Ursus americanus (American black bear): 123795350 Help Entry 123795350         CDS       T07931                                  Symbol JAK1 Name (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism uar  Ursus americanus (American black bear) Pathway uar01521   EGFR tyrosine kinase inhibitor resistance uar04151   PI3K-Akt signaling pathway uar04217   Necroptosis uar04380   Osteoclast differentiation uar04550   Signaling pathways regulating pluripotency of stem cells uar04620   Toll-like receptor signaling pathway uar04621   NOD-like receptor signaling pathway uar04630   JAK-STAT signaling pathway uar04658   Th1 and Th2 cell differentiation uar04659   Th17 cell differentiation uar05140   Leishmaniasis uar05145   Toxoplasmosis uar05152   Tuberculosis uar05160   Hepatitis C uar05161   Hepatitis B uar05162   Measles uar05163   Human cytomegalovirus infection uar05164   Influenza A uar05165   Human papillomavirus infection uar05166   Human T-cell leukemia virus 1 infection uar05167   Kaposi sarcoma-associated herpesvirus infection uar05168   Herpes simplex virus 1 infection uar05169   Epstein-Barr virus infection uar05171   Coronavirus disease - COVID-19 uar05200   Pathways in cancer uar05203   Viral carcinogenesis uar05212   Pancreatic cancer uar05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:uar00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     123795350 (JAK1)    04151 PI3K-Akt signaling pathway     123795350 (JAK1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     123795350 (JAK1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     123795350 (JAK1)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     123795350 (JAK1)    04621 NOD-like receptor signaling pathway     123795350 (JAK1)    04658 Th1 and Th2 cell differentiation     123795350 (JAK1)    04659 Th17 cell differentiation     123795350 (JAK1)   09158 Development and regeneration    04380 Osteoclast differentiation     123795350 (JAK1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     123795350 (JAK1)    05203 Viral carcinogenesis     123795350 (JAK1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     123795350 (JAK1)   09162 Cancer: specific types    05212 Pancreatic cancer     123795350 (JAK1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     123795350 (JAK1)    05161 Hepatitis B     123795350 (JAK1)    05160 Hepatitis C     123795350 (JAK1)    05171 Coronavirus disease - COVID-19     123795350 (JAK1)    05164 Influenza A     123795350 (JAK1)    05162 Measles     123795350 (JAK1)    05168 Herpes simplex virus 1 infection     123795350 (JAK1)    05163 Human cytomegalovirus infection     123795350 (JAK1)    05167 Kaposi sarcoma-associated herpesvirus infection     123795350 (JAK1)    05169 Epstein-Barr virus infection     123795350 (JAK1)    05165 Human papillomavirus infection     123795350 (JAK1)   09171 Infectious disease: bacterial    05152 Tuberculosis     123795350 (JAK1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     123795350 (JAK1)    05140 Leishmaniasis     123795350 (JAK1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     123795350 (JAK1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:uar01001]     123795350 (JAK1) Enzymes [BR:uar01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      123795350 (JAK1) Protein kinases [BR:uar01001]  Non-receptor tyrosine kinases   JAK family [OT]    123795350 (JAK1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 SH2_1 FERM_F1 ABC1 SH2 RIO1 FERM_C_FAK1 Motif Other DBs NCBI-GeneID:  123795350 NCBI-ProteinID:  XP_045658104 LinkDB All DBs Position Unknown AA seq 1153 aa AA seqDB search MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVLFYLSDREPLRLGSGEYTAEEL CIRAAQECCISPLCHNLFALYDENTKLWYAPNRTITVDDKTSLRLHYRMRFYFTNWHGTN DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN WFHPNDSGNVLYYEVMVTGNLGIQWRQKPNVVPVEKEKHKLKRKKLENKHKKDEEKNKIR EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT CFEKSEVLGGQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFVLK RCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDIVQGEHLGRGTRTHIYSGT LVDYKDDEGTAEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV ENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL LAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGT TLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI MRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPS GSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSD YSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPLHCPDEVYQLMRKCWEFQPSNRTT FQNLIEGFEALLK NT seq 3462 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatataaaagaggactgcaatgccatggctttctgtgctaaaatgagg agctccaagaagaccgaggtgaatctggaggcccccgagccaggggtggaagtgctcttc tatctttcggacagggagcccctccggctgggcagcggggagtacacggcagaggagctc tgcatcagggccgcgcaggaatgttgtatctctcctctgtgtcacaacctctttgctctg tatgatgagaacaccaagctctggtatgccccgaatcgcaccatcactgttgatgacaag acatcgctccggctccactaccggatgagattctatttcaccaactggcatgggaccaat gataatgagcagtctgtatggcgacattctccaaagaagcagaaaaatggctatgagaaa aaaaaagtcccagatgcaacccctctccttgacgccagctctctggagtatctgtttgct cagggacaatatgatttggtcaaatgcctggctcccattcgagaccccaagaccgagcag gatgggcatgatatcgagaatgagtgtctgggaatggcagtcctggccatctcccactac gctatgatgaagaagatgcagttgccagaactgcccaaggacatcagctacaagcgatat attccagaaacattgaataagtccatcagacagaggaaccttctcaccaggatgcggata aataatgttttcaaagatttcttgaaggaatttaacaacaagactatttgtgacagcagt gtatctactcatgacctgaaggtgaaatacctggccaccttggaaactttgacaaaacat tatggcgctgaaatatttgagacttccatgttactgatttcatcagaaaatgagatgaat tggtttcatccgaatgacagtggaaatgttctctactatgaagtgatggtaactggaaat cttggaatccagtggagacagaaaccaaatgttgttcctgttgaaaaagaaaaacacaaa ctgaaacggaaaaaactggaaaataaacacaagaaggatgaggagaaaaacaaaatccgg gaagagtggaacaatttttcttacttccctgaaatcactcacattgtaataaaggagtct gtggtcagcatcaataagcaggacaacaaaaaaatggaactgaagctctcatcccatgaa gaggccttgtcctttgtgtccctggtagacggctacttccggctcacagcagatgcccat cattacctctgcaccgatgtggctcccccgttgatcgtccacaacatacagaatggttgt catggtccaatctgcacagaatatgccatcaataagttgcggcaagaaggaagcgaggag gggatgtatgtgctgaggtggagctgtaccgactttgacaatatcctcatgactgtcacc tgctttgaaaaatctgaggtgctgggtggccagaaacagttcaagaactttcagatcgag gtgcagaagggccgctacagcctgcacggctcggaccgcagcttccccagcctgggggac ctgatgagccacctcaagaagcagatcctgcgcacggacaacatcagtttcgtgctgaag cgctgctgccagcccaagccccgagagatctccaatctgcttgtggctactaagaaagcc caagagtggcagcctgtctaccccatgagccagctgagttttgaccggatcctcaagaaa gatattgtgcagggcgagcacctcgggagaggcacacggacacacatctactctggtacc ctggtggattacaaggatgacgaaggaactgcggaagaaaagagaataaaagtgatcctc aaagtcttagaccccagccacagggacatttctctggccttctttgaggcagccagcatg atgaggcaggtctcccacaaacacatcgtgtacctctatggcgtctgtgtccgagatgtg gagaatatcatggtggaggagtttgtggagggggggcccctggatctcttcatgcaccgg aaaagtgatgtcctcaccacaccatggaagttcaaagttgccaagcagctggccagtgcc ctgagttacttggaggataaagaccttgtccacggaaacgtgtgcacgaaaaatcttctc ctggcccgtgagggcattgacagcgagtgcggcccgttcatcaagctcagtgaccctggc atccccatcactgtgctgtccaggcaagagtgcatagaacgaatcccatggattgctcca gagtgtgttgaagactccaagaacctgagtgtggctgctgacaaatggagctttggaacc acactctgggaaatctgctacaatggcgagatccctctgaaagacaagaccctgattgag aaagagagattctacgaaagccggtgccggccagtgacaccatcttgtaaggagctggct gaccttatgacccgctgcatgaactatgaccccaaccagagacctttcttccgagccatc atgagagacatcaataaactggaagagcagaatccagacattgtttctgaaaaaaagcca gcaaccgaagtggatcccacgcattttgaaaagcggttcttgaagaggatccgtgacttg ggagagggccacttcgggaaggtcgagctctgcaggtatgaccctgagggggacaatact ggggagcaggtggcagtcaaatccctgaagcccgagagtggaggtaaccacatagctgat ctgaagaaggaaattgaaatcctaaggaacctctatcatgagaacattgtgaagtacaaa ggcatctgtaccgaagatggaggaaatggtattaagctcatcatggaatttctgccttca ggaagccttaaggaatatcttccaaagaataagaacaaaattaacctcaaacagcagtta aaatatgccgttcagatttgtaaggggatggactatttgggttctcgtcagtatgttcac cgggacttggcagcaagaaacgtcctcgttgagagtgagcaccaagtgaaaattggagac tttggtttgaccaaagccattgaaactgacaaggagtattacacagtcaaggatgatcgg gacagccctgtgttttggtatgctcccgaatgtttaattcagtgtaaattttatatcgcc tctgacgtctggtcgtttggagtgactctgcacgagctgcttacttactgtgactccgat tacagccccatggcgttgttcctgaaaatgataggcccaactcatggccagatgacagtc acaagacttgtgaatacattaaaagaaggaaaacgtttgccttgtccacttcactgtcca gatgaggtttatcaacttatgagaaaatgctgggaattccaaccatccaatcggacaact tttcagaaccttattgaaggatttgaagcacttttaaaataa

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