Ursus americanus (American black bear): 123775609
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Entry
123775609 CDS
T07931
Symbol
SETX
Name
(RefSeq) probable helicase senataxin isoform X1
KO
K10706
ATP-dependent RNA/DNA helicase, senataxin [EC:
5.6.2.5
5.6.2.3
]
Organism
uar
Ursus americanus (American black bear)
Pathway
uar05014
Amyotrophic lateral sclerosis
Brite
KEGG Orthology (KO) [BR:
uar00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05014 Amyotrophic lateral sclerosis
123775609 (SETX)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03021 Transcription machinery [BR:
uar03021
]
123775609 (SETX)
Enzymes [BR:
uar01000
]
5. Isomerases
5.6 Isomerases altering macromolecular conformation
5.6.2 Enzymes altering nucleic acid conformation
5.6.2.3 DNA 5'-3' helicase
123775609 (SETX)
5.6.2.5 RNA 5'-3' helicase
123775609 (SETX)
Transcription machinery [BR:
uar03021
]
Eukaryotic type
RNA polymerase II system
Other transcription-related factors
Transcription termination factor
123775609 (SETX)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
AAA_11
AAA_12
AAA_19
UvrD-helicase
AAA_30
AAA_22
nSTAND3
ResIII
SLFN-g3_helicase
Helicase_RecD
AAA_16
UvrD_C_2
Motif
Other DBs
NCBI-GeneID:
123775609
NCBI-ProteinID:
XP_045626897
LinkDB
All DBs
Position
Unknown
AA seq
2692 aa
AA seq
DB search
MSTCCWCTPGGVSTVDFLQRYASKSHSSEFQTADEDLCYCLECVAEYHKARDDLPFLHEV
LWELETLRLINHFEKSMKAEIGDDDELYIVDNNGEAQLFDFTGQDFENKLRVPLLEILKY
PYLLLHERVNELCVEALCRMEQANCSFQVFDKHPGIYLFLVHPNEMVRRWAILTARNLGK
VDRDDYYDLQEVLTCLFKVIELGLLESPDIYTSSVLEKGKLILLPSHMYDTTNYKNYWLG
ICMLLTILEEQAMDSLLLGSDKQNDFMQSILHTMERQADDDSVDPFWPALHCFMVILDRL
GSKVWGQRIDPIEAFQTIINNGSYNKEIQNIRNSSVRTKLEPESYLDDMVTCSQIVYNYN
PEKTKKDSGWRSAICPDYCPNMYEEMETLASVLQSDIGQDMRVHNSTFLWFIPFVQSLMD
LKDLGVAYIVEVIHHLHSEVKHVLNQTDAMCDKVTEFFLLILVSVIELHRNKKCLHLLWV
SSQQWVEAVVKCAKLPTTAFARGSEKSSGNCSKGTAMISSLSLHSMPSNSVQLACVQLIR
SLLKEGYQLGQQTLCKRFWDKLNLFLRGNLSLGWQLTTQETHELQTCLKQIIRNIKVKVP
QCSTFVDLSPACKSSPASYSKEESEQIERKSSKDLHCLENLSPTFSKEPMKAEAYQMQEN
ILIKASNTVEEDNEQNYMKDWKLEDHFSAESCMKKSSKNLFTERAQDQVKVSTGKQKSVK
ERCTSRNVLQNCTSRNGPERGCDRGIIMSTRLLTDSSTDALGKASTSNEDFSLKDDALGK
TSKSKTKARKDEICAKLSHVIKKQHRKSTVINNTGDLEENLTVSNIDSFYSRKDSGGQKE
DGFMHNLSLDPNGILDDKNGEQKSQNSLLLKKKQLKSEELDVFSSHENSYQIQERHIDDK
DLVSFTEVTNTAVKKTSPFKDPVTLLESRDKEISKNTSPMSSHSREQAPGLSPQSDTLTD
SQIDRDLHKLSLIAQASVIKFPSDSTQKSSTHLQRRVKDDRRCFPADQNNTGEASRGQII
IISDSDDDDDDEGILGFEKHIKQDKIGIRKECPEQHTSTASTNVEKKLIKEEETKSLLQF
EESDSQFFEFESPCEVFSVWQDQEPEKNSVQENEKNSCSADIADITNDWGYETDYVSEEV
