Ursus americanus (American black bear): 123776860 Help Entry 123776860         CDS       T07931                                  Symbol NF1 Name (RefSeq) neurofibromin isoform X1   KO K08052   neurofibromin 1 Organism uar  Ursus americanus (American black bear) Pathway uar01521   EGFR tyrosine kinase inhibitor resistance uar04010   MAPK signaling pathway uar04014   Ras signaling pathway Brite KEGG Orthology (KO) [BR:uar00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     123776860 (NF1)    04014 Ras signaling pathway     123776860 (NF1)  09160 Human Diseases   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     123776860 (NF1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PH_NF1 RasGAP CRAL_TRIO_2 CRAL_TRIO MIF4G_like_2 Motif Other DBs NCBI-GeneID:  123776860 NCBI-ProteinID:  XP_045629134 LinkDB All DBs Position Unknown AA seq 2840 aa AA seqDB search MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTT ILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHF LHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQT DMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFL DSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNP SKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITN SALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEK PTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPE IAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWL REILICRNKFLLKNKADRSSCHFLFLYGVGCDVPSSGTTGQMSMNHEELLPSCTPGASLR KGKGNSSMDSAAGCSGTPPICRQAQTKLEVALYMFLWSPDTEAVLVAMSCFRHLCEEADI RCGVDEVSVHNFLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWED THAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWIN MTGFLCALGGVCLQQRSNSGLATYSPPMGPVSERKGSMISVMSSEGNADTPVSKFMDRLL SLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLTDTNTQ FVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQLV EVMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVSL LAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDENAQTGGRKRGMSRRLA SLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAET VLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWN MFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSF EVDPTRLEQSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNK ATVKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGL KLMSKILQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFI SDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHW SSLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQIN GDLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVYI YNCNSWVREYTKYHERLLTGLKGSKRLIFIDCPGKLAEHIEHEQQKLPAATLALEEDLKV FHNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQF TLTIANQGTPLTFMHQECEAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIAL LNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAANE PHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKLI TMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALA SGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAAH LPYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSLP KFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMRD IPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESCL KGPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALLE QNLHTLDSLRIFNDKSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYR HPSPAIVARTVRILHTLLTLVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRK SLLLTDISMENVPMDTYPIHHGDPSYRTLKENQPWSSPKGSEGYLAATYPTVGQTSPRAR KSMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYEM ETQRIASSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRIL YEYLAEASVVFPKVFPVVHNLLDSKISTLLSLCQDPHLLNPVHGIVQSVVYHEESPPQYQ TAYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPT SPYPPAVQSQLSITANLNLSNSMTSLATSQHSPGIDKEHVELSPTTGHCNSGRTRHGSAS QVQKQRSAGSFKRNSIKKIV NT seq 8523 nt NT seq  +upstreamnt  +downstreamnt atggccgcgcacaggccggtggaatgggtccaggccgtggtcagccgtttcgacgagcag cttccaataaaaacaggacagcagaacacgcataccaaagtcagtaccgaacacaacaag gaatgtcttattaatatttccaaatacaagttttctttggttatcagcggcctcaccact atcttaaagaatgttaacaatatgagaatatttggagaagctgctgaaaaaaatttatat ctctctcagttgattatattggatacactggaaaaatgtcttgctgggcaaccaaaggac acaatgagattagatgaaacaatgctggtcaaacagttgctgcccgaaatctgccatttt cttcatacttgtcgtgaaggaaaccaacatgccgctgagcttcggaattccgcgtctggg gttttattttctctcagctgcaacaacttcaatgcagtgtttagtcgcatttctaccaga ttacaggaattgactgtttgctcagaagacaatgttgatgttcatgatatagaattgtta cagtatatcaatgtggattgtgcaaaattaaaacgactcctaaaggaaactgcatttaaa tttaaagccctaaagaaggttgcacagttagcggttataaatagcctggaaaaagcattt tggaactgggtagaaaattatccagatgaatttacaaagctataccagattccacagact gatatggctgagtgtgcagaaaaactgtttgacttggtggatggttttgctgaaagcacc aaacgtaaagcagcagtttggccattacaaatcattctccttatcttgtgtccagaaata atccaggatatatccaaggatgtggttgatgaaaacaacatgaataagaagttgtttctg gacagtctacgaaaagcacttgctggccacggaggaagcaggcagctgacggaaagtgct gcaattgcttgtgtcaaactgtgtaaagcaagtacttacatcaattgggaagataactct gtcattttcctactagttcagtccatggtggttgatcttaagaacctgctttttaatcca agtaaaccattctcaagaggcagtcagcctgcagacgtggatctaatgattgactgcctc gtttcttgctttcgtataagccctcacaacaaccaacattttaagatctgcctggctcag aattccccttctacatttcactatgtgctggtaaattcactccatcgaatcatcaccaat tctgcgttggactggtggcccaagattgatgctgtatattgtcactcagttgagcttcga aacatgtttggcgaaacccttcataaagccgtgcagggttgtggagcacacccagccata cgaatggcaccgagtcttacatttaaagaaaaagtaacaagccttaaatttaaagaaaaa cctacagacctggagacaaggagctataagtatcttctcttgtccatggtgaaactaatt catgcagatccaaagctcttgctttgtaatccaagaaaacaggggcctgaaacccaaggc agtacagcggagttaataacagggctcgtccagctggtccctcagtcacacatgccagag attgctcaggaagcaatggaggctctgctggttcttcatcagttagatagcatcgatttg tggaatcctgatgctcctgtagaaacattttgggaaattagctctcaaatgcttttttac atctgcaagaaattaactagccatcaaatgcttagtagcacagaaattctcaaatggttg cgggaaattttgatctgcaggaataaatttcttcttaaaaataaggcagatagaagttcc tgtcactttctcttcctttatggggtaggatgtgatgttccttcgagtggaactactggt cagatgtccatgaatcatgaagaactactaccttcttgtactcctggagcctctcttcgg aaggggaaaggaaactcatccatggatagtgcagcagggtgcagcggcaccccgccgatc tgccgacaagctcagactaaactagaagtggccctgtacatgtttctgtggagccctgac actgaagctgtcctggtggccatgtcctgtttccgccacctctgcgaggaagcagatatc cggtgtggggtggatgaggtgtcggtgcacaacttcttgcccaactataacacgtttatg gaatttgcctctgtcagcaatatgatgtcaacaggaagagcagcacttcagaagagagtg atggcacttctaaggcgcattgagcatcccactgcaggaaacactgaggcttgggaagat acgcatgcaaagtgggaacaagctacaaaactaatcctcaactacccaaaagctaaaatg gaagatggccaggctgctgaaagccttcacaagaccattgttaagaggcgaatgtctcat