Ursus americanus (American black bear): 123802936
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Entry
123802936 CDS
T07931
Symbol
ERN1
Name
(RefSeq) serine/threonine-protein kinase/endoribonuclease IRE1
KO
K08852
serine/threonine-protein kinase/endoribonuclease IRE1 [EC:
2.7.11.1
3.1.26.-]
Organism
uar
Ursus americanus (American black bear)
Pathway
uar04140
Autophagy - animal
uar04141
Protein processing in endoplasmic reticulum
uar04210
Apoptosis
uar04932
Non-alcoholic fatty liver disease
uar05010
Alzheimer disease
uar05012
Parkinson disease
uar05014
Amyotrophic lateral sclerosis
uar05016
Huntington disease
uar05017
Spinocerebellar ataxia
uar05022
Pathways of neurodegeneration - multiple diseases
uar05417
Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
uar00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
123802936 (ERN1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
123802936 (ERN1)
09143 Cell growth and death
04210 Apoptosis
123802936 (ERN1)
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
123802936 (ERN1)
05012 Parkinson disease
123802936 (ERN1)
05014 Amyotrophic lateral sclerosis
123802936 (ERN1)
05016 Huntington disease
123802936 (ERN1)
05017 Spinocerebellar ataxia
123802936 (ERN1)
05022 Pathways of neurodegeneration - multiple diseases
123802936 (ERN1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
123802936 (ERN1)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
123802936 (ERN1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
uar01001
]
123802936 (ERN1)
Enzymes [BR:
uar01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
123802936 (ERN1)
Protein kinases [BR:
uar01001
]
Serine/threonine kinases: Other
IRE family
123802936 (ERN1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
Ribonuc_2-5A
PK_Tyr_Ser-Thr
PQQ_2
PQQ
Pkinase_fungal
Kdo
APH
PQQ_3
Motif
Other DBs
NCBI-GeneID:
123802936
NCBI-ProteinID:
XP_045669897
LinkDB
All DBs
Position
Unknown
AA seq
973 aa
AA seq
DB search
MPARLLLLALLLPGPGIFGSPSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVL
QVPTHVEEPAFLPDPNDGSLYTLGGKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQ
DIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDY
AASLPEDDGEYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLKKVMH
INVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLMPTLYVGKYSTSLYASPSMVHE
GVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDLKFDPGLKGKNKLNYLRNSWLLI
GHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVINLVDQTSENAPTTISQDV
EEKYEHAPAKPEAPVDSMLKDIATIILSTFLLIGWVAFIITYPLSMQQQQQLQHQQFQKE
LEKIQLLQQQQLPFHPPGDVSQDAELLDSSGLYSESSGTSSPSTSPRASNHSLHSSGSAS
KAGASPFLEQDDEDEETSMVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPE
CFSFADREVQLLRESDEHPNVIRYFCTERDRQFQYIAIELCAATLQEYVEQKDFAHLGLE
PITLLQQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHS
FSRRSGVPGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQAN
ILLGAYSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQD
VSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAM
RNKKHHYRELPAEVRETLGSLPDDFVRYFTSRFPYLLSHTYRAMEPCSHERLFQPYYFHE
PPEPRPPVTPDIL
NT seq
