KEGG   Ursus americanus (American black bear): 123778465
Entry
123778465         CDS       T07931                                 
Symbol
PLCB3
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
uar  Ursus americanus (American black bear)
Pathway
uar00562  Inositol phosphate metabolism
uar01100  Metabolic pathways
uar04015  Rap1 signaling pathway
uar04020  Calcium signaling pathway
uar04022  cGMP-PKG signaling pathway
uar04062  Chemokine signaling pathway
uar04070  Phosphatidylinositol signaling system
uar04071  Sphingolipid signaling pathway
uar04072  Phospholipase D signaling pathway
uar04081  Hormone signaling
uar04082  Neuroactive ligand signaling
uar04261  Adrenergic signaling in cardiomyocytes
uar04270  Vascular smooth muscle contraction
uar04310  Wnt signaling pathway
uar04371  Apelin signaling pathway
uar04540  Gap junction
uar04611  Platelet activation
uar04613  Neutrophil extracellular trap formation
uar04621  NOD-like receptor signaling pathway
uar04713  Circadian entrainment
uar04720  Long-term potentiation
uar04723  Retrograde endocannabinoid signaling
uar04724  Glutamatergic synapse
uar04725  Cholinergic synapse
uar04726  Serotonergic synapse
uar04728  Dopaminergic synapse
uar04730  Long-term depression
uar04742  Taste transduction
uar04750  Inflammatory mediator regulation of TRP channels
uar04911  Insulin secretion
uar04912  GnRH signaling pathway
uar04915  Estrogen signaling pathway
uar04916  Melanogenesis
uar04918  Thyroid hormone synthesis
uar04919  Thyroid hormone signaling pathway
uar04921  Oxytocin signaling pathway
uar04922  Glucagon signaling pathway
uar04924  Renin secretion
uar04925  Aldosterone synthesis and secretion
uar04926  Relaxin signaling pathway
uar04927  Cortisol synthesis and secretion
uar04928  Parathyroid hormone synthesis, secretion and action
uar04929  GnRH secretion
uar04933  AGE-RAGE signaling pathway in diabetic complications
uar04934  Cushing syndrome
uar04935  Growth hormone synthesis, secretion and action
uar04961  Endocrine and other factor-regulated calcium reabsorption
uar04970  Salivary secretion
uar04971  Gastric acid secretion
uar04972  Pancreatic secretion
uar04973  Carbohydrate digestion and absorption
uar05010  Alzheimer disease
uar05016  Huntington disease
uar05017  Spinocerebellar ataxia
uar05022  Pathways of neurodegeneration - multiple diseases
uar05142  Chagas disease
uar05143  African trypanosomiasis
uar05146  Amoebiasis
uar05163  Human cytomegalovirus infection
uar05200  Pathways in cancer
uar05415  Diabetic cardiomyopathy
uar05417  Lipid and atherosclerosis
Module
uar_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:uar00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    123778465 (PLCB3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    123778465 (PLCB3)
   04310 Wnt signaling pathway
    123778465 (PLCB3)
   04371 Apelin signaling pathway
    123778465 (PLCB3)
   04020 Calcium signaling pathway
    123778465 (PLCB3)
   04070 Phosphatidylinositol signaling system
    123778465 (PLCB3)
   04072 Phospholipase D signaling pathway
    123778465 (PLCB3)
   04071 Sphingolipid signaling pathway
    123778465 (PLCB3)
   04022 cGMP-PKG signaling pathway
    123778465 (PLCB3)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    123778465 (PLCB3)
   04081 Hormone signaling
    123778465 (PLCB3)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    123778465 (PLCB3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    123778465 (PLCB3)
   04613 Neutrophil extracellular trap formation
    123778465 (PLCB3)
   04621 NOD-like receptor signaling pathway
    123778465 (PLCB3)
   04062 Chemokine signaling pathway
    123778465 (PLCB3)
  09152 Endocrine system
   04911 Insulin secretion
    123778465 (PLCB3)
   04922 Glucagon signaling pathway
    123778465 (PLCB3)
   04929 GnRH secretion
    123778465 (PLCB3)
   04912 GnRH signaling pathway
    123778465 (PLCB3)
   04915 Estrogen signaling pathway
    123778465 (PLCB3)
   04921 Oxytocin signaling pathway
    123778465 (PLCB3)
