Venturia canescens: 122415352 Help Entry 122415352         CDS       T09386                                  Name (RefSeq) ryanodine receptor isoform X1   KO K04962   ryanodine receptor 2 Organism vcan  Venturia canescens Brite KEGG Orthology (KO) [BR:vcan00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:vcan04040]     122415352    04990 Domain-containing proteins not elsewhere classified [BR:vcan04990]     122415352 Ion channels [BR:vcan04040]  Voltage-gated cation channels   Ryanodine receptor    122415352 Domain-containing proteins not elsewhere classified [BR:vcan04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    122415352 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR SPRY Ins145_P3_rec MIR RR_TM4-6 RIH_assoc Ion_trans EF-hand_7 DASH_Spc34 Motif Other DBs NCBI-GeneID:  122415352 NCBI-ProteinID:  XP_043283346 LinkDB All DBs Position 8:complement(11457533..11515142) Genome browser AA seq 5151 aa AA seqDB search MADSEGGSEQDDVSFLRTEDMVCLSCTATGERVCLAAEGFGNRHCFLENIADKNIPPDLS QCVFVIEQALSVRALQELVTAAGSETEQATLGKGTGSGHRTLLYGNAILLRHLNSDMYLA CLSTSSSNDKLAFDVGLQQQSIGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYL HTTKENDLSVVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPPSW NTSPEQNMVVYEGGSVMSQARSLWRLELARTKWAGGFINWLHPMRIRHLTTGRYLGVKEN NELHLVDRNEATTEISTFWLRQEKNDLKTAQKNDQKIDDKDLEVIGKPIIKYGDSTVIMQ HCATCLWVSYKSYETKKKGVGKVEEKQAVLHEEGKMDDGLDFSRSQEEESRTARVIRKCS SLFTQFITGLETLQIDRRASMFFQNVNLNEMVMCLEDLINYFAQPEENIEHEEKQNKLRA LRNRQDLFQEEGILNLILEAIDKINVITSQGFLVALSGDESGQAWDQISGYLYQLLAAII KGNHTNCAQFANSNRLNWLFSRLGSQASSEGTGMLDVLHCVLIDSPEALNMMRDEHIKVI ISLLEKHGRDPKVLDVLCSLCVGNGVAVRSSQNNICDFLLPGKNLLLQTQLVDHVASVRP NIFVGRVEGSAVYQKWYFEVTVDHIERTTHMMPHLRIGWANTTGYVPYPGGGEKWGGNGV GDDLYSFGFDGAYLWTGGRKTQVMHDATEPYIRKGDVIGCALDLTVPIITFAFNGAHISG SFRNFNLDGMFFPVISCSSKLSCRFLLGGDHGRLKFQPPEEFSPLVESLLPQQILSLDPC FYFGNMNKVVLAGPWSVEDDTAFVPAPVDTSMVNLPAYVEQIRDKLAENIHEMWAMNKIE AGWIYGEQRDDLQKIHPCIVQFERLPAAEKRYDTQLAVQTLKTILALGYYITMDKPPSRI KTLRLPNEPFLQSSGYKPAPLDLSAITLTIKMEELVDQLAENTHNLWAKERISQGWTYGL NEDSEMRRSPHLVPYPKVDEAIKKANRDTASETVRTLLVYGYMLDSPTGEQHEALLLEAS RMRQLSFRTYRVEKHYGVSSGKWYFEFEVLTAGPMRVGWAKADCSPGCMLGSDENTWAFD GYNVTKVHGGTSESFGHKYQVGDIVGCFIDVADGTISFSLNGELLMDALGGETSFADVQG ECFVPAFTLGVGQKAKLTFGQDVNTLQYFTTCGLQEGYEPFCVNMNRHVTFWYTKDQPIF ENTDDMADTRIDVARIPAGSDTPPCLKISHNTFETMEKANWEFLRLSLPVICQSTFITEN EKMRRWQEIKIRQNRLMAEQVEQSQHTAPSAHMEQIMKSGFSMSDIKGLQRNYSEDAVED AEMMKESPLPMQRNRPSRPPRKNSLYGSNAGALDNATSEAEMNGYGEMNGDVKDDKKKRG RSPFRKLSNEVEDVPFFSRKAKSPDAKSKTPEPTMRSDVSDSDKTMPGRLSSRPAQVRVS TTDLKVVPPQVPERNAPKAMSVNLTGSGVEAIGNEIFDPECLKLMNEYFYGVRVFPGQDP THVYVGWVTSQYHQHTKDFNPSRVRKASVIIVDDYDRPVEQVDRQSCYMVRADELYNEVT QDASGKGASQGMFVGCFVDTVTGWVSFTCEGKETSHKFKMEPDTKLFPAIFVEATSKEIL QIELGRTSTTLPLSAAVLQNSERHVIPQFPPRLKVQCLKPHQWARVPNQSLQVHALKLSD