KEGG   Ursus americanus (American black bear): 123788422
Entry
123788422         CDS       T07931                                 
Symbol
PIK3CB
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
uar  Ursus americanus (American black bear)
Pathway
uar00562  Inositol phosphate metabolism
uar01100  Metabolic pathways
uar01521  EGFR tyrosine kinase inhibitor resistance
uar01522  Endocrine resistance
uar01524  Platinum drug resistance
uar04012  ErbB signaling pathway
uar04014  Ras signaling pathway
uar04015  Rap1 signaling pathway
uar04024  cAMP signaling pathway
uar04062  Chemokine signaling pathway
uar04066  HIF-1 signaling pathway
uar04068  FoxO signaling pathway
uar04070  Phosphatidylinositol signaling system
uar04071  Sphingolipid signaling pathway
uar04072  Phospholipase D signaling pathway
uar04081  Hormone signaling
uar04140  Autophagy - animal
uar04150  mTOR signaling pathway
uar04151  PI3K-Akt signaling pathway
uar04152  AMPK signaling pathway
uar04210  Apoptosis
uar04211  Longevity regulating pathway
uar04213  Longevity regulating pathway - multiple species
uar04218  Cellular senescence
uar04360  Axon guidance
uar04370  VEGF signaling pathway
uar04380  Osteoclast differentiation
uar04510  Focal adhesion
uar04550  Signaling pathways regulating pluripotency of stem cells
uar04611  Platelet activation
uar04613  Neutrophil extracellular trap formation
uar04620  Toll-like receptor signaling pathway
uar04625  C-type lectin receptor signaling pathway
uar04630  JAK-STAT signaling pathway
uar04650  Natural killer cell mediated cytotoxicity
uar04660  T cell receptor signaling pathway
uar04662  B cell receptor signaling pathway
uar04664  Fc epsilon RI signaling pathway
uar04666  Fc gamma R-mediated phagocytosis
uar04668  TNF signaling pathway
uar04670  Leukocyte transendothelial migration
uar04722  Neurotrophin signaling pathway
uar04725  Cholinergic synapse
uar04750  Inflammatory mediator regulation of TRP channels
uar04810  Regulation of actin cytoskeleton
uar04910  Insulin signaling pathway
uar04914  Progesterone-mediated oocyte maturation
uar04915  Estrogen signaling pathway
uar04917  Prolactin signaling pathway
uar04919  Thyroid hormone signaling pathway
uar04923  Regulation of lipolysis in adipocytes
uar04926  Relaxin signaling pathway
uar04929  GnRH secretion
uar04930  Type II diabetes mellitus
uar04931  Insulin resistance
uar04932  Non-alcoholic fatty liver disease
uar04933  AGE-RAGE signaling pathway in diabetic complications
uar04935  Growth hormone synthesis, secretion and action
uar04960  Aldosterone-regulated sodium reabsorption
uar04973  Carbohydrate digestion and absorption
uar05010  Alzheimer disease
uar05017  Spinocerebellar ataxia
uar05020  Prion disease
uar05100  Bacterial invasion of epithelial cells
uar05132  Salmonella infection
uar05135  Yersinia infection
uar05142  Chagas disease
uar05146  Amoebiasis
uar05160  Hepatitis C
uar05161  Hepatitis B
uar05162  Measles
uar05163  Human cytomegalovirus infection
uar05164  Influenza A
uar05165  Human papillomavirus infection
uar05166  Human T-cell leukemia virus 1 infection
uar05167  Kaposi sarcoma-associated herpesvirus infection
uar05168  Herpes simplex virus 1 infection
uar05169  Epstein-Barr virus infection
uar05170  Human immunodeficiency virus 1 infection
uar05171  Coronavirus disease - COVID-19
uar05200  Pathways in cancer
uar05203  Viral carcinogenesis
uar05205  Proteoglycans in cancer
uar05206  MicroRNAs in cancer
uar05207  Chemical carcinogenesis - receptor activation
uar05208  Chemical carcinogenesis - reactive oxygen species
uar05210  Colorectal cancer
uar05211  Renal cell carcinoma
uar05212  Pancreatic cancer
uar05213  Endometrial cancer
uar05214  Glioma
uar05215  Prostate cancer
uar05218  Melanoma
uar05220  Chronic myeloid leukemia
uar05221  Acute myeloid leukemia
uar05222  Small cell lung cancer