IKKVAEGIEKHTEPQSTISVGEFCEIEVKKRKRKRLEKPVAKDPLKPSPSDRNEDQPDIL
NESGLNENDLKSMDLRTASPSSSVQRDKDTTVSLKKSSPKLRTYSKPIRRVPLSKTPKKT
HSDTKKGQNKGSNYISCRTTPAIVPPKKFRQCPEPTSTVEKLGLKKAPRRAFELSQRSLE
YLVQLRDHGKTVGVVDTRKKTKLISPQTLSVKNNKKLLTSQDLQMRRQMRPKSQQNRQGL
LNYESKDATRAGPCAAQNSDLLVPESDGSDYSYKGGTEVVANNTGKQLIKSVSSEPEPMK
TKYVSQVTDDTCLLNQCAAVVLNGRIPTNEIIVSASADPLGGGDPTVHRLELATLKDGEP
ESNSDTEDENIFLTQLDPEDMDLCSQMENGNEKLIEVVHGKDTAQVEDSVSRPQLESWSS
TKCKYKDCIETPKNQGEYCSKHCEAKAADEDVFRKPGLPISASKPSRPSTAKVFSSSSTS
RIASLSKSLESTSALSPALKNKSNGAQAVLKVPQPASLLSPKSVGEVKSLYNVLRPQTPN
NSNRQAYKLTFGESKSFSTSSPVDILLSSQSISDTFVKEVLKWKYEMFVNFDQCGPPASL
CQSISRPVPVRFQDCGDYFNVFFPLMVLNTFETVAQEWISSPNKEKFYQLHLRKFPADYK
KYWEFVVHLEECELAKQFHPKENDLVFLVPERQNGEKKDTERNRMQDLREYHCGYVHKFR
RTSVMRNGKSECSLSIQTQDNLSLNLNELVKCVVISSLVTTQRKLKAMSLLSGRNQLARA
VLNPNPMDFCTKDLLTTTSERIIAYLRDFNEDQKKAIETAYAMVKHSPSVAKICLIHGPP
GTGKSKTIVGLLYRLLTENQRKGHSDENSNAKIKQNRVLVCAPSNAAVDELMKKIILEFK
EKCKDKKNPLGNCGDINLVRLGPEKSINNEVLKFSLDSQVNHRMKKDLPSHVQEMHRRKE
FLDHQLDELSRQRALCRGGREIQRQELDEKIAKVSKERQELASKIKEVQGRPQKTQSIII
LESHVICCTLSTSGGLLLESAFRGQGGVPFSCVIVDEAGQSCEVETLTPLIHRCNKLILV
GDPKQLPPTVISMKAQEYGYDQSMMARFYKLLEDNVEHNMIGRLPILQLTVQYRMHPDIC
LFPSNYVYNRSLKTNRQTETNRCSSDWPFQPYLVFDVGDGSERRDNDSYVNVQEIKLVME
IIKLIKDKRRDVTFRNIGIITHYKAQKTMIQKDLDKEFDRKGPAEVDTVDGFQGRQKDCV
IVTCVRANTMQGSIGFLASLQRLNVTITRAKYSLFILGHLRTLMENQHWNHLIQDAQKRG
AIIKTCDKNYRHDAAKILKLKPVLQRSLTHPPAAAPEASRPQGGLPSNKLDSEFAKTSFT
SSLYHTPSDSRESTGTVTTKDPERPLIQDRLRDPRLLRRMGLDPEAKGTCLRDPQPSSPQ
QPGATPPSGEPGFPGSHQDPAGAQQSAARGAAPNNHRPHVQCEPPAAGTDVPTSRRRCDW
EGGLSHRRETRAFSEGDKETWSPESHHSKRNPGWDKRGLEKEDSGSKKRRLL
NT seq
8079 nt
NT seq
+upstream
nt +downstream
nt
atgagcacatgttgctggtgtacgccaggtggcgtttccaccgttgacttcctacagcgc
tatgcatccaagagtcactccagtgaatttcagacagctgatgaagacctctgctactgc
ttagagtgtgtggccgaataccacaaagcaagggatgatctgccattcttgcatgaggtt
ttatgggaattagaaaccttacgtctcataaatcactttgaaaaatccatgaaggcagaa
attggagatgatgatgaattatatatagtagacaacaatggagaggcacaactgtttgac
tttactggccaagactttgaaaataagcttcgagttcctcttcttgaaatactgaaatat
ccttacctgcttttacatgagcgtgttaatgaattatgtgttgaagcactttgtcggatg
gaacaagctaattgctcctttcaggtttttgacaaacatccaggcatctatttgtttttg
gtccatcccaatgaaatggttcggcgttgggctatcctgaccgcaagaaatttgggaaaa
gtggacagagatgattattatgacttgcaggaggttttgacttgcctttttaaagtcatt
gaattggggcttttggaaagtccagacatttatacttcttctgtcctcgagaagggtaaa
ctgattcttctgccctcacacatgtatgataccaccaactacaaaaactattggttaggt
atttgcatgttgctgaccattctggaggagcaggccatggactcactgttgctgggctca
gacaaacagaatgactttatgcaatcaatacttcacaccatggagaggcaagcagatgac
