Ursus americanus (American black bear): 123795652
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Entry
123795652 CDS
T07931
Symbol
GCLC
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit isoform X1
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
uar
Ursus americanus (American black bear)
Pathway
uar00270
Cysteine and methionine metabolism
uar00480
Glutathione metabolism
uar01100
Metabolic pathways
uar01240
Biosynthesis of cofactors
uar04216
Ferroptosis
Module
uar_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
uar00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
123795652 (GCLC)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
123795652 (GCLC)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
123795652 (GCLC)
Enzymes [BR:
uar01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
123795652 (GCLC)
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Paralog
GFIT
Motif
Pfam:
GCS
GCS2
Motif
Other DBs
NCBI-GeneID:
123795652
NCBI-ProteinID:
XP_045658510
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All DBs
Position
Unknown
AA seq
637 aa
AA seq
DB search
MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDH
ENKKVRLVLSGEEVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EDNMRKRRKEATSLLGENQALCTITSFPRLGCPGFTLPEFKPNPVEGGASKSLFFPDEAI
NKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFPEDEEAAKASKPDHIYMDA
MGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVI
SASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSECGEKYNDIDLTIDKEIYEQLLQ
EGIDRLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDI
GWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVL
QGMFYFRKDICKGGNTVVDGYGKAQNSPELAVEEYALMSIDTIINGKEGVFPGLIPILNS
YLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYS
LILKCNQIANELCECPELLGPAFRKVKYSGSKTDSSN
NT seq
1914 nt
NT seq
+upstream
nt +downstream
nt
atggggctgctgtcccagggctcgccgctgagctgggaggagaccaagcgccacgccgac
cacgtgcggcggcacgggattctccagttcctgcacatctaccacgccgtcaaggaccgg
cacaaggacgtgctcaagtggggcgatgaggtggaatacatgttggtgtcttttgatcat
gaaaataaaaaagttcggttggtcctgtctggagaggaagttcttgaaactctgcaagaa
aagggggaaaggacaaacccaaaccatcctaccctgtggagaccagagtatggcagttac
atgattgaaggcacacctggacagccgtacggaggaacgatgtccgagttcaacacagtc
gaagacaacatgaggaaacgccggaaggaagcaacttctttattaggagaaaaccaggct
ctctgcacaataacttcatttcccagattaggctgtcctgggttcacgctgcccgagttc
aaacccaatccggttgaaggaggagcttccaagtccctcttctttcctgatgaagccata
aataagcacccccgcttcagtaccctaacacgaaatatccgacacaggagaggagaaaag
gttgtcatcaatgtaccaatatttaaggacaagaatacaccgtctccgtttatagaaaca
tttcctgaggatgaggaggcggccaaagcttctaagcctgatcatatttacatggatgcc
atgggctttgggatgggcaattgctgtcttcaggtaacgttccaagcctgcagcatatct
gaggccagatacctttatgatcagttggccactatctgtccaattgtcatggctttgagc
gctgcgtctcctttttaccgaggctatgtgtcagacattgattgtcgctggggagtgatt
tccgcatctgtagatgatagaactcgggaggagagaggactggagccgctgaagaacaat
aactataggatcagtaagtcccgatacgattcgatagacagttacttatctgagtgcggc
gagaaatacaatgacatcgacttgacaatagataaggaaatctacgaacaactcctgcag
gaaggcatcgatcgtctcctggcccagcatgttgctcatctcttcattagagaccccctg
actctgttcgaagagaaaatacacttggatgatgccaatgaatctgaccattttgagaat
attcagtccacaaattggcagacgatgcgatttaagccccctcctccaaactccgatatt
ggatggagagtagaattccgacccatggaggttcagttaacagactttgagaactctgcc
tatgtggtgtttgtggtgctgcttaccagggtgatcctttcatacaaactggattttctc
attccactatcaaaggttgatgaaaacatgaaagttgcacagaagcgagatgctgtcttg
cagggaatgttttatttcaggaaagatatttgcaaaggtggcaacaccgtggtggatggc
tacggcaaggcccagaacagcccggagctggcggtggaggagtacgccctgatgagcata
gacaccatcatcaacgggaaggaaggtgtgtttcctgggctgatcccgattctgaactct
taccttgaaaacatggaggtggatgtggacaccagatgtagtattctgaactacctgaag
ctgattaagaagagagcatctggagaactaatgacagttgccaggtggatgagagagttt
attgcaaaccatcctgactacaagcaagacagtgttataactgatgaaatgaactatagc
cttattttaaagtgtaaccaaatcgcaaatgaattatgtgaatgcccagagttacttgga
ccagcatttaggaaagtaaaatatagtggaagtaaaactgactcttccaactag
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