IRGWSMLCEDAISMLALHIPEEDRCIDILELIEMDKLLSFHAHTLTLYAALCYQSNYRAA HALCLHVDQKQLLYAIRAEYMSGPLRQGFYDLLIALHLESHATTMEVCTNEYIIPLGQEL KDLYENEEMRHSLRYLETESVRPEMKMTEIKDIPSSENQNIENIRSLYSPYFPLDIVRDY VMMALNEAVEVNQVHNRDPIGGSNENLFLPLIKLVDRLLLVGMLRNEDITKLLIMINPET WDPTFDKEGKDEHKKGLLHMKMAEGAKLQMCYLLHHLNDIQLRHRVESIIAFSHDFVGDL QADQLRRYVEIKQSDLPSAIAAKKTREFRCPPREQMNAILSFKNLEDDDPDNIPCGEDLI TKMNEFHSDLMSYVSLHALQEAADAANEVVEVEKPGAMKRLLNFINAVKEFEEEAKPEPE PEKKKTPEEVFRKVLISTIVEWAEESQIETPKLVREMFSLLVRQYDTVGELIRALEKTYV TNSKTKIDVQQMWVGLSQIRALLPVQMSQEEEELVRERLWKLVNNHTFFQHPDLIRVLRI HENVMAIMMNTLGRRAQAQSDAQAQAPVTEGGEAPSKEKDTSHEMVVACCRFLCYFCRTS RQNQKAMFDHFDFLLENSNILLSRPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAV YLSRCGLQSNSELVEKGYPDLGWDPVEGERYLDFLRFCVWVNGESVEENANLVIRLLIRR PECLGPALRGEGEGLLRAIMEANKMSERIADRRKLFNQVHDEAEGNAIVAQFEHPLPESD DDEDYIDTGAAILNFYCTLVDLLGRCAPDSSVIEQGKNESLRARAILRSLVPLDDLQGVL SLRFTLLNPAAGQERPKSDTPSGLIPGHKQSIVLFLERVYGIETQELFFKLLEEAFLPDL RAATMLDRNDGYESDMALAMNRYIGVSILPLLIQHSKFYNEADNYASLLDATLHTVYRLS KNRMLTKGQREAVSDFLVALTSQMQPNMLLKLLRKLTVDVSKLSEYTTVALRLLTLHYER CAKYYGSTGGQGAYGASSDEEKRLTMVLFSNIFDSLSKMDYDPELFGKALPCLTAIGCAL PPDYSLSKNYDDEWYGSKSASTQSPDGPYNPQPINTSSVVLNNDLNQIVQKFSEHYHDAW ASRKFENGWQYGEQWSDTNKTHPRLKPYDKLNDYERERYKEPVRESLKALLAIGWSVEHA EVDVPSTNRSSLRRSSKSQVDSATAFNYNPHPVDMTNLTLSREMQNMAERLADNAHDIWA KKKKEELIVNGGGIHPQLVPYDLLTDKEKRKDRERSQEFLKYLQYQGYKLHKPNRGGAET EVAGTGAAVELRFAYSLLEKLIAYLDKATINMKLLKPSDTFSRRNSFKTSTRDIKFFSKV VLPLMEKYFSTHRNYFIAVATATNNVGAASLKEKEMVAALFCKLASLLRSRLAAFGADVK ITVRCLQVLVKGIDAKSLTKNCPEFIRTSMLTFFNNTADDLGHTILNLQEGKYSHLRGTH LKTSTSLSYVNSVVLPVLTAMFDHLAACEYGNDLLLDEIQVASYKMLASLYTLGVDATLT HDRKYLKTEIERNKPNLGSCLGAFSSCFPVAFLEPHLNKHNQFSLLNRIADHSLEAQDIM TRMESSMPTLETILTEVDQFVESEKTYSDAPHVVDVILPLLCSYLPFWWAQGPDNVTPTE GTYVSMVTSDHMNQLLKNVLKLIKKNIGNENAPWMTRIAAYTQQIIINSSEELLKDPFLP LAERVRKRTDNMFHKEESLRGFIKSSTDDTSQVEAQIQEDWQLLVRDIYSFYPLLIKYVD LQRNHWLRNNISEAEDLYNHVAAIFNTWSKSQYFLREEQNFISANEIDNMVLIMPTATRR TVTVTDGSAPPGGAKKKKKHRDKKRDKDKEVQASLMVACLKRLLPVGLNLFAGREQELVQ HCKDRFLKKIAESDIAEFAKIQLTLPDKIDPGDEMSWQHYLYSKLGQKKDSMEPVKAQQI EDVVARITDMAKVLYGLHMIDHPQQQSKNIYRSVVSIQRKRAVIACFRQLSLHSLPRHRA INIFARTYYELWLQDENVGQEIMIEDLTQSFEDAERKKMDKPEDESKPDPLTQLVTTFCR GAMTERSGALQEDALFMSYAQIISKSCGEEEEEGEGEEGGGSEEEGAASIHCTHKLILRP MHQLMEQEMEKQKLLFHQARLANRGVAEMVLLHISACKGVPSEMVMKTLELGISILRGGN IDIQRGMLNHLKEKKDVGFFTSIAGLMNSCSVLDLDAFERNTKAEGLGVGSEGAAGEKNM HDAEFTCALFRFIQLTCEGHNLDWQNYLRTQAGNTTTVNVVICTVDYLLRLQESIMDFYW HYSSKELIDPAGKANFFKAIGVASQVFNTLTEVIQGPCAQNQQALAHSRLWDAVGGFLFL FSHMQDKLSKHSSQVDLLKELLNLQKDMITMMLSMLEGNVVNGTIGKQMVDTLVESASNV ELILKYFDMFIKLKDLVSSPSFLEVDFNSDGWVYPKDFKEKMEQQKSYTSEEIEFLLACC ETNHDGKIDYVTFMDRFHEPAKEIGFNLAVLLTNLSEHMPNEPRLARFLETAGSVLNYFE PFLGRIEILGSNNKIERVYFEIKESNIEQWEKPQIKESKRAYFYNTVVEAGEKEKLETFI NFCEDAIFEMQHASALMAVEESGGIGKARESSYTYMTEDDEERNKDPIRRGIQAFKDGVY