Vanessa cardui (painted lady): 124536374 Help Entry 124536374         CDS       T09161                                  Name (RefSeq) E3 ubiquitin-protein ligase UBR4   KO K10691   E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27] Organism vcd  Vanessa cardui (painted lady) Brite KEGG Orthology (KO) [BR:vcd00001]  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:vcd04121]     124536374 Enzymes [BR:vcd01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      124536374 Ubiquitin system [BR:vcd04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    UBR box proteins     124536374 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  E3_UbLigase_R4 E3_UBR4_N UBR4 zf-UBR Flu_PB2_1st Motif Other DBs NCBI-GeneID:  124536374 NCBI-ProteinID:  XP_046968863 LinkDB All DBs Position 2:complement(3543654..3588139) Genome browser AA seq 5249 aa AA seqDB search MAASGGNIEWSTAVKPILTALYGPFFDKNDAVEIIQAIIKSENEFENHEDVYDLFYTCFA CLSAHFISINANNLPADQLSTAHDAFRIMLRHILKKISQAVLTYDDSINMAAPKVTFKQL LLPILGLCGIDGGGLPQSELAILTSLLKSSKLPAHVNAPETQTTKSSVIPSPITSLASQS ATTEKQPPSNAQRRSDALLEQLTLPLRNTMTCLTQNQPATGVVSPGSKDSLESTKDGNAS QQASVDIKKWMYATCASLLMELRAGPMLLKVCSSLPCLYRYLTRWRDAKESAVPPQFNSE VKLLNFLMNEAYVCRMALSLPCLEPLTPERIALLSDLATAWLVCAVTAQATLHPRDDENE EMTATLVERALGLYNTIGETFKQSTRAGGYVYQNHLMIGAWVLLCGFHHALGGAPGTTAP RSPAKAPSRPYNLTKMQQSLSVVWVALGDRCLAWTGALLSDARLEALSAASAPAADTPAP LQILAHHTAHQRELRLASAAPLHQLLVSLAVVCYRKATNLKRAVVQKQNQDADPDRSDST VYFQDMILCSEDSETDDEDSEPLFGLWFESTLVAPDALESGLTRAGAPDSDDVPDDNAAA QQAFMLDKAEPYSYITLATEIFNLLTEEIIGEGVERLGASSQQLHEAHQALLAALAKDLD RETARTDTGTISPCFGARLGALYASFSSALVRYLHNLQPLLQQQLISTGSDRNNMTPLQV GPRVAKLLGGMVLSKVAADRENSILVIWHKIINTLQECALQSQPSQDHDYEDLNVEHAQL LVYLFHSLTLMQKKSVLLMTSNAIIKVVETLGISDRKRAMNLAPHQLMLTTRLMLLLEYL MKHLYDAPQTLLQQIEWNLVIAPGLAQRSSDTTTTGVKTTTDNGQLKTRIYCEVPFIELA YRTPTQDDTSMRPRFYALTNAEINNQENPKLDGLACNFVLGTPHKLKYPLLLDALLSLLN SACLCDNPQYHNSPAALAAAHYCFQTAWRLVISMPPATPHMDKLQAGIAAELPSPLPLHA LVWAPRADNKKVFNPWLKDALVKQGMYTQYAENLLAGVSASCDNIKYTAWLASETMKHLK QNLTSDGLPSLLDVISCDAALMRLKVCLVDSATASEAHQFMPDLLDLLETILECCRLSVG IEIEGSSESASNASDAAVSSVRLQVCGAAGVARAAGAAGPPALGTWLKAQLPPNVAAAVE ACAVPPPLAVNATLYESHIIPSESAVLQLVSSHSELMIVGGKYSIGASLTMLAYSAAKLL EIGSSKLAENTNLTKKTLELIVPALTDGRLQFLAEPLAATLNALVPQVNKAEQLIHEHIL KTTYSVLVDHLQPSTENTLRHMVIYWEKILDRPAGRVAYENVFADNSGYSLGKILLAAPN GKSAFTERVIKLFIKIFNGCDNSELNSALCVSVCKFIGVADQQKLLSLLSHICLVTPAPT NGNAGTANASPTETELPTPTSSAPDGNPASVALRNALRSVFRTDDAPRSDNANRNDQDLP VFDAPIPAPRPPLETVQQSSNSENGSWPEGSKENSNAVVVSSEAGNPFDSSNDNATLLSL LCKHIVHHGGEKVCERMVGALISVSGTTCAPVLLRELCRLADAHAGADHRHLFPAALGWL STCVENLSSSEVLEKLEEGQTDANITSQIESACVLLSYLTDALHTIGSSQPHTWRSVSPT WESPSDLGFDLDYADEQQDEDDTSADDSDEDAMLQYKLCTFTVTQREFMNQHWYHCHTCK MVDGVGVCTVCARVCHRGHDVSYAKFGNFFCDCGAKPDSSCQALVKRSVTLGGARGATTG MEETPPAPSIRRRPSSPTPPALLAPPRRPVLAHNIQGCRSFLLSYNGWPGCLERVRRLLG