uar05223  Non-small cell lung cancer
uar05224  Breast cancer
uar05225  Hepatocellular carcinoma
uar05226  Gastric cancer
uar05230  Central carbon metabolism in cancer
uar05231  Choline metabolism in cancer
uar05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
uar05415  Diabetic cardiomyopathy
uar05417  Lipid and atherosclerosis
uar05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:uar00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    123788422 (PIK3CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    123788422 (PIK3CB)
   04014 Ras signaling pathway
    123788422 (PIK3CB)
   04015 Rap1 signaling pathway
    123788422 (PIK3CB)
   04370 VEGF signaling pathway
    123788422 (PIK3CB)
   04630 JAK-STAT signaling pathway
    123788422 (PIK3CB)
   04668 TNF signaling pathway
    123788422 (PIK3CB)
   04066 HIF-1 signaling pathway
    123788422 (PIK3CB)
   04068 FoxO signaling pathway
    123788422 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    123788422 (PIK3CB)
   04072 Phospholipase D signaling pathway
    123788422 (PIK3CB)
   04071 Sphingolipid signaling pathway
    123788422 (PIK3CB)
   04024 cAMP signaling pathway
    123788422 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    123788422 (PIK3CB)
   04152 AMPK signaling pathway
    123788422 (PIK3CB)
   04150 mTOR signaling pathway
    123788422 (PIK3CB)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    123788422 (PIK3CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    123788422 (PIK3CB)
  09143 Cell growth and death
   04210 Apoptosis
    123788422 (PIK3CB)
   04218 Cellular senescence
    123788422 (PIK3CB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    123788422 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    123788422 (PIK3CB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    123788422 (PIK3CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    123788422 (PIK3CB)
   04613 Neutrophil extracellular trap formation
    123788422 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    123788422 (PIK3CB)
   04625 C-type lectin receptor signaling pathway
    123788422 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    123788422 (PIK3CB)
   04660 T cell receptor signaling pathway
    123788422 (PIK3CB)
   04662 B cell receptor signaling pathway
    123788422 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    123788422 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    123788422 (PIK3CB)
   04670 Leukocyte transendothelial migration
    123788422 (PIK3CB)
   04062 Chemokine signaling pathway
    123788422 (PIK3CB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    123788422 (PIK3CB)
   04923 Regulation of lipolysis in adipocytes
    123788422 (PIK3CB)
   04929 GnRH secretion
    123788422 (PIK3CB)
   04915 Estrogen signaling pathway
    123788422 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    123788422 (PIK3CB)
   04917 Prolactin signaling pathway
    123788422 (PIK3CB)
   04926 Relaxin signaling pathway
    123788422 (PIK3CB)
   04935 Growth hormone synthesis, secretion and action
    123788422 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    123788422 (PIK3CB)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    123788422 (PIK3CB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    123788422 (PIK3CB)
  09156 Nervous system
   04725 Cholinergic synapse
    123788422 (PIK3CB)
   04722 Neurotrophin signaling pathway
    123788422 (PIK3CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    123788422 (PIK3CB)
  09158 Development and regeneration
   04360 Axon guidance
    123788422 (PIK3CB)
   04380 Osteoclast differentiation
    123788422 (PIK3CB)
  09149 Aging
   04211 Longevity regulating pathway
    123788422 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    123788422 (PIK3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    123788422 (PIK3CB)
