KEGG   Ursus arctos (brown bear): 113270537
Entry
113270537         CDS       T05909                                 
Symbol
PIK3CD
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
uah  Ursus arctos (brown bear)
Pathway
uah00562  Inositol phosphate metabolism
uah01100  Metabolic pathways
uah01521  EGFR tyrosine kinase inhibitor resistance
uah01522  Endocrine resistance
uah01524  Platinum drug resistance
uah04012  ErbB signaling pathway
uah04014  Ras signaling pathway
uah04015  Rap1 signaling pathway
uah04024  cAMP signaling pathway
uah04062  Chemokine signaling pathway
uah04066  HIF-1 signaling pathway
uah04068  FoxO signaling pathway
uah04070  Phosphatidylinositol signaling system
uah04071  Sphingolipid signaling pathway
uah04072  Phospholipase D signaling pathway
uah04081  Hormone signaling
uah04140  Autophagy - animal
uah04150  mTOR signaling pathway
uah04151  PI3K-Akt signaling pathway
uah04152  AMPK signaling pathway
uah04210  Apoptosis
uah04211  Longevity regulating pathway
uah04213  Longevity regulating pathway - multiple species
uah04218  Cellular senescence
uah04360  Axon guidance
uah04370  VEGF signaling pathway
uah04380  Osteoclast differentiation
uah04510  Focal adhesion
uah04517  IgSF CAM signaling
uah04550  Signaling pathways regulating pluripotency of stem cells
uah04611  Platelet activation
uah04613  Neutrophil extracellular trap formation
uah04620  Toll-like receptor signaling pathway
uah04625  C-type lectin receptor signaling pathway
uah04630  JAK-STAT signaling pathway
uah04650  Natural killer cell mediated cytotoxicity
uah04660  T cell receptor signaling pathway
uah04662  B cell receptor signaling pathway
uah04664  Fc epsilon RI signaling pathway
uah04666  Fc gamma R-mediated phagocytosis
uah04668  TNF signaling pathway
uah04670  Leukocyte transendothelial migration
uah04722  Neurotrophin signaling pathway
uah04725  Cholinergic synapse
uah04750  Inflammatory mediator regulation of TRP channels
uah04810  Regulation of actin cytoskeleton
uah04910  Insulin signaling pathway
uah04914  Progesterone-mediated oocyte maturation
uah04915  Estrogen signaling pathway
uah04917  Prolactin signaling pathway
uah04919  Thyroid hormone signaling pathway
uah04923  Regulation of lipolysis in adipocytes
uah04926  Relaxin signaling pathway
uah04929  GnRH secretion
uah04930  Type II diabetes mellitus
uah04931  Insulin resistance
uah04932  Non-alcoholic fatty liver disease
uah04933  AGE-RAGE signaling pathway in diabetic complications
uah04935  Growth hormone synthesis, secretion and action
uah04960  Aldosterone-regulated sodium reabsorption
uah04973  Carbohydrate digestion and absorption
uah05010  Alzheimer disease
uah05017  Spinocerebellar ataxia
uah05020  Prion disease
uah05100  Bacterial invasion of epithelial cells
uah05132  Salmonella infection
uah05135  Yersinia infection
uah05142  Chagas disease
uah05146  Amoebiasis
uah05160  Hepatitis C
uah05161  Hepatitis B
uah05162  Measles
uah05163  Human cytomegalovirus infection
uah05164  Influenza A
uah05165  Human papillomavirus infection
uah05166  Human T-cell leukemia virus 1 infection
uah05167  Kaposi sarcoma-associated herpesvirus infection
