Ursus maritimus (polar bear): 103668779 Help Entry 103668779         CDS       T03271                                  Symbol TSC2 Name (RefSeq) tuberin isoform X1   KO K07207   tuberous sclerosis 2 Organism umr  Ursus maritimus (polar bear) Pathway umr04072   Phospholipase D signaling pathway umr04115   p53 signaling pathway umr04140   Autophagy - animal umr04150   mTOR signaling pathway umr04151   PI3K-Akt signaling pathway umr04152   AMPK signaling pathway umr04211   Longevity regulating pathway umr04218   Cellular senescence umr04714   Thermogenesis umr04910   Insulin signaling pathway umr04919   Thyroid hormone signaling pathway umr05163   Human cytomegalovirus infection umr05165   Human papillomavirus infection umr05168   Herpes simplex virus 1 infection umr05231   Choline metabolism in cancer Brite KEGG Orthology (KO) [BR:umr00001]  09130 Environmental Information Processing   09132 Signal transduction    04072 Phospholipase D signaling pathway     103668779 (TSC2)    04151 PI3K-Akt signaling pathway     103668779 (TSC2)    04152 AMPK signaling pathway     103668779 (TSC2)    04150 mTOR signaling pathway     103668779 (TSC2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     103668779 (TSC2)   09143 Cell growth and death    04115 p53 signaling pathway     103668779 (TSC2)    04218 Cellular senescence     103668779 (TSC2)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     103668779 (TSC2)    04919 Thyroid hormone signaling pathway     103668779 (TSC2)   09149 Aging    04211 Longevity regulating pathway     103668779 (TSC2)   09159 Environmental adaptation    04714 Thermogenesis     103668779 (TSC2)  09160 Human Diseases   09161 Cancer: overview    05231 Choline metabolism in cancer     103668779 (TSC2)   09172 Infectious disease: viral    05168 Herpes simplex virus 1 infection     103668779 (TSC2)    05163 Human cytomegalovirus infection     103668779 (TSC2)    05165 Human papillomavirus infection     103668779 (TSC2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:umr01009]     103668779 (TSC2) Protein phosphatases and associated proteins [BR:umr01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      103668779 (TSC2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Tuberin DUF3384 Rap_GAP HEAT Cnd1 Motif Other DBs NCBI-GeneID:  103668779 NCBI-ProteinID:  XP_040491455 UniProt:  A0A8M1G9E1 LinkDB All DBs Position Unknown AA seq 1769 aa AA seqDB search MAKPTSKDSGLKEKFRILLGLGTPRPNPRSAEGKQTEFIITADILRELSVECGINNRIRV IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPPEARHAVLALLKAIVQGQGDRLGVLR ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELAGFVLQWMDVGLSSEFLLVL VNLVKFNSCYLDEYIASMVHMICLLCVQTVSSVDIEVSLQVLDAVVCYNCLPAESLPLFI VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCRIMEDRAYREDAPLLRGAVFFVG MALWGAHRLYSLKNSPTSVLPSFYEAMTCPNEVVSYEIVLSITRLIKKYRRELQAVTWDL LLNIVERLLQQLQSLDSPELRAIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE SSLLNLITYRAQSIHPAKDGWIHNLQLLMERFFRNESRSAVRIKVLDVLSFVLLINRQFY EEELISSVVISQLSHIPEDKDPQVRKLATQLLVDLAEGCHTHHFNSLLDIVEKVIARPLS PPPELEERDMAAYSASLEDVKTAVLGLLVILQTKLYALPASHAMRVYEMLVSHIRLHYKH NYTLPIASSIRLQAFDFLLLLRADSLHRLGLPSKDGAVRFSPYCVCDAMEPERGPEKKAS GPLSPPTGPPGPAPAGPAVRLGSLPYSLLFRVLLQCLKQEADWKVLKLVLSKLPESLRYK VLIFTSPCSVDQLSSALCSMLSGPRTVERLRGTPEGFSRTDLHLAVVPVLTALISYHNYL