Ursus maritimus (polar bear): 103675581
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Entry
103675581 CDS
T03271
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2 isoform X1
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
umr
Ursus maritimus (polar bear)
Pathway
umr05012
Parkinson disease
umr05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
umr00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
103675581 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
103675581 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
umr01001
]
103675581 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
umr04131
]
103675581 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
umr04147
]
103675581 (LRRK2)
Enzymes [BR:
umr01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
103675581 (LRRK2)
Protein kinases [BR:
umr01001
]
Serine/threonine kinases: TKL group
LRRK family
103675581 (LRRK2)
Membrane trafficking [BR:
umr04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
103675581 (LRRK2)
Exosome [BR:
umr04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
103675581 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
LRR_8
Roc
LRR_4
COR-B
Ras
COR-A
LRR_14
LRR_9
Beta-prop_RSE1_2nd
WD40_CDC20-Fz
Beta-prop_EML_2
Arf
LRR_13
WDR55
Beta-prop_WDR36-Utp21_1st
LRR_NXF1-5
AAA_22
T2SSE
Beta-prop_THOC3
Ank_2
nSTAND3
PduV-EutP
ABC_tran
LRR_6
Beta-prop_BBS7
G-alpha
SRPRB
MMR_HSR1
GTP_EFTU
Kdo
TniB
AAA_7
WD40_WDHD1_1st
AAA_16
TsaE
Beta-prop_WDR3_1st
NB-ARC
MobB
Septin
AAA_29
NACHT
WD40_Prp19
nSTAND_NTPase5
cobW
TrwB_AAD_bind
AAA_23
ARM_CUL7_CUL9
AAA_SelU
Motif
Other DBs
NCBI-GeneID:
103675581
NCBI-ProteinID:
XP_040498269
UniProt:
A0A8M1H3B4
LinkDB
All DBs
Position
Unknown
AA seq
2534 aa
AA seq
DB search
MASGSCQGCEEEDEETLKKLIVRLNNVQEGKQIETLVQILEDMLVFTYADHASKLFQGKK
VHVPVLIVLDLYMRVASVQQVGWSLLCKLIEICPNTMQSLMGPQDIGRDWEVLGVHQLIL
KMLTVHNASVNLLTVGLKALDLLLTSGKITLLILDEESDIFLLIFDAMRTFSANDEIQKL
GCKALRVLFERVSEEQLTEFVENKDYMILLNALKNFKDEEEIVLQVLHCLHSLAIPCNNV
EVLMSGNVRCYNIVVEAMKAFPVNEKIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAV
RRYSENATLQIAGLSCLALLTETIFLNQDLEEKNENPENDDEEEDKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKEVFQASAN
ALSTLLEQNVNFRKILLSKGIYLNVLELMQRHIHSPEVAESGCKMLNHLFEGSSVTLDTM
AAVAPKIITVMKSHEASLSVQLEGLRAVLHFIVPGMPEDSREDTEYQHKLHMVKKQCFKN
DIHKLVLAALNRFIGNPGIQKCGLKVISSIARSPDALEVLSLEGAIDSVLHTLQMYPDDQ
EIQCLGLSLTGCLITKKNLCIGTGHLLAKILVSSLQRFKDMAEVQIKGFQTILTILGLSV
SFSKLLVHHSFDSVIFHQMSSSIMEQKDQQFLNLCCKCFAKLAMDDELKSVLLERACDQN
NSIMVECLLLLGADANGTKEATSLICQVCEKASSPKLVELLLNGGSREQDVRKALTISIG
KGDSQIISLLLRRLALDLANNSICLGGFCIGKIDPSWLGPLFPDKTSNLRKETNIGSTLA
RMVLRYQVKSAVEEGAASGSNGNFPEGVLDKFDEWTFIPDSYVDSVFGQSDDLDSEGSEG
SFLVKRKSNSISVGEFYRDRALQHCSPNLQRHSCSLGPIFDHEDLLRRKRKILSSDDSLR
SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISGHLEHLEKLELHQ
NALTSFPQQLCETLKCLTHLDLHSNKFTSFPSYLLKMNCIANLDVSRNDISPSVVLDSAV
KCPTLKQFNLSYNQLSSFPENLGDVVEKLEQLILEGNKIPEICSPLSLKELKILNLSKNH
ITSLSEDFLEACPKVESFSARMNYLAAMPFLPSSLTSLKLSQNRFTCVPEAILNLPHLRS
