Ursus americanus (American black bear): 123791349
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Entry
123791349 CDS
T07931
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1
KO
K05859
phosphatidylinositol phospholipase C, gamma-2 [EC:
3.1.4.11
]
Organism
uar
Ursus americanus (American black bear)
Pathway
uar00562
Inositol phosphate metabolism
uar01100
Metabolic pathways
uar01521
EGFR tyrosine kinase inhibitor resistance
uar04012
ErbB signaling pathway
uar04014
Ras signaling pathway
uar04020
Calcium signaling pathway
uar04062
Chemokine signaling pathway
uar04064
NF-kappa B signaling pathway
uar04066
HIF-1 signaling pathway
uar04070
Phosphatidylinositol signaling system
uar04072
Phospholipase D signaling pathway
uar04360
Axon guidance
uar04370
VEGF signaling pathway
uar04380
Osteoclast differentiation
uar04611
Platelet activation
uar04613
Neutrophil extracellular trap formation
uar04625
C-type lectin receptor signaling pathway
uar04650
Natural killer cell mediated cytotoxicity
uar04662
B cell receptor signaling pathway
uar04664
Fc epsilon RI signaling pathway
uar04666
Fc gamma R-mediated phagocytosis
uar04670
Leukocyte transendothelial migration
uar04722
Neurotrophin signaling pathway
uar04750
Inflammatory mediator regulation of TRP channels
uar04919
Thyroid hormone signaling pathway
uar04933
AGE-RAGE signaling pathway in diabetic complications
uar04935
Growth hormone synthesis, secretion and action
uar05167
Kaposi sarcoma-associated herpesvirus infection
uar05169
Epstein-Barr virus infection
uar05170
Human immunodeficiency virus 1 infection
uar05171
Coronavirus disease - COVID-19
uar05200
Pathways in cancer
uar05205
Proteoglycans in cancer
uar05206
MicroRNAs in cancer
uar05214
Glioma
uar05223
Non-small cell lung cancer
uar05225
Hepatocellular carcinoma
Module
uar_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
uar00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
123791349 (PLCG2)
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
123791349 (PLCG2)
04014 Ras signaling pathway
123791349 (PLCG2)
04370 VEGF signaling pathway
123791349 (PLCG2)
04064 NF-kappa B signaling pathway
123791349 (PLCG2)
04066 HIF-1 signaling pathway
123791349 (PLCG2)
04020 Calcium signaling pathway
123791349 (PLCG2)
04070 Phosphatidylinositol signaling system
123791349 (PLCG2)
04072 Phospholipase D signaling pathway
123791349 (PLCG2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
123791349 (PLCG2)
04613 Neutrophil extracellular trap formation
123791349 (PLCG2)
04625 C-type lectin receptor signaling pathway
123791349 (PLCG2)
04650 Natural killer cell mediated cytotoxicity
123791349 (PLCG2)
04662 B cell receptor signaling pathway
123791349 (PLCG2)
04664 Fc epsilon RI signaling pathway
123791349 (PLCG2)
04666 Fc gamma R-mediated phagocytosis
123791349 (PLCG2)
04670 Leukocyte transendothelial migration
123791349 (PLCG2)
04062 Chemokine signaling pathway
123791349 (PLCG2)
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
123791349 (PLCG2)
04919 Thyroid hormone signaling pathway
123791349 (PLCG2)
09156 Nervous system
04722 Neurotrophin signaling pathway
123791349 (PLCG2)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
123791349 (PLCG2)
09158 Development and regeneration
04360 Axon guidance
123791349 (PLCG2)
04380 Osteoclast differentiation
