Entry |
|
Symbol |
PLCB2
|
Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
|
KO |
|
Organism |
uar Ursus americanus (American black bear)
|
Pathway |
uar04070 | Phosphatidylinositol signaling system |
uar04072 | Phospholipase D signaling pathway |
uar04261 | Adrenergic signaling in cardiomyocytes |
uar04270 | Vascular smooth muscle contraction |
uar04613 | Neutrophil extracellular trap formation |
uar04621 | NOD-like receptor signaling pathway |
uar04723 | Retrograde endocannabinoid signaling |
uar04750 | Inflammatory mediator regulation of TRP channels |
uar04919 | Thyroid hormone signaling pathway |
uar04925 | Aldosterone synthesis and secretion |
uar04927 | Cortisol synthesis and secretion |
uar04928 | Parathyroid hormone synthesis, secretion and action |
uar04933 | AGE-RAGE signaling pathway in diabetic complications |
uar04935 | Growth hormone synthesis, secretion and action |
uar04961 | Endocrine and other factor-regulated calcium reabsorption |
uar04973 | Carbohydrate digestion and absorption |
uar05022 | Pathways of neurodegeneration - multiple diseases |
uar05163 | Human cytomegalovirus infection |
|
Module |
uar_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
Brite |
KEGG Orthology (KO) [BR:uar00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
123804253 (PLCB2)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
123804253 (PLCB2)
04310 Wnt signaling pathway
123804253 (PLCB2)
04371 Apelin signaling pathway
123804253 (PLCB2)
04020 Calcium signaling pathway
123804253 (PLCB2)
04070 Phosphatidylinositol signaling system
123804253 (PLCB2)
04072 Phospholipase D signaling pathway
123804253 (PLCB2)
04071 Sphingolipid signaling pathway
123804253 (PLCB2)
04022 cGMP-PKG signaling pathway
123804253 (PLCB2)
09133 Signaling molecules and interaction
04082 Neuroactive ligand signaling
123804253 (PLCB2)
04081 Hormone signaling
123804253 (PLCB2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
123804253 (PLCB2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
123804253 (PLCB2)
04613 Neutrophil extracellular trap formation
123804253 (PLCB2)
04621 NOD-like receptor signaling pathway
123804253 (PLCB2)
04062 Chemokine signaling pathway
123804253 (PLCB2)
09152 Endocrine system
04911 Insulin secretion
123804253 (PLCB2)
04922 Glucagon signaling pathway
123804253 (PLCB2)
04929 GnRH secretion
123804253 (PLCB2)
04912 GnRH signaling pathway
123804253 (PLCB2)
04915 Estrogen signaling pathway
123804253 (PLCB2)
04921 Oxytocin signaling pathway
123804253 (PLCB2)
04926 Relaxin signaling pathway
123804253 (PLCB2)
04935 Growth hormone synthesis, secretion and action
123804253 (PLCB2)
04918 Thyroid hormone synthesis
123804253 (PLCB2)
04919 Thyroid hormone signaling pathway
123804253 (PLCB2)
04928 Parathyroid hormone synthesis, secretion and action
123804253 (PLCB2)
04916 Melanogenesis
123804253 (PLCB2)
04924 Renin secretion
123804253 (PLCB2)
04925 Aldosterone synthesis and secretion
123804253 (PLCB2)
04927 Cortisol synthesis and secretion
123804253 (PLCB2)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
123804253 (PLCB2)
04270 Vascular smooth muscle contraction
123804253 (PLCB2)
09154 Digestive system
04970 Salivary secretion
123804253 (PLCB2)
04971 Gastric acid secretion
123804253 (PLCB2)
04972 Pancreatic secretion
123804253 (PLCB2)
04973 Carbohydrate digestion and absorption
