Ursus americanus (American black bear): 123783731 Help Entry 123783731         CDS       T07931                                  Symbol TSC2 Name (RefSeq) tuberin isoform X1   KO K07207   tuberous sclerosis 2 Organism uar  Ursus americanus (American black bear) Pathway uar04072   Phospholipase D signaling pathway uar04115   p53 signaling pathway uar04140   Autophagy - animal uar04150   mTOR signaling pathway uar04151   PI3K-Akt signaling pathway uar04152   AMPK signaling pathway uar04211   Longevity regulating pathway uar04218   Cellular senescence uar04714   Thermogenesis uar04910   Insulin signaling pathway uar04919   Thyroid hormone signaling pathway uar05163   Human cytomegalovirus infection uar05165   Human papillomavirus infection uar05168   Herpes simplex virus 1 infection uar05231   Choline metabolism in cancer Brite KEGG Orthology (KO) [BR:uar00001]  09130 Environmental Information Processing   09132 Signal transduction    04072 Phospholipase D signaling pathway     123783731 (TSC2)    04151 PI3K-Akt signaling pathway     123783731 (TSC2)    04152 AMPK signaling pathway     123783731 (TSC2)    04150 mTOR signaling pathway     123783731 (TSC2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     123783731 (TSC2)   09143 Cell growth and death    04115 p53 signaling pathway     123783731 (TSC2)    04218 Cellular senescence     123783731 (TSC2)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     123783731 (TSC2)    04919 Thyroid hormone signaling pathway     123783731 (TSC2)   09149 Aging    04211 Longevity regulating pathway     123783731 (TSC2)   09159 Environmental adaptation    04714 Thermogenesis     123783731 (TSC2)  09160 Human Diseases   09161 Cancer: overview    05231 Choline metabolism in cancer     123783731 (TSC2)   09172 Infectious disease: viral    05168 Herpes simplex virus 1 infection     123783731 (TSC2)    05163 Human cytomegalovirus infection     123783731 (TSC2)    05165 Human papillomavirus infection     123783731 (TSC2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:uar01009]     123783731 (TSC2) Protein phosphatases and associated proteins [BR:uar01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      123783731 (TSC2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Tuberin DUF3384 Rap_GAP HEAT Cnd1 Motif Other DBs NCBI-GeneID:  123783731 NCBI-ProteinID:  XP_045640613 LinkDB All DBs Position Unknown AA seq 1812 aa AA seqDB search MAKPTSKDSGLKEKFRILLGLGTPRPNPRSAEGKQTEFIITADILRELSVECGINNRIRV IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPPEARHAVLALLKAIVQGQGDRLGVLR ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELAGFVLQWMDVGLSSEFLLVL VNLVKFNSCYLDEYIASMVHMICLLCVQTVSSVDIEVSLQVLDAVVCYNCLPAESLPLFI VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCRIMEDRAYREDAPLLRGAVFFVG MALWGAHRLYSLKNSPTSVLPSFYEAMTCPNEVVSYEIVLSITRLIKKYRRELQAVTWDL LLNIVERLLQQLQSLDSPELRAIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE SSLLNLITYRAQSIHPAKDGWIHNLQLLMERFFRNESRSAVRIKVLDVLSFVLLINRQFY EEELISSVVISQLSHIPEDKDPQVRKLATQLLVDLAEGCHTHHFNSLLDIVEKVIARPLS PPPELEERDMAAYSASLEDVKTAVLGLLVILQTKLYALPASHAMRVYEMLVSHIRLHYKH NYTLPIASSIRLQAFDFLLLLRADSLHRLGLPSKDGAVRFSPYCVCDAMEPERGPEKKAS GPLSPPTGPPGPAPAGPAVRLGSLPYSLLFRVLLQCLKQEADWKVLKLVLSKLPESLRYK VLIFTSPCSVDQLSSALCSMLSGPRTVERLRGTPEGFSRTDLHLAVVPVLTALISYHNYL DKTRQREMVYCLEQGLIYRCASQCVVALAVCSVEMPDIIIKALPVLVVKLTHISATASMA IPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC RLPFRKDFVPYITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS PPVKEFKESSAAEAFRCRSISVSEHAVRRIQTSLTSASLGSADENSMAQADDNLKNLHLE LTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSLL GLDSGELQGSPELSSDPGVHVRQTKEAPAKLESQAGQQVCRGARDRVRSMSGGHGLRVGA LDTPASHFPSGPTAAGAQTALASKSERAPAGTQFPAQEKTSLAAYVPLLTQGWAEILVRR PTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKERRDTALYKSLSVPAAGSA KPPPPPRSNTVASFSSLCQSSCQAKLHRTISWADSAVVLEEGSPSESHLSAEPTELEDFE ATLGTDRRGGRAEAYSRSSSSSSQEEKYPAEELATGGIPIERAVSSEGARPSVELSFQPS QPLSKSSSSPELQTLQDILGDPGDKTDVGRLSPEAKARSQSGILDGAGASWSASGEESQG RGPAQPEGPLPSGCPRSPSGLRPRGYTISDSAPSRRGKRVERDAFKSRAGASNTEKVPGI NPSFVFLQLYHSPFFGDESNKPILLPNESFERSVQLLDQIPSYDTHKIAVLYVGEGQSDS ELAILSNEHGSYRYTEFLTGLGKLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQA VFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIRGQFNFVHVIISPLD YECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYP SKWIARLRHIKRLRHRIREEAHYSNPSLPLLQMHPLGHAKGPAQVPAEPVPTYETGQRKR LISSVDDFTEFV NT seq 5439 nt NT seq  +upstreamnt  +downstreamnt atggccaagcctacaagcaaagattcaggcttgaaggagaagttcaggattctgttggga ctgggaaccccgaggccaaaccccaggtctgcagagggcaaacagacggagtttatcatc accgcggacattctgagagaactgagtgttgaatgtggtatcaacaatcgcatccgggtg atagggcaaatctgcgaggttgcaaaaacgaagaagtttgaagagcatgcggtggaggcg ctgtggaaggccgtggcggacctgttgcagccagagcggcccccggaggcccggcacgcg gtgctggctctgctgaaggccatcgtgcaggggcagggggaccgcttgggcgttctcagg gccctcttctttaaggtcatcaaggattacccctctaatgaagacctacacgagagactg gaagtgttcaaggctctcacggacaatgggagacacatcacctacttggaagaagaactg gctggctttgtcctgcagtggatggacgtcggcctgtcctcagaattcctcctggtgctt gtgaacttggtcaagttcaacagctgttacctggatgaatacattgcatcaatggtccac atgatctgcctgctgtgtgtccagaccgtgtcatccgtggacatagaggtctcgctgcag gtgctggacgccgtggtctgctacaactgcttgccggctgagagcctccccctgttcatc gtcaccctctgccgtaccatcaacgtcaaggagctctgtgagccttgctggaagctgatg cgtaacctgctgggcacccacctgggccacagcgccatctacaacatgtgtcgtatcatg gaggacagagcctacagggaagacgccccgctgctgagaggggccgtgttcttcgtgggc atggctctctggggagcgcaccggctctattccctcaagaactctccgacgtccgtgctg ccctcgttttatgaggccatgacctgtccaaacgaggtggtgtcctacgaaattgtgctc tccataaccagacttatcaagaagtaccggcgggagctccaggcggtgacgtgggacctc ctgctcaacatcgtggagcgcctgcttcagcagctccagagcctggacagcccggagctc agagccatcgtccacgacctgctgaccacggtggaagagctgtgtgatcagaatgaattc catggctctcaggagagatactttgagctggttgagcgatgtgcagaccagaggcctgag tcctccctcctgaatttaataacctaccgggctcagtcaatccatccggcgaaggacggc tggattcacaacctgcagctgctgatggagagattcttcaggaatgaatctcgcagtgcc gtgcgcatcaaggtgctggacgtcctgtccttcgtgcttctcatcaacaggcagttctat gaggaggagctgatcagctcagtggtcatctcacagctctcccacatcccggaggacaaa gacccccaagtccggaaactggccacccagttgctggtggacctggccgagggctgtcat acccaccacttcaatagcctgctggacattgtggaaaaggtgattgcccgccccctttct ccacccccggagctggaggagagagacatggcggcgtactcggcctccctagaggatgtg aagactgccgtcttggggctcctcgtcatccttcagaccaagctgtacgccttgcctgcc agccacgcgatgcgtgtgtacgagatgctcgtcagccatatccggctccactacaaacac aactacaccctgcccatcgccagcagcatccggctgcaggcctttgactttctgctgctg ctgagggccgactcgctgcaccgcctcggcctgcccagcaaggacggggccgtgaggttc agcccctactgtgtctgcgacgccatggagccagagagaggcccagagaagaaggccagc ggccccctgtcgcctcccaccgggccgcccggccctgcgcccgcaggccccgcggtgcgg cttggctctctgccttactccctgctcttccgcgtcctgctgcagtgcttgaagcaggag gccgactggaaagtgctgaagctcgtgctcagcaagctgcccgagtccctgcgctacaag gtgctcatcttcacgtctccctgcagcgtcgaccagctgtcgtccgccctctgctccatg