Ursus americanus (American black bear): 123797462 Help Entry 123797462         CDS       T07931                                  Symbol SYNE1 Name (RefSeq) nesprin-1 isoform X1   KO K19326   nesprin-1 Organism uar  Ursus americanus (American black bear) Pathway uar04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:uar00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     123797462 (SYNE1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:uar03036]     123797462 (SYNE1) Chromosome and associated proteins [BR:uar03036]  Eukaryotic type   Centrosome formation proteins    LINC complex     123797462 (SYNE1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Spectrin Spectrin_SYNE1 CH SYNE1 KASH STIV_B116-like Motif Other DBs NCBI-GeneID:  123797462 NCBI-ProteinID:  XP_045661324 LinkDB All DBs Position Unknown AA seq 8822 aa AA seqDB search MATSRTASWSPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPLVVDDLFEDMKDG VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPS IVLGLVWTIILYFQIEELTSNLPQLQSLSGSTSSVDSMVSAETASPPSKRKVATKIQGNA KKALLKWVQYTVAKQTGIEVKDFGRSWRSGVAFHSVIHAIRPELVDLERVKGRPNRENLE EAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHHTGPDGQENDEILP GFPSFANSIQNFKREDRLILKETKVWIEQFERDLTRAQMTESNLQDKYQSFKHFRVQYEI KRKQIEHLIQPVHRDGKLSLDQALVKQSWDRVSSRLFDWHIQLDKSLPAPLGTIGAWLYR AEVALREEITIQQVHEETANTIQRKREQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPD QLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIVKYGRRESVELLL QNYISFIENTKFFEQYEVTYQILKQTAEMYIQADGSVEEAENVMKFMNETTAQWRNLSVE VRSVRSMLEEVIANWDRYGNTVASLQAWLEDAEKMLNQSEHAKKDFFRNLPHWIQQHAAM NDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYARADEMDRMKKEYTDCVTVL SDFATEAQKKLSEPLEVSFLNVKLLIQDLEDIEQRLPVMDAQYKMITKTAHLITKERSQE EANEMFATMSRLKEQLTKVKECHSPLLYESRQLLIPLEELEKQMTFFYDSLGKINEILTV LEHEAQSSALFKQKQQELSACQESCKKTMTQIEKGSQNVQKFMTLSSVLKHFDQTKLHRQ IADAHGAFQNMVKKIGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGNPEDLL KRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLL HLKIDVEKNRFLASVEECRTELDRETKLVPQAGSEKIIKEHRIFFSDKGPHHLCEKRLQL IEELCLKLPVRDPVRNTPETCHVTLKELRAAIDTTYMKLVEDPDKWKDYTIRISEFSSWI SAKETQLKGFKSEPFNTANHGEVKRAVEDIRNAVTTKGETLNWLKSRLKILIEVSSENEA QKQGDELAKLSSSFKALVALLSEVEKMLSNFGDCVQYKEIVKSSLEELISGSKEVQEQAE KILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLSGQGREELRKLEST LDNMEHSREKQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELE QTKEFSKRTEGIAVQAENLVKEASEIPLGPKNKQLLQQQAKSIKEQVKKLEDTLEEDIKT MEMVKNKWDHFGNNFEILSVWITEKEKELNALETSSSAMDMQIHQIKVTIQEIESKISSI TELEEEAQSFAQFVTTGESARIKAKLTQIRRYWEELREHAQCLEGTILAHLSQQQKFEEN LRKIQKSVSEFEDKLADPIKICSSATETYKVLQEHMDLCQALEALSSAVATTSASAQKVA DRGCSVQEAAALQQRYEETRTRAKERQTALENLLAHWQRLEKELSTFLTWLERCEAIDSS PEMDISADRVKVESELQSIQALQNEVVSQASIYSNLLQLKESLFSVASKDDVKMMKVHLE RLDERWRDLPQIISKRITFLQTVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISITDHQ AAFTRHKDHVAEVESKKGELQSLQDHLVKLGALGRAESLHLLQSKAEDCFQLFEEASQVV ERRQLALSQLAEFLQSHASLSGVLHRLRHTVEAADSMNRKQTDLLEKDLNRAIQDAKTLE SAAISLDSILAKAQYHLKSGSSEQRTSCRTTADHLCSELERIQNLLGTKQSEADALAVLK KAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKD KAKQIAQKDVAFASEVDREVNRLEVTWNDTKKLIHENQGQCCGLIDLMREYQNLKSAVSK VLENASNVIATRTTIKDQEDLKWALSKHETAKNEMCNKQKELDNFTSKGKQLLSELKKIH SSDFILVKTDMESTVDRWLDISEKIEENMDRLRVSLTIWADVLSSKDEIDGWSNSSVPQL AESISNLNNSLRAEEFLKEFESEVKNKALRLEELHCKVNDLKELTKNPETPPDLQFIEAD LRQKLEHAKEITEEAKGTLKDFTAQSTQVEKFINDITSWLTKIEESLMNCAQTETWEGLT