gtgagtggaggaggatccatagatttgtctgacacggactccctacaggaatggatcaac atgactggcttcctttgtgcccttgggggagtgtgcctgcagcagagaagcaattctggc ctggcaacctatagcccacccatgggcccagtcagtgaacgtaagggttccatgatttca gtgatgtcttcagagggaaatgcagatacacctgtcagcaaatttatggatcggctgtta tccttaatggtgtgtaaccatgagaaagtgggacttcaaatacggaccaatgttaaggac ctggtgggtcttgaattgagtcctgctctttatccaatgctgtttaacaaattgaagaat accatcagcaagttttttgactcccaaggacaggttttattgactgacaccaatacgcaa tttgtggagcaaaccatagctataatgaagaatttactagataatcatactgaaggcagc tcagaacatctggggcaagctagcattgaaacaatgatgttaaatctagtcagatatgtt cgtgtgcttgggaatatggtccatgcaattcaaataaaaacgaaactgtgtcagttagtc gaggtaatgatggcaaggagagatgacctctcattttgtcaagagatgaaatttaggaat aagatggtagaatacctgacagactgggtaatgggaacatcaaaccaagcagcagatgat gacgtaaagtgtcttacaagagacttggaccaggcgagcatggaagcagtagtttcactc ctggctggtcttccgctgcagccggaggaaggagatggtgtggaattgatggaagccaaa tcacagttatttcttaagtatttcacattgttcatgaacctcttgaatgactgtagtgaa gttgaagatgagaatgcacaaacaggtggcaggaaacgtggcatgtctcggaggctggca tcactgaggcactgtacagtccttgcaatgtcaaacttactcaatgctaatgtggacagt ggcctcatgcactccataggtttaggttatcacaaagatcttcagacaagagctacattt atggaagttctgacaaaaatcctccagcaaggcacagaatttgacacacttgcagaaacg gtgctggccgaccggtttgagaggctggtggagttggtcacaatgatgggagaccaggga gagctcccgatagccatggcgctggccaatgtggtcccgtgttctcagtgggatgaacta gctcgagttctagtgactctgtttgattctcggcatttactctaccaactgctctggaac atgttttctaaggaagtagaattggcagactccatgcagactcttttccgaggaaacagc ttagccagtaaaataatgaccttctgtttcaaggtatatggtgctacctatctacaaaaa ctcctggatccgttattacgaattgtgatcacatcctctgattggcagcatgttagcttt gaagtggatcctaccaggttagagcagtcagagagccttgaggaaaaccaacggaacctt cttcagatgactgaaaagttcttccatgccatcatcagttcctcctcagaattcccccct cagcttcgaagtgtgtgccactgtttataccaggcaacttgccactccctactgaataaa gctacagtaaaagaaaaaaaggaaaacaaaaaatcagtggttagccagcgtttccctcag aacagcatcggtgcagtgggaagtgccatgttcctcagatttatcaatcctgccatcgtc tcaccatatgaagcagggattttagataaaaagccaccacctagaatcgaaaggggcttg aagttaatgtcaaagatacttcagagtattgccaatcatgttctcttcacaaaagaagag catatgcggccttttaatgattttgtgaaaagcaactttgatgcagcacggaggtttttc cttgatatagcatctgactgtcctacaagtgatgcagtaaatcatagtctttccttcatc agtgacggcaacgtgcttgctttacatcgtctgctctggaacaatcaagagaaaattggc cagtatctttctagcaacagggatcacaaagctgttggaagacgacctttcgataagatg gcgacacttcttgcatacctgggtcctccagagcacaaacctgtggcagatacacactgg tccagccttaaccttaccagttcaaagtttgaggaatttatgactaggcatcaagtacat gaaaaagaagagttcaaggccttgaagacgttaagtattttctaccaagctgggacttcc aaagctgggaaccctatattttattatgttgcacggaggtttaaaactggtcaaatcaat ggcgatttgctgatctaccatgtcttgctgactttaaagccatattatgcaaagccatat gaaattgtagtggaccttacccatactgggcctagcaatcgctttaaaacggactttctc tccaagtggtttgttgtttttcctggctttgcttatgacaatgtctctgcagtgtatatc tataactgtaactcctgggtcagggagtacaccaagtatcacgagcggctgctgactggc ctcaaaggcagcaaaaggctcatcttcatagactgtcctgggaaactggctgagcacata gagcatgaacagcagaaactgcctgctgccacgttggctttagaagaggacctgaaggta ttccacaatgctctcaagctagctcacaaagacaccaaggtttctattaaagttggttct actgctgtccaagtaacctcagcagagcgaacaaaagtcctggggcaatcagtctttcta aatgatatctattatgcttcggaaattgaagagatctgcctggtggatgagaaccagttt accttaaccattgcaaaccagggcacaccgctcaccttcatgcaccaggagtgtgaagcc attgtccagtctatcattcatatccggacacgctgggagctgtcgcagcccgactccatc