FFFSMFSPANIKNKISEMQQMTIPELFIGFFKMIFYAFYYSGFGVGCVINYFMRLLLTLM RGPNLEEPVVEVKEEEGKPSRHLPALPPTPDESNLQVQAFGMDITKEEGGQIKIAAHESA ASTPQSSMEETGESTPEEGTAEDLAREGVSGETEPVTLADLLGGEQARAQAAASAEAAAA QQAAMAAVEAEAKHEIIVEPSASSTIDFSKYTHRVVSFLARNFYNLKYVALVLAFCINFM LLFYKVTSLVDESENGESDESIANLLNEMSGEGMSGSGSGSGAGAGGSGIEIGSGGEGDG SEEEEDPPEFVEVAEDFYYMAHVMRLMAVLHSLVSLAMLVAYYHLKVPLAIFQREKEVAR RVEFDGLYISETPEENDFKALWDKIVISAKTFPVNYWDKFVKKKVRQKYSEAYDFDHISN LLGMEKTSFSQQEVEGSGAWYFIMNIDWKYQLWKAGVTITDNSFVYSLLYFAFSVMGNYN NFFFAAHLLDVAVGFKTLRTILQSVTHNGKQLVLTVMLLTIIVYIYTVIAFNFFRKFYVQ EEDDEVDKKCHSMATCFLFHLYKGVRAGGGIGDEIGEPDGDDYEIYRIMFDITFFFFVIV ILLAIIQGLIIDAFGELRDQLDSVKTDMESKCFICGLGKETLDTVPHGFDTHVQQEHNLA NYMFFLMHLINKPDTEYTGQETYVWNMYQQRQWDFFPVGDCFRKQNEAVEA NT seq 15456 nt NT seq  +upstreamnt  +downstreamnt atggccgatagcgagggtggttccgaacaggatgacgtatccttccttcgtacggaggac atggtgtgtctgtcttgtacggccaccggagagagggtttgtctcgcagccgagggattt ggaaatcgtcactgttttctcgaaaatatagctgataagaacatacctccagacctttca cagtgtgtcttcgtgatagagcaggctttatcagtgagggctttgcaggaattggtcacg gcagctggttcagagacggagcaagcaaccttaggtaaaggaacaggctctggtcacaga acgctgctctacggcaatgccattcttctgaggcatctcaacagtgacatgtatttagca tgtttatccacgagttcttccaacgacaagctggcatttgacgtcggtctccaacagcaa tcaataggagaggcttgttggtggaccgtacatccggcatcgaaacagagatcggaaggt gaaaaagttcgagtcggtgacgacctcatcctcgtgtctgttgccaccgaaagatatttg cacacgacgaaagaaaatgatttgtcagtcgtcaacgcctcatttcacgtgacccattgg tctgtccaaccctatggaactggaataagtcgaatgaaatacgtcggctacgtttttggt ggtgacgttttgagattctttcacgggggcgatgagtgtctcactataccaccctcgtgg aatacgtcaccggaacaaaacatggtcgtatacgaaggagggagcgttatgagccaagcg agatctctttggcgacttgaattagcgaggacgaaatgggcaggcggtttcataaattgg ctacatccgatgagaataaggcacctcacaacaggtcgttatcttggcgtgaaagaaaat aacgaacttcacctggtcgacagaaacgaagcaacgactgagatctcgaccttctggctt cggcaggagaagaacgatctaaaaacagcacaaaaaaatgatcaaaaaatcgatgacaag gatctcgaagtaattggtaaaccgataatcaaatatggcgattcgacagtcataatgcag cattgcgcaacgtgcctctgggtctcgtacaagtcgtacgaaactaagaaaaaaggtgta ggtaaagtagaggagaaacaggcggttctccacgaggaaggaaaaatggacgacggtctc gatttttcgcgctcccaggaggaggaatctcgaaccgcgagagtcattagaaaatgtagc agtttattcactcaatttatcacaggcctagaaacactgcagatcgatcggagagcctcc atgttttttcaaaatgttaatcttaatgagatggtcatgtgtcttgaggatttgattaat tattttgcacagccggaggaaaacatagaacacgaggagaaacagaataagcttcgggct ctccggaaccgccaagatctgtttcaagaggagggcatattaaatttgatactggaagct attgacaaaataaatgtgataacatcgcaaggctttctcgtcgcgttgtcaggtgacgag agtggtcaagcatgggatcaaatttctggctatctctatcaacttctagcagctatcatc aaaggaaatcacacgaattgtgcccaatttgcgaatagcaatcgattgaattggctcttc agtagattgggatcacaagcctcgagcgaaggaacaggaatgctggatgtactccattgc gttctcattgactcaccagaagccctgaatatgatgagggacgagcatataaaagtgatc atttctcttctcgagaaacacggaagagatccaaaagtccttgacgtcttgtgctcgttg tgcgtcggtaatggagtcgctgtcagatcttcacaaaacaacatttgcgatttcttactg ccaggaaaaaatttattgctacagactcaacttgtcgaccacgttgccagtgtgagaccg