123804253 (PLCB2)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
123804253 (PLCB2)
09156 Nervous system
04724 Glutamatergic synapse
123804253 (PLCB2)
04725 Cholinergic synapse
123804253 (PLCB2)
04728 Dopaminergic synapse
123804253 (PLCB2)
04726 Serotonergic synapse
123804253 (PLCB2)
04720 Long-term potentiation
123804253 (PLCB2)
04730 Long-term depression
123804253 (PLCB2)
04723 Retrograde endocannabinoid signaling
123804253 (PLCB2)
09157 Sensory system
04742 Taste transduction
123804253 (PLCB2)
04750 Inflammatory mediator regulation of TRP channels
123804253 (PLCB2)
09159 Environmental adaptation
04713 Circadian entrainment
123804253 (PLCB2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
123804253 (PLCB2)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
123804253 (PLCB2)
09174 Infectious disease: parasitic
05146 Amoebiasis
123804253 (PLCB2)
05142 Chagas disease
123804253 (PLCB2)
05143 African trypanosomiasis
123804253 (PLCB2)
09164 Neurodegenerative disease
05010 Alzheimer disease
123804253 (PLCB2)
05016 Huntington disease
123804253 (PLCB2)
05017 Spinocerebellar ataxia
123804253 (PLCB2)
05022 Pathways of neurodegeneration - multiple diseases
123804253 (PLCB2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
123804253 (PLCB2)
05415 Diabetic cardiomyopathy
123804253 (PLCB2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
123804253 (PLCB2)
04934 Cushing syndrome
123804253 (PLCB2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:uar04131]
123804253 (PLCB2)
Enzymes [BR:uar01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
123804253 (PLCB2)
Membrane trafficking [BR:uar04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
123804253 (PLCB2)
Endocytosis
Macropinocytosis
Phospholipase C
123804253 (PLCB2)
|
SSDB |
|
Motif |
|
Other DBs |
|
LinkDB |
|
Position |
Unknown
|
AA seq |
1183 aa
MSLLSPVLLPPKVKAYLSQGERFIKWDDETTIASPVILRVDPKGYYLYWTYQSKEMEFLD
ITSIRDTRFGKFAKIPKSQKLRDVFNMDFPDNNFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVGQNWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKR
VEAALSACHLPKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH
LTKFINQKQRDPRLNSLLFPPARPDQVRGLIDKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLAGCRCVELDC
WKGKPPDEEPIITHGFTMTTDIYFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRMMFGDMLLTEPLEKFPLSPGTPLPSPEDLRGKILIKNKKNQFSGPAAPSTEPGEE
ASVGEDTVWAGEEGAEPEEEEEEEEEEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYE
EMSSLVNYIQPTKFISFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIY
PKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRP
DKQFNPFSVDRIDVVVATTLSITVISGQFLSDRSVRTYVEVELFGLPGDPKRRYRTKLSP
SANSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHS
ESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKFFSAQDKKSVKLKEAMGGLPEKP
FPPGSPVVGPVNGTLAPTSNGSAAGARAKQEATKEAAEPRTASLEELRELKGVVKLQRRH
EKELRDLERRGARRWEELLQRGAAQLAELGPPGAGGCGGRRLGPGKGSRKKRTLPGEEAP
GAAPREGPEGPEGADARARELKDRLELELLQQGEEQYECILKRKEQHVAEQIAKMMELAR
EKQAAELKTLKETLETDTKEMKKKLEAKRLERIQAMVKITSDKMAQERLKREINNSHIQE
VVQVIKQMTENLEKHQEKLEEKQAACLEQIREMEKQFQQEALAEYEARMKGLEAEVKESV
KACLRDCLPSEAKDKPERPCEAFRELCEQDPLTVKTGAQESRL |
NT seq |
3552 nt +upstreamnt +downstreamnt
atgtctctgctcagcccggtcctgctgccccccaaggtgaaggcttatctgagccaaggg
gagcgcttcatcaaatgggacgatgaaaccacaatagcctccccggttatcctccgtgtg
gatcccaagggctactacttatattggacatatcagagtaaggagatggagtttctggat
atcaccagcatcagggatacccgctttgggaagtttgccaagatacccaagagccagaag
