Ursus americanus (American black bear): 123778876
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Entry
123778876 CDS
T07931
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2 isoform X1
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
uar
Ursus americanus (American black bear)
Pathway
uar05012
Parkinson disease
uar05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
uar00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
123778876 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
123778876 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
uar01001
]
123778876 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
uar04131
]
123778876 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
uar04147
]
123778876 (LRRK2)
Enzymes [BR:
uar01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
123778876 (LRRK2)
Protein kinases [BR:
uar01001
]
Serine/threonine kinases: TKL group
LRRK family
123778876 (LRRK2)
Membrane trafficking [BR:
uar04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
123778876 (LRRK2)
Exosome [BR:
uar04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
123778876 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
LRR_8
Roc
LRR_4
COR
Ras
LRR_14
LRR_9
WD40_CDC20-Fz
Beta-prop_RSE1_2nd
Beta-prop_EML_2
Arf
LRR_13
WDR55
WD40_like
LRR_NXF1-5
AAA_22
T2SSE
Ank_2
PduV-EutP
LRR_6
ABC_tran
nSTAND3
G-alpha
MMR_HSR1
Beta-prop_BBS7
SRPRB
WD40_WDHD1_1st
GTP_EFTU
AAA_7
Kdo
TniB
AAA_16
Beta-prop_WDR19_1st
TsaE
cobW
MobB
Septin
AAA_29
AAA_23
NACHT
WD40_Prp19
TrwB_AAD_bind
Arm
ARM_CUL7_CUL9
SRP54
Motif
Other DBs
NCBI-GeneID:
123778876
NCBI-ProteinID:
XP_045632486
LinkDB
All DBs
Position
Unknown
AA seq
2534 aa
AA seq
DB search
MASGSCQGCEEEDEETLKKLIVRLNNVQEGKQIETLVQILEDMLVFTYADHASKLFQGKK
VHVPVLIVLDLYMRVASVQQVGWSLLCKLIEICPNTMQSLMGPQDIGRDWEVLGVHQLIL
KMLTVHNASVNLLTVGLKALDLLLTSGKITLLILDEESDIFLLIFDAMRTFSANDEIQKL
GCKALRVLFERVSEEQLTEFVENKDYMILLNALKNFKDEEEIVLHVLRCLHSLAIPCNNV
EVLMSGNVRCYNIVVEAMKAFPVNEKIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAV
RRYSENATLQIAGLSCLALLTETIFLNQDLEEKNENPENDDEEEDKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKEVFQASAN
ALSTLLEQNVNFRKILLSKGIYLNVLELMQRHIHSPEVAESGCKMLNHLFEGSSVTLDTM
AAVAPKIITVMKSHEASLSVQLEGLRAVLHFIVPGMPEDSREDTEYQHKLHMVKKQCFKN
DIHKLVLAALNRFIGNPGIQKCGLKVISSIAHSPDALEVLSLEGAIDSVLHTLQMYPDDQ
EIQCLGLSLTGCLITKKNLCIGTGHLLAKILVSSLQRFKDMAEVQIKGFQTILTILELSV
SFSKLLVHHSFDSVIFHQMSSSIMEQKDQQFLNLCCKCFAKLAMDDELKSVLLERACDQN
NSIMVECLLLLGADANGTKEATSLICQVCEKASSPKLVELLLNGGSREQDVRKALTISIG
KGDSQIISLLLRRLALDLANNSICLGGFCIGKIDPSWLGPLFPDKTSNLRKEINIGSTLA
RMVLRYQVKSAVEEGAASGSNGNFPEGVLDKFDEWTFIPDSYVDSVFGQSDDLDSEGSEG
SFLVKRKSNSISVGEFYRDRALQHCSPNLQRHSCSLGPIFDHEDLLRRKRKILSSDDSLR
SSKLQSHMRHSDSISSLASEREYITSLDLSANELKDIDALSQKCCISGHLEHLEKLELHQ
NALTSFPQQLCETLKCLTHLDLHSNKFTSFPSYLLKMNCIANLDVSRNDISPSVVLDSAV
KCPTLKQFNLSYNQLSSFPENLGDVVEKLEQLILEGNKIPEICSPLSLKELKILNLSKNH
ITSLSEDFLEACPKVESFSARMNYLAAMPFLPSSLTSLKLSQNRFTCVPEAILNLPHLRS
LDMSSNEIEYLPSPAHWKSLNLREILFSFNQISILDLSEKAYVWSRVEKLHLSHNKLKEI
PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELRLNFDFKHIGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLTKTKKSDLGVQSATVGIDVKDWPIQI
RGKGRKDLILNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVSDEKQRKACITKITKELLNKRGFPAIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPVEFPVIDRKQLLQLVKEN
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVEGYPK
HPKGIISRRDVEKFLSKKKRFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI
LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKLFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKGSLTRTLQHRIALHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVSRGNVIYNQQADVYSFGLLLYDILTTGGRIAEGLKFPNEFDELAIQGKLPDPVKEYG
CAPWPMVEKLIKKCLKENPQERPTSAQVFDNLNSAELICLMRHITIPKNFSVECMVSTNH
NNKNASIWLGCGHRDKGQLLFLDLNTEKHTSEEVIDSRILCLALVPLPVEKESWIVCGTQ
SGTLLVINTEDGEKRHTLEKMTDSVTCLYCNPFPKQSKQKNFLLVGTADGNLAIFEDKTV
KCKGAVPLKILNIGNVSTPLMCLSESMNSAEKNIMWGGCGTKLFSFSDDFTIQKRIETKT
NQLFSYAAFSDSNIIAVVVDTALYVAKKNSPFVEVWDKKTEKLCELIDCVHFLKEEMVKV
TAESKHKLSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRIIRIIHNFCDSVRVMMT
AQLEDSYFFKGSLKNVMLVLGYIRKSTESTQHQKEIQSCLSVWDLNLPHEVQNLEKHIEV
RKELAEKMRRISVE
NT seq
7605 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggcagctgtcaggggtgcgaggaggaggacgaggaaactctgaagaagttg
atagtcaggctgaacaatgtccaggaaggaaaacagatagagaccctggtgcaaattctg
gaggatatgctggtgttcacgtacgccgaccacgcctccaagttatttcaaggcaaaaaa
gtccacgtgcctgtgttgatcgtcttggacttgtatatgagagtcgctagtgtacagcag
gtgggttggtcacttctttgcaaattgatagaaatctgtccaaatacaatgcaaagctta
atgggacctcaagatattggacgtgattgggaagtacttggggttcaccaactgattctt
aaaatgctaacagttcataatgccagtgtaaacctgttaacagtcggactgaaggcctta
gatctccttctaacttcaggcaaaatcactttgctgatattggatgaagaaagtgatatt
ttcttgttaatttttgatgccatgcgcacattttcagccaatgacgaaatccagaaactt
ggatgcaaagctttacgtgtgctgtttgaaagagtttcagaggagcagctgactgaattt
gttgagaataaagattatatgatcttgctcaatgcgttaaaaaattttaaagatgaagag
gaaattgtgcttcatgtcctgcgctgtttacactccctagcaattccttgcaataatgtt
gaagtcctcatgagtggcaatgtcaggtgttacaatattgtggtagaagccatgaaagca
ttccctgtcaatgaaaaaattcaagaagtaagttgctgcttgctccataggcttacatta
ggtaatttttttaatattctggtattaaatgaggtgcacgagtttgtggtgaaagctgtg
cggcgatactcagagaacgccacgttacagatcgcggggctcagctgcttagcgcttctc
actgagaccattttcttaaatcaagacttagaggaaaagaatgagaatccggagaatgat
gatgaggaagaagataagttgttctggttggaagcttgttacaaagcattaacgtggcat
aggaagaacaagcacgtgcaggaagctgcatgctgggcccttaacaatctccttatgtac
caaaacagtttacatgagaagattggagatgaagatggccagttcccagctcatagggaa
gtgatgctttccatgctgatgcattcctcatcaaaagaagtcttccaggcatctgcaaat
gcattgtcgactctgttagaacaaaacgttaatttcagaaaaatcctgttgtcaaaagga
atatacctgaatgtattggagttaatgcagaggcatatacattctcctgaagttgctgag
agtggctgtaaaatgctaaatcatctctttgaaggaagcagtgtgactctggatacaatg
gcagcagtggcccccaaaataataacagttatgaaaagtcatgaggcatccttatcagtg
cagctggagggactaagagctgttttacatttcatagttccaggcatgccagaagactcc
agggaagatactgaatatcaacataagctacatatggttaagaaacagtgtttcaagaat
gacattcataaactggtcctagcagccttgaacaggttcattggaaatcctgggattcag
aaatgtgggttgaaagtaatttcttctatagcgcattctcctgatgcgttagaagtatta
tccttggaaggtgctattgattcagtgcttcacacactgcagatgtatccggatgaccaa