aacatattcgtagggcgagtcgaaggttcggccgtttatcagaaatggtacttcgaagtg acggtcgatcatattgaacgaacgactcacatgatgccacatttgagaatcggatgggcc aatacaacgggatacgttccttatccaggtggaggtgaaaaatggggtgggaacggagtc ggtgacgatttatattcgttcggtttcgacggtgcttatctctggaccggaggaagaaaa actcaagttatgcacgacgcgaccgagccttacatcaggaagggtgacgttatcggatgt gctctcgatctcacagttccgatcataacttttgcattcaacggtgctcacatatcaggt tcatttcgaaacttcaatctggacggaatgtttttccccgtgataagttgttcatccaaa ttatcgtgtcggtttctcttgggaggagatcacggacgactgaaatttcagccacccgaa gaattttcgccgttagtcgagagccttttgcctcagcagatactatcgttggatccttgt ttttatttcggcaacatgaataaagtggtgttggctggtccttggtcggtagaggacgac acagcgtttgttccagcaccggtggacacgtcgatggtgaatttaccggcgtacgtcgaa caaatacgagacaagttagcggagaacatccacgaaatgtgggcgatgaacaagatcgag gcgggctggatttacggcgagcaaagagacgatttgcaaaaaattcatccgtgcatagtg cagttcgagcgattgccggctgccgaaaaacgctacgacacacagctcgcggtccaaaca ctcaaaactatcttggctcttggctattacattacgatggacaaaccaccctcgagaata aaaaccctcagactaccgaacgagccgtttctacagagcagcggttacaaacccgctcct ctagatcttagcgccattactctcaccattaaaatggaagaattggtcgatcagctggcc gaaaacactcacaacctgtgggccaaggaacgcattagccagggatggacttacggtctg aacgaggactctgaaatgcggaggagccctcatctcgtaccctatcccaaagtcgacgaa gccatcaagaaagccaacagagatactgccagtgaaactgtcagaactctcctcgtttat ggctacatgctcgactctccaactggcgaacaacacgaagctctgctactcgaggccagc agaatgagacaattgtccttcagaacgtacagagttgaaaagcactatggagtcagcagt ggaaaatggtatttcgagtttgaagtattaactgctggtcccatgagagtcggttgggcc aaggctgactgctcgcccggatgcatgttaggaagtgatgaaaatacctgggctttcgac ggttacaatgtgaccaaagtacacggtggtaccagcgagtcttttggtcacaaatatcaa gtgggcgacatagttggctgtttcattgacgtcgcggacggaacgatcagtttttccctg aacggtgaacttctcatggatgcactcggcggagaaacttcgttcgctgatgtccagggc gaatgcttcgtcccggcgttcactctcggtgtcgggcaaaaagctaaattgactttcggt caagacgtcaatactctgcagtactttacaacttgcggtctacaggaaggctacgagcct ttttgcgtcaacatgaatcgtcacgttaccttttggtacacgaaagaccaaccgattttt gagaacaccgacgacatggcagacacccgaatcgacgtcgctcgaatcccagccggttcc gacactccaccgtgcctcaaaatctctcacaacactttcgaaaccatggaaaaagccaat tgggaattcctgcgattgtccttaccagtcatttgccaatctacttttattactgaaaat gaaaaaatgagacggtggcaagaaatcaaaattcgccaaaataggctcatggctgaacag gtcgaacagtcccagcatactgcgccttccgctcatatggaacaaatcatgaaatcggga ttcagcatgagcgatattaaaggtttgcagagaaactattcagaggacgcggttgaagat gctgaaatgatgaaagaatctccgttgccgatgcagcgaaatcgaccatcgagaccgccc cgtaaaaactcactttacggatcgaatgccggcgctctcgacaacgcgacgagcgaagcc gagatgaacggttatggggaaatgaacggtgacgtcaaggacgacaagaagaaacgggga cgttcaccttttcgcaagcttagcaatgaggtggaggatgtgccatttttctctcgtaaa gcaaaatctcctgatgccaaatcgaaaactcctgaaccaacgatgcgctcggatgtttcg gacagcgacaaaactatgcctggaagactttcctccagaccagctcaagttcgagtctcc acgacggatttgaaagtagtgccaccgcaagtccctgaacgaaacgcgcccaaagcaatg tccgtaaatcttaccggaagtggagtcgaagctatcggcaacgagatttttgatcccgaa tgcctcaaactgatgaacgaatatttttacggtgtgagagtcttcccaggacaggatcct