gatagtgtggatcctttctggccagcgttacactgtttcatggtgattctggatcgcctt
ggatctaaggtctggggccaacgtattgatcctattgaggcatttcagaccattatcaac
aatgggagctacaataaagagatccagaatatacggaacagctctgtaaggaccaagtta
gaaccagagtcctatttggatgatatggtgacttgcagccagattgtatacaattataat
cccgaaaagaccaaaaaggattcagggtggagatcagccatttgcccagattattgtcct
aacatgtatgaagagatggaaacattagccagtgtgcttcagtcagatattggtcaagac
atgcgtgttcataacagcacgtttctgtggttcatcccttttgttcagtccctcatggat
ctgaaggatttgggtgtggcttacatagtagaggttattcatcacctgcactccgaagtc
aaacatgtcctcaaccaaacagatgccatgtgtgacaaagttaccgaattttttcttctg
attttggtgtccgtgattgagctgcatagaaataaaaaatgtctgcatttgctgtgggtt
agttcccagcaatgggtagaagccgttgtaaaatgtgccaagcttcctaccactgcattt
gcacggggttctgagaagtcatccggaaattgctccaaaggaacagcaatgatatcatct
ctgtcactgcattcgatgccatcgaattctgtacagctggcttgtgtgcagctgattaga
agtctccttaaagaaggttatcagcttgggcagcagactctgtgtaagcgattctgggat
aagctcaacttatttctgcgtggaaatttatctctaggttggcagttgactactcaggaa
acccatgagttacaaacttgtttaaagcaaattattagaaacataaaagtcaaagtacct
caatgtagcacttttgtggatttgagtcctgcatgtaaaagctctcccgcatcttacagt
aaagaagaaagtgaacaaatagagaggaagtctagtaaagacctgcactgtctggaaaac
ttgagcccaacattttctaaagaaccaatgaaagccgaggcataccaaatgcaggagaat
atattgatcaaagcaagtaacactgtagaagaggataatgagcaaaattatatgaaagat
tggaaactagaagatcatttctcagccgagtcatgcatgaagaagagtagtaaaaacctt
ttcactgaaagagctcaagatcaagttaaagtaagtacaggcaagcagaagtctgtgaaa
gagcgttgtacttcaagaaatgtactgcagaattgtacttccaggaatggtccagaaagg
ggatgtgacagaggaataattatgtcaacacgtttgttgaccgattctagcactgatgct
ctggggaaggcatccacatcaaatgaggatttctctctcaaggatgatgcacttggcaaa
acgtcaaaatcaaaaactaaggcacgtaaagatgaaatctgtgctaagttatcacatgta
ataaagaagcaacacaggaaaagtactgtgatcaataatactggtgatttagaggaaaac
ctgactgtgtctaacattgacagcttctattcaaggaaagattcaggaggtcaaaaagag
gacggcttcatgcacaatctctccttagaccctaacggcattctggatgataaaaatggg
gaacaaaaatctcaaaacagtttattgctgaaaaagaaacaactgaagagtgaagagtta
gatgttttctcttcccatgaaaacagctatcaaatacaggaacgccacattgatgataaa
gatttggtctcgtttacagaagtgaccaatactgctgtgaagaaaacttctcccttcaaa
gatcctgtgactcttcttgaatcaagagataaggaaattagcaagaatactagtccgatg
tcttctcactcgagagaacaggctcctggcctcagtcctcagtctgacaccttaacagat
tctcagatagacagagatctccacaagttatctttaatagctcaagccagcgttattaag
ttcccgtcagattcaactcaaaaaagctcaacccacctacaaagaagagtgaaagatgac
agaagatgtttcccggccgaccagaacaatactggggaagcctcccggggccagattatt
attatttcagattctgatgatgatgatgatgatgaaggaattctgggttttgagaaacat
attaaacaagataaaataggcatcaggaaagaatgtccagagcagcatacttcaacagct
agtacgaatgtggaaaagaagctaataaaggaagaggagacaaagtcccttttgcagttt
