Ursus americanus (American black bear): 123777576
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Entry
123777576 CDS
T07931
Symbol
TYK2
Name
(RefSeq) non-receptor tyrosine-protein kinase TYK2 isoform X1
KO
K11219
non-receptor tyrosine-protein kinase TYK2 [EC:
2.7.10.2
]
Organism
uar
Ursus americanus (American black bear)
Pathway
uar04217
Necroptosis
uar04380
Osteoclast differentiation
uar04620
Toll-like receptor signaling pathway
uar04621
NOD-like receptor signaling pathway
uar04630
JAK-STAT signaling pathway
uar04658
Th1 and Th2 cell differentiation
uar04659
Th17 cell differentiation
uar05145
Toxoplasmosis
uar05160
Hepatitis C
uar05161
Hepatitis B
uar05162
Measles
uar05164
Influenza A
uar05165
Human papillomavirus infection
uar05167
Kaposi sarcoma-associated herpesvirus infection
uar05168
Herpes simplex virus 1 infection
uar05169
Epstein-Barr virus infection
uar05171
Coronavirus disease - COVID-19
Brite
KEGG Orthology (KO) [BR:
uar00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
123777576 (TYK2)
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
123777576 (TYK2)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
123777576 (TYK2)
04621 NOD-like receptor signaling pathway
123777576 (TYK2)
04658 Th1 and Th2 cell differentiation
123777576 (TYK2)
04659 Th17 cell differentiation
123777576 (TYK2)
09158 Development and regeneration
04380 Osteoclast differentiation
123777576 (TYK2)
09160 Human Diseases
09172 Infectious disease: viral
05161 Hepatitis B
123777576 (TYK2)
05160 Hepatitis C
123777576 (TYK2)
05171 Coronavirus disease - COVID-19
123777576 (TYK2)
05164 Influenza A
123777576 (TYK2)
05162 Measles
123777576 (TYK2)
05168 Herpes simplex virus 1 infection
123777576 (TYK2)
05167 Kaposi sarcoma-associated herpesvirus infection
123777576 (TYK2)
05169 Epstein-Barr virus infection
123777576 (TYK2)
05165 Human papillomavirus infection
123777576 (TYK2)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
123777576 (TYK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
uar01001
]
123777576 (TYK2)
Enzymes [BR:
uar01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
123777576 (TYK2)
Protein kinases [BR:
uar01001
]
Non-receptor tyrosine kinases
JAK family [OT]
123777576 (TYK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
Jak1_Phl
FERM_F2
SH2_1
FERM_F1
Kinase-like
RA_2
Kdo
FERM_C_FAK1
ABC1
Motif
Other DBs
NCBI-GeneID:
123777576
NCBI-ProteinID:
XP_045630283
LinkDB
All DBs
Position
Unknown
AA seq
1205 aa
AA seq
DB search
MPLCHWGATTRDSRPDGDGTQPMATRGGLKVLLHWAGPGGGDPWVTFSEATLTAEEVCIH
IAQKVGITPSCLNLFALFDAQAQVWLPPNHVLEISRDMSLTLYFRMRFYFRNWHGTNPQE
PAVYRCGPPGAKSSSEQAEQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSSEEEIHHF
KNESLGMAFLHLCHLALCHGVPLEKVAKKISFKDCIPRSFRLQIRRHNALTRLRLRNIFR
RFVRAFQPGHVSQQVIMVKYLATLEQLAPRFGTERVPVCRLQLPAQAGGEPYYIRDGGQP
PPDPGPELAPGPPTHEVLVTGTGGIQWRPVQAEGEHAGDRTVIALLHPLPHVLGFQGPRG
DGSSRNPHAGPSGKKTKAPEVVDQPADRPREAPWAYFCDFRDITHVVLKERHVSIHCQDN
KSLELTLPSRAAALSLVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIQEGIHGPLLEPFV
LAKLRPEDGLYLVHWSASHLNRLILTVAQREQAPGTQHVHLRKFPIELQAGVFTLEGWDR
SFPSVRELRAALQGCSLRAGDDCFSLRRCCLPRPGEISNLIVMRGPRASTGPPNLSQLSF
HRVCRDDITQLSHLGQGTRTNVYEGILRVGGRSPEEGMADGEDPPTPSGDRGQELRVVLK
VLDPSHHDIALAFYETASLMSQVSHVHLAFVHGICVHGSENIMVTEYVEHGPLDVWLRRE
KGHTPVAWKVVVAQQLASALSYLEDKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGV
GLGALSREERVERIPWIAPECLSGGANSLTTAADKWGFGATLLEICFDGEAPLQGRGPSE
KECFYQKQHRLPQPSCPELATLTSQCLTYEPAQRPSFRTILRDLTQLQPQNLADVLAVNP
DSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCSPQLRT
GWRREIDILRTLYHKHIVKYRGCCEDPGEKSVQLVMEYVPLGSLRDYLPRHSVGLAQLLL
FAQQICEGMAYLHGQHYVHRDLAARNVLLDNDRLVKLGDFGLTKAVPEGHEYYRVREDGD
SPVFWYAPECLKECKFYYASDVWSFGVTLYELLTYCDSSQSPPSKFIELIGLTQGQMTVL
RLTELLERGERLPRPERCPCEIYLLMKNCWEAEASFRPTFQNLIPILKTAQEKYQGQAAS
VFNVC