2922 nt
NT seq
+upstream
nt +downstream
nt
atgccggcccggctgctgctgctggcgctgctgctgcccggccccgggatttttggaagt
cccagcacagtgacacttcctgaaaccttgttgtttgtgtcaactctggatggaagtttg
catgctgtcagcaagaggacaggctcaatcaaatggactttaaaagaagatcctgttctg
caggttccaacacatgtggaagagcctgctttcctcccagatcccaatgatggcagcctg
tatacgcttgggggcaagaataatgaaggcctgacgaaacttccttttaccatcccagag
ttggtacaggcatccccatgccgaagttcagatggaattctctacatgggtaaaaagcag
gacatttggtacgttatcgatcttctgactggggagaagcagcagactttgtcatcggcc
tttgcagacagtctctgcccatcaacctctttgctgtatcttgggcgaacagagtacacc
atcaccatgtacgacaccaaaacccgagagctccggtggaacgccacctacttcgactac
gcagcctcgctgcctgaggacgacggggaatacaagatgtcccactttgtgtccaacggc
gatgggctggtggtgaccgtggacagtgaatctggcgacgtcctgtggatccaaaactac
gcttcccccgtggtggccttttacgtctggcagcgggagggtctgaagaaggtgatgcac
atcaatgtcgctgtggagaccctgcgctacctgaccttcatgtctggggaggtgggccgc
atcaccaagtggaagtacccgttccccaaggagacggaggccaagagcaagctgatgccc
accctgtatgttgggaaatactctaccagcctgtatgcctccccctccatggttcacgag
ggggttgccgttgtgccccgaggcagtactcttcctttgctggaaggcccccagaccgat
ggagtcaccattggggacaaaggggagtgtgtgatcacgcccagcacagacctcaagttt
gaccctgggctcaaaggcaagaacaagctcaactacctgaggaactcctggcttctgata
ggacaccatgaaacccccctgtctgcgtctaccaagatgctggagagattccccaacaat
ctgcccaaacatcgggaaaacgtgattcctgccgattcagagaagaagagctttgaggaa
gttatcaacctggttgaccagacttcagaaaacgcgcctaccaccatctcacaggatgtg
gaagagaaatacgagcatgcccctgccaagcccgaggcccccgtggactccatgctcaag
gacatcgccaccatcatcctgagcaccttcctgctcatcggctgggtggccttcatcatc
acctaccccttgagcatgcagcagcagcagcagctccagcaccagcagttccagaaggaa
ctagagaaaatccagctcctgcagcagcagcagctgcccttccatccacctggagacgtg
tctcaagatgctgagctcttggactcgtctggcctgtactccgagagctcaggcaccagc
agccccagcacgtcccccagagcctccaaccactcactccactccagtggctctgcctcc
aaggctggcgccagccccttcctggagcaggatgatgaggatgaggaaaccagcatggtg
atagtcgggaaaatttcattctgtcccaaggatgtgctgggtcacggagctgagggcacg
attgtgtaccggggcatgtttgacaaccgcgacgtggccgtcaagaggatcctccccgag
tgtttcagtttcgcagaccgggaagtccagctgcttcgagaatcggatgagcaccccaac
gtgatccgttacttctgcacggagagggaccggcagttccagtacattgccatcgagctg
tgtgcggccaccctgcaggagtacgtggagcagaaggactttgcccacctcggcctggag
cccatcaccttgctgcaacagaccacctcaggcctggcccatctgcactccctcaacatt
gttcacagagacctgaagccccacaacattctcctctccatgcccaacgcacatggcagg
atcaaggccatgatctcggacttcggcctctgcaagaagctggcggtcggcaggcacagt
ttcagccgccgctcaggagtgccgggcacagaaggctggattgctccagagatgctgagc
gaagactgcaaggacaacccgacctacacagtagacatcttctctgcgggctgtgtcttt
tactacgtgatatcggagggcagccacccttttggcaagtccctgcagcggcaggccaac
atcctcctgggtgcctacagcctcgactgcttgcaccccgagaagcacgaggatgtcatt
gcccgggaattaatagagaagatgatcgcaatggatcctcagaaacgcccttcggcgaag
cacgtgctgaaacacccgttcttctggagcctggaaaagcagctccagttctttcaggat
gtgagtgaccgaatagagaaggagtccctggacggcccgatagtgaagcagctggagcga
ggtgggagagctgtggtgaagatggactggagggagaacatcaccgtccccctgcagaca
gatctgcggaaattcagaacctataaaggtggctccgtccgagacctcctccgagccatg
agaaacaagaagcaccactaccgggagctccccgcggaggtgcgggagacgctgggctcc
ctccccgacgacttcgtgcgctacttcacgtcccgcttcccctacctcctgtcccacacc
taccgggccatggagccgtgcagccacgagcggctcttccagccctactacttccacgag
cccccagagccccggcctccagtgactccagacatcctttga
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