ccccagcacaccaagattcggccaaaagatgtccctgggacgctgctcaatattgcatta cttaatttaggcagttcagaccctagtttacggtcagctgcctataatcttctgtgtgcc ttaacttgtacctttaatttaaaaatcgagggccagttactagagacatcaggtttatgc atccctgccaacaacaccctctttattgtctctattagtaagacactggcagccaatgag ccacatctcaccttagaatttttggaagagtgtatttctggatttagcaaatctagtatt gaattgaaacacctttgtttggaatacatgactccatggctgtcaaatctcgtccgtttt tgtaagcacaatgatgatgccaagcgtcaaagagttactgctattcttgataagctgata acaatgaccataaatgagaagcagatgtacccatctatccaagccaaaatatgggggagc cttgggcagattacagatctccttgacgttgtactagacagtttcatcaaaaccagtgca acaggtggcctgggatcaataaaagctgaggtgatggcagatactgctgtagctttggct tctggaaatgtgaaattggtttcaagcaaggttattggaaggatgtgcaaaataattgac aagacatgcttatctccaactcctaccttagaacaacatcttatgtgggacgatattgct attttagcacgctacatgctgatgctgtccttcaacaattcccttgacgtggcagctcat ctcccctacctcttccacgttgttactttcttagtagccacagggccgctctcccttaga gcttccacacatggattggtcattaatatcattcactctctgtgtacttgttcacagctt cattttagtgaagagaccaagcaagttttgagactcagtttgacagagttctcattaccc aagttttacctgctgtttggcattagcaaagtcaagtcagctgccgtcattgccttccgc tccagttaccgggacaggtcattctctcccggctcctatgaaagggagacttttgctttg acatccctggaaacagtcacagaagctttgttggagatcatggaggcatgtatgagagat attccaacatgcaagtggctggaccagtggacagaactggctcaaagatttgcattccaa tataatccgtccttgcaaccaagagctcttgttgtcttcggctgtattagcaaacgagtg tctcatgggcagataaagcagattatccgtattcttagcaaggcacttgagagttgcttg aaaggacctgatacttacaacagtcaagttctgatagaagctacagtaatagcactaacc aagttacagccacttcttaataaggactcccctctgcacaaagccctcttctgggtcgct gtggctgtgcttcagctcgacgaggtcaacctgtactcagcaggcaccgcacttctggaa cagaacctgcacaccttagacagcctgcggatattcaacgacaagagtccagaggaggta tttatggcaatccggaatcctctggaatggcactgcaagcaaatggatcattttgttgga ctcaatttcaactctaactttaacttcgcactggttggacacctcttaaaagggtacaga catccttcacctgccattgttgcaagaacagtcagaattttgcatacactactaactctg gttaacaaacatagaaactgtgacaaatttgaggtgaacacacagagcgtggcttactta gcagccttactcacagtgtctgaggaggtccgaagtcgctgtagcctaaaacatagaaag tctcttcttcttactgatatttcaatggaaaatgttcctatggatacatatcccatccat catggcgaccctagctataggacactaaaggagaaccagccgtggtcatctcccaaaggt tctgaagggtaccttgcagccacctatccaaccgtgggccagaccagtccccgagccagg aaatccatgagtttggacatggggcagccttctcaggccaatacgaagaagttgctggga acaaggaaaagttttgatcacttgatatcagacacaaaggctcctaaaaggcaagaaatg gaatcagggatcacaacaccccccaaaatgaggagagtagcagaaactgattatgaaatg gaaactcagaggattgcctcgtcacaacagcacccacatttacgcaaagtttcagtgtcc gaatcaaatgttctcttggatgaagaagtacttactgatccgaagatccaagcacttctt cttactgttctggcgacgctggtaaaatacaccacagatgagtttgatcagcgaattctt tatgaatacttagcagaagccagtgttgttttccccaaggtttttcctgtcgtgcacaat ttattggactcaaagatcagcaccctgttgtcgttgtgccaagatccacatttgttaaat ccagttcacggaatcgtgcagagtgtggtgtaccatgaagagtccccaccgcagtaccaa acagcttacctacaaagttttggttttaatggcttgtggcggtttgcaggacccttttca aagcaaacacaaatcccagactatgctgagcttattgttaagtttcttgatgccttgatt gacacgtatttgcctggaattgatgaagaaaccagtgaggagtccctcctgacacccact tctccttatcctcctgcagtgcagagccagcttagtattactgctaaccttaacctttct aattccatgacctcacttgcaacttcccagcattccccaggaatcgacaaggagcacgtt gaactctcccccaccactgggcactgtaacagtggacgaactcgccacggatccgcaagc caagtgcagaagcaaagaagcgctggcagtttcaaacgtaatagcattaagaagatcgtg tga

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