KEGG   Ursus americanus (American black bear): 123803776
Entry
123803776         CDS       T07931                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
uar  Ursus americanus (American black bear)
Pathway
uar01522  Endocrine resistance
uar04010  MAPK signaling pathway
uar04015  Rap1 signaling pathway
uar04068  FoxO signaling pathway
uar04071  Sphingolipid signaling pathway
uar04114  Oocyte meiosis
uar04148  Efferocytosis
uar04218  Cellular senescence
uar04261  Adrenergic signaling in cardiomyocytes
uar04370  VEGF signaling pathway
uar04380  Osteoclast differentiation
uar04550  Signaling pathways regulating pluripotency of stem cells
uar04611  Platelet activation
uar04613  Neutrophil extracellular trap formation
uar04620  Toll-like receptor signaling pathway
uar04621  NOD-like receptor signaling pathway
uar04622  RIG-I-like receptor signaling pathway
uar04625  C-type lectin receptor signaling pathway
uar04657  IL-17 signaling pathway
uar04658  Th1 and Th2 cell differentiation
uar04659  Th17 cell differentiation
uar04660  T cell receptor signaling pathway
uar04664  Fc epsilon RI signaling pathway
uar04668  TNF signaling pathway
uar04670  Leukocyte transendothelial migration
uar04714  Thermogenesis
uar04722  Neurotrophin signaling pathway
uar04723  Retrograde endocannabinoid signaling
uar04728  Dopaminergic synapse
uar04750  Inflammatory mediator regulation of TRP channels
uar04912  GnRH signaling pathway
uar04914  Progesterone-mediated oocyte maturation
uar04917  Prolactin signaling pathway
uar04926  Relaxin signaling pathway
uar04932  Non-alcoholic fatty liver disease
uar04933  AGE-RAGE signaling pathway in diabetic complications
uar04935  Growth hormone synthesis, secretion and action
uar04936  Alcoholic liver disease
uar05014  Amyotrophic lateral sclerosis
uar05020  Prion disease
uar05022  Pathways of neurodegeneration - multiple diseases
uar05132  Salmonella infection
uar05133  Pertussis
uar05135  Yersinia infection
uar05140  Leishmaniasis
uar05142  Chagas disease
uar05145  Toxoplasmosis
uar05152  Tuberculosis
uar05161  Hepatitis B
uar05163  Human cytomegalovirus infection
uar05167  Kaposi sarcoma-associated herpesvirus infection
uar05169  Epstein-Barr virus infection
uar05170  Human immunodeficiency virus 1 infection
uar05171  Coronavirus disease - COVID-19
uar05205  Proteoglycans in cancer
uar05208  Chemical carcinogenesis - reactive oxygen species
uar05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
uar05415  Diabetic cardiomyopathy
uar05417  Lipid and atherosclerosis
uar05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:uar00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    123803776 (MAPK12)
   04015 Rap1 signaling pathway
    123803776 (MAPK12)
   04370 VEGF signaling pathway
    123803776 (MAPK12)
   04668 TNF signaling pathway
    123803776 (MAPK12)
   04068 FoxO signaling pathway
    123803776 (MAPK12)
   04071 Sphingolipid signaling pathway
    123803776 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    123803776 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    123803776 (MAPK12)
   04218 Cellular senescence
    123803776 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    123803776 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    123803776 (MAPK12)
   04613 Neutrophil extracellular trap formation
    123803776 (MAPK12)
   04620 Toll-like receptor signaling pathway
    123803776 (MAPK12)
   04621 NOD-like receptor signaling pathway
    123803776 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    123803776 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    123803776 (MAPK12)
   04660 T cell receptor signaling pathway
    123803776 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    123803776 (MAPK12)
   04659 Th17 cell differentiation
    123803776 (MAPK12)
   04657 IL-17 signaling pathway
    123803776 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    123803776 (MAPK12)
   04670 Leukocyte transendothelial migration
    123803776 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    123803776 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    123803776 (MAPK12)
   04917 Prolactin signaling pathway