gaaattcaatgtctggggttaagtcttacaggatgcttgattacaaagaagaatttatgc
ataggcactggacatctgctggcaaaaattctggtttccagtttacaacgatttaaggat
atggccgaagtgcagattaaaggatttcagacaatcttgacaatactggagttgtcagtg
tctttttccaagctgctggtgcaccattcctttgattccgtgatattccatcagatgtct
tccagtatcatggaacaaaaggatcaacagtttctaaacctttgttgcaagtgctttgca
aaattagctatggatgatgagttaaaaagtgtgcttctagagagagcatgcgatcagaat
aacagtatcatggttgaatgcttgcttctcttgggagcggacgccaatggaacaaaggag
gcaacgtctttaatttgtcaggtatgtgagaaagcgagtagtcccaaattggtggaactg
ttactgaatggtggttcccgtgaacaagatgtccggaaagcgctgacaataagcattggc
aaaggtgacagccagatcatcagcttacttttaaggaggcttgccctggatctggccaat
aatagcatttgccttggaggattctgtataggaaaaattgacccttcctggcttggtcct
ttatttccagataagacatctaatttaagaaaagaaataaatataggatccaccctagca
agaatggtgcttagatatcaggtgaaaagtgctgtggaagaaggagcagcttcaggcagc
aatgggaattttcctgaaggagtacttgataaatttgatgaatggaccttcattccagac
tcctatgtggacagtgtgtttggtcaaagtgatgacctggatagtgaaggaagtgaaggc
tcatttcttgtgaaaagaaaatccaattcaattagtgtaggagaattttaccgagatcgt
gccttgcagcattgttcaccaaatttgcaaaggcattcctgttcattgggacctattttt
gatcatgaagatttactgaggcgaaaaagaaaaatattgtcttcagatgactcactcagg
tcatcaaaacttcaatcccatatgaggcattcagacagcatttcttccctggcttctgag
agagaatatattacatcattagacctttcagcaaatgaactaaaagacattgatgcccta
agccagaaatgctgtatcagtggtcatttggagcatcttgaaaagctggagcttcaccag
aatgcactcacgagctttccacaacaactgtgtgaaaccctgaagtgtttgacacatttg
gacttgcacagtaataaatttacatcatttccttcttacttgttgaaaatgaattgtatt
gccaacctcgatgtctctcgaaacgacatcagcccttcagtagttttggactctgcagtg
aagtgcccaaccttgaaacagtttaacttgtcatacaatcagctgtcttcttttcctgag
aaccttggcgatgtggtagagaaattggaacagctcattttagaaggaaataaaatacca
gaaatatgttcccccttaagcctgaaggaactgaagattttaaaccttagtaaaaatcac
attacatccctgtcagaagacttccttgaggcatgtcctaaagtggagagtttcagtgcc
agaatgaattatcttgctgctatgccttttttgccttcttcgctgacaagcctaaaatta
tctcaaaacagatttacatgtgttccagaagcaattttaaatcttccacacttgcgatcc
ttagatatgagcagcaatgaaattgaatatttgccgagtcctgcacactggaaatctttg
aacttaagggaaatcttgttcagttttaatcaaatcagcatcttggacttaagtgaaaaa
gcgtatgtatggtcaagagtagagaaattacatctttctcataataaactgaaagagatt
cctcctgagattggctgtcttgaaaacctgacctcccttgatgtcagttacaatttggaa
ctgagatcctttcctaatgaaatggggaagttaagcaaaatatgggatcttcctttggat
gaactacggcttaattttgattttaaacatataggatgtaaagccaaagacatcataagg
tttcttcaacagcggttaaaaaaggctgtgccctacaaccgaatgaagcttatgattgtg
ggaaatactgggagtggtaaaaccaccttattgcagcaattaacgaaaaccaagaaatcc
gatcttggggtgcaaagcgccacagttggcatagatgtgaaagactggccgatccaaata
agaggcaaagggaggaaagacctcattctaaacgtgtgggattttgcaggtcgtgaggag
ttctatagcactcatccgcacttcatgacccaacgagccctctaccttgccgtctatgac
ctcagcaaagggcaggctgaagtggacgccatgaagccttggctcttcaatataaaggct
cgtgcttcttcttctcctgtgattcttgttggcacacatttggatgtttctgatgaaaag
cagcgtaaagcctgcataactaaaatcaccaaggaactcttgaacaagcgggggtttcct
gcaataagggattaccacttcgtgaatgccactgaggagtccgatgccttggcaaagctt
cggaaaaccatcataaatgagagtcttaatttcaagatccgagatcagcctgttgttggg
cagctgatcccagactgctatgtagaacttgagaaaatcattttatcggagcgtaaaaat
gtgccagttgaatttcctgtgatcgaccggaaacaattattacaacttgtaaaagaaaat