   04926 Relaxin signaling pathway
    123778465 (PLCB3)
   04935 Growth hormone synthesis, secretion and action
    123778465 (PLCB3)
   04918 Thyroid hormone synthesis
    123778465 (PLCB3)
   04919 Thyroid hormone signaling pathway
    123778465 (PLCB3)
   04928 Parathyroid hormone synthesis, secretion and action
    123778465 (PLCB3)
   04916 Melanogenesis
    123778465 (PLCB3)
   04924 Renin secretion
    123778465 (PLCB3)
   04925 Aldosterone synthesis and secretion
    123778465 (PLCB3)
   04927 Cortisol synthesis and secretion
    123778465 (PLCB3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    123778465 (PLCB3)
   04270 Vascular smooth muscle contraction
    123778465 (PLCB3)
  09154 Digestive system
   04970 Salivary secretion
    123778465 (PLCB3)
   04971 Gastric acid secretion
    123778465 (PLCB3)
   04972 Pancreatic secretion
    123778465 (PLCB3)
   04973 Carbohydrate digestion and absorption
    123778465 (PLCB3)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    123778465 (PLCB3)
  09156 Nervous system
   04724 Glutamatergic synapse
    123778465 (PLCB3)
   04725 Cholinergic synapse
    123778465 (PLCB3)
   04728 Dopaminergic synapse
    123778465 (PLCB3)
   04726 Serotonergic synapse
    123778465 (PLCB3)
   04720 Long-term potentiation
    123778465 (PLCB3)
   04730 Long-term depression
    123778465 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    123778465 (PLCB3)
  09157 Sensory system
   04742 Taste transduction
    123778465 (PLCB3)
   04750 Inflammatory mediator regulation of TRP channels
    123778465 (PLCB3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    123778465 (PLCB3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    123778465 (PLCB3)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    123778465 (PLCB3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    123778465 (PLCB3)
   05142 Chagas disease
    123778465 (PLCB3)
   05143 African trypanosomiasis
    123778465 (PLCB3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    123778465 (PLCB3)
   05016 Huntington disease
    123778465 (PLCB3)
   05017 Spinocerebellar ataxia
    123778465 (PLCB3)
   05022 Pathways of neurodegeneration - multiple diseases
    123778465 (PLCB3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    123778465 (PLCB3)
   05415 Diabetic cardiomyopathy
    123778465 (PLCB3)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    123778465 (PLCB3)
   04934 Cushing syndrome
    123778465 (PLCB3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:uar04131]
    123778465 (PLCB3)
Enzymes [BR:uar01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     123778465 (PLCB3)
Membrane trafficking [BR:uar04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    123778465 (PLCB3)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    123778465 (PLCB3)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2
Other DBs
NCBI-GeneID: 123778465
NCBI-ProteinID: XP_045631796
LinkDB
Position
Unknown
AA seq 1230 aa
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLRVDSNGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVAGPDPVNTTFLNF
MAVQDDTAKVWTEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL
GGEENGILPLEALDLSTDMTQPLSSYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIDPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSTGVPNS
SVRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGPEKPSLEPQKSLGE
DGLPRGPDALGSADREDEEEEEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV
KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM
PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGHSGYLLKPEFMRRPDKSFDPFTEVIV
DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP
FDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYICLRNEANQPLCLPALLI
YTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQAGPETCQETQSQQL
GSQLTPNPTPSPLDTSPRRPPGPVTSPTSPSLSSPGQRDDLIASLLSEVAPTPLDELRGH
KALVKLRSRQERELRELQKKHQRKAVALTRRLLDGLAQARAEGRCRQQRGVLGGENEKEE
EEEVRRYQEFQKRQVQSLLELREAQVDTEAERRLEHLRQAQQRLREIVLDFHTTQFKRLK
