KEGG   Ursus americanus (American black bear): 123781900
Entry
123781900         CDS       T07931                                 
Symbol
TOP2A
Name
(RefSeq) DNA topoisomerase 2-alpha
  KO
K03164  DNA topoisomerase II [EC:5.6.2.2]
Organism
uar  Ursus americanus (American black bear)
Pathway
uar01524  Platinum drug resistance
Brite
KEGG Orthology (KO) [BR:uar00001]
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    123781900 (TOP2A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:uar03032]
    123781900 (TOP2A)
   03036 Chromosome and associated proteins [BR:uar03036]
    123781900 (TOP2A)
Enzymes [BR:uar01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.2  DNA topoisomerase (ATP-hydrolysing)
     123781900 (TOP2A)
DNA replication proteins [BR:uar03032]
 Eukaryotic type
  DNA Topoisomerases
   123781900 (TOP2A)
Chromosome and associated proteins [BR:uar03036]
 Eukaryotic type
  Chromosome condensation proteins
   Other regulators of chromosome condensation
    123781900 (TOP2A)
  Centrosome formation proteins
   Centriole proteins
    123781900 (TOP2A)
SSDB
Motif
Pfam: DNA_topoisoIV TOPRIM_C DNA_gyraseB DTHCT HATPase_c Toprim Microp_apicomplexa_20
Other DBs
NCBI-GeneID: 123781900
NCBI-ProteinID: XP_045637630
LinkDB
Position
Unknown
AA seq 1533 aa
MEVSPLQPVNENMQISKTKKNADAKKGLSIERIYQKKTQLEHILLRPDTYIGSVELVTQQ
MWVYDEDIGINYREVTFVPGLYKIFDEILVNAADNKQRDPNMSCIRVTIDPENNLISIWN
NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTRFTVE
TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMV
RRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKVDETGNPLKIIHEQVNPRWEVC
LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM
WIFVNSLIENPTFDSQTKENMTLQVKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ
VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSNECTLILTEGDSAKTLAVSGLGVVGRDK
YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT
DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS
STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD
RKEWLTHFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD
GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN
LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPKDDHTLKFLYDDNQRVEPEW
YIPIVPMVLINGAEGIGTGWSCKIPNFDIREVVNNIRRLMDGEEPLPMLPSYKNFRGTIE
ELAPNQYVISGEVAILNSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY
HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR
DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR
GYDSDPVKAWKEAQQKAPDEEENEESDNENEAEKSDSVRDSGPTFNYLLDMPLWYLTKEK
KDELCKLRNEKEQELETLKRKSPSDLWKEDLAAFIEELEAVETKEKQEEQIGLPGKGGKA
KGKKTQMAEVLPSPCGKRVIPRVTIEMKAEAEKKIKKKIKNENTEGSPPEDGIELEGLKQ
RLEKKQKREAGTKTKKQATLPFKPIKKGKKRNPWSDSESDMSSNESNFDVPPREIEPRRA
ATKTKFTVDLDSDDDFSDFDEYTQDKDFVPSDVSPLKTKASPKHTTKELKPQKSATSVMD
LDTDDAKDSVPLSPGSPAADFSAETEIINPVSKKKVAVKKIAAKSQSSTSTTGAKKRAAP
KGSKKDPGLNSDVPQKPDPPKTKTRRKRKPSTSDDSDSNFEKMISKTVTNKKSKGESEDF
HLDLDSAVAPRAKSGRAKKPIKYLEESDEDDLF
NT seq 4602 nt   +upstreamnt  +downstreamnt
atggaggtgtcaccactgcagcctgtaaatgaaaatatgcaaatcagcaaaacaaagaaa
aatgcagatgctaagaaaggactgtctattgaaagaatctatcaaaagaaaacccaactg
gaacatatcttgctccgcccagacacctacattggctctgtggaactagtgacccagcaa
atgtgggtttatgatgaagatattggcattaactatagggaagtcacctttgtccctggg
ttgtacaaaatctttgatgagattctagtcaatgctgcagacaacaaacaaagggaccca
aatatgtcttgtattagagtcacaattgacccggagaacaatttaattagcatatggaat
aatgggaaaggtattcctgttgttgaacacaaagttgagaagatgtatgtcccagctctc
atctttggacagctcctaacttctagtaactatgatgatgatgaaaagaaagtaacaggt
ggtcgaaatggctatggggccaaattgtgtaacatattcagtaccagatttactgtggaa
acagccagtagagaatacaagaaaatgttcaaacagacatggatggataacatggggaga
gctggtgagatggaactcaagccctttaatggggaagattatacatgcattactttccag
cctgacttgtccaagtttaaaatgcaaagcctagataaagatatcgttgcactgatggtt
agaagagcttatgatattgctggatccactaaagatgtcaaagtctttctcaatggaaat
aagctgccagtaaaaggattccgtagctatgtagatatgtatttgaaggataaggtagat
gaaactggcaatccactgaaaattatccatgaacaagtaaaccccaggtgggaagtatgt
