KEGG   Ursus americanus (American black bear): 123799736
Entry
123799736         CDS       T07931                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
uar  Ursus americanus (American black bear)
Pathway
uar00562  Inositol phosphate metabolism
uar01100  Metabolic pathways
uar04015  Rap1 signaling pathway
uar04020  Calcium signaling pathway
uar04022  cGMP-PKG signaling pathway
uar04062  Chemokine signaling pathway
uar04070  Phosphatidylinositol signaling system
uar04071  Sphingolipid signaling pathway
uar04072  Phospholipase D signaling pathway
uar04081  Hormone signaling
uar04082  Neuroactive ligand signaling
uar04261  Adrenergic signaling in cardiomyocytes
uar04270  Vascular smooth muscle contraction
uar04310  Wnt signaling pathway
uar04371  Apelin signaling pathway
uar04540  Gap junction
uar04611  Platelet activation
uar04613  Neutrophil extracellular trap formation
uar04621  NOD-like receptor signaling pathway
uar04713  Circadian entrainment
uar04720  Long-term potentiation
uar04723  Retrograde endocannabinoid signaling
uar04724  Glutamatergic synapse
uar04725  Cholinergic synapse
uar04726  Serotonergic synapse
uar04728  Dopaminergic synapse
uar04730  Long-term depression
uar04742  Taste transduction
uar04750  Inflammatory mediator regulation of TRP channels
uar04911  Insulin secretion
uar04912  GnRH signaling pathway
uar04915  Estrogen signaling pathway
uar04916  Melanogenesis
uar04918  Thyroid hormone synthesis
uar04919  Thyroid hormone signaling pathway
uar04921  Oxytocin signaling pathway
uar04922  Glucagon signaling pathway
uar04924  Renin secretion
uar04925  Aldosterone synthesis and secretion
uar04926  Relaxin signaling pathway
uar04927  Cortisol synthesis and secretion
uar04928  Parathyroid hormone synthesis, secretion and action
uar04929  GnRH secretion
uar04933  AGE-RAGE signaling pathway in diabetic complications
uar04934  Cushing syndrome
uar04935  Growth hormone synthesis, secretion and action
uar04961  Endocrine and other factor-regulated calcium reabsorption
uar04970  Salivary secretion
uar04971  Gastric acid secretion
uar04972  Pancreatic secretion
uar04973  Carbohydrate digestion and absorption
uar05010  Alzheimer disease
uar05016  Huntington disease
uar05017  Spinocerebellar ataxia
uar05022  Pathways of neurodegeneration - multiple diseases
uar05142  Chagas disease
uar05143  African trypanosomiasis
uar05146  Amoebiasis
uar05163  Human cytomegalovirus infection
uar05200  Pathways in cancer
uar05415  Diabetic cardiomyopathy
uar05417  Lipid and atherosclerosis
Module
uar_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:uar00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    123799736 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    123799736 (PLCB4)
   04310 Wnt signaling pathway
    123799736 (PLCB4)
   04070 Phosphatidylinositol signaling system
    123799736 (PLCB4)
   04072 Phospholipase D signaling pathway
    123799736 (PLCB4)
   04071 Sphingolipid signaling pathway
    123799736 (PLCB4)
   04022 cGMP-PKG signaling pathway
    123799736 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    123799736 (PLCB4)
   04081 Hormone signaling
    123799736 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    123799736 (PLCB4)
   04613 Neutrophil extracellular trap formation
    123799736 (PLCB4)
   04062 Chemokine signaling pathway
    123799736 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    123799736 (PLCB4)
   04922 Glucagon signaling pathway
    123799736 (PLCB4)
   04929 GnRH secretion