gaagaatcggattctcagttttttgagtttgaaagtccatgtgaagtgttttcagtttgg
caagatcaggaaccagagaagaattcagttcaagagaacgaaaaaaattcttgttcagct
gacatagctgatatcacgaatgactggggttatgagacagattatgtatctgaagaggtt
attaagaaggtagcagagggcattgaaaaacacacagaaccacagagtactatttctgtt
ggggaattttgtgaaattgaagtaaaaaaacgtaagagaaaacgacttgaaaaacctgtg
gccaaagatcctctaaagccttcaccttctgatagaaatgaggaccagcctgatattctt
aatgagagcggtctgaatgaaaatgatcttaaaagtatggacctgaggacagcaagtccc
agttcaagtgttcagagagacaaagacactacggtttcattaaagaagtcttctccaaag
cttcgtacttactccaaacccattaggagagtcccactttctaaaactcctaagaagaca
cattcagataccaagaaagggcagaataaaggttcaaattacataagttgtaggacaact
cctgctatagttccaccaaagaaattccgccagtgccctgaaccaacttcaacggttgag
aaacttggcctgaagaaggctcctcggagggcatttgagttgtctcagcgatctcttgag
tatttagttcagttacgtgaccatggcaaaactgttggagtggttgatactagaaaaaag
actaagttaatttctcctcagactctgtctgtcaaaaacaataagaaactgctgacaagt
caagatcttcagatgcgaaggcagatgagacccaaatcacaacaaaatagacaaggactt
ttgaattacgaaagtaaagatgctacaagagcagggccgtgtgcagcacagaattctgac
ctacttgtcccagaatcagatggttcagattatagttataaaggaggaactgaggtggtt
gctaacaacactggcaaacagttaataaaatctgtgtcttcggaaccagaacccatgaaa
acaaaatatgtctctcaggtgactgatgatacttgtcttttgaaccagtgtgctgctgtt
gtgttaaatggaagaataccaacaaatgaaatcattgtctctgcttcagcggacccctta
ggtggaggtgacccaacagtacatcgtttagagttggcaacgttgaaagacggagagcct
gaatccaacagtgatacagaagatgagaatatatttctaacacagctcgatcctgaagat
atggatttatgttcacagatggagaatggtaatgagaaactcattgaagtagttcatggc
aaagatacagctcaggtagaagattctgtaagtcggcctcagttggaatcttggagtagc
acaaaatgtaagtacaaagattgtattgaaaccccgaaaaaccagggcgagtactgctca
aaacactgtgaagctaaagcagcggatgaagatgtgtttcgtaaacccggcttgcctatt
tctgcgtctaagccttcaagaccttccactgctaaggtttttagctcaagtagtacttca
cgaattgctagtctttccaagtctttggaaagtacctctgcactttcaccagctctaaaa
aataagtcaaatggggcacaggctgttttgaaagtcccacagccagcctctctgttgtct
ccaaagtcagtgggtgaagtgaagagtttgtacaatgttcttcgtcctcagactccaaat
aattccaacaggcaagcttacaaactgacgtttggtgaaagcaaatccttctcaacttcc
tctccagtcgacattctcttgtcatcgcagtccatctctgacacctttgtcaaagaggtc
ttaaaatggaaatacgaaatgtttgtgaactttgatcagtgcgggcccccagcaagcctt
tgtcagtccatatcaagacctgtgcctgtcagatttcaagattgtggagattattttaat
gtttttttccctttgatggtattgaatacttttgaaacagtggcacaggagtggatcagc
tctccaaacaaagagaaattctatcagttgcatttacgaaaatttcctgctgattataaa
aaatactgggagtttgtggttcatcttgaggaatgtgaactagctaaacagtttcatcca
aaggaaaatgatttggtgtttttggttcctgaaagacaaaatggagagaagaaagatacc
gagagaaatcgcatgcaagacctccgtgaataccattgcggttatgttcataagtttcgc
cgcacttcagtcatgcgcaatgggaaatctgagtgttccctttccatccagactcaagat
aatttgtcactcaatttaaatgaactcgtgaaatgcgtcgtaatcagttctctggtaact