actcacgtttatgtcggttgggtcacatcgcagtatcaccagcatacgaaagacttcaat ccatctagagttcgaaaagcttcggtcatcatcgtcgatgattacgatcgtccagttgag caagtcgacagacaaagctgttacatggttcgtgccgacgagctttacaacgaggtgact caagatgcatcaggcaagggcgcctcgcaaggaatgttcgtcggttgtttcgtcgacacg gttaccggttgggtgtcttttacatgcgagggcaaagaaacgagtcacaaattcaagatg gagcccgacactaaattattccctgcaatattcgtcgaagcaacgagcaaagaaatcctc caaatcgagctgggacgaacttcaacgacgttgccactctcagctgctgtacttcagaac tccgagcgccatgttataccgcaatttccaccgaggctgaaagttcagtgtttgaaacct catcagtgggctcgcgttcccaatcaatcgctccaagtccacgcactcaaactttccgat atacgaggctggtccatgctttgtgaagatgctatttcaatgcttgccctccatataccc gaagaggacagatgcattgacattctcgaactcatcgaaatggataaactcttgagtttc cacgcccacacgctgaccctgtacgcagctctctgttaccagtcgaattacagagcggct catgctctctgcctacacgtcgatcaaaaacaacttttgtacgcgatccgtgcggagtac atgtccggaccactgcgtcaaggattttacgatcttcttatcgccttacatctggaatct catgcaaccacgatggaagtatgcaccaacgagtacatcattcctttgggccaagaactc aaagacttgtacgagaacgaggaaatgagacacagcttgcgatacctcgaaaccgaatcg gttcgccccgagatgaaaatgaccgaaatcaaggatattccttccagtgagaatcagaac atcgagaacatcagaagtctctacagtccgtacttcccactggacatcgttcgcgactac gtgatgatggcccttaacgaagctgtcgaagtcaatcaagttcacaatcgcgaccccatc ggtggcagcaacgaaaatctctttctacctcttatcaaactcgtagatcgattacttctt gttggaatgctgaggaacgaagatatcaccaaattgcttattatgatcaaccccgaaacg tgggatccaacatttgacaaggagggaaaagatgagcacaaaaagggcttgctgcacatg aaaatggcggagggtgccaaactgcaaatgtgttatttgcttcatcatttgaacgacata caactgcgtcaccgggttgagtcgataatcgctttcagtcacgatttcgttggggatctc caagctgatcaactgcgtcgttacgttgagatcaaacaatcggatttaccctcggctatt gcggcgaaaaaaactcgtgaattccgttgtcctcctcgtgaacaaatgaacgctatattg agcttcaaaaatttagaagatgatgatcctgataatattccatgcggagaggatcttatc acgaaaatgaacgagtttcacagtgatctcatgtcctacgtgtcgttgcacgcgctccaa gaagccgcggatgcggcgaacgaggtcgttgaagtcgagaaacctggcgctatgaaacgt ctcctcaatttcatcaacgccgtcaaagaatttgaagaggaagcgaaacctgaaccggag ccggaaaagaaaaaaacaccggaagaggtgttccgaaaagttcttatttcaacgatcgta gaatgggcggaagagagtcagattgagacgccaaaattggtgcgtgaaatgtttagtctt ttggtgcggcagtacgacacggttggggaattgataagagctttggagaagacgtacgtg acgaacagtaagacgaaaatcgacgtgcagcagatgtgggtcggtctcagtcagatcagg gctcttctgcccgtccaaatgtcgcaggaggaggaagagttggtccgggaaagactttgg aaattggtgaacaatcacaccttcttccagcatcctgatcttataagagtattgagaatt cacgagaatgtgatggcgataatgatgaacacgttgggtcgaagagcgcaggctcaatcg gacgctcaggcccaagctccagtgaccgagggtggagaagcaccttccaaggaaaaagac acttcccacgaaatggttgtcgcatgttgtagatttctctgctacttttgtcgcacctcc aggcaaaatcaaaaagcaatgttcgatcattttgactttttgttagaaaacagtaatatc ttgttgtcacggccctctttgaggggctccacacctctcgatgtggcttactcttccctc atggaaaacaccgagctcgctcttgcacttcgagaacattacctcgaaaaaattgccgtc tacttgtctcggtgcggactccaatctaattctgaactcgttgaaaaaggctaccccgat cttggttgggatcccgtcgagggagaacgttatctcgatttcttacgattctgtgtttgg gtcaatggtgaaagcgtggaagagaacgctaatctagtgatcaggctgttgataagaagg