DKTRQREMVYCLEQGLIYRCASQCVVALAVCSVEMPDIIIKALPVLVVKLTHISATASMA IPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC RLPFRKDFVPYITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKRIQTSLTSASLGSAD ENSMAQADDNLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGN KLVTVTTSVGTGTRSLLGLDSGELQGSPELSSDPGVHVRQTKEAPAKLESQAGQQVCRGA RDRVRSMSGGHGLRVGALDTPASHFPSGPTAAGAQTALASKSERAPAGTQFPAQEKTSLA AYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKER RDTALYKSLSVPAAGSAKPPPPPRSNTVASFSSLCQSSCQAKLHRTISWADSAVVLEEGS PSESHLSAEPTELEDFEATLGTDRRGGRAEAYSRSSSSSSQEEKYPAEELATGGIPIERA VSSEGARPSVELSFQPSQPLSKSSSSPELQTLQDILGDPGDKTDVGRLSPEAKARSQSGI LDGAGASWSASGEESQGRGPAQPEGPLPSGCPRSPSGLRPRGYTISDSAPSRRGKRVERD AFKSRAGASNTEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESFERSVQLLDQIPSY DTHKIAVLYVGEGQSDSELAILSNEHGSYRYTEFLTGLGKLIELKDCQPDKVYLGGLDVC GEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLG TIRGQFNFVHVIISPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHAN MASQVHHSRSNPTDIYPSKWIARLRHIKRLRHRIREEAHYSNPSLPLLQMHPLGHAKGPA QVPAEPVPTYETGQRKRLISSVDDFTEFV NT seq 5310 nt NT seq  +upstreamnt  +downstreamnt atggccaagcctacaagcaaagattcaggcttgaaggagaagttcaggattctgttggga ctgggaaccccgaggccaaaccccaggtctgcagagggcaaacagacggagtttatcatc accgcggacattctgagagaactgagtgttgaatgtggtatcaacaatcgcatccgggtg atagggcaaatctgcgaggttgcaaaaacgaagaagtttgaagagcatgcggtggaggcg ctgtggaaggccgtggcggacctgttgcagccagagcggcccccggaggcccggcacgcg gtgctggctctgctgaaggccatcgtgcaggggcagggggaccgcttgggcgttctcagg gccctcttctttaaggtcatcaaggattacccctctaatgaagacctacacgagagactg gaagtgttcaaggctctcacggacaatgggagacacatcacctacttggaagaagaactg gctggctttgtcctgcagtggatggacgtcggcctgtcctcagaattcctcctggtgctt gtgaacttggtcaagttcaacagctgttacctggatgaatacattgcatcaatggtccac atgatctgcctgctgtgtgtccagaccgtgtcatccgtggacatagaggtctcgctgcag gtgctggacgccgtggtctgctacaactgcttgccggctgagagcctccccctgttcatc gtcaccctctgccgtaccatcaacgtcaaggagctctgtgagccttgctggaagctgatg cgtaacctgctgggcacccacctgggccacagcgccatctacaacatgtgtcgtatcatg gaggacagagcctatagggaagacgccccgctgctgagaggggccgtgttcttcgtgggc atggctctctggggagcgcaccggctctattccctcaagaactctccgacgtccgtgctg ccctcgttttatgaggccatgacctgtccaaacgaggtggtgtcctacgaaattgtgctc tccataaccagacttatcaagaagtaccggcgggagctccaggcggtgacgtgggacctc ctgctcaacatcgtggagcgcctgcttcagcagctccagagcctggacagcccggagctc agagccatcgtccacgacctgctgaccacggtggaagagctgtgtgatcagaatgaattc catggctctcaggagagatactttgagctggttgagcgatgtgcagaccagaggcctgag tcctccctcctgaatttaataacctaccgggctcagtcaatccatccggcgaaggacggc tggattcacaacctgcagctgctgatggagagattcttcaggaatgaatctcgcagtgcc gtgcgcatcaaggtgctggacgtcctgtccttcgtgcttctcatcaacaggcagttctat gaggaggagctgatcagctcagtggtcatctcacagctctcccacatcccggaggacaaa gacccccaagtccggaaactggccacccagttgctggtggacctggccgagggctgtcat acccaccacttcaacagcctgctggacattgtggaaaaggtgattgcccgccccctttct ccacccccggagctggaggagagagacatggcggcgtactcggcctccctagaggatgtg aagactgccgtcttggggctcctcgtcatccttcagaccaagctgtacgccttgcctgcc agccacgcgatgcgtgtgtacgagatgctcgtcagccatatccggctccactacaaacac aactataccctgcccatcgccagcagcatccggctgcaggcctttgacttcctgctgctg ctgagggccgactcgctgcaccgcctcggcctgcccagcaaggacggggccgtgaggttc agcccctactgtgtctgcgacgccatggagccagagagaggcccagagaagaaggccagc ggccccctgtcgcctcccaccgggccgcccggccctgcgcccgcgggccccgcggtgcgg cttggctctctgccctactccctgctcttccgcgtcctgctgcagtgcttgaagcaggag gccgactggaaagtgctgaagctcgtgctcagcaagctgcccgagtccctgcgctacaag