uah05168  Herpes simplex virus 1 infection
uah05169  Epstein-Barr virus infection
uah05170  Human immunodeficiency virus 1 infection
uah05171  Coronavirus disease - COVID-19
uah05200  Pathways in cancer
uah05203  Viral carcinogenesis
uah05205  Proteoglycans in cancer
uah05206  MicroRNAs in cancer
uah05207  Chemical carcinogenesis - receptor activation
uah05208  Chemical carcinogenesis - reactive oxygen species
uah05210  Colorectal cancer
uah05211  Renal cell carcinoma
uah05212  Pancreatic cancer
uah05213  Endometrial cancer
uah05214  Glioma
uah05215  Prostate cancer
uah05218  Melanoma
uah05220  Chronic myeloid leukemia
uah05221  Acute myeloid leukemia
uah05222  Small cell lung cancer
uah05223  Non-small cell lung cancer
uah05224  Breast cancer
uah05225  Hepatocellular carcinoma
uah05226  Gastric cancer
uah05230  Central carbon metabolism in cancer
uah05231  Choline metabolism in cancer
uah05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
uah05415  Diabetic cardiomyopathy
uah05417  Lipid and atherosclerosis
uah05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:uah00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    113270537 (PIK3CD)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    113270537 (PIK3CD)
   04014 Ras signaling pathway
    113270537 (PIK3CD)
   04015 Rap1 signaling pathway
    113270537 (PIK3CD)
   04370 VEGF signaling pathway
    113270537 (PIK3CD)
   04630 JAK-STAT signaling pathway
    113270537 (PIK3CD)
   04668 TNF signaling pathway
    113270537 (PIK3CD)
   04066 HIF-1 signaling pathway
    113270537 (PIK3CD)
   04068 FoxO signaling pathway
    113270537 (PIK3CD)
   04070 Phosphatidylinositol signaling system
    113270537 (PIK3CD)
   04072 Phospholipase D signaling pathway
    113270537 (PIK3CD)
   04071 Sphingolipid signaling pathway
    113270537 (PIK3CD)
   04024 cAMP signaling pathway
    113270537 (PIK3CD)
   04151 PI3K-Akt signaling pathway
    113270537 (PIK3CD)
   04152 AMPK signaling pathway
    113270537 (PIK3CD)
   04150 mTOR signaling pathway
    113270537 (PIK3CD)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    113270537 (PIK3CD)
   04517 IgSF CAM signaling
    113270537 (PIK3CD)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    113270537 (PIK3CD)
  09143 Cell growth and death
   04210 Apoptosis
    113270537 (PIK3CD)
   04218 Cellular senescence
    113270537 (PIK3CD)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    113270537 (PIK3CD)
   04550 Signaling pathways regulating pluripotency of stem cells
    113270537 (PIK3CD)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    113270537 (PIK3CD)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    113270537 (PIK3CD)
   04613 Neutrophil extracellular trap formation
    113270537 (PIK3CD)
   04620 Toll-like receptor signaling pathway
    113270537 (PIK3CD)
   04625 C-type lectin receptor signaling pathway
    113270537 (PIK3CD)
   04650 Natural killer cell mediated cytotoxicity
    113270537 (PIK3CD)
   04660 T cell receptor signaling pathway
    113270537 (PIK3CD)
   04662 B cell receptor signaling pathway
    113270537 (PIK3CD)
   04664 Fc epsilon RI signaling pathway
    113270537 (PIK3CD)
