| Entry |
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| Symbol |
SIRT1
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| Name |
(RefSeq) NAD-dependent protein deacetylase sirtuin-1 isoform X2
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| KO |
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| Organism |
umr Ursus maritimus (polar bear)
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| Pathway |
| umr00760 | Nicotinate and nicotinamide metabolism |
| umr04213 | Longevity regulating pathway - multiple species |
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| Brite |
KEGG Orthology (KO) [BR:umr00001]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00760 Nicotinate and nicotinamide metabolism
103667762 (SIRT1)
09130 Environmental Information Processing
09132 Signal transduction
04310 Wnt signaling pathway
103667762 (SIRT1)
04068 FoxO signaling pathway
103667762 (SIRT1)
04152 AMPK signaling pathway
103667762 (SIRT1)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
103667762 (SIRT1)
09143 Cell growth and death
04218 Cellular senescence
103667762 (SIRT1)
09150 Organismal Systems
09152 Endocrine system
04922 Glucagon signaling pathway
103667762 (SIRT1)
09149 Aging
04211 Longevity regulating pathway
103667762 (SIRT1)
04213 Longevity regulating pathway - multiple species
103667762 (SIRT1)
09160 Human Diseases
09161 Cancer: overview
05206 MicroRNAs in cancer
103667762 (SIRT1)
09165 Substance dependence
05031 Amphetamine addiction
103667762 (SIRT1)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
103667762 (SIRT1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:umr03036]
103667762 (SIRT1)
03029 Mitochondrial biogenesis [BR:umr03029]
103667762 (SIRT1)
Enzymes [BR:umr01000]
2. Transferases
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.286 protein acetyllysine N-acetyltransferase
103667762 (SIRT1)
Chromosome and associated proteins [BR:umr03036]
Eukaryotic type
Histone modification proteins
HDACs (histone deacetylases)
SIRTs (sirtuins, class III HDACs)
103667762 (SIRT1)
Mitochondrial biogenesis [BR:umr03029]
Mitochondrial quality control factors
Regulator of mitochondrial biogenesis
Other regulator of mitochondrial biogenesis
103667762 (SIRT1)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Position |
Unknown
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| AA seq |
446 aa
MCLCSGRKTILEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCH
GSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFH
RAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCD
VIINELCHRLGGEYAKLCCNPVKLSEISEKPPRTQKELAHLSELPPTPLNISEDSSSPER
TSPPDSSVIVTLLDQAPKSNVDDPGVSKSKDCMEEKSQEGQNSTRNIESVTEQLESPDLK
NVGSNTGEKNERTSVADTVRKCWPARLAKEQISKRLDGNQYLFLPPNRYIFHGAEVYSDS
EDDVLSSSSCGSNSDSGTCQSPSVEEHLEDESEIEEFYNGLEDEADVNERAGGTGFGIGG
GDHEAGSEAISMKQEVTDINYPSNKS |
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| NT seq |
1341 nt +upstreamnt +downstreamnt
atgtgcctgtgcagtggaaggaaaacaattttggaaatatatcctggacagttccaacca
tctctctgtcacaaattcatagccttgtcagataaagaaggaaaactacttcggaactat
actcagaacatagatacactggaacaggttgcaggaatccaaaggataattcaatgtcat
ggttcctttgcaacagcatcttgcctgatttgtaaatacaaagtagactgtgaagctgta
cgaggagatatttttaatcaggtggttcctcgttgtcctaggtgcccagctgatgagcca
cttgctatcatgaaaccagagatagtcttttttggtgaaaatttaccagagcagtttcat
agagccatgaagtatgacaaagatgaagttgatctcctcattgttattgggtcttccctg
aaagtaagaccagtagcactaattccaagttccataccccatgaagtgcctcagatatta
ataaatagagaacctttgcctcatctgcattttgatgtagagcttcttggagactgtgat
gtcataataaatgaattatgccataggttaggtggtgaatatgccaaactttgctgcaac
cctgtaaagctttcagaaattagtgaaaaacctccacgaacacaaaaagagttggctcat
ttgtcagagttgccacccacacctcttaatatttcagaagactcaagttcaccggaaaga
acttcaccacctgattcttcagtgattgttacacttttagaccaagcacctaagagtaat
gttgatgatcctggtgtgtccaaatcaaaagattgtatggaagaaaagtcacaggaagga
cagaattctactaggaacattgaaagtgttactgaacagttggaaagtccggatttgaag
aatgttggctctaacactggggagaaaaatgaaagaacttcagttgctgacacagtgagg
aagtgctggccagctagacttgcaaaggagcaaattagcaaacggcttgatggtaaccag
tatctgttcttaccaccaaatcgttatattttccatggcgctgaggtatattcggactct
gaagatgacgtcttatcctctagttcttgtggtagtaacagtgatagtggaacgtgccag
agtccaagtgtagaagaacacttggaggatgaaagtgagattgaagaattttacaatggt
ttggaagatgaagctgatgttaatgagagagctggaggaactggatttggaattggtgga
ggtgatcatgaggcaggcagtgaagctatatccatgaaacaggaagtaacagacattaac
tatccatcaaacaaatcataa |
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