acacagaggaagttgaaagccatgtctttgttgagtggacggaaccaactggcaagagct
gttctgaatccaaaccccatggacttctgtacaaaagatttactaactacaacgtctgag
agaattatcgcctacttaagagatttcaatgaagaccaaaagaaagcgatagaaactgca
tatgccatggtcaaacactccccgtcagttgccaagatctgtctgattcatggaccacct
ggaacaggaaaatcaaaaactatcgttgggcttctgtaccgcctgctgacagagaaccag
aggaaggggcattcagatgagaactccaatgccaaaatcaaacaaaaccgtgtccttgtg
tgtgcaccttccaacgcggctgttgatgaacttatgaaaaaaatcatcctcgaatttaaa
gaaaaatgtaaagacaagaagaatcctttgggaaactgtggagatataaatttagtacgg
ctgggtccagaaaagtctattaataatgaggtcctaaaattcagtttggacagccaagtt
aaccacagaatgaaaaaagacttaccttctcatgttcaggagatgcacagaagaaaggaa
tttctggatcatcagctcgatgaactttcccgccagcgtgctttatgccgaggtggaagg
gaaatacagaggcaagaattagatgaaaaaatcgcaaaggtttcaaaagagaggcaggaa
ctagcttctaaaattaaagaggttcaaggacgcccacaaaaaacacagagcatcatcatc
ctagagtcccatgtcatctgctgcacgttgagcacgagcggcggtttactgcttgagtct
gcttttcgtggacaagggggcgtccccttcagttgtgtcatcgtcgatgaggccgggcag
tcttgtgaggttgagactcttactccactcatccatcgttgtaacaagctcatcctcgtc
ggagatcctaaacagctccctcccacggtcatttctatgaaagcacaggagtatggctac
gaccagtccatgatggcgcgcttctacaagctgttggaagacaacgtggagcataatatg
atcggcaggctgcccattttacagcttactgttcagtacaggatgcacccggacatatgt
ctcttcccctctaattatgtttataacagaagcttgaaaacaaatagacagacagaaacc
aatcggtgttcatcagactggccatttcaaccttacctggtgtttgatgtcggagacggt
tcagaaagacgggataatgactcatatgtaaatgttcaagaaataaaactggtaatggaa
ataattaaacttattaaagacaaaagaagggatgttactttccggaacattggcataata
acccattacaaggctcagaagacgatgattcagaaggatttggacaaagaatttgataga
aaagggccagccgaagtagacaccgtggatgggttccagggccggcagaaggactgcgtc
attgtcacgtgtgtcagagcaaataccatgcagggctcaatcggatttctggcaagtttg
cagagactgaacgtcaccatcacacgagccaagtacagcctcttcatcctcggacattta
aggaccctcatggaaaatcagcactggaaccacctgattcaggacgcgcagaagcggggc
gccatcatcaagacgtgcgacaaaaactacaggcacgacgcagccaagattctgaagctc
aagcccgtgctgcagcgaagtctgactcaccctcccgccgcggccccagaggcgtccaga
ccccagggcggcttgcccagcaacaagctcgacagcgaatttgcgaagacatctttcact
tcttccctgtatcacacaccctctgactccagggaatctactgggactgtcacgacgaag
gatccagaaaggcctctcattcaggaccggcttcgggacccacgactgctcaggaggatg
ggcctggaccccgaagccaaagggacgtgcctgagggatccgcagccttcaagcccccag
cagcccggagcgacacctccctcgggagagccgggcttccctgggagccaccaggatcca
gctggcgcgcagcagtccgctgccagaggggctgctccgaacaaccacagacctcatgtg
cagtgcgagcctccagctgctgggaccgatgtccccacgagtagaagaaggtgtgactgg
gaaggagggctcagccacagaagagagacccgggctttcagtgagggggacaaggagacg
tggagccccgagagccaccactcgaagaggaaccctggctgggacaagaggggactggag
aaggaggacagcggttccaagaaaagaaggcttttatag
DBGET
integrated database retrieval system