   04666 Fc gamma R-mediated phagocytosis
    113270537 (PIK3CD)
   04670 Leukocyte transendothelial migration
    113270537 (PIK3CD)
   04062 Chemokine signaling pathway
    113270537 (PIK3CD)
  09152 Endocrine system
   04910 Insulin signaling pathway
    113270537 (PIK3CD)
   04923 Regulation of lipolysis in adipocytes
    113270537 (PIK3CD)
   04929 GnRH secretion
    113270537 (PIK3CD)
   04915 Estrogen signaling pathway
    113270537 (PIK3CD)
   04914 Progesterone-mediated oocyte maturation
    113270537 (PIK3CD)
   04917 Prolactin signaling pathway
    113270537 (PIK3CD)
   04926 Relaxin signaling pathway
    113270537 (PIK3CD)
   04935 Growth hormone synthesis, secretion and action
    113270537 (PIK3CD)
   04919 Thyroid hormone signaling pathway
    113270537 (PIK3CD)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    113270537 (PIK3CD)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    113270537 (PIK3CD)
  09156 Nervous system
   04725 Cholinergic synapse
    113270537 (PIK3CD)
   04722 Neurotrophin signaling pathway
    113270537 (PIK3CD)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    113270537 (PIK3CD)
  09158 Development and regeneration
   04360 Axon guidance
    113270537 (PIK3CD)
   04380 Osteoclast differentiation
    113270537 (PIK3CD)
  09149 Aging
   04211 Longevity regulating pathway
    113270537 (PIK3CD)
   04213 Longevity regulating pathway - multiple species
    113270537 (PIK3CD)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    113270537 (PIK3CD)
   05206 MicroRNAs in cancer
    113270537 (PIK3CD)
   05205 Proteoglycans in cancer
    113270537 (PIK3CD)
   05207 Chemical carcinogenesis - receptor activation
    113270537 (PIK3CD)
   05208 Chemical carcinogenesis - reactive oxygen species
    113270537 (PIK3CD)
   05203 Viral carcinogenesis
    113270537 (PIK3CD)
   05230 Central carbon metabolism in cancer
    113270537 (PIK3CD)
   05231 Choline metabolism in cancer
    113270537 (PIK3CD)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    113270537 (PIK3CD)
  09162 Cancer: specific types
   05210 Colorectal cancer
    113270537 (PIK3CD)
   05212 Pancreatic cancer
    113270537 (PIK3CD)
   05225 Hepatocellular carcinoma
    113270537 (PIK3CD)
   05226 Gastric cancer
    113270537 (PIK3CD)
   05214 Glioma
    113270537 (PIK3CD)
   05221 Acute myeloid leukemia
    113270537 (PIK3CD)
   05220 Chronic myeloid leukemia
    113270537 (PIK3CD)
   05218 Melanoma
    113270537 (PIK3CD)
   05211 Renal cell carcinoma
    113270537 (PIK3CD)
   05215 Prostate cancer
    113270537 (PIK3CD)
   05213 Endometrial cancer
    113270537 (PIK3CD)
   05224 Breast cancer
    113270537 (PIK3CD)
   05222 Small cell lung cancer
    113270537 (PIK3CD)
   05223 Non-small cell lung cancer
    113270537 (PIK3CD)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    113270537 (PIK3CD)
   05170 Human immunodeficiency virus 1 infection
    113270537 (PIK3CD)
   05161 Hepatitis B
    113270537 (PIK3CD)
   05160 Hepatitis C
    113270537 (PIK3CD)
   05171 Coronavirus disease - COVID-19
    113270537 (PIK3CD)
   05164 Influenza A
    113270537 (PIK3CD)
   05162 Measles
    113270537 (PIK3CD)