LDMSSNEIEYLPSPAHWKSLNLREILFSFNQISILDLSEKAYVWSRVEKLHLSHNKLKEI
PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELRLNFDFKHIGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLTKTKKSDLGVQSATVGIDVKDWPIQI
RGKGRKDLILNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVSDEKQRKACITKITKELLNKRGFPAIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPVEFPVIDRKRLLQLVKEN
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVEGYPK
HPKGIISRRDVEKFLSKKKRFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI
LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKLFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKGSLTRTLQHRIALHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVSRGNVIYNQQADVYSFGLLLYDILTTGGRIAEGLKFPNEFDELAIQGKLPDPVKEYG
CAPWPMVEKLIKKCLKENPQERPTSAQVFDNLNSAELICLMRHITIPKNFSVECMVSTNH
NNKNASIWLGCGHRDKGQLLFLDLNTEKHTSEEVIDSRILCLALVPLPVEKESWIVCGTQ
SGTLLVINTEDGEKRHTLEKMTDSVTCLYCNPFPKQSKQKNFLLVGTADGNLAIFEDKTV
KCRGAVPLKILNIGNVSTPLMCLSESMNSAEKNIMWGGCGTKLFSFSDDFTIQKRIETKT
NQLFSYAAFSDSNIIAVVVDTALYVAKKNSPFVEVWDKKTEKLCELIDCVHFLKEEMVKV
TAESKHKLSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRIIRIIHNFCDSVRVMMT
AQLEDSYFFKGSLKNVMLVLGYIRKSTESTQHQKEIQSCLSVWDLNLPHEVQNLEKHIEV
RKELAEKMRRISVE
NT seq
7605 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggcagctgtcaggggtgcgaggaggaggacgaggaaactctgaagaagttg
atagtcaggctgaacaatgtccaggaaggaaaacagatagagaccctggtccaaattctg
gaggatatgctggtgttcacgtacgccgaccacgcctccaagttatttcaaggcaaaaaa
gtccacgtgcctgtgttgatcgtcttggacttgtatatgagagtcgctagtgtacagcag
gtgggttggtcacttctttgcaaattgatagaaatctgtccaaatacaatgcaaagctta
atgggacctcaagatattggacgtgattgggaagtacttggggttcaccaactgattctt
aaaatgctaacagttcataatgccagtgtaaacctgttaacagtcggactgaaggcctta
gatctccttctaacttcaggcaaaatcactttgctgatattggatgaagaaagtgatatt
ttcttgttaatttttgatgccatgcgcacattttcagccaatgacgaaatccagaaactt
ggatgcaaagctttacgtgtgctgtttgaaagagtttcagaggagcagctgactgaattt
gttgagaataaagattatatgatcttgctcaatgcgttaaaaaattttaaagatgaagag
gaaattgtgcttcaggtcctgcactgtttacactccctagcaattccttgcaataatgtt
gaagtcctcatgagtggcaatgtcaggtgttacaatattgtggtagaagccatgaaagca
ttccctgtcaatgaaaaaattcaagaagtaagttgctgcttgctccataggcttacatta
ggtaatttttttaatattctggtattaaatgaggtgcacgagtttgtggtgaaagctgtg
cggcgatactcagagaacgccacgttacagatcgcggggctcagctgcttagcgcttctc
actgagaccattttcttaaatcaagacttagaggaaaagaatgagaatccggagaatgat
gatgaggaagaagataagttgttctggttggaagcttgttacaaagcattaacgtggcat
aggaagaacaagcacgtgcaggaagctgcatgctgggcccttaacaatctccttatgtac
caaaacagtttacatgagaagattggagatgaagatggccagttcccagctcatagggaa
gtgatgctttccatgctgatgcattcctcatcaaaagaagtcttccaggcatctgcaaat
gcattgtcgactctgttagaacaaaacgttaatttcagaaaaatcctgttgtcaaaagga
atatacctgaatgtattggagttaatgcagaggcatatacattctcctgaagttgctgag
agtggctgtaaaatgctaaatcatctctttgaaggaagcagtgtgactctggatacaatg
gcagcagtggcccccaaaataataacagttatgaaaagtcatgaggcatccttatcagtg
cagctggagggactaagagctgttttacatttcatagttccaggcatgccagaagactcc
agggaagatactgaatatcaacataagctacatatggttaagaaacagtgtttcaagaat
gacattcataaactggtcctagcagccttgaacaggttcattggaaatcctgggattcag
aaatgtgggttgaaagtaatttcttctatagcgcgttctcctgatgcgttagaagtatta