ctccgggatgtcttcaacatggacttccctgacaacaacttcctgcttaagacgctcact
gtggtgtccggccctgacatggtggacctcaccttccacaacttcgtctcctacaaggag
aatgtgggccagaactgggccgaagatgtgctggctctggtcaagcacccgctgacagcc
aatgcctcccgcagcaccttcttggacaaaatcctggtcaagctcaagatgcagctcaac
cccgaagggaagattcctgtgaaaaattttttccagatgtttcctgctgaccgcaagcgg
gtggaagctgccctcagcgcctgccacctcccaaaaggcaagaatgatgccatcaatcct
gaggacttcccagaatccgtctacaagagtttcctcatgagcctctgtcctcggccagaa
atagacgagatcttcacttcctaccatgccaaggccaaaccctacatgaccaaggagcac
ttgaccaagttcatcaaccagaaacagagggacccccgtctcaactctttgctgtttccg
ccggcgcggcctgaccaggtgcggggcctcatcgacaagtatgagcccagtggcatcaac
gtgcagaggggccagctctccccggagggcatggtgtggttcctctgtgggcccgagaac
agcgtgctggcccaggacaagctgcttctccaccacgacatgactcagccactcaaccat
tacttcatcaactcctcacacaacacctacctgacagccggccagttctctggcctttcc
tcggccgagatgtaccgccaggtgctgctcgctggctgccgctgtgtggagctggactgc
tggaagggcaagccccctgacgaggagcccattatcacccacggcttcaccatgaccacg
gacatctacttcaaggaagcaattgaagccatcgcagaaagtgcctttaagacctccccc
tatcctgtcatcctgtcatttgaaaaccatgtggactcaccccgccaacaggccaagatg
gctgagtactgccggatgatgtttggggatatgctgctcacagagcccctggaaaagttc
ccgttgagcccaggcacccccctgcccagccctgaggatctccgaggcaagatcctcatc
aagaacaaaaagaaccagttttctggcccagcggcccccagcacggagccgggagaggag
gcctctgtgggggaggacacagtgtgggctggcgaggaaggggcagagccggaggaggaa
gaggaggaagaggaggaagaggaggaggaggaggaagagtcgggaaacctggatgaggag
gagatcaagaagatgcagtcggatgagggcacagcgggcctggaggtgacagcttatgag
gagatgtccagcctagtgaattacatccagcccaccaagttcatctcctttgagttctct
gcccagaagaaccgaagttatgtcatctcgtccttcacagagctcaaggcctatgacctg
ctctccaaggcctcagtgcagtttgtggactacaacaagcgccagatgagccgcatttac
cctaagggcacccgcatggactcctccaactacatgccccagatgttctggaacgccggt
tgccagatggttgccctcaacttccagacgatggacctgcccatgcagcagaacatggcg
ctgtttgagttcaatgggcagagtggctacctgctcaagcatgagttcatgcggcggcca
gacaagcagttcaaccccttctccgtggaccgcatcgatgtggtggtagccaccaccctt
tccatcacggtgatctctgggcagttcctgtcggatcgcagtgtgcgtacgtatgtggaa
gtggaactgtttggccttcctggggaccccaagaggcgctatcgcaccaagctgtcaccc
agcgccaactccatcaatcctgtctggaaggaggagccttttgtctttgagaagatcttg
atgcctgagctggcctccctcagggtggctgtaatggaagaaggcaacaaatttcttggg
caccgcatcatccccattaacgccctgaattctggctaccaccacctgtgcctgcacagc
gagagcaacatgccccttaccatgcctgcactttttgtcttcctggagatgaaggactat
gtacctgacacctgggcagatctcaccgtagctctcgccaatcccatcaagttcttcagt
gcccaggataagaagtctgtgaagctcaaggaagccatgggaggtctgcccgagaaaccc
ttcccacctgggagtccagttgtcggcccggtcaacgggacattggccccaacgagcaac
gggtctgcagctggggccagggccaagcaggaggccacgaaagaagctgcggagccacgg
accgccagcctggaggagctgcgggagctgaagggcgtcgtgaagctgcagcggcggcac
gagaaggagctgcgggacctggagcggcgcggcgcgcggcgctgggaggagctgctgcag
aggggcgcggcgcagctggccgagctggggccgccgggcgcggggggctgcgggggccgc
aggctcggcccggggaagggctctcgcaagaagaggaccctgccgggcgaggaggccccc
ggggccgcgccgagagaaggccccgagggccccgagggcgcggacgcgcgtgcgcgcgag
ctgaaggaccgcctggagctggagctgctgcagcagggcgaggagcagtacgagtgcatc
ctgaagcgcaaggagcagcacgtggcggagcaaatcgccaagatgatggagctggccaga
gagaagcaggctgcagagctgaagaccctcaaggagaccttggagactgacaccaaagag
atgaagaaaaagctggaggccaagaggctggagcggattcaggccatggtcaaaatcacc
tcagacaagatggctcaggaaaggctgaagagagagattaacaactctcacatccaggag
gtggtgcaagtcattaagcagatgacagagaacctggagaagcaccaggagaagctagag
gagaagcaggcagcctgcctggaacagatccgggagatggaaaagcagttccagcaggag
gcgctggcagaatacgaggccaggatgaagggcctggaggctgaggtgaaggagtcagtg
aaggcctgcctcagggactgcttaccctctgaggccaaggacaagcctgagaggccctgt
gaggccttcagggagctgtgtgagcaggacccactcacagtaaagacgggcgcccaggag
agccgcctctga |