ccggagtgtcttggaccagcgctccgtggcgagggcgagggtctccttcgcgcgatcatg gaagccaacaaaatgtcagaacgcattgccgatcgacgtaaactctttaatcaggtacac gacgaagctgagggaaatgcaattgttgcacaattcgaacatccacttccggagtctgac gacgacgaggattatatcgacaccggtgctgcgatcctcaatttttactgcaccctcgtc gatttgttgggtcgttgtgctcctgattcttcggtcattgagcaaggaaaaaacgagtct ttgagagccagagcaattttacgatctctcgtgccattggacgatctccagggggttctt tctttgcgattcactctgttgaacccagcggctggacaagagcgaccgaaaagtgacaca ccttctggtctgatccctggacacaagcagagcatcgtgctcttcctcgagcgagtttat ggcattgagactcaggaattatttttcaaactgttggaagaagcttttctgcctgatctt cgagctgccacgatgctcgacagaaacgacggatacgaatccgacatggcacttgctatg aatagatacatcggtgtcagcattttgccactgttgattcagcactcaaagttctacaac gaggctgacaactatgccagtcttttggacgcgacccttcacaccgtttaccgactcagt aaaaacagaatgttgaccaaaggacagagagaagctgtttcagacttcctcgttgccttg accagccaaatgcaaccaaacatgcttttgaaacttttgagaaaactcacggtcgatgta tccaaattatctgaatatacaaccgtcgctctcaggctcttgacgcttcattacgaacgt tgcgcaaaatactacggttcaacgggaggccaaggagcttacggagcttcgagtgacgaa gagaaacgtttgacgatggtgctcttcagcaacatatttgattccctctcaaagatggat tacgatccagagttattcggcaaagcgttgccatgcttgaccgcgatcggttgtgcattg ccaccggattattcgctctcgaaaaattacgatgacgagtggtacggcagcaaatcagcg tcgacgcaatctcccgacggtccttacaatccacaaccaataaatacttcaagcgtcgtt ctcaacaacgacttgaatcaaatcgttcaaaagttctctgagcactaccacgacgcttgg gctagtagaaagttcgaaaacggttggcaatacggtgaacaatggtccgacaccaataaa actcatccgagactcaaaccttacgacaaactcaatgattacgaaagagaacgctacaag gaacctgtcagggaaagcctcaaagctctcttggccattgggtggagtgtcgaacatgcc gaagtcgatgtaccctcgaccaatcgtagttctttaagaagatcttccaaaagtcaggtc gattcagcaacagcttttaattacaatccccatccagtcgacatgacgaatctcactctg agcagagaaatgcaaaatatggcagagagactcgcggacaacgcacatgacatttgggcg aaaaaaaagaaggaagaattaatagtcaacggagggggaattcatccacagttagtacca tacgatcttctgacagacaaagagaagcgaaaggatcgtgagcgttcccaagaattcttg aagtatcttcagtaccagggctacaaattgcacaagccgaacagaggtggtgctgagaca gaagtcgcaggaacaggagctgcggtggagctgcgtttcgcatattcgttgttagaaaaa ttgatcgcatacctggacaaggcgacgataaatatgaaattgctgaagccgtcggatacg ttcagccgacgaaacagttttaaaacgtcaacgcgtgacatcaagtttttcagcaaagtc gttttacccttgatggaaaaatacttcagtacccacagaaattacttcatcgcagtcgca accgcgacgaacaacgtcggcgcagcttccttgaaagagaaagaaatggtcgctgcacta ttttgtaaattagccagcctcctacgatccagactcgcagcttttggcgctgatgtcaaa attactgttcgatgcttgcaagttttggtcaaaggcatcgacgccaaatcactcactaaa aattgtcctgaattcatcagaacttccatgctcaccttcttcaacaacaccgcagatgac cttggccacactatcctcaatcttcaagaaggtaaatacagtcatttgaggggaacgcat ctcaaaacttcgacctctttatcttacgtcaacagcgtcgtacttcccgttcttactgca atgtttgatcatcttgcggcgtgtgaatacggaaacgaccttttgcttgacgagatccaa gtggcctcttataagatgctggcatcgctgtacaccctcggagtcgatgcgacgctgacg cacgatcggaagtacttgaaaacggaaatcgagagaaataagccaaatttgggatcctgc ttgggagctttctcaagctgttttccggtcgccttcctcgagcctcatctaaacaaacac aatcagttttcgctcctcaatcgaatagctgatcactcattggaagctcaagatattatg