ttaacaatgagtgaaaaaggctttcagcaaattagcttcgtcaacagcatcgctacttcc
aagggtggcagacatgttgattatgtagctgatcagattgtgactaaacttgttgatgtt
gtgaagaagaagaacaagggtggtgttgcagtaaaagcacatcaggtgaaaaatcacatg
tggatttttgtgaattccttaattgaaaacccaacctttgactctcagacaaaagaaaac
atgactttacaagtcaagagctttggatcaacatgccaattaagtgaaaaattcatcaaa
gctgcaattggctgtggtattgtggaaagcatactaaactgggtgaagtttaaggcccaa
gtccaactaaataaaaagtgttcagctgtaaaacataacagaatcaagggaattcccaaa
ctcgatgatgccaatgatgcagggggtcgaaactccaatgagtgtacactcatcctgact
gaaggagactcagctaaaactttggctgtttcaggccttggtgtggttgggagagacaaa
tacggtgttttcccacttagaggaaaaatactcaatgttcgagaagcttctcataaacag
atcatggaaaatgccgaaattaataatatcatcaagattgtgggtcttcagtacaagaaa
aactatgaagatgaagattcattgaagactcttcgttatggaaagataatgattatgaca
gatcaggaccaagatggttcccatatcaaaggcctgctgattaattttatccatcacaac
tggccctctcttctacggcatcgttttctggaagagtttatcactcccattgtaaaggtg
tctaaaaacaaacaagaaatggcattctatagccttcctgaatttgaagaatggaagagt
tctactccaaatcataaaaaatggaaagtcaagtactacaaaggtttgggcaccagcaca
tcaaaagaagctaaagaatactttgcagatatgaaaagacatcgtattcaattcaaatat
tctggtcctgaagatgatgctgccatcagcctggcctttagcaagaaacagatagatgat
cgaaaggaatggctaactcatttcatggaggatagaaggcaacggaagttacttggcctt
cctgaggattacttgtatgggcaaactaccacatacctgacatataatgacttcataaat
aaggaacttatcctgttctcaaattctgataacgagagatctatcccatctatggtggat
ggtttgaaaccaggtcaaagaaaggttttgtttacctgtttcaaacggaatgacaagcga
gaggtgaaggttgcccagttagctgggtcagtggctgagatgtcctcttatcatcatggt
gagatgtcactaatgatgaccattatcaatttggctcagaattttgtgggtagcaataat
ctgaacctcttgcagcccattggtcagtttggtactaggctgcatggtggcaaggattct
gctagtcctcgatatatcttcacaatgctcagccctttggctcggttgttatttccacca
aaagatgatcacacattaaagtttttatatgatgacaatcaacgtgttgaacctgaatgg
tacattcctattgtacccatggtgctgataaatggtgctgaaggaatcggtactgggtgg
tcctgcaaaatccccaactttgatattcgtgaagttgtaaataatatcaggcgtttgatg
gatggagaagaacctttgccaatgcttccaagttacaagaacttcaggggtactattgaa
gagctggctccaaatcaatatgtgataagtggtgaagtggctattcttaattccacaacc
attgaaatctcagagcttcctatcagaacatggacccagacatataaagaacaggttcta
gagcccatgttgaacggaactgagaagacaccacctctcataacagattatagggaatac
catacagacaccactgtgaagtttgttgtgaaaatgactgaagagaaactagcagaggca
gagagagtgggactacacaaagtcttcaaactccaaactagcctcacatgcaactctatg
gtgctttttgaccatgtaggatgtttaaagaaatatgacacagtgttggatattcttaga
gacttctttgaactcaggcttaaatattatggattaagaaaagaatggcttctaggaatg
cttggtgctgaatctgctaaactgaacaaccaggctcgctttatcttagagaaaatagat
ggcaaaataatcattgaaaataagcctaagaaagaattaattaaagttctgattcagagg
ggatatgattcagatcccgtgaaggcttggaaagaagcccagcaaaaggcaccagacgaa
gaagagaatgaagagagtgacaatgaaaatgaagctgaaaagagtgactctgtacgagat
tctggaccaaccttcaactaccttcttgatatgcctctttggtatctcaccaaggagaag
aaagatgaactgtgcaagctgagaaatgaaaaagagcaagagctagaaacattaaagaga
aagagtccatcagatttgtggaaagaagacttggctgcttttattgaagagctggaggct
gttgaaacaaaggaaaaacaagaagaacaaataggacttcctgggaaaggggggaaagca
aaagggaaaaaaacacaaatggctgaagttttgccttctccatgtgggaaaagagtcatc
ccccgagtgaccatagagatgaaagcagaggcggaaaagaaaattaaaaagaaaattaag
aatgaaaacactgaagggagccctccagaagacggtatcgaactagaaggtctgaaacaa
aggttggagaaaaaacagaaaagagaagcaggtaccaagacaaagaagcaagctacattg
ccatttaaaccaatcaaaaaaggaaagaagagaaacccctggtctgattcagaatcagat
atgagcagtaacgaaagtaactttgatgtccctccacgagagatagagccacggagagca
gcaacaaaaaccaaattcacggtggatttggattcagatgacgatttctcagattttgat
gaatatactcaagataaggattttgtcccatcagatgttagtcctcttaagaccaaagct
tccccaaaacatactactaaagaactgaagccacagaaaagtgccacgtcagtaatggac
cttgacactgatgatgccaaggacagtgtgccactttctccaggttctcctgctgctgat
ttctcagctgaaactgaaattataaaccctgtttctaaaaagaaggtggcggtgaagaag
atagcagcaaaaagtcagtcttccacctccactacaggtgccaaaaaaagggcggcacca
aaaggaagcaaaaaggatccaggcttgaattctgatgtgcctcaaaagcctgatcccccc
aaaaccaaaactcgccgcaaaaggaagccatccacttctgatgattctgactctaatttt
gagaaaatgatttctaaaacagtcacaaacaagaaatccaagggggagagtgaggacttc
catctggacttagactcagctgtggctcctcgggccaaatctggacgggcaaagaaacct
ataaagtacctcgaagaatcagatgaggatgatctgttctaa

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