KVKEIQKELQSQQSNISSTQENLNSLCRKYHSVELESLGSALTGLTKNHEAVSQLCSKTQ ASLQDSLEKHFNESMQEFQEWFSGIKAAAKESSDRTGDSKVLEAKLRDLQNILDSISDGQ SKLDAVTQEGQTLYAHVSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCALELGSF EDQHRKLNLWIHEMDERLSTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSTR GQLLSEEGHGAGKEGRLCAQLLTNYQNLLRMTKERLRSCQVALQEHEALEEALQSMWSWV KGIQDRLAAAESTIGSKDTLEKRLLQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKQGQ KVIQTQLQTLKDVWANIMSSSVHAQSTLESVISKWNDYLEWKNQLEQWMESVDQKVEHPL QPQPGLKEKFSLLDHFQSIVSEAEGHAGALQSLASKSRELSQKTKDESFKETAQEELRTQ FNDIVTVSKEKMRKVEEIVKDHLMYLDAVQEFTDWLHSAKEELHRWSDMSGDSSATQKKL SKIKELMDSREIGASRLSRVESLAPAVKQNTSASGCELVDAEMQALRADWKQWEDSVLQT QTSLENLVSQMALSEQEFSGQVAHLEQALDQFSALLTTWAQQLALLEGKHTDQEIVECWQ KGHEILDALQKAEPKTEDLKSQLNELCRFSRDLSTYSGKVSALIKEYNCLCLQASKGCQN REQILQQRFRRAFKDFQQWLVNAKITTAKCFDIPQNINEVSTSLQKIQEFLSESENGQHK LNMMLSKGELLSTLLTKEKADGIQAKVATAKEDWKNFHSNLHQKESALENLKIQMKDFEV SAEPVQDWLSKTEKLVQESSNRLYDLPAKRREQQKLQSVLEEINCYEPQLNRLREKAQQL WEGQAASKSFMHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWLTDAV HMLDSYCHPTSDKSVLDSRMLKLEALLSVKQEKEIQMKMIVTRGEAILQNTSPEGGPALQ QQLQSVKAMWASLLSAAIRCKSQLEGALSKWTSYQDDVRQFSSWMDSVEASLNESERQYA ELREKTTALGKAKLLSEEVLSYSSLLETIELKGAGMTEHYVTQLEFQDLQERYRTIKERA KEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDRHSVLEGDAHTHETTLRDLQELQV RCAEGQALLNSVLHTREEVIPSGIPQTEDRALESLRQDWQAYQQRLSETRTHFNNVVNKL RLMEQKYQQVDEWLKTLESKVSVRTGRQSSRAAKEIQLHQMKKWHEETTAYKDEVEEVGA RAQEMLDENHVSSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESELSLSSYSDW YSSTHKNFKNVATKIDRVDKTMMGKKMKMLEGLLKDMEKGHSLLKSAREKGERALKYLED SEAETLRKEIQEHVEQLKELTSTVRKEHMTLEKGLLLAKEFSDKYKALTQWISEYQEILH TPEEPKMELYEKKAQLSKYKSLQQMVLSHEPSVKSVREKGEALLELVQDVTLKDEIDKLQ SDYKDLCGAGKEHVCSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLMETSSLETIT QQLAHHKAMMEEIAGFEDRLNNLKIKGDNLISQCADHLQAKLKQNVHAHLQGTKDSYSAI CSTAQRVYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLKPSQHPPLSRAEAVKQVKHFR ALQEQARTYLDLLCSMCDLSNSSVKTTAKDIQQTEQMIEQRLAQAQTLTQGWGEIKHMKA ELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQCKQASVTAITERVNKLT KKQESPEHKEISHLNDQWLDLCLQSNNLCLRREEDLQRTRDYHDCMNVVEVFLEKFTTEW DNLARSDAESTAVHLEALKKLALALQERKQAIEDLKDQKQKMIEHLNLDDKELVKEQTSH LEQRWFQLEDLVKRKIQVSVTNLEELNVVRSRFQELMEWAEEQQPTIAEALKQSPPPDMA QNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQIIQKALSDAQRHVNCLSDL VGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQ ASLKTYQNEVTGLWAQGRELMKGATEQEKSEVLGKLQELQSIYDTVLQKCSHRLQELEKS LVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESPELQTQLAKYQQILEQSPEHENLLL TLQRTGQTMLPSLNEVDHSYLNEKLNALPLQFNVIVALAKDKFYKVQEAILARKEYASLI ELTTQSLSELEDQFLKMSKVPTDLRVEEALSIQDGCRALLGEVTGFGEAVDELNQKKESF RSTGQPWQPDKMLHLVTLYHRLKRQTEQRASFLEDTTSAYQEHEKMCHQLEKQLEAVKTE QSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTVHLEDLVPHLDPLAYEKAKQQIQS WQEELNRLTSAIGATVTECESRMVQSIDFQTELSRSLDWLRSVKAELSGPVCLDLSLQDI QEEIRKIQIHQEEVQSSLRIMNALSNKEREKFTKAKELISADLQQTLAELSELDGDIQEA LRTRQAALTQIYSQCQRYYQVFQAANDWLEDAHEMLQLAGNGLDVESAEENLKSHMEFFS TEDQFHSNLEELQGLVASLDPLIRPTGKEDLAQKMASLEEKSQRIIQDSHAQLDLLQRCA AQWQDYQKAREELIELMNDAEKKLSEFSLSKTSSSHEAEEKLSEHKSLVSVVNSFHEKVV ALEDKTSQLEKTGNDASKAAISRSMTTVWQRWTRLCAVAQDQEKILEDAVDEWKSFNTKV KKASEMIDQLQDKLPGSSAEKASKAELFALLDHHDTLVLELEQQQLALGLLRQQALSMLQ DGATPSPGEEPSIIQEITAMQDRCLNIQDKVKSNGKVVKQELKEREVVETQINSVKSWVQ ETKKYLGNPTIEIDARLEELQILLTEATNHRQNIEKVTEEQKNKYLGLYSILPSELSLQL