipid signaling pathway
uah04072  Phospholipase D signaling pathway
uah04114  Oocyte meiosis
uah04140  Autophagy - animal
uah04148  Efferocytosis
uah04150  mTOR signaling pathway
uah04151  PI3K-Akt signaling pathway
uah04210  Apoptosis
uah04218  Cellular senescence
uah04261  Adrenergic signaling in cardiomyocytes
uah04270  Vascular smooth muscle contraction
uah04350  TGF-beta signaling pathway
uah04360  Axon guidance
uah04370  VEGF signaling pathway
uah04371  Apelin signaling pathway
uah04380  Osteoclast differentiation
uah04510  Focal adhesion
uah04520  Adherens junction
uah04540  Gap junction
uah04550  Signaling pathways regulating pluripotency of stem cells
uah04611  Platelet activation
uah04613  Neutrophil extracellular trap formation
uah04620  Toll-like receptor signaling pathway
uah04621  NOD-like receptor signaling pathway
uah04625  C-type lectin receptor signaling pathway
uah04650  Natural killer cell mediated cytotoxicity
uah04657  IL-17 signaling pathway
uah04658  Th1 and Th2 cell differentiation
uah04659  Th17 cell differentiation
uah04660  T cell receptor signaling pathway
uah04662  B cell receptor signaling pathway
uah04664  Fc epsilon RI signaling pathway
uah04666  Fc gamma R-mediated phagocytosis
uah04668  TNF signaling pathway
uah04713  Circadian entrainment
uah04720  Long-term potentiation
uah04722  Neurotrophin signaling pathway
uah04723  Retrograde endocannabinoid signaling
uah04724  Glutamatergic synapse
uah04725  Cholinergic synapse
uah04726  Serotonergic synapse
uah04730  Long-term depression
uah04810  Regulation of actin cytoskeleton
uah04910  Insulin signaling pathway
uah04912  GnRH signaling pathway
uah04914  Progesterone-mediated oocyte maturation
uah04915  Estrogen signaling pathway
uah04916  Melanogenesis
uah04917  Prolactin signaling pathway
uah04919  Thyroid hormone signaling pathway
uah04921  Oxytocin signaling pathway
uah04926  Relaxin signaling pathway
uah04928  Parathyroid hormone synthesis, secretion and action
uah04929  GnRH secretion
uah04930  Type II diabetes mellitus
uah04933  AGE-RAGE signaling pathway in diabetic complications
uah04934  Cushing syndrome
uah04935  Growth hormone synthesis, secretion and action
uah04960  Aldosterone-regulated sodium reabsorption
uah05010  Alzheimer disease
uah05020  Prion disease
uah05022  Pathways of neurodegeneration - multiple diseases
uah05034  Alcoholism
uah05132  Salmonella infection
uah05133  Pertussis
uah05135  Yersinia infection
uah05140  Leishmaniasis
uah05142  Chagas disease
uah05145  Toxoplasmosis
uah05152  Tuberculosis
uah05160  Hepatitis C
uah05161  Hepatitis B
uah05163  Human cytomegalovirus infection
uah05164  Influenza A
uah05165  Human papillomavirus infection
uah05166  Human T-cell leukemia virus 1 infection
uah05167  Kaposi sarcoma-associated herpesvirus infection
uah05170  Human immunodeficiency virus 1 infection
uah05171  Coronavirus disease - COVID-19
uah05200  Pathways in cancer
uah05203  Viral carcinogenesis
uah05205  Proteoglycans in cancer
uah05206  MicroRNAs in cancer
uah05207  Chemical carcinogenesis - receptor activation
uah05208  Chemical carcinogenesis - reactive oxygen species
uah05210  Colorectal cancer
uah05211  Renal cell carcinoma
uah05212  Pancreatic cancer
uah05213  Endometrial cancer
uah05214  Glioma
uah05215  Prostate cancer
uah05216  Thyroid cancer
uah05218  Melanoma
uah05219  Bladder cancer
uah05220  Chronic myeloid leukemia
uah05221  Acute myeloid leukemia
uah05223  Non-small cell lung cancer
uah05224  Breast cancer
uah05225  Hepatocellular carcinoma
uah05226  Gastric cancer
uah05230  Central carbon metabolism in cancer
uah05231  Choline metabolism in cancer
uah05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
uah05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:uah00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    113267646 (MAPK3)
   04012 ErbB signaling pathway
    113267646 (MAPK3)
   04014 Ras signaling pathway
    113267646 (MAPK3)
   04015 Rap1 signaling pathway
    113267646 (MAPK3)
   04350 TGF-beta signaling pathway
    113267646 (MAPK3)
   04370 VEGF signaling pathway
    113267646 (MAPK3)
   04371 Apelin signaling pathway
    113267646 (MAPK3)
   04668 TNF signaling pathway
    113267646 (MAPK3)
   04066 HIF-1 signaling pathway
    113267646 (MAPK3)
   04068 FoxO signaling pathway
    113267646 (MAPK3)
   04072 Phospholipase D signaling pathway
    113267646 (MAPK3)
   04071 Sphingolipid signaling pathway
    113267646 (MAPK3)
