KEGG   Ursus maritimus (polar bear): 103676125
Entry
103676125         CDS       T03271                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
umr  Ursus maritimus (polar bear)
Pathway
umr00562  Inositol phosphate metabolism
umr01100  Metabolic pathways
umr01521  EGFR tyrosine kinase inhibitor resistance
umr01522  Endocrine resistance
umr01524  Platinum drug resistance
umr04012  ErbB signaling pathway
umr04014  Ras signaling pathway
umr04015  Rap1 signaling pathway
umr04024  cAMP signaling pathway
umr04062  Chemokine signaling pathway
umr04066  HIF-1 signaling pathway
umr04068  FoxO signaling pathway
umr04070  Phosphatidylinositol signaling system
umr04071  Sphingolipid signaling pathway
umr04072  Phospholipase D signaling pathway
umr04081  Hormone signaling
umr04140  Autophagy - animal
umr04150  mTOR signaling pathway
umr04151  PI3K-Akt signaling pathway
umr04152  AMPK signaling pathway
umr04210  Apoptosis
umr04211  Longevity regulating pathway
umr04213  Longevity regulating pathway - multiple species
umr04218  Cellular senescence
umr04360  Axon guidance
umr04370  VEGF signaling pathway
umr04380  Osteoclast differentiation
umr04510  Focal adhesion
umr04550  Signaling pathways regulating pluripotency of stem cells
umr04611  Platelet activation
umr04613  Neutrophil extracellular trap formation
umr04620  Toll-like receptor signaling pathway
umr04625  C-type lectin receptor signaling pathway
umr04630  JAK-STAT signaling pathway
umr04650  Natural killer cell mediated cytotoxicity
umr04660  T cell receptor signaling pathway
umr04662  B cell receptor signaling pathway
umr04664  Fc epsilon RI signaling pathway
umr04666  Fc gamma R-mediated phagocytosis
umr04668  TNF signaling pathway
umr04670  Leukocyte transendothelial migration
umr04722  Neurotrophin signaling pathway
umr04725  Cholinergic synapse
umr04750  Inflammatory mediator regulation of TRP channels
umr04810  Regulation of actin cytoskeleton
umr04910  Insulin signaling pathway
umr04914  Progesterone-mediated oocyte maturation
umr04915  Estrogen signaling pathway
umr04917  Prolactin signaling pathway
umr04919  Thyroid hormone signaling pathway
umr04923  Regulation of lipolysis in adipocytes
umr04926  Relaxin signaling pathway
umr04929  GnRH secretion
umr04930  Type II diabetes mellitus
umr04931  Insulin resistance
umr04932  Non-alcoholic fatty liver disease
umr04933  AGE-RAGE signaling pathway in diabetic complications
umr04935  Growth hormone synthesis, secretion and action
umr04960  Aldosterone-regulated sodium reabsorption
umr04973  Carbohydrate digestion and absorption
umr05010  Alzheimer disease
umr05017  Spinocerebellar ataxia
umr05020  Prion disease
umr05100  Bacterial invasion of epithelial cells
umr05132  Salmonella infection
umr05135  Yersinia infection
umr05142  Chagas disease
umr05146  Amoebiasis
umr05160  Hepatitis C
umr05161  Hepatitis B
umr05162  Measles
umr05163  Human cytomegalovirus infection
umr05164  Influenza A
umr05165  Human papillomavirus infection
umr05166  Human T-cell leukemia virus 1 infection
umr05167  Kaposi sarcoma-associated herpesvirus infection
umr05168  Herpes simplex virus 1 infection
umr05169  Epstein-Barr virus infection
umr05170  Human immunodeficiency virus 1 infection
umr05171  Coronavirus disease - COVID-19
umr05200  Pathways in cancer
umr05203  Viral carcinogenesis
umr05205  Proteoglycans in cancer
umr05206  MicroRNAs in cancer
umr05207  Chemical carcinogenesis - receptor activation
umr05208  Chemical carcinogenesis - reactive oxygen species
umr05210  Colorectal cancer
umr05211  Renal cell carcinoma
umr05212  Pancreatic cancer
umr05213  Endometrial cancer
umr05214  Glioma
umr05215  Prostate cancer
umr05218  Melanoma
umr05220  Chronic myeloid leukemia
umr05221  Acute myeloid leukemia
umr05222  Small cell lung cancer
umr05223  Non-small cell lung cancer
umr05224  Breast cancer
umr05225  Hepatocellular carcinoma
umr05226  Gastric cancer
umr05230  Central carbon metabolism in cancer
umr05231  Choline metabolism in cancer
umr05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
umr05415  Diabetic cardiomyopathy
umr05417  Lipid and atherosclerosis
umr05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:umr00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    103676125 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    103676125 (PIK3CA)
   04014 Ras signaling pathway
    103676125 (PIK3CA)
   04015 Rap1 signaling pathway
    103676125 (PIK3CA)
   04370 VEGF signaling pathway
    103676125 (PIK3CA)