AEVALDLGTIHDQIQDKVREVEQSKAMSQEFSRQIQKIAKDLTNILSKLRAKTDNLAQAK TDQKVLGEELDGCNLELMELDAAIQKFSEQNGQLGKPLAKKIGKLTELHQQTIRQAENRL SKLGQAASHLEEYNEMLEFILKWIEKAKVLVHGKITWNSAHQLREQYILHQTMLEESEEI HGNLEAMIEKLQYLASVYSTEKMFQQVAELGRESEGLRHMIKIRLQNLQDAAKDMKKFET ELKNLQVALEQAQTTLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVHAVQICQSALRIP EDVVTSLPLCHAALHLQEEASRLQHTAIQQCNIMQEAVVQYEQYEQEMQHLQELIEGAHR EIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVT EVEGLAEGTEDLDRELLPATSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPAC RSPSPVANTDASVNQDIAYYQALSPERLQTEAARIHPSTLPPQEFYEPGLEPSATAKLDD LQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIEMKLSESLEHGRSPESQ MAEHQALMDEILMLQDEISELQSSLAEELVSASPESDPAEQLALQSTLTVLAERMSTIKM KASGKRQLLEEKLNDQLEEQRQEQALQRYRWEADELDHWLLSTKATLDTALGTAKEPMDM EAQLVDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKEEAEQLAVKLRTLKGSLLEL QRALHDKQLNIQQGTAQEKEESHADLTASQSPGVQDWLAQARTTWAHQRQSSLQQQKELE QELAEQKSLLRSVASRGEEILTQHSAAETPGGAGEKPDVLSQELGMEGEKSAAEDQMRMK WESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDGQTQDKSAVTSLLDGL NQAFEEVSSQGGGTKRQNIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETEACLFN QETLAKDIKEMSEEMDKNRNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQ MKERLQQILNFQNDLKVLCTSLADNKYIILQKLANVFEQPVAEQIEAIQEAEDGLKELDA GIIELKKRGDKLQIEQPSMQELSKLQDMYDELMMTIGSRRSGLNQNLALKSQYERALQDL ADLLETGQEKMAGGQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVLQ ETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDHQELSRQLEAVESSIPSVGLV EESEDRLIDRIALYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGEHWLN TTNKVSKELHRLETVLKHWTRYQSESAELIHWLQSAKDRLEFWTQQSVTVPQELEMVRDH LNAFLEFSKEVDAKSSLKSSVLSTGNQLLRLKKVDTAALRSELSHIDSQWTDLLTNIPTV QEKLHQLQMDKLPSRHAISEVMTWISLMENVIQKDEENIKNSIGYKAIHEYLQKYKGFKI DINCKQLTVDFVNQSMLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLE GLLESWSEYENNVQSLKTWYETQENRLKQQHRIGDQASVQNAMKDCQDLEDLIRAKEKEV EKIEQNGLALIQNKKEEVSGVVMSTLRELNQTWANLDHMVGQLKILLRSVFDQWNNHKVA LDEINSYLMEARYSLSRFRLLTGSLEAAQVQVDNLQNLQDDLEKQEKNLQRFGSVTNQLL KECHPPVTETLTNTLKDVNMRWNNLLEEIAEQLHSSKALLQLWQRYKDYSKQCASTVQQQ EGRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFVLHELGEQLKQQVDASA ASAIQSDQLSLSQHLCTLEQALCKQQTMLQAGVLDYETFTKSLEALEAWIVEAEEILQGQ DPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWS LISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHE LFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGII DSQIRQWQRYREMAEKLRKWLVEVSYLPVSALGSIPIPLQQARTLFDEVQFKEKVFLRQQ GSYILTVEAGKQLLLSADSGAEAVLQAELTEIQEKWKSASVRLDEQKKKLAFLLKDWEKC ENGIADSLEKLRTFKKKLSQPLPDHHEELHAEQTRCKELENAAGSWTDDLAQLTLLKDTL CAYISADDISILNERMELLQRQWEELCHQLSLRRQQVSERLNEWAVFSEKNKELCEWLTQ MESKVSQNGDILIEEMIEKLKKDYQEEIAVAQENKIQLQQMGERLARASHESKASEIEYK LGKVNDRWQHLLDLMAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCD SDEIQKKLTEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDR RWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKISERTAAFPSSSGVLYTVAKEE LKKFEAFQRQVHESLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTS ILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISL NHNKIEQIIAQGEQLIEKSEPLDAAVIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDD EHDLSDRELELDDSAALSDLHWRDTSVDGVLSPQPSSNPSLSLAQPLRSERSGRDTPASV DSIPLEWDHDYDLSRDLESAVSRALPSEDEEGQEDKDFYLRGAVGLSDVMIPESPEAYVK LTESAIRTTSGAPSALESQIRQLDKALDESRFQMQQTENIIRSKTPTGPELDSSYRGYMK LLSECRGSIDLVKRLEHKLKEEEENFPGFVNLNTTETQTAGVIDRWELIQAQALSKELRM KQHLQKWQQFSADLNNIWAWLAETEGELEQLRRLELSTDIQAIELQIKKLKELQKAVDHR