KEGG   Ursus maritimus (polar bear): 103664348
Entry
103664348         CDS       T03271                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
umr  Ursus maritimus (polar bear)
Pathway
umr01521  EGFR tyrosine kinase inhibitor resistance
umr01522  Endocrine resistance
umr04010  MAPK signaling pathway
umr04012  ErbB signaling pathway
umr04068  FoxO signaling pathway
umr04270  Vascular smooth muscle contraction
umr04650  Natural killer cell mediated cytotoxicity
umr04720  Long-term potentiation
umr04726  Serotonergic synapse
umr04730  Long-term depression
umr04810  Regulation of actin cytoskeleton
umr04910  Insulin signaling pathway
umr04914  Progesterone-mediated oocyte maturation
umr04928  Parathyroid hormone synthesis, secretion and action
umr05010  Alzheimer disease
umr05022  Pathways of neurodegeneration - multiple diseases
umr05034  Alcoholism
umr05160  Hepatitis C
umr05161  Hepatitis B
umr05200  Pathways in cancer
umr05205  Proteoglycans in cancer
umr05208  Chemical carcinogenesis - reactive oxygen species
umr05210  Colorectal cancer
umr05211  Renal cell carcinoma
umr05212  Pancreatic cancer
umr05213  Endometrial cancer
umr05214  Glioma
umr05215  Prostate cancer
umr05218  Melanoma
umr05219  Bladder cancer
umr05220  Chronic myeloid leukemia
umr05221  Acute myeloid leukemia
umr05223  Non-small cell lung cancer
umr05224  Breast cancer
umr05225  Hepatocellular carcinoma
umr05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:umr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    103664348 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    103664348 (ARAF)
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    103664348 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    103664348 (ARAF)
   04720 Long-term potentiation
    103664348 (ARAF)
   04730 Long-term depression
    103664348 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103664348 (ARAF)
   05205 Proteoglycans in cancer
    103664348 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    103664348 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    103664348 (ARAF)
   05212 Pancreatic cancer
    103664348 (ARAF)
   05225 Hepatocellular carcinoma
    103664348 (ARAF)
   05226 Gastric cancer
    103664348 (ARAF)
   05214 Glioma
    103664348 (ARAF)
   05221 Acute myeloid leukemia
    103664348 (ARAF)
   05220 Chronic myeloid leukemia
    103664348 (ARAF)
   05218 Melanoma
    103664348 (ARAF)
   05211 Renal cell carcinoma
    103664348 (ARAF)
   05219 Bladder cancer
    103664348 (ARAF)
   05215 Prostate cancer
    103664348 (ARAF)
   05213 Endometrial cancer
    103664348 (ARAF)
   05224 Breast cancer
    103664348 (ARAF)
   05223 Non-small cell lung cancer
    103664348 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    103664348 (ARAF)
   05160 Hepatitis C
    103664348 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103664348 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    103664348 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    103664348 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103664348 (ARAF)
   01522 Endocrine resistance
    103664348 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:umr01001]
    103664348 (ARAF)
Enzymes [BR:umr01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     103664348 (ARAF)
Protein kinases [BR:umr01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   103664348 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like ABC1 Pkinase_fungal zf-RING-like TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 103664348
NCBI-ProteinID: XP_040488307
UniProt: A0A8M1G0M5
LinkDB
Position
X
AA seq 606 aa
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNCRQFYHSVQDLSGGSRQHEAPSNRPLNEPL
TPQGPSSCTPHRDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTAAPMDSSLIQLTAQSFS
TDAAGSRGGGDGGPRGSPSPASVSSGRKSPHSKSPSEQRERKSVADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq 1821 nt   +upstreamnt  +downstreamnt
atggagccaccacggggcccccctgccaacggggccgagccgtcccgggcagtgggcact
gtcaaagtatacctgcccaacaagcaacgcacagtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggccctcaaggtacggggtctcaatcaggattgctgtgtg
gtctaccggctcatcaaggggcgaaagacagtcaccgcctgggacacagccattgccccc
ctggatggagaggagctcattgtagaggtccttgaagacgtcccactgaccatgcacaat
tttgtacggaagacgttcttcagcctggctttctgcgacttctgccttaagtttctgttc
cacggcttccgctgccaaacctgtggctacaagttccaccagcattgttcctccaaagtc
cccacagtctgtgttgacatgagcaccaactgccgacagttctaccacagtgtccaggat
ttgtccggaggctccagacagcacgaggctccctcgaaccgccccctgaatgagccgcta
acccctcagggtcccagctcctgcaccccgcaccgcgaccctgagcactttcccttccct
gcccctgccaacgccccactccagcgcatccgctccacgtccactcccaacgtccacatg
gtcagcaccgcagcccccatggactccagcctcatccagctcactgcccagagtttcagc
accgatgctgctggtagtagaggtggtggcgatggaggcccccgggggagccccagcccg
gccagcgtgtcctcggggaggaagtccccccattccaagtccccgtcggagcagcgggag
cggaagtccgtggccgatgacaagaagaaagtgaagaatctggggtaccgggactcgggc
tactactgggaggtgccgcccagcgaggtgcagctgctgaagaggatcgggacgggctcg
tttggcaccgtgtttcgcgggcggtggcatggtgatgtggccgtgaaggtgctcaaggtg
gcccaacccacagctgagcaggcccaggccttcaagaacgagatgcaggtgctcaggaag
acgcgtcatgtcaacatcctgctgttcatgggcttcatgacccggccgggatttgccatc
atcacacagtggtgtgagggctccagcctctaccaccacctgcatgtggctgacacacgc
ttcgacatggtccagctcatcgacgtggcccggcagactgcccagggcatggactacctc
catgccaagaacatcatccaccgagatctcaagtctaacaacatcttcctacatgagggg
ctcacagtgaagattggtgactttggcctggccacggtgaagacacggtggagtggggcc
cagcccttggagcagccctcaggctccgtgctgtggatggcggctgaggtgatccgtatg
caggacccgaacccctacagcttccagtcggatgtctatgcctacggggttgtgctctat
gagctcatgaccggctcgctgccttacagccacattggcagccgtgaccagattatcttt
atggtgggccgtggctatctgtccccggacctcagcaaaatctccagcaactgccctaag
gccatgcggcgcctgctgtctgactgcctcaagttccagcgggaggaacgtcccctattc
ccccagatcctggccacgattgagctgctgcagcggtcactccccaagattgagcggagt
gcctccgaaccctccttgcaccgcacccaggctgatgagttgcctgcctgcctactcagc
gcagcccgccttgtgccttag

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