EMNEREKKELQKILDRKRHNSISEAKTREKHKKEAELTEINRRHITESVNSIRRLEEAQK
QRHERLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGDTPEGLGDGRL
VACASNGHAPGSGGHLSGADSESQEENTKL
NT seq 3693 nt   +upstreamnt  +downstreamnt
atggcgggcgccaggcccggcgtccacgcgctgcagctggagccgcccaccgtggtagag
accctgcggcgcgggagtaagttcatcaaatgggacgaggaggcctccagtcggaacctg
gtaaccctgcgtgtggactcgaatggcttctttctgtactggaccggacccaacatggag
gtggacacactggacatcagttccatcagggacacgcggacggggcgttacgcccgcctg
cccaaggaccccaagatccgggaggtgctgggctttgggggccctgacgcccggctggag
gagaagttgatgacggtggtggccgggccagacccagtgaatacgacgttcttgaacttc
atggccgtgcaggatgacacagccaaggtctggaccgaggagctgttcaagctggctatg
aacatcctggctcagaacgcctcccggaacaccttcctgcgaaaagcatacacaaagctg
aagctgcaagtgaaccaggacggacggatcccggtgaagaatatcctgaagatgttttca
gcagataaaaagcgagtagagactgcactggaatcctgtggcctcaatttcaaccggagt
gagtccatccggccggacgaattttccttggaaatcttcgagcggttcctgaataagttg
tgtttgcggccagacattgacaagatcctgctggagataggcgccaagggcaagccgtac
ctgacgctggagcagctcatggacttcatcaaccagaagcaacgggacccgaggctcaac
gaagtgctgtacccacccctgcggccctcgcaggcccggctgctcattgagaagtatgag
cccaaccagcagttcctggagcgagaccagatgtccatggagggcttcagccgctacctg
ggaggtgaggagaacggcatcctgcctctggaggccctggatctgagcacagacatgacc
cagccgctgagctcctacttcatcaactcctcgcacaacacctatctcacagcggggcag
ctggccgggacctcgtcggtggagatgtaccgccaggcgctgctgtggggctgccgctgc
gtggagctggatgtgtggaaagggcggccgccggaggaggagcccttcatcacccacggc
ttcaccatgaccaccgaggtgccgctgcgagatgtgctcgaggccatcgcggaaaccgcc
ttcaagacctcgccctaccccgtcatcctctccttcgagaaccacgtggactcggcaaag
cagcaggccaagatggccgagtactgccgttccatctttggggatgcgctgctcattgac
ccgctggacaagtacccgctggccccaggcgtccccctgcccagcccccaggacctgatg
ggccgcatcctggtgaagaacaaaaagcgacaccggcccagcactggtgtccccaacagc
tctgtgcgtaagcggccgctggagcagagcaactcggccctgagcgagagctctgccgcc
accgagccctcctcacctcagctcgggtcccccagttctgacagctgcccaggcctgagc
aacggggaagaggtgggcccggagaagcccagcctggagcctcaaaagtctctgggcgag
gacgggctaccgaggggccctgatgctcttgggtctgctgaccgtgaggacgaggaggaa
gaggaggaagaggaggaacagacagatcctaaaaagccgaccacagatgagggcactgct
agcagtgaggtcaatgccaccgaggaaatgtcaacactcgtcaactacatcgagcctgtc
aagttcaagtcctttgaggctgctcgaaaaaggaacaaatgcttcgagatgtcatccttc
gtggaaaccaaggccatggagcagctgaccaagagccccatggagtttgtggaatacaat
aagcagcagctcagccggatctaccccaagggcacccgcgtggactcgtccaactacatg
ccccagctcttctggaacgtcggctgccagcttgtcgcgctcaacttccagaccctggac
gtggcgatgcagctcaacgcgggcgtgttcgagtacaacgggcacagcggctacctgctc
aagcccgagttcatgcggcggccagacaagtccttcgatcccttcaccgaggtcatcgtg
gacggcatcgtggccaatgccttgcgggtcaaggtgatctcggggcagttcctgtccgac
aggaaggtgggcatctacgtggaggtggacatgttcggcctccccgtggacacgcggcgc
aagtaccgcactcggacctctcaggggaactccttcaatcctgtgtgggacgaggagccc
tttgacttccccaaggtagtgctgcccacactggcttcactgcgcatcgcggcctttgag
gagggcggcaagtttgtggggcatcggattctgcccgtctctgccatccgctcaggatac
cactacatctgtctgcggaacgaggccaaccagccactctgcctgccggccctgctcatc
tacaccgaagcctctgactacatccctgatgaccaccaggactacgccgaggccctgatc
aaccccatcaagcacgtcagcctgatggaccagagagccaagcagttggccgccctcatt
ggggagagcgaggctcaggccggcccagagacctgccaggagactcagtctcagcagctg
gggtcccagctgaccccaaaccccacacccagccctctggacacctccccgcgccggccc
ccaggccctgtcacgtcccctaccagcccctcgctcagcagtccagggcagcgggacgac
ctcatcgccagtctcctgtcagaggtggccccgaccccgctggatgagctccgaggccac
aaggcgctggtgaagctccggagccggcaggagcgagagctgcgggagctgcagaagaag
caccagcgaaaggccgtcgccctcacgcgccggctcctcgacggcctggctcaggcgcgg
gcagagggcaggtgccgccagcagcggggggtcctaggcggggaaaacgagaaggaggag
gaggaagaggtgaggcggtatcaagagttccagaagagacaggtgcagagtctgctggag
ctgagggaggcccaggtagatacagaggctgagcggaggctggagcacctgagacaggct
cagcagcggctcagggagattgtcctggattttcacacaactcagttcaagaggctgaag
gagatgaacgagagggagaagaaggaactgcagaagattctggacaggaagcgccacaac
agtatctcagaggccaagacaagggagaaacataagaaggaggcggaactgacagagatt
aaccggcggcatatcaccgagtcggtcaactccatccgccggctggaggaggcccagaag
cagcggcatgagcgccttgtggccgggcagcagcaggtcctacagcagctggcagaagag
gagcccaagctgctggcccagctggcccaggagtgtcaggagcagcgggcgaggctgccc
caggagatccgccggagcctgctgggcgacacgccggaggggctgggggacgggcgtctg
gtggcctgtgccagcaacggtcacgcacccgggagcggcgggcacctgtctggcgctgac
tcggagagccaagaggagaatacgaagctctga

DBGET integrated database retrieval system