KAIILSINLCSSEFTQTGSEKSQDLQDRLSQMNGCWDHVCSLLEEWRGLLQDALMQCQDF HEMSHGLLLMLENIDRRKNEIVPIDSNLDAETLQDHHKQLMQIRHELSESQLRVASLQDM SCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDMSSSQQDLSSWSSA DELDTSGSVSPTSGRSTPNRQRTPRGKCSLSQPGPSVNSPHSRSTRGGSDSSLSEPRPVR SGRAFLLRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPP PL NT seq 26469 nt NT seq  +upstreamnt  +downstreamnt atggcaacctccaggacggcctcatggtctcctcgggacattgccaacgtgatgcaaaga ctgcaagatgagcaagagatagtacaaaaacgtactttcacaaaatggatcaactctcat ctggccaagcggaaacccccactggtggtagatgatctttttgaagacatgaaagatggt gttaagctgcttgctcttctggaggtcctgtctgggcagaaactgccatgtgaacaagga cgccgtatgaagcgaatccatgctgtggctaatattggcacggcactcaagttccttgaa ggaaggaagattaaattagtcaacattaactccactgatatagctgatggccgaccatca atagttctcggattggtgtggaccattattctatatttccagatcgaggagttgaccagc aacctgccacagctgcagtctctgtcaggcagcacatcctctgtggacagcatggttagc gctgagaccgccagccccccaagtaaacggaaagtggccaccaagatccaaggaaatgct aagaaggctttattaaagtgggttcagtacacagtagccaagcagacgggaatagaagta aaagactttgggcggagctggagaagtggggttgccttccattctgtcatccatgctatt cgaccggaactagtggacttggagagagtgaaagggagaccaaaccgggaaaacctggag gaggctttcactattgctgaaacagaactaggaatcccaagactactggatcctgaagat gttgatgtggataaaccagatgagaagtctattatgacctatgtagcccagttcctgaag cattaccctgacatccaccatacaggccctgatgggcaagagaatgacgaaatacttcca ggttttccatcttttgcaaattctatccaaaattttaagagagaagacaggctaattttg aaggaaacaaaagtttggatagaacaatttgaaagagatttgacaagggcacaaatgaca gaatcaaatttgcaagataaatatcagtcatttaagcacttcagagttcaatatgaaata aaaaggaaacagattgaacatttaatacaaccagtacacagagacggtaaactgtcactt gaccaagcgttggtaaaacaatcctgggacagagtgtcctccaggctctttgattggcat atacagcttgataaatctctccctgcacctctgggcaccataggcgcctggttatacaga gcagaggtggcgctgagagaggaaattaccattcagcaggtccatgaggaaacagccaac acaatacaacgaaaacgcgagcaacacaaggatctgcttcaaaacacagatgcccacaaa agagcattccatgaaatctaccggaccaggtctgttaacgggatcccagtgccacctgat caattagaggacatggccgagaggtttcattttgtttcctccacatcagagctacactta atgaaaatggaatttctagaattaaagtaccgtctgctctcactgctggttcttgcggag tcaaagctgaaatcttggatcgtcaagtatgggaggagagagtcagtggagctgcttctg caaaactacatctcttttatagaaaataccaagttctttgaacagtatgaagtgacatac cagatcttgaaacagacagcagagatgtacatccaagccgacggttcagtggaagaagcc gagaatgtgatgaaattcatgaacgaaaccactgcccagtggaggaacctctcagtagaa gttaggagcgtgcggagcatgctggaagaagtaatcgctaactgggatcgatatggcaat actgtggccagtcttcaggcctggctagaggatgcagagaaaatgctaaatcaatcagag catgccaaaaaggattttttccgaaatttgcctcactggatacagcagcatgctgccatg aatgatgcgggcaattttctaatcgaaacatgtgatgagatggtttcccgagatcttaaa cagcagttactgttgctcaatgggcgatggagggagttattcatggaagtcaagcaatat gctcgggctgatgaaatggacagaatgaagaaggagtacacagactgtgttactgtcctg tctgattttgcaactgaggcccaaaagaaactttctgaacccttagaagtctcttttctt aatgtcaagttactaattcaagacttagaggacattgagcagaggttgcctgtaatggat gctcaatacaagatgattacgaagaccgcacacctcattaccaaagagcgctcccaggaa gaagctaatgaaatgttcgcaaccatgtctaggctcaaagaacagctgaccaaggtcaaa gaatgccattctccactcctttatgagtctcgccagctgttgataccattggaagaatta gaaaagcagatgacattcttttatgactcacttgggaaaatcaatgaaattttaacagtt cttgagcatgaggcacaatctagtgctctttttaaacagaaacaacaggaactgtcagct tgtcaagagagctgtaagaaaaccatgacacaaattgagaaaggcagtcaaaatgttcaa aagttcatgaccttgagtagtgtcttaaagcattttgatcagacaaagctccacagacag attgcggatgcccatggtgctttccagaacatggtgaagaaaattggagactggaagaaa cacgtggaaaccaacagtcgcttgatgaagaaatttgaggagtctcgagcagagttggag aaggtgctgcggattgctcaggagggcctggaggagaaggggaacccagaagacctcctg