Ursus maritimus (polar bear): 103675618 Help Entry 103675618         CDS       T03271                                  Symbol ADCY6 Name (RefSeq) adenylate cyclase type 6   KO K08046   adenylate cyclase 6 [EC:4.6.1.1] Organism umr  Ursus maritimus (polar bear) Pathway umr00230   Purine metabolism umr01100   Metabolic pathways umr01522   Endocrine resistance umr04015   Rap1 signaling pathway umr04022   cGMP-PKG signaling pathway umr04024   cAMP signaling pathway umr04062   Chemokine signaling pathway umr04072   Phospholipase D signaling pathway umr04081   Hormone signaling umr04082   Neuroactive ligand signaling umr04114   Oocyte meiosis umr04211   Longevity regulating pathway umr04213   Longevity regulating pathway - multiple species umr04261   Adrenergic signaling in cardiomyocytes umr04270   Vascular smooth muscle contraction umr04371   Apelin signaling pathway umr04540   Gap junction umr04611   Platelet activation umr04713   Circadian entrainment umr04714   Thermogenesis umr04723   Retrograde endocannabinoid signaling umr04724   Glutamatergic synapse umr04725   Cholinergic synapse umr04727   GABAergic synapse umr04742   Taste transduction umr04750   Inflammatory mediator regulation of TRP channels umr04911   Insulin secretion umr04912   GnRH signaling pathway umr04913   Ovarian steroidogenesis umr04914   Progesterone-mediated oocyte maturation umr04915   Estrogen signaling pathway umr04916   Melanogenesis umr04918   Thyroid hormone synthesis umr04921   Oxytocin signaling pathway umr04923   Regulation of lipolysis in adipocytes umr04924   Renin secretion umr04925   Aldosterone synthesis and secretion umr04926   Relaxin signaling pathway umr04927   Cortisol synthesis and secretion umr04928   Parathyroid hormone synthesis, secretion and action umr04934   Cushing syndrome umr04935   Growth hormone synthesis, secretion and action umr04961   Endocrine and other factor-regulated calcium reabsorption umr04962   Vasopressin-regulated water reabsorption umr04970   Salivary secretion umr04971   Gastric acid secretion umr04972   Pancreatic secretion umr04976   Bile secretion umr05032   Morphine addiction umr05163   Human cytomegalovirus infection umr05166   Human T-cell leukemia virus 1 infection umr05200   Pathways in cancer umr05207   Chemical carcinogenesis - receptor activation umr05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:umr00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     103675618 (ADCY6)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     103675618 (ADCY6)    04072 Phospholipase D signaling pathway     103675618 (ADCY6)    04024 cAMP signaling pathway     103675618 (ADCY6)    04022 cGMP-PKG signaling pathway     103675618 (ADCY6)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     103675618 (ADCY6)    04081 Hormone signaling     103675618 (ADCY6)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     103675618 (ADCY6)    04062 Chemokine signaling pathway     103675618 (ADCY6)   09152 Endocrine system    04911 Insulin secretion     103675618 (ADCY6)    04923 Regulation of lipolysis in adipocytes     103675618 (ADCY6)    04913 Ovarian steroidogenesis     103675618 (ADCY6)    04915 Estrogen signaling pathway     103675618 (ADCY6)    04921 Oxytocin signaling pathway     103675618 (ADCY6)    04926 Relaxin signaling pathway     103675618 (ADCY6)    04935 Growth hormone synthesis, secretion and action     103675618 (ADCY6)    04918 Thyroid hormone synthesis     103675618 (ADCY6)    04928 Parathyroid hormone synthesis, secretion and action     103675618 (ADCY6)    04924 Renin secretion     103675618 (ADCY6)    04925 Aldosterone synthesis and secretion     103675618 (ADCY6)    04927 Cortisol synthesis and secretion     103675618 (ADCY6)   09154 Digestive system    04970 Salivary secretion     103675618 (ADCY6)    04971 Gastric acid secretion     103675618 (ADCY6)    04972 Pancreatic secretion     103675618 (ADCY6)    04976 Bile secretion     103675618 (ADCY6)   09155 Excretory system    04962 Vasopressin-regulated water reabsorption     103675618 (ADCY6)    04961 Endocrine and other factor-regulated calcium reabsorption     103675618 (ADCY6)   09156 Nervous system    04724 Glutamatergic synapse     103675618 (ADCY6)    04727 GABAergic synapse     103675618 (ADCY6)    04725 Cholinergic synapse     103675618 (ADCY6)    04723 Retrograde endocannabinoid signaling     103675618 (ADCY6)   09157 Sensory system    04742 Taste transduction     103675618 (ADCY6)    04750 Inflammatory mediator regulation of TRP channels     103675618 (ADCY6)   09149 Aging    04211 Longevity regulating pathway     103675618 (ADCY6)    04213 Longevity regulating pathway - multiple species     103675618 (ADCY6)   09159 Environmental adaptation    04713 Circadian entrainment     103675618 (ADCY6)    04714 Thermogenesis     103675618 (ADCY6)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103675618 (ADCY6)    05207 Chemical carcinogenesis - receptor activation     103675618 (ADCY6)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103675618 (ADCY6)    05163 Human cytomegalovirus infection     103675618 (ADCY6)   09165 Substance dependence    05032 Morphine addiction     103675618 (ADCY6)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     103675618 (ADCY6)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     103675618 (ADCY6)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     103675618 (ADCY6) Enzymes [BR:umr01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      103675618 (ADCY6) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc AC_N Adcy_cons_dom HNOBA TBK1_ULD GBR2_CC Motif Other DBs NCBI-GeneID:  103675618 NCBI-ProteinID:  XP_040498327 UniProt:  A0A8M1GU57 LinkDB All DBs Position Unknown AA seq 1164 aa AA seqDB search MSWFSGLLVPKVDERKTAWGERNGQKRPRRGTRPGGFCTPRYMSCLRDAQPPSPTPAAPP RCPWQDEAFIRRGGPGKGTELGLRAVALGFEDVEAAAGAAEAAPDATPGGRRSCWRRLAQ VFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPRPAYVALL ACAAALFVALMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSSGLWCPVF FVYIAYTLLPIRMRAAVFSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGI CTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKED MMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIK ILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGV LGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKE QHIETFLILGASQKRKEEKAMLAKLQRTRANSVEGLMPRWVPDRAFSRTKDSKAFRQMGI DDSSKDNRGAQDALNPEDEVDEFLGRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRK ADPRFGAYVACALLVFCFICFIQLLVFPHSTLMLGTYAGIFLLLLTAVLTCAVSSCGSLF PKALRRLSRSIVRSRAHSTVVGIFSVLLVFTSAIANMFTCNHTPIRTCAARMLNVTPADI TACHLQQLNYSLGLDAPLCEGTAPTCSFPEYFVGNMLLSLLASSVFLHISSIGKLAVIFV LGLVYLVLLLLGPPATVFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVILLV FALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARE RRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERF RQLEKIKTIGSTYMAASGLNASTYDQAGRSHITALADYAMRLMEQMKHINEHSFNNFQMK IGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLE CRGVVKVKGKGEMTTYFLNGGPPS NT seq 3495 nt NT seq  +upstreamnt  +downstreamnt atgtcatggtttagtggcctcctggtccccaaagtggatgaacggaaaacagcctggggt