   05206 MicroRNAs in cancer
    123788422 (PIK3CB)
   05205 Proteoglycans in cancer
    123788422 (PIK3CB)
   05207 Chemical carcinogenesis - receptor activation
    123788422 (PIK3CB)
   05208 Chemical carcinogenesis - reactive oxygen species
    123788422 (PIK3CB)
   05203 Viral carcinogenesis
    123788422 (PIK3CB)
   05230 Central carbon metabolism in cancer
    123788422 (PIK3CB)
   05231 Choline metabolism in cancer
    123788422 (PIK3CB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    123788422 (PIK3CB)
  09162 Cancer: specific types
   05210 Colorectal cancer
    123788422 (PIK3CB)
   05212 Pancreatic cancer
    123788422 (PIK3CB)
   05225 Hepatocellular carcinoma
    123788422 (PIK3CB)
   05226 Gastric cancer
    123788422 (PIK3CB)
   05214 Glioma
    123788422 (PIK3CB)
   05221 Acute myeloid leukemia
    123788422 (PIK3CB)
   05220 Chronic myeloid leukemia
    123788422 (PIK3CB)
   05218 Melanoma
    123788422 (PIK3CB)
   05211 Renal cell carcinoma
    123788422 (PIK3CB)
   05215 Prostate cancer
    123788422 (PIK3CB)
   05213 Endometrial cancer
    123788422 (PIK3CB)
   05224 Breast cancer
    123788422 (PIK3CB)
   05222 Small cell lung cancer
    123788422 (PIK3CB)
   05223 Non-small cell lung cancer
    123788422 (PIK3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    123788422 (PIK3CB)
   05170 Human immunodeficiency virus 1 infection
    123788422 (PIK3CB)
   05161 Hepatitis B
    123788422 (PIK3CB)
   05160 Hepatitis C
    123788422 (PIK3CB)
   05171 Coronavirus disease - COVID-19
    123788422 (PIK3CB)
   05164 Influenza A
    123788422 (PIK3CB)
   05162 Measles
    123788422 (PIK3CB)
   05168 Herpes simplex virus 1 infection
    123788422 (PIK3CB)
   05163 Human cytomegalovirus infection
    123788422 (PIK3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    123788422 (PIK3CB)
   05169 Epstein-Barr virus infection
    123788422 (PIK3CB)
   05165 Human papillomavirus infection
    123788422 (PIK3CB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    123788422 (PIK3CB)
   05135 Yersinia infection
    123788422 (PIK3CB)
   05100 Bacterial invasion of epithelial cells
    123788422 (PIK3CB)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    123788422 (PIK3CB)
   05142 Chagas disease
    123788422 (PIK3CB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    123788422 (PIK3CB)
   05017 Spinocerebellar ataxia
    123788422 (PIK3CB)
   05020 Prion disease
    123788422 (PIK3CB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    123788422 (PIK3CB)
   05418 Fluid shear stress and atherosclerosis
    123788422 (PIK3CB)
   05415 Diabetic cardiomyopathy
    123788422 (PIK3CB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    123788422 (PIK3CB)
   04932 Non-alcoholic fatty liver disease
    123788422 (PIK3CB)
   04931 Insulin resistance
    123788422 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    123788422 (PIK3CB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    123788422 (PIK3CB)
   01524 Platinum drug resistance
    123788422 (PIK3CB)
   01522 Endocrine resistance
    123788422 (PIK3CB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:uar04131]
    123788422 (PIK3CB)
Enzymes [BR:uar01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     123788422 (PIK3CB)
Membrane trafficking [BR:uar04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    123788422 (PIK3CB)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 Tom37_C DUF4381
Other DBs
NCBI-GeneID: 123788422
NCBI-ProteinID: XP_045647826
LinkDB
Position
Unknown
AA seq 1070 aa
MCFNFIMPPAMADILDIWAVDSQLASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHNYPMFNLLMEIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDALKDPEVNEFRIKMRKFSEEKIQSLVGLSWMDWLKQTYPPEH