   04024 cAMP signaling pathway
    113267646 (MAPK3)
   04022 cGMP-PKG signaling pathway
    113267646 (MAPK3)
   04151 PI3K-Akt signaling pathway
    113267646 (MAPK3)
   04150 mTOR signaling pathway
    113267646 (MAPK3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    113267646 (MAPK3)
   04148 Efferocytosis
    113267646 (MAPK3)
  09143 Cell growth and death
   04114 Oocyte meiosis
    113267646 (MAPK3)
   04210 Apoptosis
    113267646 (MAPK3)
   04218 Cellular senescence
    113267646 (MAPK3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    113267646 (MAPK3)
   04520 Adherens junction
    113267646 (MAPK3)
   04540 Gap junction
    113267646 (MAPK3)
   04550 Signaling pathways regulating pluripotency of stem cells
    113267646 (MAPK3)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    113267646 (MAPK3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    113267646 (MAPK3)
   04613 Neutrophil extracellular trap formation
    113267646 (MAPK3)
   04620 Toll-like receptor signaling pathway
    113267646 (MAPK3)
   04621 NOD-like receptor signaling pathway
    113267646 (MAPK3)
   04625 C-type lectin receptor signaling pathway
    113267646 (MAPK3)
   04650 Natural killer cell mediated cytotoxicity
    113267646 (MAPK3)
   04660 T cell receptor signaling pathway
    113267646 (MAPK3)
   04658 Th1 and Th2 cell differentiation
    113267646 (MAPK3)
   04659 Th17 cell differentiation
    113267646 (MAPK3)
   04657 IL-17 signaling pathway
    113267646 (MAPK3)
   04662 B cell receptor signaling pathway
    113267646 (MAPK3)
   04664 Fc epsilon RI signaling pathway
    113267646 (MAPK3)
   04666 Fc gamma R-mediated phagocytosis
    113267646 (MAPK3)
   04062 Chemokine signaling pathway
    113267646 (MAPK3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    113267646 (MAPK3)
   04929 GnRH secretion
    113267646 (MAPK3)
   04912 GnRH signaling pathway
    113267646 (MAPK3)
   04915 Estrogen signaling pathway
    113267646 (MAPK3)
   04914 Progesterone-mediated oocyte maturation
    113267646 (MAPK3)
   04917 Prolactin signaling pathway
    113267646 (MAPK3)
   04921 Oxytocin signaling pathway
    113267646 (MAPK3)
   04926 Relaxin signaling pathway
    113267646 (MAPK3)
   04935 Growth hormone synthesis, secretion and action
    113267646 (MAPK3)
   04919 Thyroid hormone signaling pathway
    113267646 (MAPK3)
   04928 Parathyroid hormone synthesis, secretion and action
    113267646 (MAPK3)
   04916 Melanogenesis
    113267646 (MAPK3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    113267646 (MAPK3)
   04270 Vascular smooth muscle contraction
    113267646 (MAPK3)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    113267646 (MAPK3)
  09156 Nervous system
   04724 Glutamatergic synapse
    113267646 (MAPK3)
   04725 Cholinergic synapse
    113267646 (MAPK3)
   04726 Serotonergic synapse
    113267646 (MAPK3)
   04720 Long-term potentiation
    113267646 (MAPK3)
   04730 Long-term depression
    113267646 (MAPK3)
   04723 Retrograde endocannabinoid signaling
    113267646 (MAPK3)
   04722 Neurotrophin signaling pathway
    113267646 (MAPK3)
  09158 Development and regeneration
   04360 Axon guidance
    113267646 (MAPK3)
   04380 Osteoclast differentiation
    113267646 (MAPK3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    113267646 (MAPK3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    113267646 (MAPK3)
   05206 MicroRNAs in cancer
    113267646 (MAPK3)
   05205 Proteoglycans in cancer
    113267646 (MAPK3)
   05207 Chemical carcinogenesis - receptor activation
    113267646 (MAPK3)
   05208 Chemical carcinogenesis - reactive oxygen species
    113267646 (MAPK3)
   05203 Viral carcinogenesis
    113267646 (MAPK3)
   05230 Central carbon metabolism in cancer
    113267646 (MAPK3)
   05231 Choline metabolism in cancer
    113267646 (MAPK3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    113267646 (MAPK3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    113267646 (MAPK3)
   05212 Pancreatic cancer
    113267646 (MAPK3)
   05225 Hepatocellular carcinoma
    113267646 (MAPK3)
   05226 Gastric cancer
    113267646 (MAPK3)
   05214 Glioma
    113267646 (MAPK3)
   05216 Thyroid cancer
    113267646 (MAPK3)
   05221 Acute myeloid leukemia
    113267646 (MAPK3)
   05220 Chronic myeloid leukemia
    113267646 (MAPK3)
   05218 Melanoma
    113267646 (MAPK3)
   05211 Renal cell carcinoma
    113267646 (MAPK3)