gagcgcaatgggcagaagcgtccacgccgtgggactcggcccgggggcttctgcacgcct cgctacatgagctgcctccgggatgcgcagccccccagtcccacccctgcagctccgcct cggtgcccctggcaggatgaggccttcatccggaggggcggcccgggcaagggcacggag ctgggcctgcgggcggtggccctgggctttgaggacgtggaggcggcggccggggcggct gaggcggcccccgacgcgacacccgggggccggcgatcgtgctggcgccgcctggcccag gtgttccagtcgaagcagttccgctcggccaagctggagcgcctgtaccagcggtacttc tttcagatgaaccagagcagcctgacgctgctgatggccgtgctggtgctgctcacggcc gtgctgctggcctttcacgcggcgcccgcccgcccccggcctgcctacgtggccctgctg gcctgtgccgccgccctcttcgtggcgctcatggtggtgtgtaaccggcacagcttccgc caggactccatgtgggtggtgagctacgtggtgctgggcatcctggcggccgtgcaggtg gggggtgccctggctgccgacccccgcagcccctcctcgggcctctggtgccctgtgttt ttcgtctacatcgcctacacgctcctgcccatccgcatgcgggcggctgtcttcagcggc ctgggcctctccaccctgcatttgatcttggcctggcagctcaaccgcggcgacgccttc ctctggaagcagctgggtgccaacgtgctgctgttcctctgcaccaacgtcatcggcatc tgcacgcactacccggcggaggtgtctcagcgccaggcctttcaggagacccgcggttac atccaggcccggctgcacctgcagcatgagaatcggcagcaggaacggctgctgctgtcc gtgttgccccagcatgttgccatggagatgaaagaagatatcaacacaaagaaagaagac atgatgttccacaagatctatatccagaagcatgacaatgtcagcatcctgtttgcagac atcgaaggcttcaccagcctggcatcccagtgcaccgcgcaggagctggtcatgaccctg aacgagctctttgcccggtttgacaagctggctgcggaaaatcactgcctgagaatcaag atcttaggggactgttactactgtgtgtcggggctgccggaggcccgggcagaccatgcc cactgctgtgtggagatgggggtggacatgatcgaggccatctcgctggtgcgtgaggtg acgggcgtgaacgtgaacatgcgcgtgggcatccacagcggccgcgtgcactgtggcgtc cttggcctgcggaaatggcagttcgacgtgtggtccaacgacgtgacgctggccaaccac atggaggcggggggccgggccggccgcatccacatcacccgggccacgctgcagtacctg aacggcgactacgaggtggagccgggccgcggcggcgagcgcaacgcctacctcaaggag cagcacatcgagaccttcctcatcctgggggccagccagaaacggaaagaggagaaggcc atgctggccaagctgcagcggacgcgggccaactccgtggaagggctgatgccgcgctgg gtgcccgaccgcgccttctcccggaccaaggactccaaggctttccgccagatgggcatt gatgattccagcaaagacaaccggggtgcccaagatgccctgaaccccgaggatgaagta gatgagttcctgggccgtgccatcgatgcccgcagcatcgatcagctacggaaggaccac gtgcgccgcttcctgctcaccttccagagagaagatcttgaaaagaagtactcgcggaag gcggacccccgcttcggagcctacgtggcctgcgcgctgttggtcttctgcttcatctgc tttatccagctcctcgtcttcccacactccaccctgatgcttgggacctatgccggtatc ttcctgctgttgctgaccgccgtgctgacctgtgccgtgtcctcctgtggctccctcttc cccaaggccctgcgacgcctttcccgcagcattgtccgctctcgggcgcacagcactgtg gttggcatcttttcagtcttgcttgtgttcacctctgccattgccaacatgttcacctgt aaccacacccccatacggacctgcgcagcccggatgctgaatgtgacgcccgcggacatc acagcctgccacctgcagcagctcaattactccctgggcctggatgctccgctgtgtgag ggcaccgcacccacttgcagcttccccgagtacttcgttgggaacatgctgctgagtctc ctggccagctctgtcttcctgcacatcagcagcatcgggaagttggccgtgatctttgtc ctggggctcgtctatttggtgctgcttctgctgggccccccagccaccgtctttgacaac tatgacctgctgcttggtgtccatggcttggcttcttccaatgagactttcgacgggctg gactgcccagctgcagggagggtggcgctcaaatacatgacccccgtgattctgctggtg tttgcactggcgttgtatctgcacgcccagcaggtggagtcaactgcgcgcctggacttc ctctggaaactgcaggcaacaggggagaaggaggagatggaggaactccaggcctacaac cgaagactgctgcataacattctgcccaaggacgtggctgcccacttcctggcccgggag cgccggaatgacgagctctactatcagtcgtgtgagtgtgtggccgtcatgtttgcctcc attgccaacttttctgagttctatgtggagctggaggccaacaacgagggcgttgagtgt ctgcggttgctcaacgagatcatcgctgacttcgacgagatcatcagcgaggagcggttc cggcagctggagaagatcaaaacgattggtagcacctacatggctgcctcggggctgaac gccagcacctatgatcaggccggccgctcccacatcactgccctggccgactatgccatg cggctcatggagcagatgaaacacatcaatgagcactccttcaacaatttccagatgaag attgggctgaacatgggcccagtcgtggcaggtgtcattggggctcggaagccgcagtat gacatctgggggaacacagtgaatgtctctagccgtatggacagcacaggggtccctgac cgaatccaggtgaccacggacttgtaccaggttctagctgccaaaggctaccagctggag tgtcgaggggtggtcaaggtgaagggcaagggggagatgaccacctacttcctcaatggg ggcccccccagttag

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