aagagacataccgagtttttcagtcagctggatcagagagtgctcaatgctttcctgaaa gcttgtgacgagctcaccgacattctccccgagcaggaacagcagggcctgcaggaagcc gttagaaagctccataaacagtggaaggatcttcaaggagaagccccatatcatttgctt catctgaagattgatgtggagaagaacagattcttagcttctgtagaagaatgcagaact gagctggatcgagagaccaagctggtgccccaggcaggcagtgaaaagattattaaagag cacaggattttcttcagtgacaaaggtcctcatcatctttgtgagaaaaggttacagctt attgaagaactgtgtctgaaactcccagtccgggacccggtaaggaacacacctgaaacc tgtcacgtgactctcaaagagctcagagctgccattgatacgacctacatgaagcttgtg gaagacccagacaagtggaaggactacactatcagaatttctgagttctcatcttggata tctgcaaaggagacacagttgaaagggtttaagagtgaacccttcaatactgctaaccac ggagaggttaaacgtgctgtggaggatatcagaaatgctgttaccacaaagggtgagact ctcaactggctgaaatccagacttaaaattttaattgaagtttcttctgagaatgaagcc caaaagcaaggagatgagctggcaaaattatctagttctttcaaggctcttgtggctttg ttgtcagaggttgaaaagatgttaagcaactttggggactgtgtccagtacaaagaaata gtgaaaagttcccttgaagagttaatttctggctctaaagaagtccaggagcaggctgag aagattctggacaccgaaaatctgtttgaagcacagcagttacttcttcatcaccagcaa aagacaaagaggatttctgcaaagaagagagacgtacagcagcagatagctcaggctcag cagggagaaggtgggctgtccggccaaggccgggaggagcttcggaagctggagagcacc ctggacaacatggagcacagcagggagaagcaggaacgccgcattcaggtcacattaaga aagtgggagcgatttgaaacaaacaaagagacagtggtcagatacctttttcaaacaggt tccagccatgagcgcttcttgagtttcagcagtttggaaagtttatcttcagaactggaa cagacaaaggagttttctaaacgaacagaaggtattgcagtccaggctgaaaatcttgtg aaggaagcttccgagataccacttgggcccaagaataagcagctgcttcagcagcaggcc aagtcaatcaaagagcaagtcaaaaaattagaagacacacttgaagaagatattaaaacc atggaaatggtgaaaaacaagtgggatcattttggcaataattttgagatcctgtccgtc tggataactgagaaagaaaaagaactcaatgccttggaaacttcatcatctgccatggac atgcaaatccaccagattaaggtcacaattcaggaaatagaaagcaagatcagcagcatt acagaattagaagaagaagctcagtcttttgctcagtttgtcaccactggagaatctgca 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tcccagaagacaaaggatgaatctttcaaggaaacagctcaagaggaactgagaactcag tttaatgatatagtcactgtttccaaggagaaaatgaggaaagtagaagagattgtgaaa gatcacctcatgtacttagatgcagtccaggaattcacggattggctccattcagcgaag gaggagcttcaccggtggtcggatatgtctggagactcgtcagccacccagaagaaattg tctaaaatcaaggagctgatggattccagagagattggtgcaagccgcctaagcagagtg gagtcgctggctccggcagtgaaacagaacacaagtgccagtgggtgtgagctcgtggac gcggagatgcaggccctgcgcgccgactggaagcagtgggaagacagtgtactccagacg cagaccagcttggagaacctggttagccaaatggccctttcggagcaggagttctcgggc caggtggctcatctcgagcaggcgctggatcagttcagtgcccttctgacaacgtgggcc cagcagttagccctcctggaaggcaagcacacggatcaggagatagtggaatgctggcag aaaggacacgagatactggatgccctacaaaaagcagagcctaaaacagaggatcttaag tctcagctgaatgagctttgtcgattttccagagacctaagtacatacagtggaaaagtt tctgccttgattaaagaatataactgtctttgtttgcaagcatccaagggctgtcagaat agagaacagattttacaacaaagatttcgaagagccttcaaggatttccagcagtggttg gttaacgcaaaaatcactactgccaaatgtttcgatatacctcaaaatattaatgaagtt tcaacaagtcttcagaaaatacaggaatttttgtcagaaagtgaaaatggacagcacaag 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gctttgcaggaacaggcaaggacttacttagatctcctctgctccatgtgtgacttgtca aactcttcagtgaaaaccacagcgaaagacattcaacaaacagagcaaatgattgaacaa aggcttgcccaggcgcagaccttaactcagggctggggagagatcaagcacatgaaggct gagctttggatttacctccaggatgctgaccagcaactacagaatatgaagaggaggcac tcagagctggaactcaacattgcacagaacatggtttcccaagtgaaggattttgttaag aagctgcagtgcaaacaggcatcggtgaccgctattacggaaagggtgaataagttaacc aagaagcaggagtctcctgaacacaaggaaattagtcacttaaatgaccagtggttagat ctgtgtcttcagtccaacaatctgtgcttgcgaagggaagaggatcttcagagaaccaga gattaccatgactgtatgaatgtcgttgaagtgttcttagaaaaatttactacagaatgg gataacttagccagatcggatgcagaaagtacagctgtccatctagaagctttgaaaaag