KEGG   Ursus americanus (American black bear): 123800861
Entry
123800861         CDS       T07931                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
uar  Ursus americanus (American black bear)
Pathway
uar01521  EGFR tyrosine kinase inhibitor resistance
uar01522  Endocrine resistance
uar04010  MAPK signaling pathway
uar04012  ErbB signaling pathway
uar04014  Ras signaling pathway
uar04015  Rap1 signaling pathway
uar04022  cGMP-PKG signaling pathway
uar04024  cAMP signaling pathway
uar04062  Chemokine signaling pathway
uar04066  HIF-1 signaling pathway
uar04068  FoxO signaling pathway
uar04071  Sphingolipid signaling pathway
uar04072  Phospholipase D signaling pathway
uar04114  Oocyte meiosis
uar04140  Autophagy - animal
uar04148  Efferocytosis
uar04150  mTOR signaling pathway
uar04151  PI3K-Akt signaling pathway
uar04210  Apoptosis
uar04218  Cellular senescence
uar04270  Vascular smooth muscle contraction
uar04370  VEGF signaling pathway
uar04371  Apelin signaling pathway
uar04380  Osteoclast differentiation
uar04510  Focal adhesion
uar04540  Gap junction
uar04550  Signaling pathways regulating pluripotency of stem cells
uar04613  Neutrophil extracellular trap formation
uar04620  Toll-like receptor signaling pathway
uar04650  Natural killer cell mediated cytotoxicity
uar04660  T cell receptor signaling pathway
uar04662  B cell receptor signaling pathway
uar04664  Fc epsilon RI signaling pathway
uar04666  Fc gamma R-mediated phagocytosis
uar04668  TNF signaling pathway
uar04720  Long-term potentiation
uar04722  Neurotrophin signaling pathway
uar04725  Cholinergic synapse
uar04726  Serotonergic synapse
uar04730  Long-term depression
uar04810  Regulation of actin cytoskeleton
uar04910  Insulin signaling pathway
uar04912  GnRH signaling pathway
uar04914  Progesterone-mediated oocyte maturation
uar04915  Estrogen signaling pathway
uar04916  Melanogenesis
uar04917  Prolactin signaling pathway
uar04919  Thyroid hormone signaling pathway
uar04921  Oxytocin signaling pathway
uar04926  Relaxin signaling pathway
uar04928  Parathyroid hormone synthesis, secretion and action
uar04929  GnRH secretion
uar04934  Cushing syndrome
uar04935  Growth hormone synthesis, secretion and action
uar05010  Alzheimer disease
uar05022  Pathways of neurodegeneration - multiple diseases
uar05034  Alcoholism
uar05132  Salmonella infection
uar05135  Yersinia infection
uar05160  Hepatitis C
uar05161  Hepatitis B
uar05163  Human cytomegalovirus infection
uar05164  Influenza A
uar05165  Human papillomavirus infection
uar05166  Human T-cell leukemia virus 1 infection
uar05167  Kaposi sarcoma-associated herpesvirus infection
uar05170  Human immunodeficiency virus 1 infection
uar05200  Pathways in cancer
uar05205  Proteoglycans in cancer
uar05206  MicroRNAs in cancer
uar05207  Chemical carcinogenesis - receptor activation
uar05208  Chemical carcinogenesis - reactive oxygen species
uar05210  Colorectal cancer
uar05211  Renal cell carcinoma
uar05212  Pancreatic cancer
uar05213  Endometrial cancer
uar05214  Glioma
uar05215  Prostate cancer
uar05216  Thyroid cancer
uar05218  Melanoma
uar05219  Bladder cancer
uar05220  Chronic myeloid leukemia
uar05221  Acute myeloid leukemia
uar05223  Non-small cell lung cancer
uar05224  Breast cancer
uar05225  Hepatocellular carcinoma
uar05226  Gastric cancer
uar05230  Central carbon metabolism in cancer
uar05231  Choline metabolism in cancer
uar05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:uar00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    123800861 (MAP2K1)
   04012 ErbB signaling pathway
    123800861 (MAP2K1)
   04014 Ras signaling pathway
    123800861 (MAP2K1)
   04015 Rap1 signaling pathway
    123800861 (MAP2K1)
   04370 VEGF signaling pathway
    123800861 (MAP2K1)
   04371 Apelin signaling pathway
    123800861 (MAP2K1)
   04668 TNF signaling pathway
    123800861 (MAP2K1)
   04066 HIF-1 signaling pathway
    123800861 (MAP2K1)
   04068 FoxO signaling pathway
    123800861 (MAP2K1)
   04072 Phospholipase D signaling pathway
    123800861 (MAP2K1)
   04071 Sphingolipid signaling pathway
    123800861 (MAP2K1)
   04024 cAMP signaling pathway
    123800861 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    123800861 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    123800861 (MAP2K1)
   04150 mTOR signaling pathway
    123800861 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    123800861 (MAP2K1)
   04148 Efferocytosis
    123800861 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    123800861 (MAP2K1)
   04210 Apoptosis
    123800861 (MAP2K1)
   04218 Cellular senescence
    123800861 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    123800861 (MAP2K1)
   04540 Gap junction
    123800861 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    123800861 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    123800861 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    123800861 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    123800861 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    123800861 (MAP2K1)
   04660 T cell receptor signaling pathway
    123800861 (MAP2K1)
   04662 B cell receptor signaling pathway
