Ursus maritimus (polar bear): 103670449
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Entry
103670449 CDS
T03271
Symbol
FPGS
Name
(RefSeq) folylpolyglutamate synthase, mitochondrial isoform X1
KO
K01930
folylpolyglutamate synthase [EC:
6.3.2.17
]
Organism
umr
Ursus maritimus (polar bear)
Pathway
umr00790
Folate biosynthesis
umr01100
Metabolic pathways
umr01240
Biosynthesis of cofactors
umr01523
Antifolate resistance
umr04981
Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:
umr00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
103670449 (FPGS)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
103670449 (FPGS)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
103670449 (FPGS)
Enzymes [BR:
umr01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.17 tetrahydrofolate synthase
103670449 (FPGS)
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Ortholog
Paralog
GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Motif
Other DBs
NCBI-GeneID:
103670449
NCBI-ProteinID:
XP_040487879
UniProt:
A0A8M1G6Q7
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All DBs
Position
Unknown
AA seq
593 aa
AA seq
DB search
MSQARCHLRAALFLAAVSPRGATTGVTAWRGLSAWPAPQEPGMEYQDAVRTLNTLQTNAG
YLEQVKRQRGDPQTQLEAMKLYLARSGLQVEDLDQLNIIHVTGTKGKGSTCAFTERILRS
YGLKTGFFSSPHLVQVRERIRINGQPVSPELFTKHFWRLYHRLEETKDSSSCVSMPAYFR
FLTLMAFHIFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEEI
AWQKGGIFKCGVPAFTVLQPDGPLAVLQDRAQHISCPLYLCPPLEALEEGGPPLTLGLEG
EHQRSNAALALQLARCWLQQKGHQAPPSSGLGELKVFRPNVLRQMPLAPVFQPTSHMRHG
LRDTEWLGRTQVLQRGPLTWYLDGAHTASSVQACVRWFRQALHRSHRPSRGPEVRILLFN
ATGDRDPAALLKLLQPCQFDYAVFCPNLTDVSSAGSADQQNFMVTLDQVLLRCLAHQQHW
SRLAEEQASPDPWSPASPEPGEPTSLLLASRPPCTHSTSSLVFSCISHALQWISQGRDPV
FQPPSPPQGLLAHPVAGSGAGVLREAAAIHVLVTGSLHLVGGVLKLLEPALSQ
NT seq
1782 nt
NT seq
+upstream
nt +downstream
nt
atgtcgcaggcacgttgccacttgcgcgccgctctcttcctggcagcagtttctccgcgc
ggtgcaacgaccggggtcacggcgtggcgagggttgagcgcgtggcccgcgccgcaggag
ccgggcatggagtatcaggatgctgtgcgcacactgaacaccctgcagaccaatgctggc
tacctggagcaggtgaagcgccagcggggagaccctcagacacagctggaagcgatgaag
ctgtacttggcccggagtgggctgcaggtggaagacttggaccagctgaacatcattcac
gtcactgggaccaaggggaagggttccacttgtgccttcaccgaacgtattctccgcagc
tatggcctgaagacaggattctttagctctccccacctggtgcaggtgcgggagcggatc
cgcatcaacgggcagcccgtaagccccgagctcttcaccaagcacttctggcgcctctac
caccggctggaggagaccaaggacagcagcagctgtgtctccatgcccgcctacttccgc
ttcctcacactcatggccttccacatcttcctccaagagaaggtggacctggcggtggtg
gaagtgggcattggtggcgcttacgactgcaccaacatcatcaggaagcctgtggtgtgt
ggcgtctcctctcttggcatcgaccacaccagccttctgggggacacagtggaagagatc
gcatggcagaaagggggcatcttcaagtgtggcgtccctgctttcactgtgctccagccc
gacggtcccctggcagtgctgcaggaccgtgcccagcacatctcttgtcctctctacctg
tgcccaccactggaagccctggaggaaggggggccgccgctgaccctgggcctggaggga
gagcaccagcggtccaatgctgccttggccttgcagctggctcgctgctggctgcagcaa
aagggccaccaggcccctccctcctcaggcctcggggagctgaaggtgtttcggcccaac
gtcttgcggcagatgcccctggcacccgtgttccagcccacgtcccacatgcggcatggg
cttcgggacacggagtggctgggccggacgcaggtgctgcagcgcgggcccctcacctgg
tacctggacggtgcgcacaccgccagcagcgtgcaggcctgcgtgcgctggttccgccag
gcgctgcaccgcagccacaggccgagccgcggccctgaggtacgcatcttgctcttcaac
gccaccggggaccgggatcccgcggccctgctgaagctgctgcagccctgtcagtttgac
tatgctgtcttctgccctaacctgacagacgtgtcgtctgctggcagcgcagaccagcag
aacttcatggtgaccctggaccaggtgctgctccgctgtcttgcgcaccagcagcactgg
agccgcctggctgaggagcaggccagcccggacccttggagccccgccagcccggagcct
ggtgagcccacgtccttgctgctggcttcccgcccaccctgcacccacagcaccagctcc
ctcgtcttcagctgcatctcccacgccctgcagtggatcagccaaggccgggaccccgtc
tttcagccacccagtccccctcagggcctccttgcccacccggtggcaggcagcggggcc
ggtgtgctccgggaggccgccgccatccacgtactggtcacgggcagcttgcacctggtg
ggcggcgtcctgaagctgctggaacctgccctgtcccagtag
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