Ursus americanus (American black bear): 123795526 Help Entry 123795526         CDS       T07931                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism uar  Ursus americanus (American black bear) Pathway uar04020   Calcium signaling pathway uar04024   cAMP signaling pathway uar04260   Cardiac muscle contraction uar04261   Adrenergic signaling in cardiomyocytes uar04371   Apelin signaling pathway uar04713   Circadian entrainment uar04911   Insulin secretion uar04921   Oxytocin signaling pathway uar04972   Pancreatic secretion uar05020   Prion disease uar05022   Pathways of neurodegeneration - multiple diseases uar05410   Hypertrophic cardiomyopathy uar05412   Arrhythmogenic right ventricular cardiomyopathy uar05414   Dilated cardiomyopathy uar05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:uar00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     123795526 (RYR2)    04020 Calcium signaling pathway     123795526 (RYR2)    04024 cAMP signaling pathway     123795526 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     123795526 (RYR2)    04921 Oxytocin signaling pathway     123795526 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     123795526 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     123795526 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     123795526 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     123795526 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     123795526 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     123795526 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     123795526 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     123795526 (RYR2)    05414 Dilated cardiomyopathy     123795526 (RYR2)    05415 Diabetic cardiomyopathy     123795526 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:uar04040]     123795526 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:uar04990]     123795526 (RYR2) Ion channels [BR:uar04040]  Voltage-gated cation channels   Ryanodine receptor    123795526 (RYR2) Domain-containing proteins not elsewhere classified [BR:uar04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    123795526 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  123795526 NCBI-ProteinID:  XP_045658294 LinkDB All DBs Position Unknown AA seq 4970 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV TTGKYLSLMEDKSLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSV CYIQHINTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKVKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD DLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREY KQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEEK VKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDPGARAEVCSG TGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGF KAQRWHQGNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGEILLDDSGSELAFKDFDVGDG FIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSSTDIMFYRLSMPIECAEVFSKTVAG GLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEK PSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPAN VWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR NNNGLEIGCVVDAASGLLTFTANGKELGTYYQVEPSTKLFPAVFAQATSPNVFQFELGRI KNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQ CLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHV DEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNSEFIVPMTEETKSITLFP DENKKHGLPGIGLSTSLRPRIQFSSPSFVSVNNECYQYSPEFPLDILKAKTIQMLTEAVK EGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILRLIEPSVFKEAATLDEE TDALEKEPSPEDARPEGAGEEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRH RIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFK DDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLK KKQAEKPVESDSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVR ALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPN LMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSY LLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQML VSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGG NGLLAAMEEAIKIAEDPSRDGPSPTSGSSKTLDAEEEEDDTIHMGNAIMTFYAALIDLLG RCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGF CPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYL CTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDAIEVCLLSICGQL RPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHL SRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGN FNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPY KLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHG YSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAK EKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYI LEFDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKE KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAF LDNAAEDLEKTMENLKQGQFTHTRNQPRGVTQIINYTTVALLPMLSSLFEHIGQHQFGED LILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNV YSIYNTKSSRERAALNLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILP MLCSYMSRWWEHGPENNPERAEMCCTALSSEHMNTLLGNILKIIYNNLGIDEGAWMKRLA VFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEFT TLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEDLFRMVAEVFIYWSKSHNFKREEQNFV VQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRRGDRYSMQTSLIVAALKRLLPIGLNI CAPGDQELIALAKNRFSMKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTED TSDPEKTVERVLDIANVLFHLEQKSTCMRRRYYSLGSTVEHPQRSKKAVWHKLLSKQRKR AVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGADPPEEEEG TKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEK EMEKQKLLYQQARLHDRGAAEMVLQTISASKGDTGPMVAATLKLGIAILNGGNSTVQQKM LDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTC DLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDV IDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMK LSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFF DMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENET LDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIE IMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTI FEMQLAAQISESDLNERSANKDESEKEKPEEQGPRMGFFSILTVKSALLALRYNILTLMR MLSLKSLKKQMKKVKKMTMKDMVTAAFSSYWSIFLSLLHFVASVSRGFFRIVCSLLLGGS LVEGAKKIRVAELLANMPDPTQDEVRGDGEEGDRKPMEAALPSEDLTDLKELTEESDLLS DIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPIPDVQEKFQEQKAKEDEKEEKEENKS EPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFAR NFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRSLSENAKVSSLDSGSPRIMAV HYVLEESSGYMEPTLKILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYI TEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAAL DFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNF FFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSE DGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVI LLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLAN YLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14913 nt NT seq  +upstreamnt  +downstreamnt atggccgatgggggagagggcgaggacgagatccagttcctgcgaactgacgacgaggtg gtcctgcaatgcaccgctaccatccacaaggaacaacagaagctgtgtttggccgcagaa gggtttggcaaccgactctgtttcttggagtccacttcgaattccaagaatgtcccccca gacctctccatctgcaccttcgtgctggaacagtctctctctgtccgcgccctgcaggag atgctggctaacaccgtggagaagtcagaagggcaagttgatgtggaaaaatggaaattc atgatgaagaccgctcaaggtggtggtcatcgaacactcctctacggacacgccatattg ctgcgccattcctatagtggcatgtatctgtgctgcctgtccacctcccggtcttcaact gataaactggcttttgatgttggcttgcaagaggacacaacaggggaggcctgttggtgg accatccatcctgcctcaaagcagcggtcagaaggagagaaggtgcgagttggagatgac ctcatcttggtcagcgtgtcctcggagaggtacctgcacctgtcttatggcaacggcagt ttacacgtggacgcggctttccagcagactctctggagcgtggcccccatcagctcagga agcgaagccgcccaagggtatctcattggtggtgacgtcctcaggttgctgcacggacac atggacgagtgcctcactgtcccttcaggagaacacggggaagagcagcggagaactgtt cactatgaaggtggtgctgtatccgtccatgcacgttccctgtggagactagagacgcta agagttgcgtggagtggaagccacataagatggggccagcctttccgactacgccatgtc acaacaggaaaatacttgagtctcatggaagacaaaagccttctactcatggacaaagaa aaggctgatgtaaaatcaacagcatttaccttccgatcttccaaggaaaaattggatgta ggagtgagaaaagaagtcgatggcatggggacatctgaaataaaatacggagactcagta tgctatatacagcatataaatacaggcctatggcttacttaccagtctgtggatgtgaaa tcagtgagaatggggtccatacaacgtaaggctattatgcatcatgaaggtcacatggat gatggcttaaatttatctagatctcagcatgaagaatcacggactgcacgtgtcatccgg agtacagtcttccttttcaatagatttataaggggccttgatgcactcagcaaaaaagtg aaggcttccacggtggacctccctatagaatctgtgagtctaagtctgcaggacctgatt ggctactttcatcccccagatgaacatttagagcatgaagacaagcagaacagattacga gctctaaagaaccggcagaatctcttccaggaagagggaatgatcaacctcgtgctcgaa tgtatagacaggctgcacgtgtacagcagtgcggcccactttgctgacgtcgccgggaga gaagccggcgagtcctggaagtcaattctgaattctctctatgagttgctagcggcacta attagaggaaatcgtaaaaactgtgctcagttttctggctcccttgactggttgatcagc cgattggaaagactggaagcttcttctggtattcttgaagttttacactgtgtgttagta gaaagtccagaagctctaaatattattaaggaaggacacattaaatccataatctcactt ttagacaagcatgggagaaaccacaaggtcctggacgtcttgtgctccctgtgtgtctgc catggagtggcagtccgttctaaccagcatctcatctgtgacaatctgctgccaggaaga gatctactgttgcagacgcgtcttgtgaaccatgtcagcagcatgagacccaatattttt ctgggcgtcagtgaaggctccgctcagtacaagaagtggtactatgagctgatggtggac cacacggagccgttcgtgaccgccgaagccacgcacctgcgggtgggctgggcttccacc gaagggtactctccctacccaggaggcggtgaggagtggggtggaaacggagttggagac gatctcttctcctacggattcgacggccttcacctctggtcaggctgtattgctcgtact gtaagctcaccaaaccagcatctgctgagaaccgatgacgtcatcagttgctgtctagat ctcagtgccccgagcatctcattccgaattaacggacaacctgttcaaggaatgtttgag aatttcaacattgatggcctcttctttccagttgttagtttctctgcaggaataaaggta cgctttctgcttggggggagacacggagaatttaaattcctcccgccacctgggtatgct ccttgttatgaagccgttctgccgaaagaaaagttgaaagtggagcacagccgagagtac aagcaagaaagaacgtacacacgggacctgctgggccccacagtctccctgacgcaggcc