123791349 (PLCG2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
123791349 (PLCG2)
05206 MicroRNAs in cancer
123791349 (PLCG2)
05205 Proteoglycans in cancer
123791349 (PLCG2)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
123791349 (PLCG2)
05214 Glioma
123791349 (PLCG2)
05223 Non-small cell lung cancer
123791349 (PLCG2)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
123791349 (PLCG2)
05171 Coronavirus disease - COVID-19
123791349 (PLCG2)
05167 Kaposi sarcoma-associated herpesvirus infection
123791349 (PLCG2)
05169 Epstein-Barr virus infection
123791349 (PLCG2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
123791349 (PLCG2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
123791349 (PLCG2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
uar04131
]
123791349 (PLCG2)
Enzymes [BR:
uar01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
123791349 (PLCG2)
Membrane trafficking [BR:
uar04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
123791349 (PLCG2)
Endocytosis
Macropinocytosis
Phospholipase C
123791349 (PLCG2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PI-PLC-X
SH2
PI-PLC-Y
EF-hand_PLCG2
C2
SH3_1
PH
SH3_9
PH_12
EF-hand_PLCG1
SH2_1
PH_14
SH3_2
EF-hand_like
Motif
Other DBs
NCBI-GeneID:
123791349
NCBI-ProteinID:
XP_045652030
LinkDB
All DBs
Position
Unknown
AA seq
1265 aa
AA seq
DB search
MTALVNVDTLPEYEKSQIKRALELGTVMTVFSFRKYTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTVLYGTQFVLSTLSLAADSKEDAT
KWLSGLKILHQEAMSASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVNSA
KFLKDKFLEIGAHKDELSFEQFHLFYKNLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VYLHDFQRFLLHEQQELWAQDLTKVRERMTKFIHDTVRETAEPFLFVDEFLMYLFSRENS
IWDEKYDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYVRCLRMGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCCVEQQRHMARV
FKEVFGDQLLMKPTEASADQLPSPSQLRERIIIKHKKLGPRGDVDVNMEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTAEEELPQDIPPTELHFGEEWFHKKVEKR
ASAEKLLQEYCAETGGKDGTFLVRESKTFPNDYTLSFWRSGRVQHCRIRSTMEGGTMKYF
LTDNLTFTSIYALIQHYRETHLRCTEFELRLTDPVPNPNPHESKPWYYDGLSRGEAEDML
MRVPRDGAFLIRRREGTDSYAITFRARGKVKHCRIHRDGRHFVLGTSAYFESLVELVSYY
EKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRSDELSFCRGALIHNVSKEPWGWWKGDYGTRIQQYFPSNYVEDISTFDGEEMEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKQFVFILEPKKQGDPPVEFATDKVEELFEWF
QSIREITWKMDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSVVRQKPIDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKY
MQMNHALFSLNGRTGYVLQPESMRSEKYDPMPPESQRKILMTLSVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPVWAATQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMQPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFNVNENQLQLYQEKCNRRLREKRVSN
SRFYS
NT seq
3798 nt
NT seq
+upstream
nt +downstream
nt
atgaccgccctggtcaacgtggacacccttcctgagtacgagaagagtcagatcaagaga
gcgctggagctgggcacagtgatgacggtgttcagtttccgcaagtacaccccagagcgg
aggaccgtccaggtgatcatggagacgcgccaggtggcctggagcaagacagccgacaag
atcgagggcttcttggatatcatggaaatcaaggaaatccgcccagggaagaactccaag
gactttgagcgtgccaaagctgtccgccagaaggaagactgctgctttaccgtcctgtac
ggcacccagtttgttctcagcacgctcagcttggcagctgactccaaagaagatgcgact
aagtggctgtctggcttgaaaatcttacaccaggaagcaatgagcgcctccacacccacc
attattgagagttggctgagaaagcagatttattcagtggatcaaaccagaagaaacagc
atcagcctccgagagctgaagacaatcttacccctggtcaacttcaaagtgaacagtgcc
aagttcctcaaagataagtttctggaaatcggcgcgcacaaagatgaactcagcttcgag