   04630 JAK-STAT signaling pathway
    103676125 (PIK3CA)
   04668 TNF signaling pathway
    103676125 (PIK3CA)
   04066 HIF-1 signaling pathway
    103676125 (PIK3CA)
   04068 FoxO signaling pathway
    103676125 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    103676125 (PIK3CA)
   04072 Phospholipase D signaling pathway
    103676125 (PIK3CA)
   04071 Sphingolipid signaling pathway
    103676125 (PIK3CA)
   04024 cAMP signaling pathway
    103676125 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    103676125 (PIK3CA)
   04152 AMPK signaling pathway
    103676125 (PIK3CA)
   04150 mTOR signaling pathway
    103676125 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    103676125 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    103676125 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    103676125 (PIK3CA)
   04218 Cellular senescence
    103676125 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    103676125 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    103676125 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    103676125 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    103676125 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    103676125 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    103676125 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    103676125 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    103676125 (PIK3CA)
   04660 T cell receptor signaling pathway
    103676125 (PIK3CA)
   04662 B cell receptor signaling pathway
    103676125 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    103676125 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    103676125 (PIK3CA)
   04670 Leukocyte transendothelial migration
    103676125 (PIK3CA)
   04062 Chemokine signaling pathway
    103676125 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    103676125 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    103676125 (PIK3CA)
   04929 GnRH secretion
    103676125 (PIK3CA)
   04915 Estrogen signaling pathway
    103676125 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    103676125 (PIK3CA)
   04917 Prolactin signaling pathway
    103676125 (PIK3CA)
   04926 Relaxin signaling pathway
    103676125 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    103676125 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    103676125 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    103676125 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    103676125 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    103676125 (PIK3CA)
   04722 Neurotrophin signaling pathway
    103676125 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    103676125 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    103676125 (PIK3CA)
   04380 Osteoclast differentiation
    103676125 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    103676125 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    103676125 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103676125 (PIK3CA)
   05206 MicroRNAs in cancer
    103676125 (PIK3CA)
   05205 Proteoglycans in cancer
    103676125 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    103676125 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    103676125 (PIK3CA)
   05203 Viral carcinogenesis
    103676125 (PIK3CA)
   05230 Central carbon metabolism in cancer
    103676125 (PIK3CA)
   05231 Choline metabolism in cancer
    103676125 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103676125 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    103676125 (PIK3CA)
   05212 Pancreatic cancer
    103676125 (PIK3CA)
   05225 Hepatocellular carcinoma
    103676125 (PIK3CA)
   05226 Gastric cancer
    103676125 (PIK3CA)
   05214 Glioma
    103676125 (PIK3CA)
   05221 Acute myeloid leukemia
    103676125 (PIK3CA)
   05220 Chronic myeloid leukemia
    103676125 (PIK3CA)
   05218 Melanoma
    103676125 (PIK3CA)
   05211 Renal cell carcinoma
    103676125 (PIK3CA)
   05215 Prostate cancer
    103676125 (PIK3CA)
   05213 Endometrial cancer
    103676125 (PIK3CA)
   05224 Breast cancer
    103676125 (PIK3CA)
   05222 Small cell lung cancer
    103676125 (PIK3CA)
   05223 Non-small cell lung cancer
    103676125 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    103676125 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    103676125 (PIK3CA)
   05161 Hepatitis B
    103676125 (PIK3CA)
   05160 Hepatitis C
    103676125 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    103676125 (PIK3CA)