gccttcacgccgatcccggtggataccagtcagattgtgttgcctcctcatctagagaga ataagagaaaaactggcagagaatatccatgaactctgggttatgaataaaattgaactt ggctggcagtatggtccggttagagatgacaataagagacaacacccatgtctggtggag ttctccaagctgcccgaacaggagcgcaattacaacttgcagatgtcgcttgagaccctg aagactttgctggcactaggatgtcatgtgggtatctcagatgagcatgctgaagaaaag gtgaaaaaaatgaagcttcccaagaattaccagctgacaagtgggtataagcctgcccca atggacctgagcttcattaaactcaccccatctcaggaagcgatggtggacaagttggca gaaaatgcccataatgtgtgggcccgggatcgaatccggcagggctggacttacggcatc caacaggatgtaaagaacaggagaaaccctcgcctggtgccctacgcccttctggatgac cgcaccaagaaatccaataaggacagcctccgtgaggctgtgcgcacgctgctggggtat ggctacaacctggaggcaccagatcaggatcccggggccagagccgaagtgtgcagcggc accggggagaggttccgaatcttccgcgccgagaagacctatgctgtcaaggcaggaagg tggtattttgagttcgaggccgtcactgctggcgacatgagggttggctggagcaggccc ggctgtcaacctgatcaagagcttggctcagacgaacgtgcctttgcttttgatggcttc aaggcccagcggtggcaccagggtaacgaacactacgggcgctcttggcaagcgggcgac gttgtggggtgcatggtagatatgacagagcacaccatgatgttcacgctgaatggtgaa atccttcttgacgattcgggctcagagctggcattcaaggactttgatgttggtgatgga ttcattcctgtctgtagccttggagtggctcaagtgggcaggatgaactttggaaaagat gtcagcaccttgaaatatttcaccatctgtggcttacaagagggctatgaaccgtttgct gttaacacaaacagggatattaccatgtggctaagcaagaggcttcctcagtttctccag gtcccatcaaatcatgagcatatcgaggtgaccagaatagacggcaccatcgacagttct ccgtgtttaaaggtgactcagaagtccttcggttctcagaacagcagcacggacatcatg ttctatcgcctgagcatgcccatcgagtgcgcagaagtgttctccaagacggtggccggg ggactcccaggcgctggcctctttgggcccaagaatgatctggaggactacgatgcagat tccgactttgaggttctaatgaagacggctcatggccatctggtgccagatcgcgttgac aaagacaaggaagccacaaaaccagagtttaataaccacaaagattacgctcaggagaag ccctctcgtctgaaacaaagatttttgcttagaagaacaaagccggattacagcacaagc cattctgcaagactcactgaagacgtgcttgcagatgatcgggatgattacgattacttg atgcaaacgtccacgtactattactcagtgagaatctttcctggccaagaacctgctaac gtctgggtaggctggattacatcagatttccatcaatatgatacaggctttgacttggac agagttcgcacagtaaccgttactctaggagatgaaaagggaaaagtacatgaaagcatc aaacgcagcaactgctatatggtgtgtgcgggtgagagcatgagcccggggcaaggacgc aacaacaatggcctggagatcgggtgcgtggtggatgccgccagtgggctgcttacattc accgccaacggcaaggagctgggcacatactaccaggtggaaccaagtacaaaattattt cctgcagtgtttgcacaagctacaagtcccaatgttttccagtttgagttgggaagaata aagaatgtgatgcctctgtcggcgggattattcaagagcgagcacaaaaaccctgtgcca cagtgtccgccgcgtctccacgtgcaatttctttcccatgtcctatggagcaggatgcct aaccagttcttgaaggtagatgtctctcgaatcagtgagcgccaaggctggctggtgcag tgtttggatcctctgcagttcatgtctcttcatatcccagaggagaacagatctgtcgac atactggaattgacagagcaggaggagctgctaaaattccactatcacactctccgcctt tactccgccgtctgcgctcttgggaaccaccgggtggcacatgccttgtgcagccacgtg gatgagcctcagctgctctacgccatcgagaacaagtacatgcccggtttgctgcgcgcc ggctactatgacctgctgatcgacatccaccttagctcctacgccacggccaggctcatg atgaacagtgagttcatcgtgcccatgacggaggagaccaagagcatcacccttttccct gatgagaacaaaaaacatggcctcccggggattggcctcagcacctcccttaggccacgg atacagttttcctcccccagttttgtaagcgttaacaatgaatgttaccagtatagtcca gagttcccgctggacatcctcaaggccaaaaccattcagatgttgacagaagctgttaaa gagggcagccttcatgcccgggaccccgttggggggaccactgagttcctctttgtacct ctcatcaagcttttctatactctgctcatcatggggatcttccacaatgaggacttgaaa cacatcttgcgattgatagagcccagtgtgttcaaggaagccgccactctggatgaggag acagacgcgctggagaaagagcccagcccagaagatgccagaccagaaggagctggtgaa gaagaagccaaagggggtaagaggcccaaggaaggcctgctccagatgaaactgcctgag