NT seq
3618 nt
NT seq
+upstream
nt +downstream
nt
atgcctctgtgccattggggtgccaccaccagggacagcaggcctgatggcgatggaact
cagcccatggccaccaggggaggcctgaaggttcttctgcactgggctggccctggtggc
ggggacccatgggtcaccttcagcgaagccacactgaccgcagaggaggtctgcatccac
attgcacaaaaagttggtatcactccatcctgcctcaatctctttgctctcttcgatgcc
caggctcaggtctggctgcccccaaaccatgtcttggagatctccagagacatgagcctg
acattgtatttccgcatgaggttttatttccggaactggcatggcacaaaccctcaggaa
ccggctgtgtaccgctgtgggcccccaggggccaagtcttcctcagaacaggcagagcag
gggatgcaattgctggacccagcctcctttgagtacctctttgagcagggcaagcatgag
tttgtgaatgacgtggcatcactgtgggagctgtcgagcgaggaggagatccaccatttt
aagaacgagagtctgggcatggcctttctgcacctctgccacctggctctctgccatggc
gtccccctggagaaggtggccaagaagatcagcttcaaggactgtatcccgcgctccttc
cggctgcagatccggcggcacaacgcgctgacgaggctacgcttgcggaacatcttccgc
aggttcgtgcgggccttccagccgggccacgtctcgcagcaggtcatcatggtcaagtac
ctggccacgctcgagcagctggcaccccgcttcggcacggagcgcgtgcccgtgtgccgc
ctgcagctaccggcccaggccggtggggagccctactacatccgggacggcgggcagcct
cccccagatcctgggccggagttggcccccggaccccccactcatgaggtgctggtgacg
ggcacgggtggcatccagtggcggccggtacaggcagagggagaacatgcgggagaccga
acggtcatagccctgcttcatcccctgccccacgtgctgggtttccagggtcccagaggc
gatggcagcagcaggaatccccatgctggcccatctgggaagaaaaccaaggccccagag
gtggtcgaccagccagcagacaggcctcgggaagcgccatgggcctacttctgtgacttc
cgggatatcacgcacgtggtgctgaaagaacgccacgtcagcatccactgtcaggacaac
aagagcctggagctgaccctgccttcccgggccgcggccctgtccttggtgtcgctggtg
gacggctatttccgccttaccgccgactcgagccactacctgtgccacgaggtggctcct
ccgcggctggtgatgagcatccaggagggtatccacggacccctgctggagccgtttgtg
ctggccaagctgcggccggaggatggcctctacctcgtccactggagcgccagccacctc
aaccgcctcatcctgaccgtggcccagcgtgagcaggcaccgggcacacagcacgtgcac
ctgcgtaaattccccattgagctgcaggcgggggtcttcacgctggagggctgggaccgg
tccttccccagcgtgcgcgagctgcgagctgccctgcagggttgctccctgcgggctggc
gatgactgtttctccctgcgtcgctgctgcctgccgcggccgggagagatctccaacctc
atcgtcatgcgggggcctcgggccagcacgggcccccccaacctcagccagctcagcttc
caccgggtctgccgggatgacatcacccagctctcccacttgggccaaggcacaaggacc
aatgtgtatgagggcatcttacgagtggggggcagaagccccgaggagggcatggcagat
ggtgaggacccccccacgcccagtggggaccgtgggcaagagctccgagtggtactcaag
gtgctggaccccagtcaccatgatatcgccctggccttctacgagacagccagcctcatg
agccaggtgtcccacgtgcacctggccttcgtgcacggcatctgcgtgcacggctctgag
aacatcatggtgacggagtacgtggagcacgggcccctggatgtgtggctgcggcgagag
aagggccacacgcctgtggcctggaaggtggtggtggcccagcagctggccagcgccctc
agctacctggaagacaagaacctggttcatggtaatgtgtgtggccggaacattctgctg
gcacgactggggctggcggagggcaccagccccttcatcaagctgagcgaccccggtgtg
ggcctgggcgccctttccagggaggagcgggtggagcggatcccctggatagcccccgag
tgtctctctggtggagccaacagcctaaccaccgcagccgataaatggggctttggtgcc
accctcctggagatctgcttcgacggggaggcccctctgcagggccgtggcccctctgag
aaagagtgtttctaccagaagcagcaccggcttcctcagccctcctgcccggagctggcc
acactcaccagccagtgcctgacctatgaaccagctcagcggccctccttccgcaccatc
ctgcgtgacctcactcaactgcagccccagaatcttgctgacgtcttggctgtgaacccc
gactcgcctgcgtcagaccccaccgttttccacaagcgctatttgaaaaagatccgggat
ctgggcgagggtcatttcggcaaggtcagcctgtactgctacgaccccacgaacgacggc
actggggagatggtggccgtgaaggccctcaaggcggactgcagcccccagctgcgcacc
ggctggaggcgggagatcgacatcctgcgcacgctctaccacaagcacatcgtcaagtac
aggggctgctgcgaggacccaggagagaagtcggtgcagctcgtcatggagtacgtgcct
ctgggaagcctgcgcgactacctgccgcggcacagcgtcggactcgcgcagctgctgctc
ttcgctcagcagatctgtgagggcatggcctaccttcacggacagcactacgtgcaccga
gacctggctgcccgcaacgtgctgctggacaacgacaggctggtcaaacttggggacttt
ggcctgaccaaggctgtgcctgagggccatgaatactaccgcgtgcgcgaggacggggac
agccccgtattctggtatgccccagagtgcctgaaggagtgtaagttctactatgcgtcc
gacgtctggtccttcggcgtcaccctctacgagctgctgacctactgtgactccagccag
agccccccctcgaaattcatcgagctcataggcctcacccaggggcagatgacggtgctg
aggctcactgagctgctggaacgaggggagaggctgccccggccagagagatgtccttgt
gagatctatctcctcatgaagaactgctgggaggcagaggcttcattccgtcccaccttc
cagaacctcatacccattctcaagaccgcccaggagaaataccaaggccaggccgcctca
gtgttcaatgtgtgctga
DBGET
integrated database retrieval system