ttagccctagcactgcaggagagaaagcaggctattgaggatctgaaagatcaaaagcaa aaaatgatagaacatctgaatttagatgacaaagaattggtcaaagaacagacaagtcac cttgaacaacgttggtttcagctcgaggaccttgtcaaaaggaaaatccaagtgtcagtc accaacctggaggagttaaatgtggtgaggtccaggtttcaagagctgatggagtgggca gaagagcaacagcccaccattgctgaggccctgaagcagagccccccaccagatatggct cagaacctcctcatggaccacctcgccatttgcagtgaactggaggccaaacagatgctc 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gagtcactcaagccaaaggtccacgccgtgcagatctgccagagcgcactccggatcccc gaggatgtggtcaccagcttgccgctctgccacgccgctctgcacctgcaggaggaggcc agccggctgcagcacacggccatccagcagtgcaacatcatgcaggaggctgtggtgcaa tatgaacagtatgagcaagaaatgcagcacctccaggagcttatagaaggagctcacaga gaaattgaggacaaacctgtggccaccagtaacatccaggagctgcaggcccagatttct cggcatgaggagctggctcagaaaatcaagggctaccaggagcagatcgcctctttgaac tccaagtgcaagatgctgacgatgaaagccaagcacgccaccatgctgctgacggtgacg gaggtggaggggctggcggaggggacagaggacctggacagggagctcctccccgcgacc tcggcccacccctctgtggtcatgatgactgcaggtcgctgtcacactttgctgtcacct gtcactgaggagtctggggaggagggaaccaacagtgaaatttcctctccacctgcctgt cgctccccttcacctgtggctaatacagatgcttctgttaaccaggacattgcttattac caagcgctatctcccgagaggttgcagaccgaggccgcgaggatccaccccagcacgttg ccacctcaggagttctacgaaccaggactagagccatctgctactgctaaactggatgat ttgcagcgctcttgggaaaccttaaagaatgtgatcagtgaaaagcagcgtactctctat gaagctttggagcgtcagcagaagtaccaggactccctccagtccatctccacgaagatg gaggccatcgagatgaaactcagcgagagcctggagcacggcaggagtccagaaagccag atggctgaacatcaggcattgatggacgagattctcatgcttcaagatgagatcagcgag ctccagtcgtctcttgcggaggagctggtgtccgcgtctcccgagtccgaccccgccgaa cagctggccttgcagtccacactcaccgtcttagccgagcgaatgtccaccatcaagatg aaggcctcagggaagcgacagctgttggaggagaagttaaatgaccagctcgaggaacag agacaggaacaggctctgcagaggtaccgctgggaagccgacgagctggatcactggctg ttgagcaccaaggctactctggacactgccctgggtacagccaaggagcctatggacatg gaggcccagctggtggactgccagaacatgctggtggaaatagagcagaaggtggtggcc ttgtccgaactctccgtgcacaatgaaaacctgctgctggagggcaaggcgcacaccaag gaggaggccgagcagctggcggtgaagctgagaaccctcaaggggagcctcctggagctg cagagagcgctgcatgacaaacagctcaacatccagcagggcacagcgcaagagaaggag gagagccatgccgacctaactgccagccagagccccggggtccaggactggctggcccaa gcacggaccacgtgggcccaccagcgacagagcagcctgcagcaacaaaaagagttggaa caggaattagccgagcagaagagcctcctgcggtcagtagccagtcgcggggaggaaatt ctcacccagcactcagctgcagagacccctggtggagctggcgaaaaacctgatgtgtta tcccaggagttggggatggaaggggagaaatcagctgctgaagaccagatgagaatgaaa tgggaaagcctacatcaagaatttagtaccaagcagaagctactacagaatgttctggaa caggaacaagagcaagtgctctacagcaggccgaatcgtctcctatctggtgtgccactg tacaaaggggatgggcagacccaagacaaatctgcagtgacatctttgctggacggattg aaccaggcctttgaggaggtttcatcccagggtggggggacaaagaggcagaacattcac ttggaacagaagttatatgatggggtctcagctacctctacatggttggatgacgttgag gaacgtttatttgttgccacagcacttttaccagaagaaacggaagcttgcctcttcaac caagagactcttgctaaagatattaaggaaatgtctgaagaaatggataagaacaggaac ttgttttcccaagcatttccagagaatggtgataaccgagatgtcattgaagacactttg ggttgtcttttgggcaggttgtccttgctagactcagtagtaaatcaacgctgtcatcag atgaaggaaagacttcagcaaatactaaatttccagaatgatctgaaggtgctgtgtaca tcgctggctgacaacaaatacatcattctgcagaaactggcgaacgtgtttgaacagcct gtggcagaacaaatagaggcaatacaagaggctgaagatgggctaaaggaattggatgca ggaatcatcgaattaaaaaagcgtggggacaagttgcagattgagcagccatccatgcag gaactgtccaaacttcaggacatgtatgatgaactgatgatgaccattggctcccggcgg agtgggctgaaccagaatcttgcactcaagagtcagtacgaaagggccctgcaagatctg gctgacctgctggagactggacaggagaagatggcaggcggccagaaaatcattgtgtcc tccaaagaggaaattcaacaactacttgacaaacataaggaatactttcagggcctggaa