EPSVLENLEDKLYGGKLIVAVHFENCQDVFSFQISPNMNPIKINELAIQKRLTIHGKEDE
VSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFMLVECCKIKKMYEQEIIAI
EAAINRNSSNLPLPLPPKKMRIISHVWENNNPFQIVLVKGNKLNTEESVKVHVRAGLFHG
TELLCKTIVSSEISGKNDHIWNEPLEFDINTCDLPRMARLCFAVYAVLDKVKTKKSTKTI
NPSKYQTIRKSGKVHYPVAWVNTMVFDFKGQLRSGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLAVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALANRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAVKLNRAKGKEAMHTCLKQNAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgcttcaatttcataatgcctcctgctatggcagacatccttgacatctgggcagtg
gattcacagttagcatctgatggctccatacctgtggatttccttttgcccactgggatt
tatattcagttggaggttcctcgggaagctaccatttcctatattaaacagatgttatgg
aaacaagttcacaattacccaatgtttaacctccttatggaaatcgactcctatatgttt
gcatgtgtgaatcaaactgctgtatatgaggagcttgaagatgaaacaagaagactctgt
gatgtcagaccctttcttccagttctcaaattagtgacaagaagttgtgacccaggggaa
aaattagactcaaaaattggagtccttataggaaaaggtctacatgaatttgatgcactg
aaggatcccgaagtgaatgaattccgaataaaaatgcgcaaattcagtgaggaaaagatc
cagtcgcttgtgggattgtcttggatggattggctaaagcagacgtatccaccagaacat
gaaccatcagtccttgaaaacttagaagataaactttatggaggaaagctcattgtggct
gttcattttgaaaattgtcaggatgtgtttagttttcaaatatctcctaatatgaatcct
atcaaaataaatgaactggcaatccagaaacgtttgactattcatgggaaagaagatgaa
gttagtccctatgactatgtgttgcaagtcagtgggagagtagaatacgtgtttggtgat
cacccactcattcagttccagtatatccggaactgtgtaatgaacaggaccttgccccat
tttatgcttgtggaatgttgcaagatcaagaagatgtatgaacaggaaataattgccata
gaggctgccataaatcgaaattcatcaaaccttcctcttcctttaccaccaaagaaaatg
cgaattatttctcatgtttgggaaaataacaaccctttccaaattgtattggttaaggga
aataaacttaacacagaagaaagtgtaaaagttcatgtcagggctggcctttttcatggt
actgaactcctctgtaaaaccatcgtaagctcagagatatcagggaaaaatgatcacatt
tggaatgaaccgctggaatttgatataaatacttgtgacctgccacgaatggctcgatta
tgttttgctgtttatgcagttttggataaagtgaaaacgaaaaagtcgactaaaactatt
aatccctctaaatatcagaccatccggaaatctgggaaagtgcattatcctgtagcatgg
gtaaatacgatggtttttgactttaaaggacagttgagatctggagacataatattgcac
agctggtcttcatttcctgatgaacttgaagaaatgttgaatccaatgggaactgttcaa
acaaatccatatactgaaaatgcaacagctttgcatatcaaattcccagagaataaaaaa
caaccttactattatcctcccttcgataagataatcgagaaggcagctgagattgcaagc
agtgacagtgctaatgtatccagtcgaggtggaaaaaagtttcttgctgtactgaaagaa
atcttggacagggatcccttgtctcagttgtgtgagaatgaaatggatcttatttggact
ttgcgacaagattgcagagagaatttcccacagtcactgccaaaattactgctgtcaatc
aagtggaataaacttgaggatgttgctcagcttcaggcactacttcagatttggcctaaa
ctgcccccccgggaggccttagagcttctagatttcaactatccagatcagtacgtgcga
gaatatgctgtgggctgcctgcgacagatgagtgatgaagaactctctcaatatctttta
caactggtgcaagttttaaaatatgagccttttcttgattgtgccctctctagattccta
ttagaaagagcactggctaatcggaggatagggcaatttctattttggcaccttaggtca
gaagtgcatattcctgctgtctcagtacagtttggtgtcatccttgaagcatactgccgg
ggaagcgtagggcacatgaaagtgctttctaagcaggttgaagccctcaataagttaaaa
actttaaatagtttaatcaaactgaatgcagtgaagctaaacagagccaaagggaaggag
gccatgcatacttgtttaaagcagaacgcttaccgggaagccctctcggacctgcagtcg
cctctgaatccgtgtgttatcctctcagaactctatgttgaaaagtgtaaatacatggat
tccaaaatgaagcctttgtggctcgtgtacaataacaaagtgtttggtgaggattcagtt
ggagtgatttttaaaaatggtgatgatttacgacaagatatgttgacactccaaatgctg
cgcttgatggatttactttggaaagaagctggtctggatcttcggatgctgccttatggc
tgtttagcaacaggagaccgctctggcctcattgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgtggctgctgcagcagccttcaacaaagatgcc
cttctgaactggcttaaagaatacaattctggggatgacctagaccgagccattgaggag
tttaccttgtcctgtgccggctactgtgtagcttcttatgtccttgggattggtgataga
catagtgacaacatcatggtcaaaaaaaccggccagctcttccacattgactttggacat
attcttggaaatttcaagtctaaatttggcattaaaagggaacgggtaccttttattctt
acctatgatttcattcatgtgattcaacaaggaaaaacaggaaacacagagaagtttggc
cgcttccgccagtgttgtgaggatgcatatctgattctacgacggcacgggaatctcttc
atcactctttttgcactgatgttgactgcagggcttcctgagctcacatcagtcaaggat
atacagtatcttaaggactctcttgccttagggaagagtgaagaagaagcactcaagcaa
tttaagcaaaaatttgatgaggcactcagggaaagctggactactaaagtaaactggatg
gcccacacagttcggaaagactacagatcttaa

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