    123799736 (PLCB4)
   04915 Estrogen signaling pathway
    123799736 (PLCB4)
   04921 Oxytocin signaling pathway
    123799736 (PLCB4)
   04926 Relaxin signaling pathway
    123799736 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    123799736 (PLCB4)
   04918 Thyroid hormone synthesis
    123799736 (PLCB4)
   04919 Thyroid hormone signaling pathway
    123799736 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    123799736 (PLCB4)
   04924 Renin secretion
    123799736 (PLCB4)
   04925 Aldosterone synthesis and secretion
    123799736 (PLCB4)
   04927 Cortisol synthesis and secretion
    123799736 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    123799736 (PLCB4)
   04971 Gastric acid secretion
    123799736 (PLCB4)
   04972 Pancreatic secretion
    123799736 (PLCB4)
   04973 Carbohydrate digestion and absorption
    123799736 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    123799736 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    123799736 (PLCB4)
   04725 Cholinergic synapse
    123799736 (PLCB4)
   04728 Dopaminergic synapse
    123799736 (PLCB4)
   04726 Serotonergic synapse
    123799736 (PLCB4)
   04720 Long-term potentiation
    123799736 (PLCB4)
   04730 Long-term depression
    123799736 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    123799736 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    123799736 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    123799736 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    123799736 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    123799736 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    123799736 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    123799736 (PLCB4)
   05142 Chagas disease
    123799736 (PLCB4)
   05143 African trypanosomiasis
    123799736 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    123799736 (PLCB4)
   05016 Huntington disease
    123799736 (PLCB4)
   05017 Spinocerebellar ataxia
    123799736 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    123799736 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    123799736 (PLCB4)
   05415 Diabetic cardiomyopathy
    123799736 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    123799736 (PLCB4)
   04934 Cushing syndrome
    123799736 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:uar04131]
    123799736 (PLCB4)
Enzymes [BR:uar01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     123799736 (PLCB4)
Membrane trafficking [BR:uar04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    123799736 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    123799736 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 123799736
NCBI-ProteinID: XP_045664866
LinkDB
Position
Unknown
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
ECSLINSVRLGATPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLLGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESTAPVSILEDDNEEEIESADQEEEAHPEYKFGNELSADDLGHKEAVANSVKKASD
DLEHEINKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNRLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQ
SSSELRPTTTVALGSGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLISAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKTCHAVSQTQGEGDAADGEVGSRDGPQASNSSV
KLQSPN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaactggcagaaggaagttccttcctttttgcaagaagga
gctgtttttgacagatatgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgaatttggcttctttctgacctggaggagtgaaggcaaggaaggacaagtgcta