   05219 Bladder cancer
    113267646 (MAPK3)
   05215 Prostate cancer
    113267646 (MAPK3)
   05213 Endometrial cancer
    113267646 (MAPK3)
   05224 Breast cancer
    113267646 (MAPK3)
   05223 Non-small cell lung cancer
    113267646 (MAPK3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    113267646 (MAPK3)
   05170 Human immunodeficiency virus 1 infection
    113267646 (MAPK3)
   05161 Hepatitis B
    113267646 (MAPK3)
   05160 Hepatitis C
    113267646 (MAPK3)
   05171 Coronavirus disease - COVID-19
    113267646 (MAPK3)
   05164 Influenza A
    113267646 (MAPK3)
   05163 Human cytomegalovirus infection
    113267646 (MAPK3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    113267646 (MAPK3)
   05165 Human papillomavirus infection
    113267646 (MAPK3)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    113267646 (MAPK3)
   05135 Yersinia infection
    113267646 (MAPK3)
   05133 Pertussis
    113267646 (MAPK3)
   05152 Tuberculosis
    113267646 (MAPK3)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    113267646 (MAPK3)
   05140 Leishmaniasis
    113267646 (MAPK3)
   05142 Chagas disease
    113267646 (MAPK3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    113267646 (MAPK3)
   05020 Prion disease
    113267646 (MAPK3)
   05022 Pathways of neurodegeneration - multiple diseases
    113267646 (MAPK3)
  09165 Substance dependence
   05034 Alcoholism
    113267646 (MAPK3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    113267646 (MAPK3)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    113267646 (MAPK3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    113267646 (MAPK3)
   04934 Cushing syndrome
    113267646 (MAPK3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    113267646 (MAPK3)
   01524 Platinum drug resistance
    113267646 (MAPK3)
   01522 Endocrine resistance
    113267646 (MAPK3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:uah01001]
    113267646 (MAPK3)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:uah03036]
    113267646 (MAPK3)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:uah04147]
    113267646 (MAPK3)
Enzymes [BR:uah01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     113267646 (MAPK3)
Protein kinases [BR:uah01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   113267646 (MAPK3)
Chromosome and associated proteins [BR:uah03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Protein kinases
     113267646 (MAPK3)
Exosome [BR:uah04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   113267646 (MAPK3)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Haspin_kinase FTA2 Kdo
Other DBs
NCBI-GeneID: 113267646
NCBI-ProteinID: XP_026371504
LinkDB
Position
Unknown
AA seq 391 aa
MHCLMEKIIPKAPSNSVVWGAGAGEPRGADGVGPGVSGEVEVVKGQPFDVGPRYTELHYI
GEGAYGMVSSAYDHVRKIRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILR
APTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHVCYFLYQILRGLKYIHSANVLHRDLK
PSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDI
WSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKT
KVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTF
DMELDDLPKERLKELIFQETARFQPGALEAP
NT seq 1176 nt   +upstreamnt  +downstreamnt
atgcactgtctgatggagaaaattattccaaaagctccttccaactcagtagtttggggg
gcgggggcgggggagccccggggagctgatggggtcggcccgggggtctcgggggaggtg
gaggtagtgaaggggcagccgttcgacgtgggcccgcgctacacggagctgcattacatc
ggcgagggcgcgtacggcatggtcagctcagcttacgaccacgtgcgcaagattcgcgtg
gccatcaagaaaatcagccccttcgagcatcagacctactgccagcgcacactgcgggag
atccagatcttgctgcgcttccgccacgagaacgtcattggcattcgggacattctgcgg
gcgcccaccctggaagccatgagagatgtctacattgtgcaggacctgatggagacagac
ctgtacaagttgctcaaaagccagcagctgagcaacgaccatgtttgctacttcctctac
cagatcctgcggggcctcaagtacatccactcagccaacgtgctccaccgggatctaaag
ccctctaacctgctcatcaacaccacctgcgaccttaagatctgcgattttggcctggcc
cggattgcggaccctgagcatgaccacaccggcttcctgacagaatatgtggccacacgc
tggtaccgggctccagaaatcatgcttaactctaagggctacaccaagtccatcgacatc
tggtctgtgggctgcattctggctgagatgctctccaaccggcccatcttccctggcaag
cactacctggaccagctcaaccacattctgggtatcctgggctccccatcccaggaggac
ttgaattgtatcatcaatatgaaggcccgaaactacctgcagtctctgccctccaagacc
aaggtggcctgggccaagctttttcccaagtcggactccaaagcccttgacctgctagac
cggatgttgacctttaaccccaacaaacggatcacagtggaagaagcgctggctcacccc
tacttggagcagtactacgacccaacagatgagccggtggccgaggagcctttcaccttt
gacatggagctggatgatctacccaaggagcggctgaaggagctcatcttccaggagaca
gcccgcttccagcctggggcgctggaggccccctaa

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