Ursus americanus (American black bear): 123794794 Help Entry 123794794         CDS       T07931                                  Symbol ADCY6 Name (RefSeq) adenylate cyclase type 6   KO K08046   adenylate cyclase 6 [EC:4.6.1.1] Organism uar  Ursus americanus (American black bear) Pathway uar00230   Purine metabolism uar01100   Metabolic pathways uar01522   Endocrine resistance uar04015   Rap1 signaling pathway uar04022   cGMP-PKG signaling pathway uar04024   cAMP signaling pathway uar04062   Chemokine signaling pathway uar04072   Phospholipase D signaling pathway uar04081   Hormone signaling uar04082   Neuroactive ligand signaling uar04114   Oocyte meiosis uar04211   Longevity regulating pathway uar04213   Longevity regulating pathway - multiple species uar04261   Adrenergic signaling in cardiomyocytes uar04270   Vascular smooth muscle contraction uar04371   Apelin signaling pathway uar04540   Gap junction uar04611   Platelet activation uar04713   Circadian entrainment uar04714   Thermogenesis uar04723   Retrograde endocannabinoid signaling uar04724   Glutamatergic synapse uar04725   Cholinergic synapse uar04727   GABAergic synapse uar04742   Taste transduction uar04750   Inflammatory mediator regulation of TRP channels uar04911   Insulin secretion uar04912   GnRH signaling pathway uar04913   Ovarian steroidogenesis uar04914   Progesterone-mediated oocyte maturation uar04915   Estrogen signaling pathway uar04916   Melanogenesis uar04918   Thyroid hormone synthesis uar04921   Oxytocin signaling pathway uar04923   Regulation of lipolysis in adipocytes uar04924   Renin secretion uar04925   Aldosterone synthesis and secretion uar04926   Relaxin signaling pathway uar04927   Cortisol synthesis and secretion uar04928   Parathyroid hormone synthesis, secretion and action uar04934   Cushing syndrome uar04935   Growth hormone synthesis, secretion and action uar04961   Endocrine and other factor-regulated calcium reabsorption uar04962   Vasopressin-regulated water reabsorption uar04970   Salivary secretion uar04971   Gastric acid secretion uar04972   Pancreatic secretion uar04976   Bile secretion uar05032   Morphine addiction uar05163   Human cytomegalovirus infection uar05166   Human T-cell leukemia virus 1 infection uar05200   Pathways in cancer uar05207   Chemical carcinogenesis - receptor activation uar05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:uar00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     123794794 (ADCY6)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     123794794 (ADCY6)    04371 Apelin signaling pathway     123794794 (ADCY6)    04072 Phospholipase D signaling pathway     123794794 (ADCY6)    04024 cAMP signaling pathway     123794794 (ADCY6)    04022 cGMP-PKG signaling pathway     123794794 (ADCY6)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     123794794 (ADCY6)    04081 Hormone signaling     123794794 (ADCY6)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     123794794 (ADCY6)   09144 Cellular community - eukaryotes    04540 Gap junction     123794794 (ADCY6)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     123794794 (ADCY6)    04062 Chemokine signaling pathway     123794794 (ADCY6)   09152 Endocrine system    04911 Insulin secretion     123794794 (ADCY6)    04923 Regulation of lipolysis in adipocytes     123794794 (ADCY6)    04912 GnRH signaling pathway     123794794 (ADCY6)    04913 Ovarian steroidogenesis     123794794 (ADCY6)    04915 Estrogen signaling pathway     123794794 (ADCY6)    04914 Progesterone-mediated oocyte maturation     123794794 (ADCY6)    04921 Oxytocin signaling pathway     123794794 (ADCY6)    04926 Relaxin signaling pathway     123794794 (ADCY6)    04935 Growth hormone synthesis, secretion