gaatgctccctcatcaacagtgttcgcctgggagccaccccaaaggatcccaaaatcctg
gccgctcttgaagctgttggaaagtcagagaatgatctggaagggcggatagtttgtgtc
tgcagtggcacggatctggtgaacatcagtttcacatacatggtggctgaaaatccggaa
gtaactaagcaatgggtagaaggactgagatcaatcatacacaacttcagggccaacaat
gtcagtccaatgacctgcctcaagaagcactggatgaaattggcgtttatgaccaacaca
aacggtaaaattccagttaggagcattactagaacctttgcatcggggaaaacagaaaag
gtgatctttcaagcactcaaggagttaggtcttcccagtggaaagaatgatgaaattgag
cctgcagcctttacatacgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaggatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcagcgagaccctcgactgaatgaaattttattc
ccattttatgatgctaaaagggcaatgcagatcatcgagatgtatgagcctgatgaagac
ttgaagaaaaaaggcctcatatcaagcgacgggttttgcagatatctgatgtccgatgaa
aatgccccagtcttcctggatcgtttagaactttaccaagaaatggaccatcccctggcc
cactacttcatcagttcttcccacaacacctatctcacgggccgacagtttggcgggaaa
tcttcagtagaaatgtacagacaggtgctcctggctggttgcagatgtgttgaacttgac
tgttgggatggaaaaggtgaagaccaagaaccaataataactcatggaaaagcaatgtgt
acagatatcctttttaaggatgttattcaagccatcaaggaaaccgcatttgtcacgtcc
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctattgggggacctcctgttgaaacaagcacttgaatcacat
ccacttgaaccaggcaggcccttaccatcccccaatgacctcaaaagaaaaatactcatc
aaaaataaacggctgaaacctgaggttgaaaaaaaacagctcgaagctttgaaaagcatg
atggaagctggagaatccactgccccagttagcatcctagaggacgataatgaagaggag
atagaaagtgctgaccaagaggaggaggctcacccggaatacaaatttggaaacgaactt
tctgctgatgacttgggccacaaggaggctgttgccaatagtgtcaagaaggcttcagat
gaccttgaacatgaaatcaacaaaaagggcctggtcactgtggaagatgaacaggcatgg
atggcatcgtataaatacgtaggtgctaccactaatatccatccgtatttgtctacaatg
atcaactatgcacagcctgtaaagttccaaggtttccatgtggctgaagagcgcaatatc
cattataacatgtcttcttttaatgagtccgtcggtctgggctatttgaagacacacgcg
attgaatttgtgaattataacaaacggcaaatgagccgcatttaccccaagggaggccgg
gtcgattccagtaattacatgcctcagattttctggaatgctggctgccagatggtttcg
ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat
ggatcgtgcgggtacctcctcaaaccagatttcatgagacggccggatcgaacgttcgat
cccttctctgaaactcctgttgatggggttattgcagccacttgctcagtgcaggtcata
tcaggtcagtttttatcagataagaaaattggtacatacgtagaagtggatatgtacggg
ttgcccaccgacaccatacgtaaggaattccgaactcgcatggtgatgaacaacggactc
aatccagtgtacaatgaagaatcatttgtgtttcggaaggtaatcctccctgacctggca
gtcttgagaatagcagtgtatgatgacaacaacaggctgataggccagaggattcttcca
ctggatggcctccaagcaggctatcgacacatttctcttcgaaatgagggaaataaacca
ttatcactgccaacaattttctgcaatattgttcttaaaacatatgtgcctgacggattt
ggagatattgtggatgctttatcagatccaaagaaatttctttccattacggaaaagaga
gcagaccaaatgagagctatgggcattgaaactagtgacatagcagatgtgcccagtgat
acttctaagaatgacaagaaaggaaaagccaacactgccaaagcaaacgtgaccccacag
agcagctccgagctcagaccaaccaccacggtggccctggggtctggcgtggaagccaag
aaaggtatcgaacttatccctcaagtgaggatagaagatttaaagcagatgaaggcttac
ttgaagcatttaaagaaacaacagaaggagctaaattctttaaagaagaaacatgcaaag
gagcacagcacaatgcagaagttgcactgcacgcaagttgacaaaattgtggcccagtat
gacaaagagaagtcaacgcatgagaaaatcctagagaaggcgatgaagaagaagggggga
agtaattgtctcgaaatgaaaaaagaaacagaaattaaaattcagacactgacatcagat
cacaaatctaaggtcaaagagatagtggcccagcacacaaaggagtggtcagaaatgatc
aacacccacagtgctgaggagcaagagatccgggacctccacctcagccagcagtgtgag
ctcctgcgaaagctactgatcagtgcccacgagcagcaaacccagcagctcaaactgtcc
catgacagggaaagcaaggaaatgcgagcacaccaggctaagatttctatggaaaacagc
aaagccatcagccaagataaatctatcaagaacaaagcagaacgggaaaggcgagtcagg
gaattaaatagcagcaacaccaaaaagtttctggaagaaagaaagagactcgcaatgaaa
cagtccaaagaaatggatcagttgaaaaaagtccagcttgaacaccttgagttcctagag
aaacagaatgaacagctattgaaaacctgccatgcagtgtcccaaacacaaggcgaagga
gatgcagcagatggtgaagttggaagccgagatggaccgcaggccagcaacagtagtgtg
aaactccagagcccaaactga

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