acgcggatggaatcgagtatgccaacgttagaaacgattttaacggaagtcgatcagttt gtcgagtccgagaaaacttatagcgacgcgcctcacgtggtagacgtgattttaccactc ctttgctcttacttgccattttggtgggctcagggacctgacaacgtgacacctaccgaa ggaacttacgtgagcatggtaacgagcgatcacatgaatcagctcctgaaaaacgttttg aaacttataaaaaagaatatcggcaacgagaacgcaccttggatgacccgcatcgcagcc tacacccaacaaatcatcatcaactcttccgaggaacttcttaaagatcccttcctacct cttgccgagagagtccgcaaaagaaccgacaacatgttccacaaggaagaatctcttcgt ggctttatcaaatccagtaccgacgacacctcccaagtcgaagcacaaattcaggaagat tggcaactccttgttcgtgatatttactcattttatcctttgctcatcaaatacgtcgat cttcaacgcaatcattggctcagaaacaacatatccgaagctgaagatctctacaatcat gttgctgccattttcaacacttggtccaagtcccagtatttcttacgcgaagaacaaaac ttcatttctgccaacgagatcgataatatggtcttgataatgccaactgccactagacga actgtaactgtcactgatggctcagctccacctggtggtgccaagaaaaagaaaaaacat cgagataaaaaacgtgacaaggacaaagaggttcaagcctcgttgatggtggcatgtttg aaaagattgctgcccgtaggtctcaatttattcgctggacgcgagcaggaactcgttcaa cactgtaaagatcgttttctcaagaaaatcgcggagtcagatatcgctgaatttgcaaaa atccagctcactctgcccgataaaatagatcctggtgatgaaatgtcatggcagcattat ttgtactcgaaactaggacaaaaaaaggattctatggagcctgtaaaggctcaacagatc gaggatgtcgtggcaagaatcacggacatggctaaggtcttgtacggcttacacatgatt gatcatccgcaacagcagagcaaaaatatttatcgttccgtcgtctcaatacagcggaag cgagccgtaattgcttgtttccgtcagctctccctacattccttacccaggcacagagcg atcaacatttttgcgaggacgtactacgagctttggctgcaagacgagaatgttggacag gaaatcatgatcgaagatcttacgcaatcctttgaagacgctgaaagaaaaaaaatggac aaaccggaagacgaaagcaaaccggatccacttactcaactggtaactactttttgccgt ggcgcgatgaccgagcgttccggcgcccttcaagaggacgctttgttcatgagctacgct caaatcatatcaaaatcctgtggcgaagaagaggaggaaggcgaaggcgaagagggcgga ggcagcgaagaagagggcgccgcgtctattcactgtacacataaactaatattgaggccg atgcatcaactcatggagcaagaaatggaaaaacaaaagctacttttccatcaagcgaga ttagcgaatcgtggagttgctgaaatggttttgcttcacatatcagcgtgcaaaggtgtg cccagcgagatggttatgaaaaccctcgagcttggaatttcaattttgcggggtggtaac atcgacatccaacgaggaatgttgaaccatttgaaggagaaaaaggatgttggtttcttc acgtcaatagctggactgatgaattcttgcagtgttttggacctggacgctttcgaaaga aacacaaaagctgaaggccttggcgttggctctgagggagctgcgggcgagaaaaacatg cacgacgctgaattcacttgcgcactcttcagattcatccaactcacctgcgaaggtcac aatctcgattggcagaattatttgagaactcaagccggtaacacgacgacagtaaacgtc gttatttgcaccgtcgattacctgctaagattgcaagaatcgataatggatttctactgg cactattcgagcaaagaattgatcgatccagctggtaaagccaattttttcaaggccatc ggtgtcgccagccaagtgttcaacaccttgaccgaagtaattcaaggaccctgcgctcag aatcagcaagctcttgctcattcgagattgtgggacgctgtcggtggtttcctcttccta ttttcacacatgcaagacaaactgtccaagcactcgagtcaggtcgatctcttgaaggaa cttctcaatctccagaaagacatgatcactatgatgctttctatgctcgaaggtaacgtc gtgaatggcacgatcggtaaacaaatggtggatacactcgtcgaatctgcgagcaacgtc gagctcatattgaaatatttcgacatgtttatcaagctcaaagatctcgtgtcttcgccc agttttctggaagttgatttcaacagtgatggctgggtgtatcctaaagactttaaggaa aagatggaacagcagaagagttacaccagcgaggagatcgaatttttgttagcctgttgc