ccagttaaattgcagatgtgcctgctgcttcagtacctctgtgactgtcaggtccgacac cggatagaagccatcgtggccttttcagatgactttgtagcaaagctccaagacaatcag cgcttccgatacaacgaagtgatgcaagccttaaacatgtcagctgccctcaccgccagg aaaacgaaggaatttagatcaccacctcaagagcagatcaatatgcttctcaattttaag gatgacaaaagtgaatgtccatgtcctgaagaaatccgtgaccaactcttagattttcat gaagatttgatgacacattgtggaattgagctggatgaagatgggtctttagatggaaac agtgacttaacaattcgaggacgcctgctgtccctggtagaaaaggtgacatacctgaag aagaaacaagctgagaaaccagttgagagtgactccaagaagtcctccactcttcagcag ttgatttctgagaccatggtccgatgggcgcaagagtctgtcattgaagaccctgaattg gtgagggccatgtttgtgttgctccatcgacagtatgatggcattggtggtctggtccgg gctctgccaaagacctacactatcaatggtgtctccgtggaggataccatcaacctgctg gcatctcttggtcagattcgttctctgctgagtgtaagaatgggcaaagaagaagagaag cttatgattcgtggattaggggatatcatgaataataaagtgttttaccagcaccctaat ctcatgagggcccttgggatgcatgagacggtgatggaggtcatggtgaatgtccttgga ggtggagagtccaaggaaatcacttttcccaagatggtggccaactgttgccgtttcctt tgttacttctgtcgtataagtaggcagaatcaaaaagctatgtttgatcatctcagctat ttattggagaatagcagtgttggccttgcctcaccagctatgaggggctcaacaccactg gatgtggcagctgcctcggtgatggataataacgaactggccttagcactgcgtgagcca gatttggaaaaggtagttcgatatttggctggttgtggactgcagagctgccagatgctg gtgtctaagggttatccagacattggatggaatccagttgaaggagagagatatcttgac tttctccgatttgctgtcttctgtaatggggagagtgtggaagagaacgctaatgtcgtg gtgaggttgcttatccggaggcccgagtgttttggtcctgctttgagaggggaaggtggg aacggtctgctcgcagccatggaggaagccataaaaatagctgaggatccttctcgagat ggtccctcaccaactagcggatccagtaaaacacttgatgcagaagaggaggaggatgac actatccacatggggaatgccatcatgaccttttacgcagccttgattgacctgttagga cgctgtgctcctgaaatgcatttgattcatgctggtaagggggaagccatcagaatccgg tccattttgagatccctaattccactgggagatttggtgggagtaatcagcattgctttt cagatgccaacaatagccaaagatgggaatgtggtggagcctgacatgtctgcggggttt tgcccagatcacaaggcagccatggttttgttccttgacagggtctatgggattgaggtt caagatttcctcctccatcttctcgaggttggctttctgccagatctccgggctgctgct tctttagacacggctgctctgagtgctacagacatggccttggccctcaatcggtacctt tgcacagccgtgctgcctctgttaacgagatgtgcccctctttttgcgggcacagagcac catgcctctctcattgactccttacttcacactgtgtacagactctctaagggctgctct cttaccaaagctcagcgggatgccatagaagtttgtttgctctctatttgtggccaattg agaccttctatgatgcaacacttgctccgaagattagtatttgatgtcccattattaaat gaacatgccaagatgcctcttaagctgctgacaaatcattatgaaagatgctggaaatat tactgcctgcctggagggtgggggaactttggagctgcctcagaggaagagcttcattta tcaagaaagttgttttggggcatttttgacgccctgtctcaaaagaaatatgaacaagaa cttttcaaactggcactgccttgcctgagtgcagttgcgggagctttgcctccagactac atggagtcaaattatgtcagtatgatggaaaaacagtcatcaatggattctgaagggaac tttaacccacaacctgttgatacctcaaatatcacaattcctgagaagttggaatacttc attaacaaatatgcggaacattctcatgacaagtggtcaatggacaagttggcaaatgga tggatttatggagaaatatattcagactcgtctaaagttcaaccattaatgaagccatat aaactattatctgaaaaggaaaaagaaatttatcgctggcctatcaaagagtctttaaaa accatgctggcgtggggttggaggattgagagaacgcgggagggagacagcatggcgctc tataaccggactcgtcgcatttctcagacaagccaggtttctgtagatgccgcacatggc tatagcccccgagccattgacatgagcaatgtcacactgtccagagacctgcacgctatg gcagaaatgatggctgaaaactaccataatatttgggccaagaaaaagaaaatggaactg gaatccaaaggaggtggaaaccatcccctgctggttccctatgacacgctcacagccaaa gagaaagccaaggatagggagaaagcacaggacatcctcaagttcttgcagatcaatggc tatgcggtgtccagaggattcaaggacctggagttggacacaccttccattgagaaacga