gtgctcatcttcacgtctccctgcagcgtcgaccagctgtcgtccgccctctgctccatg ctttcaggtcccagaactgtggagcggcttcgaggcaccccggaagggttctctagaact gacctccatctggctgtggttcccgtgttgacggcgctaatctcttaccacaactatttg gacaagaccagacagcgggagatggtgtactgcctggagcagggcctgatctaccgctgc gccagccagtgcgtggtggcgctggccgtctgcagcgtggagatgccggacatcatcatc aaggcgcttcccgtgctggtcgtgaagctcacgcacatctcggccacggccagcatggcc attccactccttgaattcctgtcaactctggccaggctgccccacctctacaggaacttc gcggcagagcagtatgcgagcgtgttcgccatctccctgccttacaccaacccctccaag tttaatcagtacatcgtgtgtctggcccatcacgtcatagccatgtggttcattaggtgc cgcctgcccttccggaaggattttgtcccttacatcactaagggcctgcgctccaacgtc ctcctgtccttcgatgacacccccgagaaggacagcttcagagcacgaagcaccagtctc aacgagaggcccaagaggatccagacgtctctcacaagtgccagcttggggtctgcagac gagaattcgatggcccaggctgatgacaacttgaaaaatctccacctggagctcacggaa acgtgtctggacatgatggccagatacgtgttctccaacttcacagcggtccccaagagg tctcctgtgggagagttcctcctggctggtggcaggaccaaaacctggctggttgggaac aagcttgtcaccgtgacaacgagcgtggggaccgggacccggtcgctgctgggcttagac tccggagagctgcagggtagcccagagttgagctctgaccctggcgtgcacgtgagacag accaaggaggcgcccgccaagctggagtcccaggcggggcagcaggtgtgccgcggggcc cgggaccgggtccgctccatgtctgggggccacggccttcgtgttggtgccctggacact ccagcctcccacttcccaagtggccccactgccgcgggcgcacagacggccctagccagc aagtctgagagggcgccagctggcacccagttcccggcgcaggagaagacgagcctggcg gcctacgtccccctgctgacccagggctgggcagagatcctggtccggaggcctacaggg aacaccagctggctgatgagcctggagaacccactcagccccttctcctcggacatcaac aacatgcctctgcaggagctgtccaacgcactcatggccgccgagcgctttaaggagcgt cgtgacacagccctgtacaagtcgctgtcggtgcccgcggctggctcggccaagccccct ccgccgccccgctctaacacggtggcctctttctcctccctgtgccagtccagctgccag gcaaagctgcacaggaccatttcctgggcagactcggcggtggtcctagaggagggaagt ccgagcgagagtcatttgtccgcggagcccacggagttggaggactttgaggcaacgcta ggcacagacaggcgcggcggccgcgcggaggcatacagcaggtcatcttcaagctccagc caagaggagaagtaccctgcggaggagctggctaccggagggatccccattgagcgggcc gtctcttccgagggtgcccggccttctgtggagctctccttccagccctcccagcccctg agcaagtccagctcctcgcctgagctgcagaccctgcaggacatacttggggaccctggg gacaagacggatgttggccggctgagccctgaggccaaggcacggtcacagtccgggatc ctggacggggcaggtgcctcctggtcagcctcaggtgaagagagccagggccggggccct gcgcagcccgagggtcccttgccttccggctgcccccgctcccccagtggcctgcggccc agagggtacaccatctctgattcggccccgtcacgcagaggcaagagggtagagagggac gccttcaagagcagagctggggcctccaatactgagaaggtgccaggtatcaatcccagc tttgtgttcctgcagctgtaccattcacccttctttggtgacgagtccaacaagcccatc cttctacccaatgagtccttcgagcggtcagtgcagcttctcgaccagattccatcctac gacacacacaagattgccgtcctgtacgtgggagaaggccagagcgacagcgagctcgcc atcctgtccaacgagcacggctcgtacaggtacacagagttcctgaccggcctgggcaag ctcatcgagctcaaggactgccagccggacaaggtgtatctgggtggcctggatgtatgt ggggaggatggccagttcacctactgctggcatgacgacatcatgcaagccgtcttccac attgccaccctgatgcccaccaaggacgtggacaagcaccgctgtgacaagaagcgtcac ttaggcaacgacttcgtgtccatcgtctacaacgactccggcgaggacttcaagctgggc accatcagaggccagttcaacttcgttcacgtgattatcagccccctggactacgagtgc aacctggtgtccctgcagtgcaggaaagacatggagggtctcgtggacaccagcgtggcc aagattgtgtctgaccgcaacctgccttttgtggcccgtcagatggctctgcacgccaac atggcctcccaggtgcatcatagccgctccaaccccaccgacatctacccttccaaatgg atcgccaggctccgccacatcaagcggctccgccaccggatccgtgaggaagcccactac tccaaccccagcctgcccctgctgcagatgcaccccctgggccacgccaaaggccctgct caggtgccggcagagcccgtgcccacgtacgagacgggccagcggaagcgcctcatctcc tcagtggacgacttcacagagttcgtgtga

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