Ursus americanus (American black bear): 123784210
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Entry
123784210 CDS
T07931
Symbol
GART
Name
(RefSeq) trifunctional purine biosynthetic protein adenosine-3
KO
K11787
phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:
6.3.4.13
2.1.2.2
6.3.3.1
]
Organism
uar
Ursus americanus (American black bear)
Pathway
uar00230
Purine metabolism
uar00670
One carbon pool by folate
uar01100
Metabolic pathways
uar01523
Antifolate resistance
Module
uar_M00048
De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:
uar00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
123784210 (GART)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
123784210 (GART)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
123784210 (GART)
Enzymes [BR:
uar01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.2.2 phosphoribosylglycinamide formyltransferase 1
123784210 (GART)
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.3 Cyclo-ligases
6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase
123784210 (GART)
6.3.4 Other carbon-nitrogen ligases
6.3.4.13 phosphoribosylamine---glycine ligase
123784210 (GART)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
GARS_A
Formyl_trans_N
AIRS_C
GARS_N
GARS_C
AIRS
ATP-grasp
ATP-grasp_2
ATP-grasp_3
ATP-grasp_4
CPSase_L_D2
Dala_Dala_lig_C
RimK
Sacchrp_dh_NADP
Motif
Other DBs
NCBI-GeneID:
123784210
NCBI-ProteinID:
XP_045641503
LinkDB
All DBs
Position
Unknown
AA seq
1010 aa
AA seq
DB search
MAARVLVIGSGGREHTLAWKLAQSNHVKHVLVAPGNAGTACLEKISNTAISINDHTALAQ
FCKDEKIEFVVVGPEAPLAAGIVGNLTSAGVRCFGPTAEAAQLESSKRFAKEFMDRHGIP
TARWRAFTKPEEACSFIMSSDFPALVVKASGLAAGKGVIVAKSTEEACRAVQEIMQDKAY
GAAGETIVIEELLEGEEVSCLCFTDGRTVAPMPPAQDHKRLLEGDHGPNTGGMGAYCPAP
QVSKDLLLKIKNTILQRTVDGMQQEGMPYTGVLYAGIMLTKDGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVIQSTLDGLLCTSLPVWLENRTAITVVMASKGYPGDYTKGVEITGFPEA
QALGLEVFHAGTVLKDGKVVTNGGRVLTVTAIRENLNVALEEAKKGLAAIKFEGAIYRKD
IGYRAIAFLQQPRGLTYKESGVDIAAGNMLVKKIKPLAKATSRPGCDVDLGGFAGLFDLK
AAGFKDPLLASGTDGVGTKLKIAQQCNKHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDLNTTEAVVAGIARACGKAGCALLGGETAEMPDMYSPGEYDLAGFAVGAMERDQKLP
HLERITEGDVVIGIASSGLHSNGFSLVRKIVAKSSLQYSSPAPEGCGDQTLGDLLLTPTR
IYSHSLLPVLRSGHVKAFAHITGGGLLENIPRVLPQKFGVDLDAQTWRVPRIFSWLQQEG
HLSEEEMARTFNCGIGAALVVSKDLTEQILRDIKQHKEEAWVIGNVVACPEGSPRVKVKN
LIETMQINRSVLENGTLKNHFSVQPKKARVAVLISGTGSNLQALIDSTREPSSCAHIVVV
ISNKAAVAGLDKAERAGIPTRVINHKLYKSRVEFDTAIDQVLEEYSTDIVCLAGFMRILS
GPFVRKWDGKMLNIHPSLLPSFKGSNAHEQALEAGVTVTGCTVHFVAEDVDAGQIILQES
VPVKRGDTVATLSERVKLAEHRIFPAALQLVASGAVRLGQNGKIHWVTEE
NT seq
3033 nt
NT seq
+upstream
nt +downstream
nt
atggcagcccgagtacttgtaattggcagtggaggaagggaacacacactggcctggaaa
cttgcacagtctaatcatgtcaaacatgtgttggttgccccaggaaatgcaggcactgcc
tgcttggaaaagatttcaaatactgccatctcgatcaatgaccacactgcccttgctcaa
ttctgcaaagatgagaaaattgaattcgtagttgttggaccagaggcacctctggctgct