   05168 Herpes simplex virus 1 infection
    113270537 (PIK3CD)
   05163 Human cytomegalovirus infection
    113270537 (PIK3CD)
   05167 Kaposi sarcoma-associated herpesvirus infection
    113270537 (PIK3CD)
   05169 Epstein-Barr virus infection
    113270537 (PIK3CD)
   05165 Human papillomavirus infection
    113270537 (PIK3CD)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    113270537 (PIK3CD)
   05135 Yersinia infection
    113270537 (PIK3CD)
   05100 Bacterial invasion of epithelial cells
    113270537 (PIK3CD)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    113270537 (PIK3CD)
   05142 Chagas disease
    113270537 (PIK3CD)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    113270537 (PIK3CD)
   05017 Spinocerebellar ataxia
    113270537 (PIK3CD)
   05020 Prion disease
    113270537 (PIK3CD)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    113270537 (PIK3CD)
   05418 Fluid shear stress and atherosclerosis
    113270537 (PIK3CD)
   05415 Diabetic cardiomyopathy
    113270537 (PIK3CD)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    113270537 (PIK3CD)
   04932 Non-alcoholic fatty liver disease
    113270537 (PIK3CD)
   04931 Insulin resistance
    113270537 (PIK3CD)
   04933 AGE-RAGE signaling pathway in diabetic complications
    113270537 (PIK3CD)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    113270537 (PIK3CD)
   01524 Platinum drug resistance
    113270537 (PIK3CD)
   01522 Endocrine resistance
    113270537 (PIK3CD)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:uah04131]
    113270537 (PIK3CD)
Enzymes [BR:uah01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     113270537 (PIK3CD)
Membrane trafficking [BR:uah04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    113270537 (PIK3CD)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_p85B PI3K_rbd PI3K_C2
Other DBs
NCBI-GeneID: 113270537
NCBI-ProteinID: XP_026375673
LinkDB
Position
Unknown
AA seq 1044 aa
MPPGVDCPMEFWTKEENQSVAVDFLLPTGVYLNFPVSRNANLSTIKKVLWHRAQYEPLFH
MLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLVAREGDRVKKLVNSQISLL
IGKGLHEFDSLHDPEVNAFRTKMRQFCEEAAARRQQLGWEAWLQYSFPLQLEPSARSWGA
GTLRVPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYT
LQVNGRQEYLYGGYPLCQFQYICGCLHSGLTPHLTMVHSSSILAMRDEQSDPTPQVQKPR
TKPPPIPMKKPSSLSLWSLEQPFCVELIQGSKVNADERMKLVVQAGLFHGNETLCKTVSS
SEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAW
ANLMLFDYKDQLKTGECCLYMWPSVPDEKGELLNPTGTVRSNPNTESAAALVICLPEVAP
YPVYYPTLDKILELGRHGEHGRFSEEEQLQLREILERRGSGELYEHEKDLVWKMRHEVQE
RFPEALARLLLVTKWNKHEDVAQMLYLLGSWPELPVLSALELLDCSFPDRHVGSFAIKSL
RKLTDDELFRYLLQLVQVLKYESYLDCELAKFLLARALANRKIGHFLFWHLRSEMHVPSV
ALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKVSSQKTTKPQTKELMHVCMR
QETYLEALSNVQSPLDPSTLLAEVCVEQCTFMDSKMKPLWLVYSSEEAGSDGSVGIIFKN
GDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLSTGDRTGLIEVVLHSDTIANIQLN
KSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIM
IRENGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYC
ERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFN
EALRESWKTKVNWLAHNVSKDNRQ
NT seq 3135 nt   +upstreamnt  +downstreamnt
atgccccctggggttgactgccccatggaattctggaccaaggaggagaatcagagtgtg