gagacgaatcacgatggaaaaattgactatgtaacgtttatggatcgtttccacgagcct gcaaaggaaatcggtttcaatctcgctgtcttattgacgaacctttccgaacatatgcca aacgagccgagattggcacgtttccttgaaactgcaggctccgtccttaattacttcgag ccattcctcggtaggatcgagattttgggcagtaacaataaaatcgagcgtgtgtatttc gagattaaagaatcgaacatagagcaatgggaaaagccacagatcaaggaatcaaaaaga gcctatttttacaacacggtggtcgaggctggtgagaaagagaagctcgaaacgtttatc aacttctgtgaggatgctatttttgaaatgcaacatgcgagtgccttaatggcggtcgag gaaagtggcggaattggtaaagcccgagaatcttcctacacttacatgaccgaagacgac gaggaaaggaacaaagatcccatcagaagaggcatccaagctttcaaggacggcgtttat ttcttcttctcgatgttctcgccagctaatattaaaaacaaaatatcagaaatgcaacaa atgacgatacccgaactcttcatcggtttcttcaaaatgatattttacgctttttactat tccggatttggagttggctgtgtcatcaattacttcatgaggctactcctcactctcatg agaggacccaaccttgaagaacccgtcgttgaagtcaaggaagaagagggaaaaccttcg agacacttacccgcgcttccaccaacacctgacgaatctaatttacaagtacaagcgttt ggcatggacataacgaaagaagaaggtggccagattaaaatagcagcccacgaatcggca gcttcgacgcctcaatcgagtatggaagaaacaggcgaaagtaccccggaagaaggaacc gcggaagacctcgcgagagagggcgtttccggtgaaacggaaccggtcacattggcagat ttgctcggtggtgaacaagcgagagcccaagctgcagcatccgccgaagctgctgcagcc caacaagctgcgatggcagctgttgaggccgaagccaaacacgaaattattgtcgaacca tcagcgagctcaaccatcgatttttccaaatacactcatcgggtcgtctcctttttggct cgaaacttttacaatctcaaatacgttgctctcgtactggccttctgcatcaactttatg ctgctcttctataaggtgacatccctcgtggacgaatcagaaaacggtgaaagtgacgaa tcgattgccaatttgttgaacgaaatgtccggtgaaggaatgtccggatcgggttccggt tccggtgccggcgcgggtggtagcggaatagaaatcggaagtggaggagaaggcgatggg tccgaggaggaagaagatcctccggaattcgtcgaagttgctgaagatttttattatatg gctcacgttatgagattgatggctgttcttcactccctcgtttcgttggctatgctcgtt gcgtattaccatctcaaggttccattggccattttccaacgtgaaaaggaggttgctcgt cgcgttgaattcgacggtctctacatatcggaaactcccgaagaaaacgacttcaaagca ctctgggacaaaatagtcatttcagccaaaacttttcccgtcaactattgggacaaattc gtcaagaaaaaagtacggcaaaagtacagtgaagcttacgatttcgatcacatcagcaat cttcttggcatggaaaaaacgtcgttcagtcaacaagaagtcgaaggttccggcgcatgg tatttcattatgaatatcgattggaagtatcaactttggaaagcgggagttacgatcacc gataactccttcgtctacagtttactgtacttcgctttctccgtaatgggaaattacaac aattttttcttcgcggctcatctgctcgacgtagctgtaggattcaaaacgctaagaacg atattgcagtcagtaacgcacaacggaaaacagctcgttctcacggtgatgctgttgact attatcgtctacatatacaccgtcatagctttcaactttttccgcaaattttacgtccag gaggaagacgatgaagtcgacaaaaagtgtcacagcatggctacgtgtttcttattccat ttgtacaagggagtgagagcaggtggtggaatcggtgacgaaattggagagccggatggc gacgactacgaaatatatcgaataatgtttgacatcacctttttcttcttcgttattgtt attctactcgctatcattcagggtttgatcatcgacgctttcggagagctccgtgatcaa ttggatagcgtgaaaacggacatggagagcaaatgtttcatctgcggattgggcaaagaa acgttggatactgtgcctcatgggttcgacacacacgttcagcaagagcacaatcttgca aattacatgtttttcttgatgcatctgatcaataagccggacacggagtacacgggtcag gagacatacgtttggaacatgtatcagcagcgtcaatgggatttctttccagttggtgat tgtttccgcaaacagaacgaagctgtcgaagcttag

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