and action     123794794 (ADCY6)    04918 Thyroid hormone synthesis     123794794 (ADCY6)    04928 Parathyroid hormone synthesis, secretion and action     123794794 (ADCY6)    04916 Melanogenesis     123794794 (ADCY6)    04924 Renin secretion     123794794 (ADCY6)    04925 Aldosterone synthesis and secretion     123794794 (ADCY6)    04927 Cortisol synthesis and secretion     123794794 (ADCY6)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     123794794 (ADCY6)    04270 Vascular smooth muscle contraction     123794794 (ADCY6)   09154 Digestive system    04970 Salivary secretion     123794794 (ADCY6)    04971 Gastric acid secretion     123794794 (ADCY6)    04972 Pancreatic secretion     123794794 (ADCY6)    04976 Bile secretion     123794794 (ADCY6)   09155 Excretory system    04962 Vasopressin-regulated water reabsorption     123794794 (ADCY6)    04961 Endocrine and other factor-regulated calcium reabsorption     123794794 (ADCY6)   09156 Nervous system    04724 Glutamatergic synapse     123794794 (ADCY6)    04727 GABAergic synapse     123794794 (ADCY6)    04725 Cholinergic synapse     123794794 (ADCY6)    04723 Retrograde endocannabinoid signaling     123794794 (ADCY6)   09157 Sensory system    04742 Taste transduction     123794794 (ADCY6)    04750 Inflammatory mediator regulation of TRP channels     123794794 (ADCY6)   09149 Aging    04211 Longevity regulating pathway     123794794 (ADCY6)    04213 Longevity regulating pathway - multiple species     123794794 (ADCY6)   09159 Environmental adaptation    04713 Circadian entrainment     123794794 (ADCY6)    04714 Thermogenesis     123794794 (ADCY6)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     123794794 (ADCY6)    05207 Chemical carcinogenesis - receptor activation     123794794 (ADCY6)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     123794794 (ADCY6)    05163 Human cytomegalovirus infection     123794794 (ADCY6)   09165 Substance dependence    05032 Morphine addiction     123794794 (ADCY6)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     123794794 (ADCY6)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     123794794 (ADCY6)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     123794794 (ADCY6) Enzymes [BR:uar01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      123794794 (ADCY6) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc AC_N Adcy_cons_dom HNOBA TBK1_ULD GBR2_CC Motif Other DBs NCBI-GeneID:  123794794 NCBI-ProteinID:  XP_045657109 UniProt:  A0A452SSM3 LinkDB All DBs Position Unknown AA seq 1164 aa AA seqDB search MSWFSGLLVPKVDERKTAWGERNGQKRPRRGTRPGGFCTPRYMSCLRDAQPPSPTPAAPP RCPWQDEAFIRRGGPGKGTELGLRAVALGFEDVEAAAGAAEAAPDATPGGRRSCWRRLAQ VFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPRPAYVALL ACAAALFVALMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSSGLWCPVF FVYIAYTLLPIRMRAAVFSGLGLSALHLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGI CTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKED MMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIK ILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGV LGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKE QHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGI DDSSKDNRGAQDALNPEDEVDEFLGRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRK ADPRFGAYVACALLVFCFICFIQLLVFPHSTLMLGTYAGIFLLLLTAVLTCAVSSCGSLF PKALRRLSRSIVRSRAHSTVVGIFSVLLVFTSAIANMFTCNHTPIRTCAARMLNVTPADI TACHLQQLNYSLGLDAPLCEGTAPTCSFPEYFVGNMLLSLLASSVFLHISSIGKLAVIFV LGLVYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVILLV FALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARE RRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERF RQLEKIKTIGSTYMAASGLNASTYDQAGRSHITALADYAMRLMEQMKHINEHSFNNFQMK IGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLE CRGVVKVKGKGEMTTYFLNGGPPS NT seq 3495 nt NT seq  +upstreamnt  +downstreamnt atgtcatggtttagtggcctcctggtccccaaagtggatgaacggaaaacagcctggggt gagcgcaatgggcagaagcgtccacgccgtgggactcggcccgggggcttctgcacgcct cgctacatgagctgcctccgggatgcgcagccccccagtcccacccctgcagctccgcct cggtgcccctggcaggatgaggccttcatccggaggggcggcccgggcaagggcacggag ctgggcctgcgggcggtggccctgggctttgaggacgtggaggcggcggccggggcggct gaggcggcccccgacgcgacacccgggggccggcgatcgtgctggcgccgcctggcccag gtgttccagtcgaagcagttccgctcggccaagctggagcgcctgtaccagcggtacttc tttcagatgaaccagagcagcctgacgctgctgatggccgtgctggtgctgctcacggcc gtgctgctggcctttcacgcggcgcccgcccgcccccggcctgcctacgtggccctgctg gcctgtgccgccgccctcttcgtggcgctcatggtggtgtgtaaccggcacagcttccgc caggactccatgtgggtggtgagctacgtggtgctgggcatcctggcggccgtgcaggtg gggggtgccctggctgccgacccccgcagcccctcctcgggcctctggtgccctgtgttt ttcgtctacatcgcctacacgctcctgcccatccgcatgcgggcggctgtcttcagcggc ctgggcctctccgccctgcatttgatcttggcctggcagctcaaccgtggcgacgccttc ctctggaagcagctgggtgccaacgtgctgctgttcctctgcaccaacgtcatcggcatc tgcacgcactacccggcggaggtgtctcagcgccaggcctttcaggagacccgcggttac atccaggcccggctgcacctgcagcatgagaatcggcagcaggaacggctgctgctgtcc gtgttgccccagcatgttgccatggagatgaaagaagatatcaacacaaagaaagaagac atgatgttccacaagatctatatccagaagcatgacaatgtcagcatcctgtttgcagac atcgaaggcttcaccagcctggcatcccagtgcaccgcgcaggagctggtcatgaccctg aacgagctctttgcccggtttgacaagctggctgcggaaaatcactgcctgagaatcaag atcttaggggactgttactactgtgtgtcggggctgccggaggcccgggcagaccatgcc cactgctgtgtggagatgggggtggacatgatcgaggccatctcgctggtgcgtgaggtg acgggcgtgaacgtgaacatgcgcgtgggcatccacagcggccgcgtgcactgtggcgtc cttggtctgcggaaatggcagttcgacgtgtggtccaacgacgtgacgctggccaaccac atggaggcggggggccgggccggccgcatccacatcacccgggccacgctgcagtacctg aacggcgactacgaggtggagccgggccgcggcggcgagcgcaacgcctacctcaaggag cagcacatcgagaccttcctcatcctgggggccagccagaaacggaaagaggagaaggcc atgctggccaagctgcagcggacgcgggccaactccatggaagggctgatgccgcgctgg gtgcccgaccgcgccttctcccggaccaaggactccaaggctttccgccagatgggcatt gatgattccagcaaagacaaccggggtgcccaagatgccctgaaccccgaggatgaagta gatgagttcctgggccgtgccatcgatgcccgcagcatcgatcagctacggaaggaccac gtgcgccgcttcctgctcaccttccagagagaagatcttgaaaagaagtactcgcggaag gcggacccccgcttcggagcctacgtggcctgcgcgctgttggtcttctgcttcatctgc tttatccagctcctcgtcttcccacactccaccctgatgcttgggacctatgccggtatc ttcctgctgttgctgaccgccgtgctgacctgtgccgtgtcctcctgtggctccctcttc cccaaggccctgcgacgcctttcccgcagcattgtccgctctcgggcgcacagcaccgtg gttggcatcttttcagtcttgcttgtgttcacctctgccattgccaacatgttcacctgt aaccacacccccatacggacctgcgcagcccggatgctgaatgtgacacccgcggacatc acagcctgccacctgcagcagctcaattactccctgggcctggatgctccgctgtgtgag ggcaccgcacccacttgcagcttccccgagtacttcgttgggaacatgctgctgagtctc ctggccagctctgtcttcctgcacatcagcagcatcgggaagttggccgtgatctttgtc ctggggctcgtctatttggtgctgcttctgctgggccccccagccaccatctttgacaac tatgacctgctgcttggtgtccatggcttggcttcttccaatgagactttcgacgggctg gactgcccagctgcagggagggtggcgctcaaatacatgacccccgtgattctgctggtg tttgcactggcgttgtatctgcacgcccagcaggtggagtcaactgcgcgcctggacttc ctctggaaactgcaggcaacaggggagaaggaggagatggaggaactccaggcctacaac cgaagactgctgcataacattctgcccaaggacgtggctgcccacttcctggcccgggag cgccggaatgacgagctctactatcagtcgtgtgagtgtgtggccgtcatgtttgcctcc attgccaacttttctgagttctatgtggagctggaggccaacaacgagggcgtcgagtgt ctgcggttgctcaacgagatcatcgctgacttcgacgagatcatcagcgaggagcggttc cggcagctggagaagatcaaaacgattggtagcacctacatggctgcctcggggctgaac gccagcacctatgatcaggccggccgctcccacatcactgccctggccgactatgccatg cggctcatggagcagatgaaacatatcaatgagcactccttcaacaatttccagatgaag attgggctgaacatgggcccagtcgtggcaggcgtcattggggctcggaagccgcagtat gacatctgggggaacacagtgaatgtctctagccgtatggacagcacaggggtccctgac cgaatccaggtgaccacggacttgtaccaggttctagctgccaaaggctaccagctggag tgtcgaggggtggtcaaggtgaagggcaagggggagatgaccacctacttcctcaatggg ggcccccccagttag

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