    123800861 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    123800861 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    123800861 (MAP2K1)
   04062 Chemokine signaling pathway
    123800861 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    123800861 (MAP2K1)
   04929 GnRH secretion
    123800861 (MAP2K1)
   04912 GnRH signaling pathway
    123800861 (MAP2K1)
   04915 Estrogen signaling pathway
    123800861 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    123800861 (MAP2K1)
   04917 Prolactin signaling pathway
    123800861 (MAP2K1)
   04921 Oxytocin signaling pathway
    123800861 (MAP2K1)
   04926 Relaxin signaling pathway
    123800861 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    123800861 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    123800861 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    123800861 (MAP2K1)
   04916 Melanogenesis
    123800861 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    123800861 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    123800861 (MAP2K1)
   04726 Serotonergic synapse
    123800861 (MAP2K1)
   04720 Long-term potentiation
    123800861 (MAP2K1)
   04730 Long-term depression
    123800861 (MAP2K1)
   04722 Neurotrophin signaling pathway
    123800861 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    123800861 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    123800861 (MAP2K1)
   05206 MicroRNAs in cancer
    123800861 (MAP2K1)
   05205 Proteoglycans in cancer
    123800861 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    123800861 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    123800861 (MAP2K1)
   05230 Central carbon metabolism in cancer
    123800861 (MAP2K1)
   05231 Choline metabolism in cancer
    123800861 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    123800861 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    123800861 (MAP2K1)
   05212 Pancreatic cancer
    123800861 (MAP2K1)
   05225 Hepatocellular carcinoma
    123800861 (MAP2K1)
   05226 Gastric cancer
    123800861 (MAP2K1)
   05214 Glioma
    123800861 (MAP2K1)
   05216 Thyroid cancer
    123800861 (MAP2K1)
   05221 Acute myeloid leukemia
    123800861 (MAP2K1)
   05220 Chronic myeloid leukemia
    123800861 (MAP2K1)
   05218 Melanoma
    123800861 (MAP2K1)
   05211 Renal cell carcinoma
    123800861 (MAP2K1)
   05219 Bladder cancer
    123800861 (MAP2K1)
   05215 Prostate cancer
    123800861 (MAP2K1)
   05213 Endometrial cancer
    123800861 (MAP2K1)
   05224 Breast cancer
    123800861 (MAP2K1)
   05223 Non-small cell lung cancer
    123800861 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    123800861 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    123800861 (MAP2K1)
   05161 Hepatitis B
    123800861 (MAP2K1)
   05160 Hepatitis C
    123800861 (MAP2K1)
   05164 Influenza A
    123800861 (MAP2K1)
   05163 Human cytomegalovirus infection
    123800861 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    123800861 (MAP2K1)
   05165 Human papillomavirus infection
    123800861 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    123800861 (MAP2K1)
   05135 Yersinia infection
    123800861 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    123800861 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    123800861 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    123800861 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    123800861 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    123800861 (MAP2K1)
   01522 Endocrine resistance
    123800861 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:uar01001]
    123800861 (MAP2K1)
Enzymes [BR:uar01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     123800861 (MAP2K1)
Protein kinases [BR:uar01001]
 Serine/threonine kinases: STE group
  STE7 family
   123800861 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 123800861
NCBI-ProteinID: XP_045666743
LinkDB
Position
Unknown
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDGEEVDFAGWLCSTIGLNQPSTPTHAAGI
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagctcgatgagcagcagcggaagcgcctggaggccttcctcacccagaagcagaaggtc
ggggaattgaaggatgacgactttgagaagatcagtgagctgggcgctggcaacggtggt
gtggtgttcaaggtctcccacaagccctccggcctggtcatggccagaaagctaattcac
ctggagatcaaacctgcaatccggaatcagatcataagagagctgcaggttctgcacgag
tgcaactcgccttacatcgtgggcttctatggtgcgttctacagcgatggcgagatcagt
atctgcatggaacatatggatgggggttccttggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggtctgacttacctg
agggagaagcacaagattatgcacagagatgtcaagccttccaacatcctcgtgaactcc
cgtggggagatcaagctctgtgactttggggtcagtgggcagctcatcgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tcggtgcagtcggacatctggagcatggggctctctctggttgagatggcggtggggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaagtggag
ggagatgcggctgagacgccacccagaccaaggacccccggaaggcccctcagctcttac
ggaatggacagccggcctcccatggcgatttttgagttgctggattacatagtcaacgag
cctcctccaaaactgcccagtggagttttcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccccgcagagagagcagatctgaagcaactcatggttcatgccttc
atcaagagatcggacggggaagaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagcacaccgacccatgcagccggcatctaa

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