cagttccacctgttctacaaaaaccttatgtttgagcaacaaaagtcgattcttgacgaa
ttcaaaaaagattcttctgtgttcatcttgggcaacaccgacaggccggacgcctccgcc
gtttacctgcacgacttccagcgctttctcttacacgagcagcaggagctttgggctcag
gatctgaccaaagtccgtgagcggatgactaagtttatccacgacaccgtgagggaaact
gctgagcccttcttgtttgtcgatgagttcctcatgtacctgttctcgcgggagaacagc
atctgggatgagaagtacgacgtggtggacatgcaggacatgaacaaccccttgtcgcat
tactggatctcctcttcgcataacacgtacctcaccggtgaccaactgcggagcgagtca
tccacggaagcgtacgtccgctgcctgcggatgggctgtcgctgcattgagctggactgc
tgggatgggcccgacgggaagcccatcatctaccacggctggacacggaccaccaagatc
aagtttgatgacgtcgtgcaggccatcaaagaccatgcctttgtcacttcaagcttccca
gtgatcctgtccatcgaggagcactgttgcgttgaacagcagcgccacatggccagggtg
ttcaaggaggtgtttggcgaccagctgctgatgaagcccacggaggccagtgctgaccag
ctgccctcgcccagccagctgcgggagaggataatcatcaagcataagaagctgggcccg
cgaggtgacgtggatgtcaacatggaggataagaaagatgagcacaaacaacagggtgaa
ctgtacatgtgggattccatcgaccagaagtggactcggcactactgtgccatcgctgat
gccaagctgtcgttcagcgacgacattgaacagactgcagaagaggaactgccccaggac
ataccccctacggagctgcactttggggaggagtggttccacaagaaggtggagaagagg
gcgagtgccgagaagctgctgcaggaatactgtgcggagacagggggcaaggatgggacc
ttcctggtgcgggagagcaagaccttccccaacgactacacgctgtccttctggcggtcc
ggccgggtccagcactgccggatccgttccaccatggagggcgggaccatgaagtacttc
ctgactgacaacctcacattcaccagcatctatgccctcatccagcactaccgcgagacg
cacctgcgttgcacagagtttgagctccggctcaccgaccctgtgcccaaccccaacccc
cacgagtcaaagccgtggtactatgatgggctgagccgcggggaagcagaggacatgctc
atgagggttccccgggatggcgccttcctgatccggaggcgggagggcaccgactcctac
gccatcaccttcagggccaggggcaaggtaaagcactgtcgcattcaccgggacggccgg
cactttgtgctggggacctcggcctacttcgagagcctcgtggagctcgtcagctactac
gagaagcacgcgctctaccggaagatgcggctgcgctaccccgtgacgccggagctcctg
gagcgctacaatatggaaagagacataaactccctctatgacgtcagcagaatgtatgtg
gatcccagcgaaatcaatccttccatgcctcagagaaccgtgaaagctctgtatgactac
aaagccaagcgaagcgatgagctgagcttctgccgtggggccctcattcacaacgtctcc
aaggaaccctggggctggtggaaaggagactatgggaccagaatccagcagtacttccca
tccaattacgtcgaggacatttcaacattcgacggggaggagatggagaagcagattatt
gaagacaatcccttagggtctctttgtaggggaatattggatctcaacacctataacgtc
gtgaaagccccccaggggaaaaaccagaaacagttcgtgtttatcctggagcccaagaag
caaggcgaccccccagtcgagtttgccacggacaaggtggaggagctcttcgagtggttc
cagagcatccgggagatcacctggaagatggacaccaaggagaacaacatgaagtactgg
gagaagaaccagtccatcgccatcgagctctcggacctggtagtttactgcaagccgacc
agcaagaccaaggataatctagaaaaccccgacttccgagaaatccgctcctttgtggag
acgaaggcggacagtgtcgtcaggcagaaacccatcgacctcctgaagtacaatcagaag
ggcctgacccgtgtttacccaaagggacagagggtggactcctccaactacgaccccttt
cgcctctggctgtgcggctcccagatggtggcactcaacttccagacgccagacaagtac
atgcagatgaatcacgccttgttctcactcaacgggcggacgggctacgtcctccagcct
gagagcatgaggtccgagaagtatgaccccatgccaccggagtcccagaggaagatcctg
atgactctgtcagtcaaggttctcggggctcgccatctccccaagcttggacgaagtatt
gcgtgtccctttgtggaggtggaaatctgcggagccgaatatgacaacaacaagtttaag
acaacagttgtgaatgacaatggcctaagtcctgtttgggctgcaacacaggagaaagtg
acctttgaaatttacgaccccaacctggcatttctgcgctttgtggtctacgaggaagat
atgttcagtgatcccaatttcctcgcccacgccacttaccccatcaaaggaatcaaatca
ggattcagatctgttcctctgaagaacgggtacagcgaagacattgagctggcttccctc
ctggttttctgtgagatgcagccagtcctggagagcgaagaggagctgtactcctcctgc
cgccagctgcgacggcggcaggaagaactgaacaaccagctcttcctgtacgacacgcac
cagaacttgcgcaacgccaaccgggatgccctcgtgaaagagttcaacgtcaatgagaac
cagctccagctctatcaggagaagtgcaatcggaggttgagagagaagagggtcagcaac
agcaggttttactcctag
DBGET
integrated database retrieval system