tctcatatgatcttgactgaaacactcttcagaaagataatcagctttgcagtcctacag gaaacgcaattccacacagaactgatggcacaggcttcagctgtactaaagcgggctcac aagaggggtgtggagttggagtacattctagagacgtggtctcatctggatgaagaccac caggagctcagcagacagctggaggcggtggaaagtagcatcccgagtgtggggttggtg gaggagagtgaggacaggctcatcgaccggatagcactctaccagcatttgaaatccagc cttaatgaataccagcccaaattatatcaagtattagatgatgggaaacgactgctcata tccattagctgctcagatctagaaagccagctaaatcaactgggagaacactggttaaat actaccaacaaagtgtctaaggagcttcacagattggaaacagtattgaaacactggacc agatatcaaagcgaatctgcagaacttattcactggttacagtctgcaaaagacaggcta gaattttggactcaacaatctgtgacagtcccacaagaactggaaatggtccgtgatcat ctaaatgctttcctggagttttccaaagaagtggatgccaaatcttccctgaaatcatct gttctgagcactggaaatcagcttcttcgattaaagaaagtggacacagctgccctacgt tcagagctgtcacacattgatagccagtggactgacctgctgacaaatattcccactgtc caggagaagctccaccagctccagatggataagctgccttcccgccatgccatttctgaa gttatgacttggatttctctcatggaaaatgttattcaaaaggatgaagagaatataaaa aattcaataggttacaaggcaattcatgaataccttcagaaatataagggttttaagata gatattaactgtaaacagttgacagttgattttgtgaatcagtccatgctacaaatcagt agtcaggatgtggaaagtaaacgcagtgataagactgattttgctgagcagcttggagcc atgaataaaagttggcaaatcctgcagggtctagtgactgagaagatccagctgttggaa ggcttattggaatcttggtcagaatatgaaaataatgtacaaagtctgaaaacttggtat gaaacccaggaaaacagactaaagcaacaacatcgcattggagatcaggcttcagttcag aacgcaatgaaagactgtcaggatctagaagatttgattagagcaaaagaaaaagaggta gagaaaattgagcagaacggacttgctttgattcagaacaagaaagaagaagtctctggt gttgtcatgagcacgctgcgggagctcaaccaaacctgggcaaatttagaccacatggtt gggcaattaaagatactgttgaggtccgtgtttgaccaatggaacaatcacaaggtggcc ttggatgagataaacagctacctcatggaagccagatactctctttcccgcttccgtctg ctgactggctctttagaagccgcacaagttcaggtggacaatcttcagaatcttcaagat gatctggaaaaacaggaaaagaacttgcagaggtttggctctgtcaccaaccaactgtta aaagagtgtcacccacccgtgacagaaacgcttaccaatacgttaaaagatgtcaatatg agatggaacaacttgctggaagagattgctgagcagctgcactccagcaaagccctactt caactttggcaaagatacaaggactactccaaacagtgtgcttccacagttcagcagcag gagggtcgaaccaatgagctcctgaaggcagccaccaacaaggacattgctgatgacgaa gttgctacatggattcaagattgcaacgatctcctcaaaggactggggacagtgaaggat tccctttttgttctgcatgagctgggagagcagctcaagcaacaggtggatgcttcggcg gcatcagccattcaatctgatcagctgtctttgagtcaacacctatgtaccctagagcag gctctttgcaagcagcagactatgttacaggctggagttcttgactatgaaacctttacc aagagcttagaagcattggaggcctggatagtagaagctgaagaaatattacaagggcag gaccctagccactcatctgatctctcaaccatccaggagaggatggaagaacttaagggg cagatgttaaaattcagcagcatggcccccgacctagaccgtctaaatgagcttggatat aggctaccgctgaatgataaagaaatcaaaaggatgcagaatctgaaccggcactggtct ctgatctcctctcagaccacagagagattcagtaagttgcagtcatttttgctgcaacac cagactttcttggaaaaatgtgaaacatggatggaattcctggttcagacggaacagaag ttagcagtagagatttcaggcaattatcagcatcttttggagcagcagagagcacatgag ttgtttcaagcagagatgttcagtcgccagcagattttgcactcgatcattattgatggg cagcgtctcctagaacaaggtcaagttgatgacagggatgaattcaacctgaaattgaca cttctcagcaatcagtggcagggagtgattcgcagggcccagcagagacggggcatcatc gacagccagattcgccagtggcagcggtacagggagatggcagagaagcttcgtaaatgg ttggttgaagtgtcctatcttcccgtgagtgctctcggaagcatcccaataccactgcaa caggcaaggaccctcttcgatgaagtgcagttcaaagaaaaagtgttcctgcgacaacaa ggcagctacatcctaacagtggaggcaggcaagcagctcctgctctcggccgacagtggg gctgaggccgtcttgcaggcagagctcactgaaatccaggagaagtggaaatcagccagc gtgcgtctggatgaacagaagaaaaagctggccttcttgttgaaagactgggaaaaatgt gagaacggaatagctgattctctggagaaactgcgaactttcaaaaagaagctttctcag cctctgccagatcaccacgaagagctgcacgccgagcaaacgcgttgcaaggagctggaa aatgcagctgggagctggacagatgacttggctcagctgacactgctgaaagacaccctc