Ursus maritimus (polar bear): 103682010 Help Entry 103682010         CDS       T03271                                  Symbol TOP2B Name (RefSeq) DNA topoisomerase 2-beta   KO K03164   DNA topoisomerase II [EC:5.6.2.2] Organism umr  Ursus maritimus (polar bear) Pathway umr01524   Platinum drug resistance Brite KEGG Orthology (KO) [BR:umr00001]  09160 Human Diseases   09176 Drug resistance: antineoplastic    01524 Platinum drug resistance     103682010 (TOP2B)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03032 DNA replication proteins [BR:umr03032]     103682010 (TOP2B)    03036 Chromosome and associated proteins [BR:umr03036]     103682010 (TOP2B) Enzymes [BR:umr01000]  5. Isomerases   5.6  Isomerases altering macromolecular conformation    5.6.2  Enzymes altering nucleic acid conformation     5.6.2.2  DNA topoisomerase (ATP-hydrolysing)      103682010 (TOP2B) DNA replication proteins [BR:umr03032]  Eukaryotic type   DNA Topoisomerases    103682010 (TOP2B) Chromosome and associated proteins [BR:umr03036]  Eukaryotic type   Chromosome condensation proteins    Other regulators of chromosome condensation     103682010 (TOP2B)   Centrosome formation proteins    Centriole proteins     103682010 (TOP2B) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  DNA_topoisoIV TOPRIM_C DNA_gyraseB DTHCT Toprim HATPase_c Motif Other DBs NCBI-GeneID:  103682010 NCBI-ProteinID:  XP_008709803 UniProt:  A0A384DS33 LinkDB All DBs Position Unknown AA seq 1658 aa AA seqDB search MWKPQLGRCESLIKSNLEDVFLVVGFGVVAWDQKAFTSMVIVKFLIFMPMIENSSKLMTL FDQNNAAKKEESETANKNDSSKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQLMWVY DEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIVSIWNNGKG IPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACK EYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAY DLAGSCKGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLS EKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGVSVKPFQVKNHIWVFI NCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLN KKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVF PLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQ DGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIEN QKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEW LTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKP GQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLL QPIGQFGTRLHGGKDAASPRYIFTMLSSLSRLLFPAVDDNLLKFLYDDNQRVEPEWYIPI IPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQELGQ NQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDT TVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFD LRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYES DPVKAWKEAQEKAAEEEETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQ RDSKGREVNDLKRKSPSDLWKEDLAAFVEELDKVEAQEREDILAGMAGKAIKGKVGKPKV KKLQLEETMPSPYGRRIVPEITAMKADASKKLLKKKKGDLDTTAVKVEYDEEFSGTPVEG TGEEALIPSAPVNKGPKPKREKKEPGTRVRKTPTSAGKSSAKKVKKRNPWSDDESKSESD LEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDDNNDLEELKVKASPITNDG EDEFVPSDGLDKDEYTFSPGKSKATPEKSSHDKKSQDFGTLFSFPSYSQKSEDDSAKFDS NEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPSSDTTAKPKRAPKQKKVEPINSDSDSE FGIPKKTTPPKGKGRGAKKRKASGSENEGDYNPGRKTSRTASKKPKKTSFDQDSDVDIFP SDFTSEPPSLPRTGRARKEVKYFAESDEEEDVDFAMFN NT seq 4977 nt NT seq  +upstreamnt  +downstreamnt atgtggaagccccaattaggtagatgtgagtccctgattaagtctaatcttgaagatgtt ttcttagttgtgggatttggagtcgtagcctgggatcagaaagcttttacttccatggtt attgttaagttcctcatctttatgccaatgattgaaaacagttctaagttaatgactctt tttgatcagaacaatgctgcaaaaaaagaagagtcagaaactgcaaacaaaaatgattct tcaaagaagttgtctgttgagagagtgtatcagaaaaagacacaacttgaacatattctc cttcgtcctgatacatatattgggtcagtggaaccattgacacagctaatgtgggtatat gatgaagatgtaggaatgaattgcagagaggttacctttgtgccaggtttatacaagatc tttgatgaaattttggttaatgcagctgacaacaaacagagggataagaatatgacctgt attaaagtttctattgatcctgaatcaaatattgtaagcatttggaataatgggaaaggc attccagtagtagaacacaaagtagagaaagtttatgttcctgcgttaatttttggacag cttttaacatccagtaactatgatgatgatgagaaaaaagtaacaggtgggcgcaatggt tacggtgcaaaactttgtaatattttcagtacaaagtttacagtagaaactgcttgcaaa gaatacaaacatagttttaagcagacatggatgaataacatgatgaagacttctgaagcc aaaattaagcattttgatggtgaagattatacatgcataacattccaaccagatctgtct aaatttaagatggaaaaacttgacaaggatattgtggccctcatgaccagaagagcttat