ggaattgttgggaacctgacatctgcaggagtgcgatgctttggtcccactgcagaagcc
gctcagttagagtccagcaagagattcgccaaagagtttatggaccgacatggaatccca
actgcacggtggagagctttcaccaaacctgaagaagcctgcagctttataatgagttca
gacttccctgctttggttgtgaaggccagtggtcttgcggctggaaaaggggtgattgtt
gccaagagcacagaagaggcctgcagggctgtacaggagatcatgcaggataaagcttat
ggagcagctggagaaacaattgtcattgaagaacttcttgaaggagaagaggtgtcttgt
ctgtgcttcactgatggaaggacggtggctcctatgcccccagcacaagaccataagcga
ctgctggagggagatcacggccccaacacagggggaatgggagcctattgtccagcacct
caggtttctaaggatttgttactgaaaataaaaaataccattcttcaaaggacagtggat
ggcatgcagcaggagggaatgccgtacacaggtgttctctatgctggtataatgctgacc
aaggatggcccaaaagttctggagtttaattgccgtttcggtgatccagagtgccaagtg
atcctcccacttcttaaaagtgatctttatgaagtgattcagtctaccttggatggcctg
ctctgcacatctctgcctgtttggcttgaaaaccgcactgccataactgttgtgatggca
agtaaaggctatccaggagattacaccaagggtgtggagataacagggtttcctgaggct
caggctttaggactggaggtgttccacgcaggcactgtgctgaaagatggcaaagtggtg
actaacgggggtagagtccttacagtaacagccatccgggaaaatcttaacgtggccctt
gaagaagccaagaaaggactagccgctataaaatttgagggagccatttacaggaaggac
attggctatcgtgccatagcttttctccagcagcccaggggcctgacttacaaggaatct
ggggtagacattgcagctggaaatatgctggtcaagaaaattaaacctttagcaaaagct
acctccagaccaggctgtgatgttgatcttggaggttttgctggtctttttgatttgaaa
gcagctggtttcaaagatcctcttctggcaagtggaacagatggtgttggaactaaactg
aagattgcccagcagtgtaataaacatgataccattggtcaagatttggttgcaatgtgt
gtcaatgacattctggcccaaggggcagagccccttttcttcctcgattacttttcctgt
ggaaaacttgacctgaatacaactgaagccgttgtcgctggaatcgccagagcttgtgga
aaagctggatgtgctctccttggaggtgaaactgcagagatgccggacatgtattctccg
ggagaatatgacctagccggttttgccgttggtgccatggagcgggatcagaaactccct
cacctggaaagaatcactgaaggggatgttgttattggaatagcttcatctggtcttcac
agcaatggatttagccttgtaaggaaaattgtagcaaaatcttctctccagtactcgtct
ccagcacctgaaggctgtggtgaccagaccttaggggacttacttctcactccaaccaga
atttacagccattcactgctacctgtcctacgttcaggacatgtcaaggcctttgcccat
attactggtggaggattgctagaaaacattcccagagtccttcctcagaagtttggggtg
gatttagatgcccagacctggagggtccccaggatcttctcgtggttacagcaggaagga
cacctctctgaggaagagatggccagaacatttaactgtgggattggggctgccctcgtg
gtatcaaaggatctgacagagcagattctgagggatattaagcagcacaaggaagaagcc
tgggtgatcggcaacgtggttgcatgtcccgaaggttctcctcgtgtgaaagtcaagaat
ctgatagaaaccatgcaaataaatagatcagtattggagaatggcaccctgaaaaatcat
ttctctgtccaaccaaaaaaggcaagagtggctgtcttaatatctggaacaggatcaaac
ctacaagctctcatagacagtactagggagccaagtagctgtgcacacattgttgttgtt
atctccaacaaagccgcagtggctggcttagataaagcggaaagagctggaattcccacc
agagtaattaatcataaattatataaaagtcgtgtagaatttgacactgccattgaccaa
gtccttgaagagtactccacagacatagtctgtcttgcaggattcatgagaattttatct
ggcccctttgtcaggaaatgggatgggaagatgctcaatatccacccatccttgctccct
tcttttaagggttcaaatgcccacgagcaagccctagaagctggggtcacagtcactggg
tgtactgtgcactttgtagctgaagatgtagatgctggacaaattattttacaagaatct
gttccagtgaagagaggtgacactgttgcaactctgtctgaaagagtgaaattagcagag
cacagaatatttcccgcagccctccagctggtagccagtggagctgtacgacttggacaa
aatggcaaaattcattgggtcacagaggagtga
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