gccgttgacttcctgttgcccacgggggtctatctgaacttccctgtgtcccggaatgcc
aacctcagcaccatcaagaaggtgttgtggcaccgggcccagtatgagccactcttccac
atgctcagcgaccccgaggcctatgtgttcacctgcgtcaaccagacggccgagcagcaa
gagctggaggacgagcagcggcggctctgcgacatccagcccttcctgccggtgctgcgg
ctcgtggcccgagagggcgacagggtgaagaagctggtcaattctcagatcagcctcctc
atcggcaaaggcctccacgagttcgactccctgcatgacccagaagtgaacgcctttcgc
accaagatgcgccagttctgcgaggaggcggccgcccggcggcagcagctgggctgggag
gcttggctacagtacagcttcccactgcagctggagccctcggcgcggagctggggggcc
ggcaccctgcgggtccccaaccgggccctcctggtcaacgtcaagttcgagggcagcgag
gagagcttcaccttccaggtgtccaccaaggacgtgccactggcgctgatggcgtgcgcg
ctgcggaagaaggccaccgtgttccggcagcccctggtggagcagcccgaggactacacg
ctgcaggtgaacgggaggcaggagtacctgtacggcggctacccgctctgccagttccag
tacatatgcggctgcctgcacagcgggctgaccccccacctgaccatggtgcactcgtcc
tccatccttgccatgcgggacgagcagagcgaccctaccccccaagtccagaaaccgcgc
accaaaccaccccccattcccatgaagaagccttcctccttgtccctgtggtccctggag
cagcctttctgcgtggagctgattcagggcagcaaagtgaatgccgatgagcggatgaag
ctggtcgtgcaggcggggctgttccacggcaacgagacgctgtgcaagacggtgtccagc
tcggaggtgagcgtgtgctcggagcccgtgtggaaacagcggctggagtttgacatcaac
atctgtgacctgccccgcatggcccgtctctgctttgcactttacgccgtgatcgagaag
gccaagaaggctcgctccaccaagaagaagtccaagaaggcggactgccccatcgcctgg
gccaacctcatgctgtttgactacaaggaccagctcaagaccggtgaatgctgcctgtac
atgtggccgtccgtcccagacgagaaaggggagctgctgaaccccacggggacagtgcgg
agtaaccccaacacggagagcgctgcggccctcgtcatctgcctccccgaggtggccccc
taccctgtgtactaccccaccctggacaagattctggagctggggcggcatggggagcac
gggcgcttcagcgaggaggagcagctacagctgcgggaaatcctggagcggcgggggtcc
ggcgagctgtacgagcacgagaaggacctggtgtggaagatgcggcacgaggtccaggag
cgctttcccgaggcgctggcccgcctgctgctggtcaccaagtggaacaagcacgaggac
gtggcccagatgctctacctgctgggctcctggcccgagctgcctgtcctgagcgccctg
gagctgctggactgcagcttccccgaccgccacgtgggctccttcgccatcaagtctctg
cggaagttgacggacgacgagctcttccggtacctgctgcagctggtgcaggtgctcaag
tacgagtcctacctggactgcgagctggccaagttcctgctggcccgggccctggccaac
cgcaagatcggccacttcctcttctggcacctccgctccgagatgcacgtgccgtccgtg
gccctgcgcttcggcctcatcatggaggcctactgccggggtagcacccaccacatgaag
gtgctcatgaagcagggggaggcgctgagcaaactgaaggccctgaatgactttgtcaaa
gtgagctcccagaagaccaccaagccccagaccaaggagctgatgcacgtgtgcatgcgt
caggagacctacctggaggccctttccaacgtgcagtccccgctggaccccagcaccctg
ctggctgaagtctgtgtggagcagtgcaccttcatggactccaagatgaagcccttgtgg
ctcgtgtacagcagcgaggaggcgggcagcgacggcagcgtgggcatcatctttaagaac
ggggacgacctccgccaggacatgctgactctgcagatgatccagctcatggacgttctg
tggaagcaggagggactggacctgaggatgaccccctacggctgcctctccaccggggac
cgcactggcctcatcgaggtggtgcttcactcagacaccatcgccaacatccagttgaac
aaaagcaacatggcggccacagctgccttcaacaaggatgccctgctcaactggctcaag
tccaagaaccctggggaggccttggatcgagccatcgaggagtttaccctctcctgtgct
ggctactgtgtggccacttacgtgctgggcatcggagaccggcacagcgacaacatcatg
atccgcgagaacgggcagctcttccacattgatttcggccactttctgggcaatttcaag
accaagtttggaatcaaccgtgagcgagtcccgttcatcctcacgtatgactttgtgcac
gtgatccagcaggggaaaacgaataacagtgagaaatttgaaaggttccggggttactgt
gagcgagcctacaccatcctgaggcgccacgggctgctctttctccacctcttcgccctg
atgcgggccgccggcctgcctgagctcagctgctccaaagacatccagtatctcaaggac
tctctggcgttgggaaagacggaggaggaggccctaaagcacttccgagtgaagttcaac
gaagccctccgggagagctggaagaccaaagtgaactggctggcccacaatgtgtccaaa
gataacaggcaatag

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