KEGG   Ursus maritimus (polar bear): 121099746
Entry
121099746         CDS       T03271                                 
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
umr  Ursus maritimus (polar bear)
Pathway
umr00562  Inositol phosphate metabolism
umr01100  Metabolic pathways
umr04015  Rap1 signaling pathway
umr04020  Calcium signaling pathway
umr04022  cGMP-PKG signaling pathway
umr04062  Chemokine signaling pathway
umr04070  Phosphatidylinositol signaling system
umr04071  Sphingolipid signaling pathway
umr04072  Phospholipase D signaling pathway
umr04081  Hormone signaling
umr04082  Neuroactive ligand signaling
umr04261  Adrenergic signaling in cardiomyocytes
umr04270  Vascular smooth muscle contraction
umr04310  Wnt signaling pathway
umr04371  Apelin signaling pathway
umr04540  Gap junction
umr04611  Platelet activation
umr04613  Neutrophil extracellular trap formation
umr04621  NOD-like receptor signaling pathway
umr04713  Circadian entrainment
umr04720  Long-term potentiation
umr04723  Retrograde endocannabinoid signaling
umr04724  Glutamatergic synapse
umr04725  Cholinergic synapse
umr04726  Serotonergic synapse
umr04728  Dopaminergic synapse
umr04730  Long-term depression
umr04742  Taste transduction
umr04750  Inflammatory mediator regulation of TRP channels
umr04911  Insulin secretion
umr04912  GnRH signaling pathway
umr04915  Estrogen signaling pathway
umr04916  Melanogenesis
umr04918  Thyroid hormone synthesis
umr04919  Thyroid hormone signaling pathway
umr04921  Oxytocin signaling pathway
umr04922  Glucagon signaling pathway
umr04924  Renin secretion
umr04925  Aldosterone synthesis and secretion
umr04926  Relaxin signaling pathway
umr04927  Cortisol synthesis and secretion
umr04928  Parathyroid hormone synthesis, secretion and action
umr04929  GnRH secretion
umr04933  AGE-RAGE signaling pathway in diabetic complications
umr04934  Cushing syndrome
umr04935  Growth hormone synthesis, secretion and action
umr04961  Endocrine and other factor-regulated calcium reabsorption
umr04970  Salivary secretion
umr04971  Gastric acid secretion
umr04972  Pancreatic secretion
umr04973  Carbohydrate digestion and absorption
umr05010  Alzheimer disease
umr05016  Huntington disease
umr05017  Spinocerebellar ataxia
umr05022  Pathways of neurodegeneration - multiple diseases
umr05142  Chagas disease
umr05143  African trypanosomiasis
umr05146  Amoebiasis
umr05163  Human cytomegalovirus infection
umr05200  Pathways in cancer
umr05415  Diabetic cardiomyopathy
umr05417  Lipid and atherosclerosis
Module
umr_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:umr00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    121099746
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    121099746
   04310 Wnt signaling pathway
    121099746
   04371 Apelin signaling pathway
    121099746
   04020 Calcium signaling pathway
    121099746
   04070 Phosphatidylinositol signaling system
    121099746
   04072 Phospholipase D signaling pathway
    121099746
   04071 Sphingolipid signaling pathway
    121099746
   04022 cGMP-PKG signaling pathway
    121099746
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    121099746
   04081 Hormone signaling
    121099746
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    121099746
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    121099746
   04613 Neutrophil extracellular trap formation
    121099746
   04621 NOD-like receptor signaling pathway
    121099746
   04062 Chemokine signaling pathway
    121099746
  09152 Endocrine system
   04911 Insulin secretion
    121099746
   04922 Glucagon signaling pathway
    121099746