    123803776 (MAPK12)
   04926 Relaxin signaling pathway
    123803776 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    123803776 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    123803776 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    123803776 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    123803776 (MAPK12)
   04722 Neurotrophin signaling pathway
    123803776 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    123803776 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    123803776 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    123803776 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    123803776 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    123803776 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    123803776 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    123803776 (MAPK12)
   05161 Hepatitis B
    123803776 (MAPK12)
   05171 Coronavirus disease - COVID-19
    123803776 (MAPK12)
   05163 Human cytomegalovirus infection
    123803776 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    123803776 (MAPK12)
   05169 Epstein-Barr virus infection
    123803776 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    123803776 (MAPK12)
   05135 Yersinia infection
    123803776 (MAPK12)
   05133 Pertussis
    123803776 (MAPK12)
   05152 Tuberculosis
    123803776 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    123803776 (MAPK12)
   05140 Leishmaniasis
    123803776 (MAPK12)
   05142 Chagas disease
    123803776 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    123803776 (MAPK12)
   05020 Prion disease
    123803776 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    123803776 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    123803776 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    123803776 (MAPK12)
   05415 Diabetic cardiomyopathy
    123803776 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    123803776 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    123803776 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    123803776 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    123803776 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:uar01001]
    123803776 (MAPK12)
Enzymes [BR:uar01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     123803776 (MAPK12)
Protein kinases [BR:uar01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   123803776 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Kdo Haspin_kinase UvrD_C
Other DBs
NCBI-GeneID: 123803776
NCBI-ProteinID: XP_045671421
LinkDB
Position
Unknown
AA seq 367 aa
MSSPPPARRGFYRQEVTKTAWEVRAVYQDLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
KHEKLSEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSAGCIMAEMITGKTLFKGSDHLDQLKEIMK
VTGTPPADFVQRLQSADAKNYMKGLPELEKKDFASILTSASPLAVNLLEKMLVLDAERRV
TAAEALTHPYFESLHDTEDEPKAQKYDESFDDMDRTLDEWKRVTYKEVLSFKPPLQLGTK
VSKETAL
NT seq 1104 nt   +upstreamnt  +downstreamnt
atgagctctccgccgcccgcccgcaggggcttctaccgccaggaggtgaccaagacggct
tgggaggtgcgcgccgtgtaccaggacctgcagcccgtgggctccggcgcctacggcgcg
gtgtgctcggccgtggacagccgcacgggcgccaaggtggccatcaagaagctgtaccgg
cccttccagtcggagctcttcgccaagcgcgcctaccgcgagctgcgtctgctcaagcac
atgcgccacgagaacgtcatcgggctgctggacgtgttcactcctgatgaaaccctggat
gatttcacagacttttacctggtgatgccgttcatggggactgacctaggaaagctcatg
aagcacgagaaactgagcgaggaccgaatccagttccttgtctaccagatgctgaagggg
ctaaagtacattcacgctgctggcgtcatccacagggacctgaagcctggcaacctcgcc
gtgaatgaggactgtgagctgaagattctggacttcggcctggcgaggcaggcggacagc
gagatgactgggtatgtggtgacccggtggtaccgggcgcctgaggtcatcttgaactgg
atgcgttacacgcagacagtggacatctggtcagcgggctgcatcatggcggagatgatc
acggggaagacgctgtttaagggcagtgaccacctggaccagctgaaggagatcatgaag
gtgacagggacgcctcccgctgactttgtgcagaggctgcagagtgcggacgcgaagaac
tacatgaagggcctccccgagttggagaagaaggattttgcctccatcctgactagtgca
agccctctggctgtgaacctcctggagaaaatgctggtgctagatgcagagcggcgggtg
acggcggccgaggcgctgacccacccctacttcgagtcactgcatgacacggaggatgag
cccaaggcccagaagtacgatgagtcctttgatgatatggaccgcacgctggacgagtgg
aaacgtgtcacatataaagaagtgctcagcttcaagcctcccctgcagctggggaccaag
gtctccaaggagacggctctgtga

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