| Entry |
|
|---|
| Symbol |
IDH1
|
|---|
| Name |
(RefSeq) isocitrate dehydrogenase [NADP] cytoplasmic
|
|---|
| KO |
|
|---|
| Organism |
umr Ursus maritimus (polar bear)
|
|---|
| Pathway |
| umr01210 | 2-Oxocarboxylic acid metabolism |
| umr05230 | Central carbon metabolism in cancer |
|
|---|
| Module |
| umr_M00010 | Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate |
|
|---|
| Brite |
KEGG Orthology (KO) [BR:umr00001]
09100 Metabolism
09101 Carbohydrate metabolism
00020 Citrate cycle (TCA cycle)
103659809 (IDH1)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
103659809 (IDH1)
09140 Cellular Processes
09141 Transport and catabolism
04146 Peroxisome
103659809 (IDH1)
09160 Human Diseases
09161 Cancer: overview
05230 Central carbon metabolism in cancer
103659809 (IDH1)
Enzymes [BR:umr01000]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.42 isocitrate dehydrogenase (NADP+)
103659809 (IDH1)
|
|---|
| SSDB |
|
|---|
| Motif |
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| Position |
Unknown
|
|---|
| AA seq |
414 aa
MSQKIRGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
AEAIKKYNVGIKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTSSDGSKKMTYLVHNFEEGGGVAM
GMYNQDKSIEDFAHSSFQMALSKSCPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALE
EVCVETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLNIKLAQAKL |
|---|
| NT seq |
1245 nt +upstreamnt +downstreamnt
atgtctcagaaaatccgtggcggttctgtggtagagatgcaaggagatgaaatgacacga
atcatttgggagttgattaaagaaaaactcatatttccgtatgtggaactggacctgcac
agctatgatttaggcatagagaatcgtgatgccaccaatgaccaggtcaccaaggatgct
gcggaagctataaagaagtacaacgttggtatcaagtgtgctaccatcacccccgatgag
aagagggttgaggagttcaagttgaaacaaatgtggaaatcaccaaatggcactatccga
aatattttgggtggcaccgtcttcagggaagctattatctgcaaaaatatcccccgtctt
gtgagcggatgggtaaaacccatcatcataggtcgtcatgcttatggggatcaatacaga
gcaactgattttgttgttcctgggcctggtaaagttgagataacctacacgtcaagtgat
ggatccaaaaaaatgacatacctggtgcataactttgaagagggcggcggtgtggccatg
gggatgtacaatcaagataagtcaatcgaagattttgcgcatagttctttccagatggct
ctgtctaagagttgccctttgtatttgagcaccaaaaacactattctgaagaaatatgat
ggacgttttaaagacatctttcaggaaatatatgacaagcagtacaaatcccaattcgaa
gcccaaaaaatctggtatgagcataggctcattgacgacatggtggcccaagctatgaaa
tccgagggaggcttcatctgggcctgtaaaaactatgatggtgacgtgcagtcggactcc
gtggcccaaggttatggttctcttggcatgatgaccagcgtgctgatttgtccagacggc
aagacagtagaagcagaggctgcccacgggaccgtaacccgtcactaccgcatgtatcag
aaaggacaggagacgtccaccaatcccattgcttccatttttgcctggaccagagggtta
gcccacagggctaagcttgataacaataaagagctcagcttctttgccaaggctttggaa
gaagtctgtgttgagaccattgaggctggcttcatgaccaaggacttggctgcttgtatt
aaaggtttgcccaacgtgcaacgttctgactacttgaatacatttgagttcatggacaaa
ctcggagaaaacttgaatataaaactggctcaggccaaactttaa |
|---|