   04929 GnRH secretion
    121099746
   04912 GnRH signaling pathway
    121099746
   04915 Estrogen signaling pathway
    121099746
   04921 Oxytocin signaling pathway
    121099746
   04926 Relaxin signaling pathway
    121099746
   04935 Growth hormone synthesis, secretion and action
    121099746
   04918 Thyroid hormone synthesis
    121099746
   04919 Thyroid hormone signaling pathway
    121099746
   04928 Parathyroid hormone synthesis, secretion and action
    121099746
   04916 Melanogenesis
    121099746
   04924 Renin secretion
    121099746
   04925 Aldosterone synthesis and secretion
    121099746
   04927 Cortisol synthesis and secretion
    121099746
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    121099746
   04270 Vascular smooth muscle contraction
    121099746
  09154 Digestive system
   04970 Salivary secretion
    121099746
   04971 Gastric acid secretion
    121099746
   04972 Pancreatic secretion
    121099746
   04973 Carbohydrate digestion and absorption
    121099746
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    121099746
  09156 Nervous system
   04724 Glutamatergic synapse
    121099746
   04725 Cholinergic synapse
    121099746
   04728 Dopaminergic synapse
    121099746
   04726 Serotonergic synapse
    121099746
   04720 Long-term potentiation
    121099746
   04730 Long-term depression
    121099746
   04723 Retrograde endocannabinoid signaling
    121099746
  09157 Sensory system
   04742 Taste transduction
    121099746
   04750 Inflammatory mediator regulation of TRP channels
    121099746
  09159 Environmental adaptation
   04713 Circadian entrainment
    121099746
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    121099746
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    121099746
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    121099746
   05142 Chagas disease
    121099746
   05143 African trypanosomiasis
    121099746
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    121099746
   05016 Huntington disease
    121099746
   05017 Spinocerebellar ataxia
    121099746
   05022 Pathways of neurodegeneration - multiple diseases
    121099746
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    121099746
   05415 Diabetic cardiomyopathy
    121099746
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    121099746
   04934 Cushing syndrome
    121099746
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:umr04131]
    121099746
Enzymes [BR:umr01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     121099746
Membrane trafficking [BR:umr04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    121099746
 Endocytosis
  Macropinocytosis
   Phospholipase C
    121099746
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 IATP Prothymosin Nop14
Other DBs
NCBI-GeneID: 121099746
NCBI-ProteinID: XP_040476391
UniProt: A0A8M1EZG7
LinkDB
Position
Unknown
AA seq 1038 aa
MSLLSPVLLPPKVKAYLSQGERFIKWDDETTIASPVILRVDPKGYYLYWTYQSKEMEFLD
ITSIRDTRFGKFAKIPKSQKLRDVFNMDFPDNNFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVGQNWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKR
VEAALSACHLPKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH
LTKFINQKQRDPRLNSLLFPPARPDQVRGLIDKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLAGCRCVELDC
WKGKPPDEEPIITHGFTMTTDIYFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRMMFGDMLLTEPLEKFPLSPGTPLPSPEDLRGKILIKNKKNQFSGPAAPSTEPGEE
ASVGDDTVWAGEEGAEPEEEEEEEEEEEEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTA
YEEMSSLVNYIQPTKFISFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSR
IYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMR
RPDKQFNPFSVDRIDVVVATTLSITVISGQFLSDRSVRTYVEVELFGLPGDPKRRYRTKL
SPSANSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCL
HSESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKFFSAQDKKSVKLKEAMGGLPE
KPFPPGSPVVGPVNGTLAPTSNGSAAAGARAKQEATKEAAEPRTASPEELRELKGVVKLQ
RRHEKELRDLERRGARRWEELLQRGAAQLAELGAAAGGCVGRRLGPGKGSRKKRTLPGEE
APGAAPSEGPEGPEGADARARELKDRLELELLQQGEEQYECILKRKEQHVAEQISKMMEL
AREKQAAELKTLKETLRR
NT seq 3117 nt   +upstreamnt  +downstreamnt
atgtctctgctcagcccggtcctgctgccccccaaggtgaaggcttatctgagccaaggg
gagcgcttcatcaaatgggacgatgaaaccacaatagcctccccggttatcctccgtgtg
gatcccaagggctactacttatattggacatatcagagtaaggagatggagtttctggat
atcaccagcatcagggatacccgctttgggaagtttgccaagatacccaagagccagaag
ctccgggatgtcttcaacatggacttccctgacaacaacttcctgcttaagacgctcact
gtggtgtccggccctgacatggtggacctcaccttccacaacttcgtctcctacaaggag
aatgtgggccagaactgggccgaagatgtgctggctctggtcaagcacccgctgacagcc
aatgcctcccgcagcaccttcttggacaaaatcctggtcaagctcaagatgcagctcaac
cctgaagggaagattcctgtgaaaaattttttccagatgtttcctgctgaccgcaagcgg
gtggaagctgccctcagcgcctgccacctcccaaaaggcaagaatgatgccatcaatcct
gaggacttcccagaatccgtctacaagagtttcctcatgagcctctgtcctcggccagaa
atagacgagatcttcacttcctaccatgccaaggccaaaccctacatgaccaaggagcac
ttgaccaagttcatcaaccagaaacagagggacccccgtctcaactctttgctgtttccg
ccggcgcggcctgaccaggtgcggggcctcatcgacaagtatgagcccagtggcatcaac
gtgcagaggggccagctctccccggagggcatggtgtggttcctctgtgggcccgagaac
agcgtgctggcccaggacaagctgcttctccaccatgacatgactcagccactcaaccat
tacttcatcaactcctcacacaacacctacctgacagccggccagttctctggcctttcc
tcggccgagatgtaccgccaggtgctgctcgctggctgccgctgtgtggagctggactgc
tggaagggcaagccccctgacgaggagcccattatcacccacggcttcaccatgaccacg
gacatctacttcaaggaagcaattgaagccatcgcagaaagtgcctttaagacctccccc
tatcctgtcatcctgtcatttgaaaaccatgtggactcaccccgccaacaggccaagatg
gctgagtactgccggatgatgtttggggatatgctgctcacagagcccctggaaaagttc
ccgttgagcccaggcacccccctgcccagccctgaggatctccgaggcaagatcctcatc
aagaataaaaagaaccagttttctggcccagcggcccccagcacggagcctggagaggag
gcctctgtgggggacgacacagtgtgggctggcgaggaaggggcagagccggaggaggaa
gaggaggaagaggaggaggaggaggaggaggaggaggaggaagagtcgggaaacctggat
gaggaggagatcaagaagatgcagtcggatgagggcacagcgggcctggaggtgacagct
tatgaggagatgtccagcctagtgaattacatccagcccaccaagttcatctcctttgag
ttctctgcccagaagaaccgaagttatgtcatctcgtctttcacagagctcaaggcctat
gacctgctctccaaggcctcggtgcagtttgtggactacaacaagcgccagatgagccgc
atttaccctaagggcacccgcatggactcctccaactacatgccccagatgttctggaac
gccggttgccagatggttgccctcaacttccagacgatggacctgcccatgcagcagaac
atggcgctgtttgagttcaatgggcagagtggctacctgctcaagcatgagttcatgcgg
cggccagacaagcagttcaaccccttctccgtggaccgcatcgacgtggtggtagccacc
accctttccatcacggtgatctctgggcagttcctgtcggatcgcagtgtgcgcacgtat
gtggaagtggaactgtttggccttcctggggaccccaagaggcgctatcgcaccaagctg
tcacccagcgccaactccatcaatcctgtctggaaggaggagccttttgtctttgagaag
atcttgatgcctgagctggcctccctcagggtggctgtaatggaagaaggcaacaaattt
cttgggcaccgcatcatccccattaacgccctgaattctggctaccaccacctgtgcctg
cacagcgagagcaacatgccccttaccatgcctgcactttttgtcttcctggagatgaag
gactatgtacctgacacctgggcagatctcaccgtagctctcgccaatcccatcaagttc
ttcagtgcccaggataagaagtctgtgaagctcaaggaagccatgggaggtctgcccgag
aaacccttcccacctgggagtccagttgtcggcccggtcaacgggacattggccccaacg
agcaacgggtctgcagcagctggggccagggccaagcaggaggccacgaaagaagctgca
gagccacggaccgccagcccggaggagctgcgggagctgaagggcgtcgtgaagctgcag
cggcggcacgagaaggagctgcgggacctggagcggcgcggcgcgcggcgctgggaggag
ctgctgcagaggggcgcggcgcagctggccgagctgggggccgccgctgggggctgcgtg
ggccgcaggctcggcccggggaagggctctcgcaagaagaggaccctgccgggcgaggag
gcccccggggccgcgccgagcgaaggccccgagggccccgagggcgcggacgcgcgtgcg
cgcgagctgaaggaccgcctggagctggagctgctgcagcagggcgaggagcagtacgag
tgcatcctgaagcgcaaggagcagcacgtggcggagcaaatctccaagatgatggagctg
gccagagagaagcaggctgcagagctgaagaccctcaaggagaccttgagacgatga

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