KEGG   Ursus americanus (American black bear): 123776417
Entry
123776417         CDS       T07931                                 
Symbol
JAK2
Name
(RefSeq) tyrosine-protein kinase JAK2 isoform X1
  KO
K04447  Janus kinase 2 [EC:2.7.10.2]
Organism
uar  Ursus americanus (American black bear)
Pathway
uar01521  EGFR tyrosine kinase inhibitor resistance
uar04062  Chemokine signaling pathway
uar04081  Hormone signaling
uar04148  Efferocytosis
uar04151  PI3K-Akt signaling pathway
uar04217  Necroptosis
uar04550  Signaling pathways regulating pluripotency of stem cells
uar04630  JAK-STAT signaling pathway
uar04658  Th1 and Th2 cell differentiation
uar04659  Th17 cell differentiation
uar04725  Cholinergic synapse
uar04917  Prolactin signaling pathway
uar04920  Adipocytokine signaling pathway
uar04933  AGE-RAGE signaling pathway in diabetic complications
uar04935  Growth hormone synthesis, secretion and action
uar05140  Leishmaniasis
uar05145  Toxoplasmosis
uar05152  Tuberculosis
uar05161  Hepatitis B
uar05164  Influenza A
uar05167  Kaposi sarcoma-associated herpesvirus infection
uar05168  Herpes simplex virus 1 infection
uar05200  Pathways in cancer
uar05207  Chemical carcinogenesis - receptor activation
uar05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
uar05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:uar00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    123776417 (JAK2)
   04151 PI3K-Akt signaling pathway
    123776417 (JAK2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    123776417 (JAK2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    123776417 (JAK2)
  09143 Cell growth and death
   04217 Necroptosis
    123776417 (JAK2)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    123776417 (JAK2)
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    123776417 (JAK2)
   04659 Th17 cell differentiation
    123776417 (JAK2)
   04062 Chemokine signaling pathway
    123776417 (JAK2)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    123776417 (JAK2)
   04917 Prolactin signaling pathway
    123776417 (JAK2)
   04935 Growth hormone synthesis, secretion and action
    123776417 (JAK2)
  09156 Nervous system
   04725 Cholinergic synapse
    123776417 (JAK2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    123776417 (JAK2)
   05207 Chemical carcinogenesis - receptor activation
    123776417 (JAK2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    123776417 (JAK2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    123776417 (JAK2)
   05164 Influenza A
    123776417 (JAK2)
   05168 Herpes simplex virus 1 infection
    123776417 (JAK2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    123776417 (JAK2)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    123776417 (JAK2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    123776417 (JAK2)
   05140 Leishmaniasis
    123776417 (JAK2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    123776417 (JAK2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    123776417 (JAK2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    123776417 (JAK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:uar01001]
    123776417 (JAK2)
Enzymes [BR:uar01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     123776417 (JAK2)
Protein kinases [BR:uar01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   123776417 (JAK2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 SH2_1 Jak1_Phl SH2 ABC1 FERM_C_FAK1 RIO1 Kinase-like FERM_M
Other DBs
NCBI-GeneID: 123776417
NCBI-ProteinID: XP_045628329
UniProt: A0A452QRK9
LinkDB
Position
Unknown
AA seq 1132 aa
MGMACLTMTEMEGTSVSPVHQNGDIPGNANPVKDIEPLLQVYLYHSLEKAEGEYLKFPTG
EYVAEDICVAASKACGITPVYHSMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYF
PYWYCNGSNRTYRHGISRGAEAPLLDDFVMAYLFAQWRHDFLHGWIKIPVTHETQEECLG
MAVLDMMRLAKEKDQTPLDIYSSISYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIEQF
SHCKATARNLKLKYLINLETLQSAFYTEQFEVKEPGSGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPDIIDVTIKQASQEGSNESRIVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPMVLENIQSNCHGPILMDFAISKLKKAGNQT
GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLSGTKKNFSNLKDLLNC
YQMETVRSDSIIFQFTKCCPPKLKDKSNLLVFRTNGVSDVPTSPTLQRHNNVNQMVFHKI
RNEDLMFNESLGQGTFTKIFKGIRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWA
MHFLEEKALIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTEL
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE
LLKNNGRLPRPDGCPDEIYLIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
NT seq 3399 nt   +upstreamnt  +downstreamnt
atgggaatggcttgccttacaatgacagaaatggaaggaacatccgtatctcctgtacat
cagaatggtgatattcctggaaacgctaatcccgtgaaggacatagaaccgctcctacag
gtgtatctttatcattctcttgagaaagctgaaggagagtatctgaagtttccaactggg
gagtatgttgcggaagatatttgtgttgctgcttctaaagcttgtggaatcacacctgtg
tatcatagtatgtttgctttaatgagtgaaacagaaaggatctggtatccgcccaaccat
gtcttccatatagatgagtcaaccagacacaatgtactctacagaataagattttacttt
ccttactggtattgtaatggcagcaacagaacctatcggcatggaatatctcgaggtgct
gaagctcctcttcttgacgactttgtcatggcttacctttttgctcagtggcggcatgat
tttttacatggatggataaaaatacctgtgacccatgaaacacaggaagaatgtcttgga
atggctgtgttagatatgatgagactagccaaagagaaggatcaaaccccactggacatc
tatagctctatcagctacaagacattcttaccaaaatgtgttcgagcaaagatccaagac
tatcatattttgacaaggaaacgaataaggtacaggtttcgcagatttattgagcagttc
agccattgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaact
cttcagtctgccttctacacagagcagtttgaagtaaaagaacctggaagtggtccttca
ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga
gggaaacataaagaaagtgagacactgacagaacaggatttacagttatattgtgacttt
cctgatattattgatgttactattaagcaagcaagccaagaaggctcaaatgaaagtaga
attgtaactatccataagcaagatggtaaaaacctggaaattgaacttagctcattaaga
gaagctttgtcctttgtgtcattaattgatggctattatagattaactgcagacgcacat
cattacctctgtaaagaagtagcacctccaatggtccttgaaaatatacaaagcaactgt
catggcccaattttaatggatttcgccatcagtaaactgaagaaagcaggtaatcagact
ggactctatgtacttcgatgcagtcctaaggactttaataagtattttctgacttttgct
gtcgagcgagaaaatgtcattgaatataagcactgtttgattacgaaaaatgagaatgga
gaatacaacctcagtggaaccaagaagaacttcagtaatcttaaagatcttttgaattgc
taccaaatggaaactgttcgctcagacagtataattttccagtttactaaatgctgtccc
ccaaagttgaaagataaatcaaaccttctggtcttcagaaccaatggtgtttctgatgtt
ccaacatcaccaacattacagaggcataataatgtgaaccaaatggtgtttcacaaaatc
agaaatgaagatttgatgtttaatgaaagccttggtcaaggcacttttacaaaaattttt
aaaggtataagaagagaagtaggagactatggtcaactccatgaaacagaagttctttta
aaagttctggataaagcacacagaaactactcagagtctttctttgaagcagcaagcatg
atgagccagctttctcacaagcatctggttttaaattatggagtatgtgtctgtggggag
gagaatattctggttcaagagtttgtaaaatttggatcattagatacatatctgaaaaag
aataaaaattctataaatatattatggaaacttgaagtggctaaacagttggcatgggcc
atgcattttctagaagaaaaagcacttattcatggaaatgtgtgtgccaaaaatattctg
cttatcagagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatcct
ggaattagtattacagttttgccaaaggacattcttcaggagagaataccatgggtacca
cctgaatgcattgaaaatcctaaaaatctaaatttggcaacagacaaatggagttttggt
accactttgtgggaaatctgcagtggaggagataagcctctgagtgctttggattctcaa
agaaagctacagttttatgaagataggcaccagcttcctgcaccaaagtggacagaatta
gcaaatcttattaataattgtatggattatgaaccagattttagaccttctttcagagcc
atcatacgagatcttaatagtttgtttactccagattatgaactattaacagaaaatgac
atgttaccaaatatgagaataggtgccctagggttttccggtgcttttgaagaccgagac
cctacacagtttgaagagagacacttgaaatttctacagcaacttggcaagggtaatttt
ggcagtgtggagatgtgccggtatgaccctctgcaagacaacactggggaggtggtggct
gtgaagaagctccagcacagtactgaagagcacctgagagactttgaaagggaaattgaa
atcctcaaatcgctgcagcatgacaacattgtaaagtacaaaggagtgtgctacagtgct
ggtcggcgtaatctaagattaattatggaatatttaccatatggaagtttacgagactat
ctccaaaaacataaagaacggatagatcataaaaaacttctgcagtatacatctcagata
tgcaagggcatggagtatcttggtacaaaaaggtatatccacagggatctggcaacaagg
aatatattggtggaaaacgaaaacagagttaaaattggagattttgggttaaccaaagtc
ttgccacaagacaaagaatattacaaagtaaaagaacctggtgaaagtcccatattctgg
tatgctccggaatcactgacggagagcaagttttctgtggcttcagatgtctggagcttt
ggagtggttctgtatgaacttttcacgtatattgagaagagtaaaagtcccccagcggaa
tttatgcgtatgattggcaatgacaaacaaggacagatgattgtgtttcatttgatagaa
ctcctaaagaataatggaagattaccaagaccagatggatgcccagatgagatttatttg
atcatgacagaatgctggaacaataatgtcaatcaacgcccctcttttagagacctagct
cttcgagttgatcaaataagggacaacatggctggatga

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