tccttggaaggtgctattgattcagtgcttcacacactgcagatgtatccggatgaccaa
gaaattcaatgtctggggttaagtcttacaggatgcttgattacaaagaagaatttatgc
ataggcactggacatctgctggcaaaaattctggtttccagtttacaacgatttaaggat
atggccgaagtgcagattaaaggatttcagacaatcttgacaatactggggttgtcagtg
tctttttccaagctgctggtgcaccattcctttgattccgtgatattccatcagatgtct
tccagtatcatggaacaaaaggatcaacagtttctaaacctttgttgcaagtgctttgca
aaattagctatggatgatgagttaaaaagtgtgcttctagagagagcatgcgatcagaat
aacagtatcatggttgaatgcttgcttctcttgggagcggacgccaatggaacaaaggag
gcaacgtctttaatttgtcaggtatgtgagaaagcgagtagtcccaaattggtggaactg
ttactgaatggtggttcccgtgaacaagatgtccggaaagcgctgacaataagcattggc
aaaggtgacagccagatcatcagcttacttttaaggaggcttgccctggatctggccaat
aatagcatttgccttggaggattctgtataggaaaaattgacccttcctggcttggtcct
ttatttccggataagacatctaatttaagaaaagaaacaaatataggatccaccctagca
agaatggtgctcagatatcaggtgaaaagtgctgtggaagaaggagcagcttcaggcagc
aatgggaattttcctgaaggagtacttgataaatttgatgaatggaccttcattccagac
tcctatgtggacagtgtgtttggtcaaagtgatgacctggatagtgaaggaagtgaaggc
tcatttcttgtgaaaagaaaatccaattcaattagtgtaggagaattttaccgagatcgt
gccttgcagcattgttcaccaaatttgcaaaggcattcctgttcattgggacctattttt
gatcatgaagatttactgaggcgaaaaagaaaaatattgtcttcagatgactcactcagg
tcatcaaaacttcaatcccatatgaggcattcagacagcatttcttccctggcttctgag
agagaatatattacatcattagacctttcagcaaatgaactaagagacattgatgcccta
agccagaaatgctgtatcagtggtcatttggagcatcttgaaaagctggagcttcaccag
aatgcactcacgagctttccacaacaactgtgtgaaaccctgaagtgtttgacacatttg
gacttgcacagtaataaatttacatcatttccctcttacttgttgaaaatgaattgtatt
gccaacctcgatgtctctcgaaacgacatcagcccttcagtagttttggactctgcagtg
aagtgcccaaccttgaaacagtttaacttgtcatacaatcagctgtcttcttttcctgag
aaccttggcgatgtggtagagaaattggagcagctcattttagaaggaaataaaatacca
gaaatatgttcccccttaagcctgaaggaactgaagattttaaaccttagtaaaaatcac
attacatccctgtcagaagacttccttgaggcatgtcctaaagtggagagtttcagtgcc
agaatgaattatcttgctgctatgccttttttgccttcttcgctgacaagcctaaaatta
tctcaaaacagatttacatgtgttccagaagcaattttaaatcttccacacttgcgatcc
ttagatatgagcagcaatgaaattgaatatttgccgagtcctgcacactggaaatctttg
aacttaagggaaatcttgttcagttttaatcaaatcagcatcttggacttaagtgaaaaa
gcgtatgtatggtcaagagtagagaaattacatctttctcataataaactgaaagagatt
cctcctgagattggctgtcttgaaaacctgacctcccttgatgtcagttacaatttggaa
ctgagatcctttcctaatgaaatggggaagttaagcaaaatatgggatcttcctttggat
gaactacggcttaattttgattttaaacatataggatgtaaagccaaagacatcataagg
tttcttcaacagcggttaaaaaaggctgtgccctacaaccgaatgaagcttatgattgtg
ggaaatactgggagtggtaaaaccaccttattgcagcaattaacgaaaaccaagaaatcc
gatcttggggtgcaaagcgccacagttggcatagatgtgaaagactggccgatccaaata
agaggcaaagggaggaaagacctcattctaaacgtgtgggattttgcaggtcgtgaggag
ttctatagcactcatccgcacttcatgacccaacgagccctctaccttgccgtctatgac
ctcagcaaagggcaggctgaagtggacgccatgaagccttggctcttcaatataaaggct
cgtgcttcttcttctcctgtgattcttgttggcacacatttggatgtttctgatgaaaag
cagcgtaaagcctgcataactaaaatcaccaaggaactcttgaacaagcgggggtttcct
gcaataagggattaccacttcgtgaatgccactgaggagtccgatgccttggcaaagctt
cggaaaaccatcataaatgagagtcttaatttcaagatccgagatcagcctgttgttggg
cagctgatcccagactgctatgtagaacttgagaaaatcattttatcggagcgtaaaaat
gtgccagttgaatttcctgtgatcgaccggaaacgattattacaacttgtaaaagaaaat
