Ursus maritimus (polar bear): 103663212
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Entry
103663212 CDS
T03271
Symbol
JAK2
Name
(RefSeq) tyrosine-protein kinase JAK2 isoform X1
KO
K04447
Janus kinase 2 [EC:
2.7.10.2
]
Organism
umr
Ursus maritimus (polar bear)
Pathway
umr01521
EGFR tyrosine kinase inhibitor resistance
umr04062
Chemokine signaling pathway
umr04081
Hormone signaling
umr04148
Efferocytosis
umr04151
PI3K-Akt signaling pathway
umr04217
Necroptosis
umr04550
Signaling pathways regulating pluripotency of stem cells
umr04630
JAK-STAT signaling pathway
umr04658
Th1 and Th2 cell differentiation
umr04659
Th17 cell differentiation
umr04725
Cholinergic synapse
umr04917
Prolactin signaling pathway
umr04920
Adipocytokine signaling pathway
umr04933
AGE-RAGE signaling pathway in diabetic complications
umr04935
Growth hormone synthesis, secretion and action
umr05140
Leishmaniasis
umr05145
Toxoplasmosis
umr05152
Tuberculosis
umr05161
Hepatitis B
umr05164
Influenza A
umr05167
Kaposi sarcoma-associated herpesvirus infection
umr05168
Herpes simplex virus 1 infection
umr05200
Pathways in cancer
umr05207
Chemical carcinogenesis - receptor activation
umr05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
umr05417
Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
umr00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
103663212 (JAK2)
04151 PI3K-Akt signaling pathway
103663212 (JAK2)
09133 Signaling molecules and interaction
04081 Hormone signaling
103663212 (JAK2)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
103663212 (JAK2)
09143 Cell growth and death
04217 Necroptosis
103663212 (JAK2)
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
103663212 (JAK2)
09150 Organismal Systems
09151 Immune system
04658 Th1 and Th2 cell differentiation
103663212 (JAK2)
04659 Th17 cell differentiation
103663212 (JAK2)
04062 Chemokine signaling pathway
103663212 (JAK2)
09152 Endocrine system
04920 Adipocytokine signaling pathway
103663212 (JAK2)
04917 Prolactin signaling pathway
103663212 (JAK2)
04935 Growth hormone synthesis, secretion and action
103663212 (JAK2)
09156 Nervous system
04725 Cholinergic synapse
103663212 (JAK2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
103663212 (JAK2)
05207 Chemical carcinogenesis - receptor activation
103663212 (JAK2)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
103663212 (JAK2)
09172 Infectious disease: viral
05161 Hepatitis B
103663212 (JAK2)
05164 Influenza A
103663212 (JAK2)
05168 Herpes simplex virus 1 infection
103663212 (JAK2)
05167 Kaposi sarcoma-associated herpesvirus infection
103663212 (JAK2)
09171 Infectious disease: bacterial
05152 Tuberculosis
103663212 (JAK2)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
103663212 (JAK2)
05140 Leishmaniasis
103663212 (JAK2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
103663212 (JAK2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
103663212 (JAK2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
103663212 (JAK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
umr01001
]
103663212 (JAK2)
Enzymes [BR:
umr01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
103663212 (JAK2)
Protein kinases [BR:
umr01001
]
Non-receptor tyrosine kinases
JAK family [OT]
103663212 (JAK2)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
FERM_F2
FERM_F1
SH2_1
Jak1_Phl
SH2
ABC1
FERM_C_FAK1
RIO1
Kinase-like
FERM_M
Motif
Other DBs
NCBI-GeneID:
103663212
NCBI-ProteinID:
XP_040476237
UniProt:
A0A8M1F5T3
LinkDB
All DBs
Position
Unknown
AA seq
1132 aa
AA seq
DB search
MGMACLTMTEMEGTSVSPVHQNGDIPGNANPVKDIEPLLQVYLYHSLEKAEGEYLKFPTG
EYVAEDICVAASKACGITPVYHSMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYF
PYWYCNGSNRTYRHGISRGAEAPLLDDFVMAYLFAQWRHDFLHGWIKIPVTHETQEECLG
MAVLDMMRLAKEKDQTPLDIYSSISYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIEQF
SHCKATARNLKLKYLINLETLQSAFYTEQFEVKEPGSGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPDIIDVTIKQASQEGSNESRIVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPMVLENIQSNCHGPILMDFAISKLKKAGNQT
GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLSGTKKNFSNLKDLLNC
YQMETVRSDSIIFQFTKCCPPKLKDKSNLLVFRTNGVSDVPTSPTLQRHNNVNQMVFHKI
RNEDLMFNESLGQGTFTKIFKGIRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWA
MHFLEEKALIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTEL
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE
LLKNNGRLPRPDGCPDEIYLIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
NT seq
3399 nt
NT seq
+upstream
nt +downstream
nt
atgggaatggcttgccttacaatgacagaaatggaaggaacatccgtatctcctgtacat
cagaatggtgatattcctggaaacgctaatcccgtgaaggacatagaaccgctcctacag
gtgtatctttatcattctcttgagaaagctgaaggagagtatctgaagtttccaactggg
gagtatgttgcggaagatatttgtgttgctgcttctaaagcttgtggaatcacacctgtg
tatcatagtatgtttgctttaatgagtgaaacagaaaggatctggtatccgcccaaccat
gtcttccatatagatgagtcaaccagacacaatgtactctacagaataagattttacttt
ccttactggtattgtaatggcagcaacagaacctatcggcatggaatatctcgaggtgct
gaagctcctcttcttgacgactttgtcatggcttacctttttgctcagtggcggcatgat
tttttacatggatggataaaaatacctgtgacccatgaaacacaggaagaatgtcttgga
atggctgtgttagatatgatgagactagccaaagagaaggatcaaaccccactggacatc
tatagctctatcagctacaagacattcttaccaaaatgtgttcgagcaaagatccaagac
tatcatattttgacaaggaaacgaataaggtacaggtttcgcagatttattgagcagttc
agccattgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaact
cttcagtctgccttctacacagagcagtttgaagtaaaagaacctggaagtggtccttca
ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga
gggaaacataaagaaagtgagacactgacagaacaggatttacagttatattgtgacttt
cctgatattattgatgttactattaagcaagcaagccaagaaggctcaaatgaaagtaga
attgtaactatccataagcaagatggtaaaaacctggaaattgaacttagctcattaaga
gaagctttgtcctttgtgtcattaattgatggctattatagattaactgcagacgcacat
cattacctctgtaaagaagtagcacctccaatggtccttgaaaatatacaaagcaactgt
catggcccaattttaatggatttcgccatcagtaaactgaagaaagcaggtaatcagact
ggactctatgtacttcgatgcagtcctaaggactttaataagtattttctgacttttgct
gtcgagcgagaaaatgtcattgaatataagcactgtttgattacgaaaaatgagaatgga
gaatacaacctcagtggaaccaagaagaacttcagtaatcttaaagatcttttgaattgc
taccaaatggaaactgttcgctcagacagtataattttccagtttactaaatgctgtccc
ccaaagttgaaagataaatcaaaccttctggtcttcagaaccaatggtgtttctgatgtt
ccaacatcaccaacattacagaggcataataatgtgaaccaaatggtgtttcacaaaatc
agaaatgaagatttgatgtttaatgaaagccttggtcaaggcacttttacaaaaattttt
aaaggtataagaagagaagtaggagactatggtcaactccatgaaacagaagttctttta
aaagttctggataaagcacacagaaactactcagagtctttctttgaagcagcaagcatg
atgagccagctttctcacaagcatctggttttaaattatggagtatgtgtctgtggggag
gagaatattctggttcaagagtttgtaaaatttggatcattagatacatatctgaaaaag
aataaaaattctataaatatattatggaaacttgaagtggctaaacagttggcatgggcc
atgcattttctagaagaaaaagcacttattcatggaaatgtgtgtgccaaaaatattctg
cttatcagagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatcct
ggcattagtattacagttttgccaaaggacattcttcaggagagaataccatgggtacca
cctgaatgcattgaaaatcctaaaaatctaaatttggcaacagacaaatggagttttggt
accactttgtgggaaatctgcagtggaggagataagcctctgagtgctttggattctcaa
agaaagctacagttttatgaagataggcaccagcttcctgcaccaaagtggacagaatta
gcaaatcttattaataattgtatggattatgaaccagattttagaccttctttcagagcc
atcatacgagatcttaatagtttgtttactccagattatgaactattaacagaaaatgac
atgttaccaaatatgagaataggtgccctagggttttccggtgcttttgaagaccgagac
cctacacagtttgaagagagacacttgaaatttctacagcaacttggcaagggtaatttt
ggcagtgtggagatgtgccggtatgaccctctgcaagacaacactggggaggtggtggct
gtgaagaagctccagcacagtactgaagagcacctgagagactttgaaagggaaattgaa
atcctcaaatcgctgcagcatgacaacattgtaaagtacaagggagtgtgctacagtgct
ggtcggcgtaatctaagattaattatggaatatttaccatatggaagtttacgagactat
ctccaaaaacataaagaacggatagatcataaaaaacttctgcagtatacatctcagata
tgcaagggcatggagtatcttggtacaaaaaggtatatccacagggatctggcaacaagg
aatatattggtggaaaacgaaaacagagttaaaattggagattttgggttaaccaaagtc
ttgccacaagacaaagaatattacaaagtaaaagaacctggtgaaagtcccatattctgg
tatgctcctgaatcactgacggagagcaagttttctgtggcttcagatgtctggagcttt
ggagtggttctgtatgaacttttcacgtatattgagaagagtaaaagtcccccagcggaa
tttatgcgtatgattggcaatgacaaacaaggacagatgattgtgtttcatttgatagaa
ctcctaaagaataatggaagattaccaagaccagatggatgcccagatgagatttatttg
atcatgacagaatgctggaacaataatgtcaatcaacgcccctcttttagagacctagct
cttcgagttgatcaaataagggacaacatggctggatga
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