KEGG   Ursus maritimus (polar bear): 103678627
Entry
103678627         CDS       T03271                                 
Symbol
TGFBR1
Name
(RefSeq) TGF-beta receptor type-1 isoform X1
  KO
K04674  TGF-beta receptor type-1 [EC:2.7.11.30]
Organism
umr  Ursus maritimus (polar bear)
Pathway
umr04010  MAPK signaling pathway
umr04060  Cytokine-cytokine receptor interaction
umr04068  FoxO signaling pathway
umr04144  Endocytosis
umr04218  Cellular senescence
umr04350  TGF-beta signaling pathway
umr04371  Apelin signaling pathway
umr04380  Osteoclast differentiation
umr04390  Hippo signaling pathway
umr04520  Adherens junction
umr04659  Th17 cell differentiation
umr04926  Relaxin signaling pathway
umr04933  AGE-RAGE signaling pathway in diabetic complications
umr05142  Chagas disease
umr05161  Hepatitis B
umr05166  Human T-cell leukemia virus 1 infection
umr05200  Pathways in cancer
umr05210  Colorectal cancer
umr05212  Pancreatic cancer
umr05220  Chronic myeloid leukemia
umr05225  Hepatocellular carcinoma
umr05226  Gastric cancer
umr05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:umr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    103678627 (TGFBR1)
   04350 TGF-beta signaling pathway
    103678627 (TGFBR1)
   04390 Hippo signaling pathway
    103678627 (TGFBR1)
   04371 Apelin signaling pathway
    103678627 (TGFBR1)
   04068 FoxO signaling pathway
    103678627 (TGFBR1)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    103678627 (TGFBR1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    103678627 (TGFBR1)
  09143 Cell growth and death
   04218 Cellular senescence
    103678627 (TGFBR1)
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    103678627 (TGFBR1)
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    103678627 (TGFBR1)
  09152 Endocrine system
   04926 Relaxin signaling pathway
    103678627 (TGFBR1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    103678627 (TGFBR1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103678627 (TGFBR1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    103678627 (TGFBR1)
   05212 Pancreatic cancer
    103678627 (TGFBR1)
   05225 Hepatocellular carcinoma
    103678627 (TGFBR1)
   05226 Gastric cancer
    103678627 (TGFBR1)
   05220 Chronic myeloid leukemia
    103678627 (TGFBR1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    103678627 (TGFBR1)
   05161 Hepatitis B
    103678627 (TGFBR1)
  09174 Infectious disease: parasitic
   05142 Chagas disease
    103678627 (TGFBR1)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    103678627 (TGFBR1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    103678627 (TGFBR1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:umr01001]
    103678627 (TGFBR1)
Enzymes [BR:umr01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.30  receptor protein serine/threonine kinase
     103678627 (TGFBR1)
Protein kinases [BR:umr01001]
 Receptor serine/threonine kinases (RSTK): TKL group
  TGFBR1 family [OT]
   103678627 (TGFBR1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr TGF_beta_GS Activin_recp Pkinase_fungal APH FTA2 Haspin_kinase
Other DBs
NCBI-GeneID: 103678627
NCBI-ProteinID: XP_040487594
UniProt: A0A8M1G5U7
LinkDB
Position
Unknown
AA seq 503 aa
MEAAAAAPRPRLLLLVLAAAATLVPGTTALQCFCHLCTKDNFTCVTDGLCFVSVTETTDK
VIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTVGPFSGKPSSG
LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL
IYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER
SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE
GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS
ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI
HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA
ARLTALRIKKTLSQLSQQEGIKM
NT seq 1512 nt   +upstreamnt  +downstreamnt
atggaggcggcggccgctgctccgcgtccccggctgctcctcctcgtgctggcggcggcg
gcgacgctagtcccggggacgacggcattacagtgtttctgccacctttgtacaaaagat
aattttacttgtgtgacagatgggctctgctttgtctctgtcacagagaccacagacaaa
gttatacacaatagcatgtgtatagctgaaattgacctaattcctcgagacagaccattt
gtatgtgcaccatcttcaaaaactgggtctgttactacaacctattgctgcaaccaggac
cattgcaataaaatagaactcccaactgttggccctttttcaggaaagccatcatctggc
cttggtcccgtcgaattggcagctgtcattgctggaccggtctgctttgtctgcatctcg
ctcatgttgatggtttatatctgccataaccgtactgtcattcaccatcgagtgccaaat
gaagaggatccttccttagatcgtccttttatttcggagggcactacattaaaagattta
atttatgatatgacgacatcaggttctggatcaggtttaccattgcttgttcagagaaca
attgcaagaactattgtgttacaagaaagtattggcaaaggtcgatttggagaagtttgg
cgaggaaagtggagaggagaagaagttgctgttaaaatattctcctctagagaagagcgc
tcatggttccgtgaggcagagatttatcagaccgtaatgttacgtcatgaaaacatcttg
ggatttatagcagcagacaataaagacaatggtacatggactcagctctggttggtgtca
gattatcatgagcatggatccctttttgattatttgaacagatacacagttactgtggaa
ggaatgataaaacttgctttgtccacagcaagtggacttgcccatctccacatggagatc
gttggtacccaagggaaaccagccattgctcatagagatttgaaatccaagaatatcttg
gtaaagaagaatggaacttgctgtattgcagacttaggactggcagtgagacacgattca
gccacagatacgattgatattgctccaaatcacagagtgggaacaaaaaggtacatggcc
cctgaagttctagatgattccataaatatgaaacactttgaatccttcaaacgtgctgac
atctatgcaatgggcttagtattctgggaaatagctcgacgatgttccattggtggaatt
catgaagattaccagctgccttattatgatcttgtaccttctgatccgtcagttgaagaa
atgagaaaagttgtttgtgaacagaagttaaggccaaatattccaaacagatggcagagt
tgtgaagccttgagggtaatggctaaaattatgagagaatgttggtatgccaacggagcg
gcgaggcttacggctttgcggattaagaaaacattgtcacaactcagtcaacaggaaggc
atcaaaatgtag

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