cagctgcagttggatgaaaatgagcttcctcatgcagttcacttcctcaatgaatcaggg
gtccttcttcattttcaagacccagcattgcagttaagtgacttatattttgtggaaccc
aagtggctttgtaaagtcatggcacagattttgacagtgaaagtggaaggctacccaaaa
catcctaaggggatcatttcacgtagagatgtggaaaaatttctttcaaagaaaaagaga
tttccaaagaactacatgtcacagtactttaaactcctagaaaaattccagattgccttg
ccaataggagaagaatatttgcttgttccaagcagtttgtctgaccacaggcctgtgata
gagcttccccattgtgagaactctgaaattatcattcgactatatgaaatgccttatttt
ccaatgggattttggtcccggttaatcaatcgattacttgaaatttcaccttacatgctt
tcaggaagagaacgagcacttcgcccaaacagaatgtattggcgacaaggcatctacttg
aattggtctcctgaagcttattgtctggtaggatctgaagtcttagacaatcacccagag
agtttcttaaaaattacagttccttcttgtagaaaaggctgtattcttctgggccaagtt
gtggaccacattgattctctcatggaagaatggtttcctggattactggagattgatatc
tgtggtgaaggagaaactctgttgaagaaatgggcattatatagttttaatgatggtgaa
gagcatcaaaaaatcttacttgatgacttgatgaagaaagcagaagaaggagaccttcta
gtaaatccagatcaaccaaggctcaccatcccaatatctcaaattgctcctgacttaatt
ttggctgacctgcctagaaatattatgttgaataatgatgaattggaatttgaacaagct
ccagagtttctcttaggtgatggcagttttggatctgtttatcgagcagcctatgaagga
gaagaagtggctgtgaagcttttcaataaacatacatcacttagactgttaagacaggag
ctggtggtcctttgccacctccaccaccccagcttaatatctttgctggcggctgggatt
cgtcctcgcatgttggtgatggagttggcctccaagggttcgctggaccgcttgcttcag
caggacaaaggaagtctcaccaggaccctgcagcacaggattgcgctacatgtggctgat
ggcttgagatacctccactcggccatgattatataccgtgacttgaagccccacaacgtg
ctgctcttcaccctgtatcccaatgcagccatcatcgcgaagattgcagactatgggatt
gctcagtactgctgtagaatggggataaagacgtcagagggcacaccagggtttcgcgca
cctgaggtttctagaggaaatgttatttataaccaacaggctgatgtttattcatttggt
ttactactctatgacattttgacaactggagggagaatagcggagggtttgaagtttcca
aatgagtttgatgagctggcaatacaaggaaaattacctgatccggttaaagaatatggc
tgtgccccatggcccatggttgagaagttaattaaaaagtgtttgaaggaaaatcctcaa
gaaaggcctacttctgcccaggtctttgacaatttgaattcagctgagttaatctgtctg
atgagacatataacaatacctaaaaactttagtgttgagtgcatggtctctacaaatcat
aacaacaagaatgcaagcatctggctgggctgtgggcaccgtgacaaaggacagctctta
tttcttgacttaaatacagaaaaacacacttctgaggaagttattgatagtagaatactg
tgcctggctttggtgcctcttcctgtggaaaaggaaagctggatcgtgtgtgggacacag
tctggcacgctcctggtcatcaataccgaagatggggaaaagagacatactcttgaaaag
atgactgattccgtgacttgcttgtattgcaatccctttcccaagcaaagcaagcaaaaa
aattttcttctggtgggaactgctgatggcaatttagcaatttttgaagataaaactgtt
aagtgtagaggagctgttcctttgaagatactaaatataggaaacgtcagtactccactg
atgtgtttgagtgaatccatgaattcagctgaaaaaaacattatgtggggaggatgtggt
acaaaacttttctcattttctgatgatttcaccattcagaagcgcattgagacaaagaca
aatcagctgttttcttatgcagctttcagtgactccaacatcatagcagtggtggtagac
acggctctctacgttgctaagaaaaatagtccatttgtggaagtatgggataagaaaact
gaaaaactctgtgaactaatagactgcgtgcactttttaaaggaggaaatggtaaaagta
actgcagaatcaaaacacaaactgtcttattctgggagggtaaaaaccctgtgcctccag
aagaacaccgctctctggataggaactggaggaggccatattttactccttgatctttca
actcgtcgaattatacgtataattcacaatttttgtgattctgtcagagtcatgatgaca
gcacaattagaagactcatatttttttaaaggaagccttaaaaatgtcatgctggttttg
gggtatatccggaaaagtactgaaagtacacaacaccaaaaagagatacaatcttgttta
tctgtttgggacctcaatcttccacatgaagtgcaaaatttagaaaaacatattgaagtg
agaaaagaattagctgagaaaatgagaagaatatctgttgaataa
DBGET
integrated database retrieval system