   05164 Influenza A
    103676125 (PIK3CA)
   05162 Measles
    103676125 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    103676125 (PIK3CA)
   05163 Human cytomegalovirus infection
    103676125 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103676125 (PIK3CA)
   05169 Epstein-Barr virus infection
    103676125 (PIK3CA)
   05165 Human papillomavirus infection
    103676125 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    103676125 (PIK3CA)
   05135 Yersinia infection
    103676125 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    103676125 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    103676125 (PIK3CA)
   05142 Chagas disease
    103676125 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103676125 (PIK3CA)
   05017 Spinocerebellar ataxia
    103676125 (PIK3CA)
   05020 Prion disease
    103676125 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    103676125 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    103676125 (PIK3CA)
   05415 Diabetic cardiomyopathy
    103676125 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    103676125 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    103676125 (PIK3CA)
   04931 Insulin resistance
    103676125 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    103676125 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103676125 (PIK3CA)
   01524 Platinum drug resistance
    103676125 (PIK3CA)
   01522 Endocrine resistance
    103676125 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:umr04131]
    103676125 (PIK3CA)
Enzymes [BR:umr01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     103676125 (PIK3CA)
Membrane trafficking [BR:umr04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    103676125 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 103676125
NCBI-ProteinID: XP_040477516
UniProt: A0A8M1F2H3
LinkDB
Position
Unknown
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEXXXF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgacgttagaatgcctccgtgaggct
acactaataactataaagcatgaattatttaaagaagcaagaaagtaccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgagccagtaggcaaccgagaagaaaagatcctcaatcgagaaattggttttgct
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttcgggatcttaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcctcaccagaactgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtgtctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactagaagtatgttgctatcatctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttccttgaaaaataccctctaagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctttactcccaactgccaatggac
tgtttcacaatgccttcatattccagacgcatctccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaatcctttgt
gcaacctatgtgaatgtaaatattagagacattgacaagatctatgttcgaacaggtatc
tatcatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctaaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactttagtatctggaaaa
atggctctgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactgggtcaaatccaaataaagaaaccccatgcttagagttggagttnnnnnggttc
agcagtgtggtcaagttcccagatatgtcagtgattgaagagcatgccaactggtcggtg
tctcgggaagcaggatttagttattcccatgcaggactgagtaacagattagctagagac
aacgagttaagagaaaatgataaagaacagctccgagcaatttgtacccgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaacc
atccctgaaattctacccaaattgcttctgtccgttaaatggaattctagagatgaagta
gctcagatgtactgcttagtaaaagattggcctccaatcaaacctgaacaggctatggag
cttctggactgtaattacccagatcccatggttcgaggttttgctgtccggtgcttggaa
aaatacttaacagatgacaagctttctcagtacctaattcagctagtacaggtcctaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacggtg
agtcagcggtttggcctccttttggagtcctattgtcgtgcatgcgggatgtatttgaag
cacctaaataggcaagttgaggctatggaaaagctcattaacttaactgacattctcaaa
caagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcagatgcgg
cgaccagatttcatggatgctctacaaggttttctgtctcctctaaatcctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacacttcaaataattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtca
atcggtgactgtgtgggacttatcgaggtggtgcgaaactcgcacacgattatgcagatt
cagtgcaaaggtggcctgaaaggcgctctgcagttcaacagccacacactccaccagtgg
ctcaaagacaagaacaaaggagaaatatacgatgcagccattgacctgttcacacgttca
tgtgctggatattgtgttgctactttcatactgggcattggagatcgtcacaatagtaac
atcatggttaaagatgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgggaacgtgtgccatttgttttgacacaagatttc
ttaatagtcattagtaaaggagcccaggaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgaacaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgctttgaactga

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