gatttggctggttcatgcaagggggtcaaggtcatgtttaatgggaagaaattgcccgta aatggatttcgcagttatgtagatctttatgtgaaagacaagttggatgaaactggagtg gccctgaaagttattcatgaacttgcaaatgaaagatgggatgtttgtctcacgctgagt gaaaagggattccagcaaatcagctttgtaaatagtattgcaacaacaaaaggtggacgt cacgtggattatgtggtagatcaagttgttggtaaactaattgaagtagttaagaaaaag aacaaagctggtgtatcagtaaaaccatttcaagtgaaaaaccatatatgggtttttatt aattgtcttatcgaaaatccaacttttgattctcaaactaaagaaaacatgactctgcaa cctaaaagttttgggtccaaatgccaactgtcagaaaaattttttaaagcagcttctaac tgtggcattgtagaaagtattctgaattgggtgaaatttaaggctcagactcagctgaac aagaagtgttcatcagtgaagtatagtaaaatcaaaggtattcccaaactggatgacgct aatgatgctggtggcaaacattccctggagtgtacactgatactaacagagggcgactct gccaaatcgttggctgtgtctggattaggtgtgattgggcgagacagatacggagtcttt ccacttaggggaaaaattcttaacgtacgggaagcttctcataaacagatcatggaaaat gcagaaataaacaatattattaaaatagttggtctacagtacaagaaaagttatgatgat gcagaatctctgaaaactttacgctatggaaaaattatgattatgactgatcaggatcaa gatggttctcacataaaaggcctgcttattaatttcatccatcacaattggccatcactt ttgaagcatggttttcttgaagagttcattactcctattgtaaaggctagcaaaaataag caggaactttccttctatagtattcctgaatttgatgaatggaaaaaacatatagaaaac cagaaagcctggaaaataaaatactacaaagggttgggtaccagtacagccaaagaagca aaggaatattttgctgatatggaaaggcaccgcatcttgtttagatatgctggtcccgaa gatgatgctgccattaccttggcattcagtaaaaagaagattgatgacagaaaagaatgg ttaacaaatttcatggaagaccggagacagcgtaggttacatggcttaccagagcaattt ttgtatggtacagcaacaaagcatttgacttacaatgatttcatcaacaaggaattgatt ctcttctcaaactcagacaatgaaagatctataccatctcttgttgatggttttaaacca ggacaacgaaaagttttatttacctgtttcaagaggaatgataaacgtgaagtaaaagtt gcccagttggctggatctgttgcggaaatgtctgcttatcatcatggagaacaagcattg atgatgacgattgtgaatttggctcagaactttgtgggaagcaacaacattaacttgctt cagcctattggtcagtttggaactcggcttcatggtggcaaagatgctgcaagccctcgt tatattttcacaatgttaagctctttatcaagactgctttttcctgctgtggatgacaac ctgcttaaattcctttatgatgataatcaacgtgttgagcctgagtggtatattcctatt attcccatggttttaataaatggtgctgagggcattggtactggatgggcttgtaaacta cccaactatgatgctagggaaattgtgaacaatgtcagacgaatgctagatggcttggat cctcatcctatgcttccgaactacaaaaacttcaaaggaaccatccaagagcttggtcaa aaccagtatgctgtcagtggtgaaatatttgtggtggatagaaacacagtagagattaca gagcttccagttagaacttggacacaggtatacaaagaacaggttttagaacctatgcta aatggaacagataaaacaccggcattaatttctgattataaagaatatcatactgataca actgtgaaatttgtggtgaaaatgactgaagagaagctagcacaagcagaagctgctgga ttgcacaaagtttttaaacttcaaactactcttacttgtaattccatggtactctttgat catatgggatgtctcaagaagtatgaaaccgtgcaagacattttgaaagaattctttgat ttacgattaagttattatggtttacgtaaggagtggcttgtaggaatgttgggagcagag tctacaaagcttaacaatcaagcccgtttcattttagagaagatacaaggaaaaattact atagagaataggtcaaagaaagatttgattcaaatgttagtccagagaggttatgaatct gacccagtgaaagcctggaaagaagcacaagaaaaggcagcagaagaggaagaaacacaa aaccagcatgatgatagttcctctgattcaggaactccttcaggccccgattttaattat attttaaatatgtctctgtggtctcttactaaagaaaaagttgaagaactgattaaacag agagattcaaaagggcgagaggtcaatgatcttaaaagaaaatctccttcagatctttgg aaagaagacttagcagcatttgttgaagaactggataaagtggaagcgcaagaacgagag gatattctggccggaatggctggaaaagcaataaaaggtaaagttggcaaacctaaggtg aagaaacttcaattggaagagacaatgccctcaccttatggaagaagaatagttcctgaa attactgctatgaaggcagatgccagcaaaaagttgctgaagaagaaaaagggtgatctt gataccacagcagtaaaagtagaatatgatgaagaattcagtggaacaccagtagagggt actggagaagaggcgttgatcccttcagctcctgtaaataaaggtcccaaacccaaaagg gagaaaaaggagcctggtaccagggtgagaaaaacacctacatcagctggtaaatccagt gcaaagaaagtgaagaaacggaatccttggtcagatgatgaatccaagtcagaaagtgac ttggaagaaacagaacctgtggttattccaagagattcgttgcttaggagagcagctgct gaaaggcctaagtacacatttgatttctcagaagaagaggatgatgatgctgatgacgac gacgacaataatgatttagaggaattgaaagttaaagcatctcccataacaaatgatggg gaagatgaatttgttccttcagatggcctagataaagatgaatatacattttcaccaggc aaatcaaaagctactccggaaaaatcttcacatgacaaaaaaagtcaagattttgggact ctcttctcatttccttcatactctcagaagtcagaagatgattcagctaagtttgacagt aatgaagaagattctgcctctgttttttcaccatcatttggtctgaaacaaacagataaa gttccaagtaaaacagtagctgctaaaaagggaaaaccgtcttcagatacaactgctaag cccaagagagcccctaaacagaagaaagtagagcctatcaactctgactcagattcagaa tttggcattccaaagaagactacacccccaaaaggtaaaggccgaggggcaaagaaaagg aaagcatctggctctgaaaacgaaggtgactataaccctggcaggaaaacatccagaaca gcaagcaagaaaccgaagaaaacatcttttgatcaggattcagatgtggacatcttccca tcagacttcacttctgaaccaccttctctgccacggaccggtagggctaggaaagaagta aaatattttgcagagtctgatgaagaagaagatgttgattttgcaatgtttaattaa

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