tttgcctatagcttccttcagcaactcattcgctatgtggatgaagcccatcagtacatc ctggagtttgatggtgggagtagaagcaaaggagagcatttcccttacgaacaagaaatc aagttcttcgctaaagttgtgcttcctttaattgaccagtacttcaaaaaccatcgctta tacttcttatctgcagcaagcagacctctctgctctggaggacatgcatcaaacaaggag aaagaaatggtgactagcctattctgcaaacttggagttcttgtcaggcataggatttca ctatttggaaatgatgccacatcaattgtcaactgccttcacattttgggtcagactttg gatgccaggactgtgatgaagactggcctcgagagtgttaaaagtgcactccgagctttt ctggacaacgccgcggaggatctggagaagaccatggagaatctcaagcaaggccagttc acccacacccgaaaccaacccagaggtgtcactcagattatcaattacaccacggtggct ctgttgccgatgctgtcgtcattatttgagcacattggccagcatcagtttggagaagat ctaatattggaagatgtacaggtgtcatgttacagaattctgactagcttatatgctttg ggaaccagcaaaagtatttatgtggaaaggcaacgctctgcattaggagaatgtctcgcg gcttttgcgggtgcctttcctgtagcgtttttggaaactcatctcgacaaacataatgtt tactctatctacaatactaagtcctcacgagaaagagcagctctcaatttgccaactaat gtggaagatgtttgcccaaatataccctctttggagaagctcatggaagaaattgtggaa ctagccgagtctggtattcgatacacacaaatgccacatgtaatggaagtcatactgccc atgctttgcagctacatgtcccgttggtgggagcacggacctgaaaacaacccagagagg gctgagatgtgctgcacagcgctgagctctgagcacatgaacacactcctggggaacata ctgaaaatcatctataataacttgggaattgatgagggcgcctggatgaagaggttagca gttttctcgcagcccattataaataaagtgaaacctcagctcctgaaaactcatttcttg ccattaatggagaaactcaagaaaaaagcagcgatggttgtgtctgaggaggaccatctg aaggccgaggccaggggggatatgtccgaggcagaacttctcattcttgatgagttcacc acgctggccagagatctctatgccttctacccgctcttgattagattcgtggattataac agggcaaagtggctaaaagagcctaacccagaagcagaggacctgttccgcatggtggcc gaagtgtttatctactggtcgaaatcccataatttcaaaagagaagagcagaacttcgtg gtacagaatgaaatcaacaatatgtctttccttatcactgacaccaagtcaaagatgtca aaggcggctgtttctgaccaggaaaggaagaaaatgaagcgcagaggagatcggtactcc atgcagacttctctaatagtggcagctctgaagcgactgctgcccatcgggttgaacatc tgtgccccgggggaccaggagctcattgctctggccaaaaaccgattcagtatgaaagac acggaggatgaagtacgagatataatccgcagtaatattcacttacaaggcaagttggag gatcctgctatcagatggcaaatggctctttacaaagacttaccgaacaggactgaagat acatcagatccggagaagactgtggaaagagtattagacatagcaaatgtgctttttcat ctcgagcagaaatctacatgtatgcgccggagatattacagtctgggaagtacagtggag cacccacagagatcgaagaaggcggtgtggcacaagctgttgtccaagcagaggaagagg gcggtggtcgcctgcttcaggatggctcctttatacaatctgccaaggcatcgggctgtc aatctctttcttcagggatatgaaaagtcttggattgaaacagaagaacactattttgaa gataaactgatagaagatttagcaaagcctggagccgaccctccagaagaagaggaaggc acgaagagagttgatcccctccatcagctcatccttctgtttagtcgaacagctttaaca gagaaatgcaaactggaggaagattttttatacatggcctatgcagatattatggcaaag agttgtcatgatgaggaagatgatgatggtgaagaagaagtgaagagttttgaagagaaa gaaatggaaaagcaaaagcttctctaccagcaagccaggctgcacgaccgcggggctgct gagatggtgctgcagaccatcagcgccagcaaaggtgatactggaccaatggtagctgcg actttgaaacttggaattgctatcttaaatggtgggaactccacagtccagcagaaaatg cttgactacctcaaggagaaaaaggatgtgggcttctttcagagtctggctggcctgatg cagtcatgtagtgtcctcgacctaaatgcatttgagcgccaaaacaaagctgaaggactt ggaatggtgaccgaggaaggatcaggagaaaaggttctccaggatgacgagttcacttgc gacctcttccgcttcctacaactgctttgtgagggacacaactcagattttcaaaattat ctgagaactcagaccggcaataacacaaccgtcaacataatcatctctaccgtagactac ctcctgagagtccaggaatccattagtgatttctattggtattattctgggaaagatgtt attgatgaacaaggacaacggaatttctccaaagcaattcaagtagcaaagcaagtcttt aacactctcacggagtatattcagggtccttgcactgggaatcagcagagcttggcccat agcaggctgtgggatgcggttgtgggctttcttcatgtatttgcccacatgcagatgaag