ctttcaggtcccagaactgtggagcggcttcgaggcaccccggaagggttctctagaact gacctccatctggctgtggttcccgtgttgacggcgctaatctcttaccacaactatttg gacaagaccagacagcgggagatggtgtactgcctggagcagggcctgatctaccgctgc gccagccagtgcgtggtggcgctggccgtctgcagcgtggagatgccggacatcatcatc aaggcgcttcccgtgctggtcgtgaagctcacgcacatctcggccacggccagcatggcc attccactccttgaattcctgtcaactctggccaggctgccccacctctacaggaacttc gcggcagagcagtacgcgagcgtgttcgccatctccctgccttacaccaacccctccaag tttaatcagtacatcgtgtgtctggcccatcacgtcatagccatgtggttcattaggtgc cgcctgcccttccggaaggattttgtcccttacatcactaagggcctgcgctccaacgtc ctcctgtccttcgatgacacccccgagaaggacagcttcagagcacgaagcaccagtctc aacgagaggcccaagagtttgaggatagccagaccccccaaacaaggcttgaataactct ccacccgtgaaagaattcaaggagagctctgcagccgaggccttccggtgccgcagcatc agtgtgtctgaacatgcggtccgcaggatccagacgtctctcacaagtgccagcttgggg tctgcagacgagaattcgatggcccaggctgatgacaacttgaaaaatctccacctggag ctcacggaaacgtgtctggacatgatggccagatacgtgttctccaacttcacagcggtc cccaagaggtctcctgtgggagagttcctcctggctggtggcaggaccaaaacctggctg gttgggaacaagcttgtcaccgtgacaacgagcgtggggaccgggacccggtcgctgctg ggcttagactccggagagctgcagggtagcccagagttgagctctgaccctggcgtgcac gtgagacagaccaaggaggcgcccgccaagctggagtcccaggcggggcagcaggtgtgc cgcggggcccgggaccgggtccgctccatgtctgggggccacggccttcgtgttggtgcc ctggacactccagcctcccacttcccaagtggccccactgccgcgggcgcacagacggcc ctagccagcaagtctgagagggcgccagctggcacccagttcccggcgcaggagaagacg agcctggcggcctacgtccccctgctgacccagggctgggcagagatcctggtccggagg cctacagggaacaccagctggctgatgagcctggagaacccactcagccccttctcctcg gacatcaacaacatgcctctgcaggagctgtccaacgcactcatggccgccgagcgcttt aaggagcgtcgtgacacagccctgtacaagtcgctgtcggtgcccgcggctggctcggcc aagccccctccgccgccccgctctaacacggtggcctctttctcctccctgtgccagtcc agctgccaggcaaagctgcacaggaccatttcctgggcagactcggcggtggtcctagag gagggaagtccgagcgagagtcatttgtccgcggagcccacggagttggaggactttgag gcaacactaggcacagacaggcgcggcggccgcgcggaggcatacagcaggtcatcttca agctccagccaagaggagaagtaccctgcggaggagctggctaccggagggatccccatt gagcgggccgtctcttccgagggtgcccggccttctgtggagctctccttccagccctcc cagcccctgagcaagtccagctcctcgcctgagctgcagaccctgcaggacatacttggg gaccctggggacaagacggatgttggccggctgagccctgaggccaaggcacggtcacag tccgggatcctggacggggcaggtgcctcctggtcagcctcaggtgaagagagccagggc cggggccctgcgcagcccgagggtcccttgccttccggctgcccccgctcccccagtggc ctgcggcccagagggtacaccatctctgattcggccccgtcacgcagaggcaagagggta gagagggacgccttcaagagcagagccggggcctccaatactgagaaggtgccaggtatc aatcccagctttgtgttcttgcagctgtaccattcacccttctttggtgacgagtccaac aagcccatccttctacccaatgagtccttcgagcggtcagtgcagcttctcgaccagatt ccatcctacgacacacacaagattgccgtcctgtacgtgggggaaggccagagcgacagc gagctcgccatcctgtccaacgagcacggctcgtacaggtacacagagttcctgaccggc ctgggcaagctcatcgagctcaaggactgccagccggacaaggtgtacctgggtggcctg gatgtatgtggggaggatggccagttcacctactgctggcatgacgacatcatgcaagcc gtcttccacattgccaccctgatgcccaccaaggacgtggacaagcaccgctgtgacaag aagcgtcacttaggcaacgacttcgtgtccatcgtctacaacgactccggcgaggacttc aagctgggcaccatcagaggccagttcaacttcgttcacgtgattatcagccccctggac tacgagtgcaacctggtgtccctgcagtgcaggaaagacatggagggtctcgtggacacc agcgtggccaagattgtgtctgaccgcaacctgccttttgtggcccgtcagatggctctg cacgccaacatggcctcccaggtgcatcatagccgctccaaccccaccgacatctaccct tccaagtggatcgccaggctccgccacatcaagcggctccgccaccggatccgtgaggaa gcccactactccaaccccagcctgcccctgctgcagatgcaccccctgggccacgccaaa ggccctgctcaggtgccggcagagcccgtgcccacgtacgagacgggccagcggaagcgc ctcatctcctcagtggacgacttcacagagttcgtgtga

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