tgtgcctacattagtgccgatgatatctccatcctgaacgaacgcatggagcttctgcaa aggcagtgggaagagctgtgccaccagctctccttaaggcggcagcaagtaagcgagaga ttgaacgaatgggcagtcttcagtgagaagaacaaggagctttgtgaatggttgacccag atggaaagcaaagtttctcaaaatggagacatcctcattgaagaaatgatagagaagctc aagaaggattatcaagaggaaattgctgttgcccaagagaacaaaatacagctccagcaa atgggagaacgacttgccagagccagccacgaaagcaaagcctctgagattgaatacaag ctcggaaaggtcaacgaccggtggcagcatctcctggatctcatggccgccagggttaag aagctgaaggagaccctggtcgccgtacagcagctggataagaacatgagcagcctgagg acgtggctggctcacatcgagtctgagctggccaagccgatagtctatgattcctgtgac tcagatgaaatacagaagaagctcactgagcagcaggagcttcagagagacattgagaaa cacagcacgggtgtggcctccgtcctcaacctgtgtgaggtcctgctgcatgactgcgat gcctgtgccacagatgccgagtgcgattccatccagcaggcgacgcgaaacctggaccgg cggtggagaaatatctgcgccatgtccatggaaagaaggctcaaaattgaagagacatgg cgattgtggcagaaatttctggatgattattctcgttttgaagattggctcaagatttcg gaaaggacggctgccttccccagctcttccggggtgctctatacagttgccaaggaagaa ttaaagaaatttgaggctttccagcgacaggttcacgagagcctgacgcagctggaactg atcaacaagcagtaccgtcgcctggccagagagaaccgcaccgattctgcctgtagccta aagcagatggttcacgaaggcaaccagagatgggacaacctacaaaagcgtgtcacctcc atcttgcgcagactcaagcacttcatcggccagcgtgaggagtttgagaccgcgcgggac agcattctggtgtggctgacagagatggacctccagctcactaacattgagcatttttct gagtgtgatgttcaagctaaaataaagcaactcaaggccttccagcaggaaatttcactg aaccacaataagattgagcagataattgcccaaggagaacagcttatagaaaagagtgag cccttggatgccgcagtcatcgaggaagagctggatgaactccggcgttactgtcaggag gtctttgggcgcgtggaaagataccataagaaactgattcgcctgcctctcccagatgat gagcatgacctctctgaccgggagctggagctggatgactctgcagctctctcggacctc cactggcgtgacacctctgtggacggcgtgctttccccccagccttcctccaacccctcc ctctcactcgcccagcccctgcggagcgagcggtcgggacgagatacccccgccagtgtg gactccatccccctggagtgggaccatgactatgacctcagtcgtgacctggagtctgct gtgtccagagctctgccctctgaggatgaagagggtcaggaggataaagatttctacctc aggggagctgtcggcttatcagatgtaatgatccctgaaagtcctgaggcctatgtaaaa ctcacagaaagtgcaatcagaactacctctggagctcccagtgccttagagtcacagatt cgacaactggacaaagccttggatgagagccgttttcagatgcaacaaactgaaaatatc atccgcagcaagactcccacaggaccggagctagactccagctacagaggctatatgaag ctgctaagtgagtgccgtggcagcatagacttagtgaagagactagaacacaaactgaag gaggaagaagagaatttccccggctttgttaacctgaataccacggaaacccaaacagct ggtgtgattgaccggtgggaactcatccaggcacaggccctgagcaaggagctgagaatg aaacagcacctccagaagtggcagcagttcagcgcggacctgaacaacatctgggcgtgg ctggcggagacggagggagagctggagcagctgcggcgcctggagctcagcaccgacatc caggctatcgagctccagataaagaagctcaaggagctccagaaagctgtggaccaccgc aaagccatcatcctctccatcaacctgtgcagctccgagttcacccagactggcagtgag aaaagccaggatctgcaggatcgcctgtcacagatgaacgggtgctgggaccatgtgtgc tccctgctggaagagtggcggggcctgctccaggatgcactgatgcagtgtcaggatttc catgaaatgagtcatggtttgcttcttatgctggagaacatcgacagaaggaaaaatgaa attgtccctattgattctaacctggatgcagagacacttcaggaccatcacaaacagctt atgcaaataaggcatgagctatcggaatcccagctccgagtggcctcgctgcaagacatg tcttgccaactcctggtgaatgcggaaggcacagactgtttagaagctaaagaaaaagtc catgtgattggaaatcggctcaaacttctcttgaaggaggtcagtcgtcacataaaggag ctggagaagctattagacatgtcaagcagtcagcaggatttgtcttcctggtcttctgct gatgaactggacacctcaggatctgtgagtcctacgtctggaagaagcaccccaaacaga caaagaacgccacgaggcaaatgtagtctctcacagcctggaccctctgtcaacagtcca catagcaggtccacaagaggtggctccgattcctccctttctgagcctcggccagttcgg tccggccgagccttcttactcagagtcctccgagcggctcttccacttcagcttctcctg ctgctcctcatcgggctcgcctgccttgtaccaatgtcagaggaagactatagttgtgcc ctctccaacaactttgcccgatcattccaccccatgctcagatacacaaatggccctcct ccgctctga

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