ctgtctcaggattccagtcaaattgagctattaaaagaattaatggatcttcagaaggat atggtggtcatgctgctgtccatgttagaaggtaatgttgttaatggaaccattggcaaa cagatggtcgatatgctcgtggagtcttccaacaatgtggagatgattctcaagtttttt gacatgttcttaaaactaaaggatttgacatcctctgacacgtttaaggaatacgatccc gatggcaagggagtcatttccaagagggacttccataaagcgatggaaagccataagcac tacacacagtcggaaaccgagtttcttctgtcctgtgcagagaccgatgaaaatgagacc ctcgactatgaggagtttgtcaaacggttccatgagcccgcaaaggacatcggcttcaac gtcgccgttctcctgaccaacctgtccgaacacatgcccaatgacacgcgactgcagact ttcctggagttggcagagagcgtgctgaattacttccagccctttctgggccgcatcgag atcatgggcagtgccaaacgcatcgagagggtttatttcgaaatcagtgagtccagccgc acccagtgggagaagccccaggtcaaggagtccaaacggcagttcatatttgacgtggtc aatgaagggggagaaaaggagaagatggagcttttcgtcaacttctgtgaggacaccata tttgaaatgcagctggcggcacagatctcagagtcggatctgaatgaaaggtcagcgaat aaggacgaaagtgagaaggagaagcccgaagagcagggacccaggatgggtttcttttcc attctgacagtcaagtcggccctgctggctctcaggtacaatatcttgaccctcatgcgg atgctaagcctgaagagcctgaagaaacagatgaagaaggtgaagaagatgaccatgaag gatatggtcacagccgccttttcatcctactggagtatattcctgagcctcctgcatttc gtggccagcgtttccagaggctttttccgcattgtttgcagcctgctgctggggggcagc ctggtagaaggagcaaaaaagatcagagtggcagagctcttagccaacatgccggacccc actcaggatgaggtgaggggggacggcgaggagggggacaggaagcccatggaagccgcc ctgccctcggaagacctgacggacctaaaggaactgacagaggaaagcgaccttctttcg gacatatttggcttggatctaaagagagaaggaggacagtacaaactcattcctcataac ccaaacgctggcctcagtgacctcatgagcaacccggtccccattcctgacgtgcaagaa aaattccaggaacagaaggcgaaagaggacgaaaaggaggaaaaagaagaaaacaaatct gaaccagaaaaggccgagggagaagatggagaaaaagaagaaaaagccaaagaagataag ggtaaacagaagttgaggcagctccacacgcacagatacggagagcccgaagttcccgag tcagcgttctggaagaagatcatagcgtatcaacagaaacttctaaactattttgctcgc aacttttacaacatgagaatgttagccttatttgtcgcatttgcaatcaatttcatcttg ctcttttataaggtctccacttcttctgtggttgaaggaaaggagctccccactcgcagt ttgagtgaaaatgccaaagttagcagcctagacagcggctcgcccagaatcatggcggtt cactacgtcctggaggagagcagtggctacatggagcccacactgaagatcttagctatt ctgcacacggtcatttctttcttctgcatcatcggatactactgcttgaaagtcccactg gttatttttaagcgagaaaaggaagtagctcgaaaattggaatttgatgggctttatatt acagaacagccttcagaagatgatattaaaggccagtgggatagacttgtaatcaacaca cagtcatttcccaacaactactgggacaaatttgttaaaagaaaggttatggacaagtac ggagagttctatggccgggacagaatcagcgagctcctgggtatggacaaagccgctctg gacttcagcgatgcccgggagaagaagaagccgaagaaagacagctccctatcggccgta ctgaactctatcgacgtaaagtatcagatgtggaaactaggagtcgtcttcaccgacaac tccttcctctacctggcctggtatatgactatgtccgttcttggacactataacaacttt ttttttgctgctcatcttcttgacattgctatgggattcaagacgctaagaaccatcttg tcatcagtaacgcacaatggcaagcagcttgtattaactgttggcttattagctgttgtc gtatacctatatactgtggtggcattcaattttttccgaaaattctacaataaaagcgaa gacggtgacactccagatatgaaatgtgatgacatgctaacgtgctatatgttccacatg tatgtcggggtacgtgccggagggggtatcggtgatgaaatcgaagacccagcaggcgac gaatatgagatctatcgaatcatctttgacatcaccttcttcttctttgtgattgtcatt ctcttggccataatacaaggtttaattattgatgctttcggagaactgagagaccagcag gagcaagtcaaagaagacatggagaccaaatgcttcatctgtgggatagggaacgattac ttcgacacagtgccacatggctttgaaacccacactttacaggaacacaacctggccaat tacctgttttttctgatgtatcttataaacaaagatgaaacagagcacacaggacaggaa tcttatgtctggaagatgtatcaagaaaggtgctgggaatttttcccagcaggggactgt ttccggaaacagtatgaggaccagctaaattag

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