cagctgcagttggatgaaaatgagcttcctcatgcagttcacttcctcaatgaatcaggg
gtccttcttcattttcaagacccagcattgcagttaagtgacttatattttgtggaaccc
aagtggctttgtaaagtcatggcacagattttgacagtgaaagtggaaggctacccaaaa
catcctaaagggatcatttcacgtagagatgtggaaaaatttctttcaaagaaaaagaga
tttccaaagaactacatgtcacagtactttaaactcctagaaaaattccagattgccttg
ccaataggagaagaatatttgcttgttccaagcagtttgtctgaccacaggcctgtgata
gagcttccccattgtgagaactctgaaattatcattcgactatatgaaatgccttatttt
ccaatgggattttggtcccggttaatcaatcgattacttgaaatttcaccttacatgctt
tcaggaagagaacgagcacttcgcccaaacagaatgtattggcgacaaggcatctacttg
aattggtctcctgaagcttattgtctggtaggatctgaagtcttagacaatcacccagag
agtttcttaaaaattacagttccttcttgtagaaaaggctgtattcttctgggccaagtt
gtggaccacattgattctctcatggaagaatggtttcctggattactggagattgatatc
tgtggtgaaggagaaactctgttgaagaaatgggcattatatagttttaatgatggtgaa
gagcatcaaaaaatcttacttgatgacttgatgaagaaagcagaagaaggagaccttcta
gtaaatccagatcaaccaaggctcaccatcccaatatctcaaattgctcctgacttaatt
ttggctgacctgcctagaaatattatgttgaataatgatgaattggaatttgaacaagct
ccagagtttctcttaggtgatggcagttttggatctgtttatcgagcagcctatgaagga
gaagaagtggctgtgaagcttttcaataaacatacatcacttagactgttaagacaggag
ctggtggtcctttgccacctccaccaccccagcttaatatctttgctggcggctgggatt
cgtcctcgcatgttggtgatggagttggcctccaagggttcgctggaccgcttgcttcag
caggacaaaggaagcctcaccaggaccctgcagcacaggattgcgctacatgtggctgat
ggcttgagatacctccactcggccatgattatataccgtgacttgaagccccacaacgtg
ctgctcttcaccctgtatcccaatgcagccatcatcgcgaagattgcggactatgggatt
gctcagtactgctgtagaatggggataaagacgtcagagggcacaccagggtttcgtgca
cctgaggtttctagaggaaatgttatttataaccaacaggctgatgtttattcatttggt
ttactactctatgacattttgacaactggagggagaatagcggagggtttgaagtttcca
aatgagtttgatgagctggcaatacaaggaaaattacctgatccggttaaagaatatggc
tgtgccccatggcccatggttgagaagttaattaaaaagtgtttgaaggaaaatcctcaa
gaaaggcctacttctgcccaggtctttgacaatttgaattcagctgagttaatctgtctg
atgagacatataacaatacctaaaaactttagtgttgagtgcatggtctctacaaatcat
aacaacaagaatgcaagcatctggctgggctgtgggcaccgtgacaaaggacagctctta
tttcttgacttaaatacagaaaaacacacttctgaggaagttattgatagtagaatactg
tgcctggctttggtgcctcttcctgtggaaaaggaaagctggatcgtgtgtgggacacag
tctggcacgctcctggtcatcaataccgaagatggggaaaagagacatactcttgaaaag
atgactgattccgtgacttgcttgtattgcaatccctttcccaagcaaagcaagcaaaaa
aattttcttctggtgggaactgctgatggcaatttagcaatttttgaagataaaactgtt
aagtgtaaaggagctgttcctttgaagatactaaatataggaaatgtcagtactccactg
atgtgtttgagtgaatccatgaattcagctgaaaaaaacattatgtggggaggatgtggt
acaaaacttttctcattttctgatgatttcaccattcagaagcgcattgagacaaagaca
aatcagctgttttcttatgcagctttcagtgactccaacatcatagcagtggtggtagac
acggctctctacgttgctaagaaaaatagtccatttgtggaagtatgggataagaaaact
gaaaaactctgtgaactaatagactgcgtgcactttttaaaggaggaaatggtaaaagta
actgcagaatcaaaacacaaactgtcttattctgggagggtaaaaaccctgtgcctccag
aagaacaccgctctctggataggaactggaggaggccatattttactccttgatctttca
actcgtcgaattatacgtataattcacaatttttgtgattctgtcagagtcatgatgaca
gcacaattagaagactcatatttttttaaaggaagccttaaaaatgtcatgctggttttg
gggtatatccggaaaagtactgaaagtacacaacaccaaaaagagatacaatcttgttta
tctgtttgggacctcaatcttccacatgaagtgcaaaatttagaaaaacatattgaagtg
agaaaagaattagctgagaaaatgagaagaatatctgttgaataa
DBGET
integrated database retrieval system