ALAGPVRAACERGAAVGAHGRAQRALAQLHLGEKRFTHTDTLMLPTLGSQEGAFENVRMS YTGENGQTIRQLMSAHKLRRVAMCCLASPHGRRQHLAVSHEKGKITVLQLSALLKQADSS KHKLTLTRLSSAPIPFTVLSLSGNPWNEDLLAVCGLKECHVLTFNSGGAVADHFVLNTGL EANNYVIKAIWLPGSQTQLALVTSDFVKIFDLSKDLNNPMHHFLVPSGKVRDVTFVNQED IMHMLCMSSAGHIYWQPMSEESRATLGTFYVTNTLEVLHPEIQDVAGLVGGGGVSIYYSH ILKMLFFSYAQGKSFLAPLNTVEDSVKGTAMITLSSSSAQKEGGRGKQGGVQSLCQWAEV PGHPGLVSAVMQASNNPVVLMLTPSNIYVQEIKVVPAKAKITDMVAVRHWCGGGGEQKST LILLCEDGSLRMYAANNEQTGYWLSPAIQPVHAPRRRPRLLTHHTKGKTQQVVTKSNING SPQFPIDFFEHCVAMSDIEFGGNDLLQVYNTAQIKHRLNTTGLYVVSTKMSGFVMEVVNS DPNMVICGIRVLLGNQDVARTPAYVEIHGRSIQTIVVRNRWFDIPLTREESLQSDKKLVI NFGPSQDPDGVTMVDSVKVYGKNKEQFGWPEENEDPSTCASSSKVAQESESNSGSWKPSS LERLACAALEALELGAGAPASSGAAAGAEAGAEAARKLLCAPASAHLHARAQCLLRAVHQ SQYHQFKDQAILKYISVSLRELRDTADARNIDPEAYFRLVLLARGVAVARPQHLVKYSAP TPPKPQDGDWSVLWKSEAQDEPDREPHLCALLSSVLWKLTACRSQTTGPPGILSYGLRHA EHTLHALADTIHAFQLHGDSDCIDFGNQIYLSLLLAEDQSISFGAKAALMRVLRPRVKRR RVYIPSPPNTPGAGSSVTTAQPASSITEAAVSESELSANRDDQQENQYMDVDDSLEPMVL LAPDGGLEALLDIPTDADDETMVELAIALSLQEQGRRAPPPAPAQPPAASASAAPHAPAY SDATASPNGSDDEGSTAATDGSTLRTSPAEAGGSAASDSGGSAADSIGGVSGRSSAYGEM SAPSGQPCSTVVEVPAAVAAGPSSSSQPMASTSRAVEVENETRKLHALRLSLLSAALDAL PTLRTLPGVRAIPFVQVVLMLAGDLDSSAEGDRVVLERLLEVLVGELDIQPEEPTSGEDR TEKRELQLAIMRLELLVSELDAQAIEHSPPVHERTNRRELQLIIMRLLSVLMARWKTCGA GGGGSVSRGEVSGAACAAHVSRLAAAALVRAGAPKHCYNVLAALLPYWKEKTSASGTTTT VQQLLKPQPPQPLPDMQPFFVKEYVKSHALEVFDNYPQLVMEMALRLPCQIHKHCDPKHF DARWRTLLCEYMMNQQTPLRKQVRKLLLLLCGTRERYRQLRDVHALDTHLNAARALLATD AAYDKLVRLMDHLKACAEIVSARTGNWQHTCSTERRETLGWLVGIARRLHPHVAPTVLQL LQAALCAPAPPAPATPPGPPPTAPRPGQDKNASEWPDRERSTESDAFVSDGSKFQEQRVP QLVQQILKQVNQDELKLFVKAFLLETNSTAVRWQAHALLLAIYNNCSPTEQASLVSLLWG LWPTLPQYGRKAVQFVDLLGYFTLKTPNVDNEKYIGSAVELLRNQNQLLSSHGNSALYAA LGAYVELDGYYLESEPCLVCNNPEVPMATIKLPTIKIDSKFTTTTQIVKLVNSHMISRIS LRIGDIKRSKMVRVINFYYNNRTVQAVQELKNKPSMWHKAKRVQLQSGQSEVRVDFPLPI VACNLMMEYADFYENQQATGESLQCPRCSQSVPANPGVCANCGENVFQCHKCRAINYDEK DPFLCHACGFCKYAKFDYTLTARPCCAVDTIENDEERKKMVQTIGALLDKADRVYRQLIA NKPILESLVHKISEHRVEGRADENCNGGGGSFGGAQINRVIQTLAHKYCVESKGHFEDLS KIIQKVLACRKELVAYDRSQSEQLEGDTLPVYAGLVQNYDGDVTKECGGGGCYGCSLACA EQCLTLLRALASQREHRARLVRFGLVHELVHHNLHRGTPQCQDEVRSLICLVTRDNLPAT KQLCYLLSQRITLSLMGHAASQDHNNSVRPLVLLLGALVKVQDSVECWEVRLRCIVKLWV WCCPQLTEVVGIPPAATAILKSEALSGIPGINTSSPNSHQFALQQVALPCLRYMQELMVP AAPAPPAPAPPADDQPKDDKESSQPTAPPPIVLQANTGNLVVDLSAWLAGRVPHNQWRKL VAKNEIPPADTTLPTRDLHLAHKYLGKWKEKMLLSHGMRTISLDEGGWLRPVMFDPSSRI ARDTACQMVKSLCDSYDRTKAVLILLTSFLPEVGSAGEASEQFLLLYQSLASEAPWKQFL ALRGVLQQIADLMTKEIEQLHRLEETTLTSDLAQGYALKRLTELLAMFLEEAGARRAYKT RLVGAVLGGYLSLRRLVVQRTRLTDDTQEKLLELLEEMTTGTEAETAEFMTVCIETVQKY PLHDYRTPVFIFERLCSIIYPEENDVGEFFLTLEKDPQQEDFLQGRMLGNPYSSLEPGMG PLMRDVKNKICTDCELVALLEDDNGMELLVCNKIMSLDLPVKEVYKKVWCTSGEGVDAMR VVYRMRGLLGDATEEFVETLSQTNAETVDDEQVYRMANVLADCGGLEVMLQRLAAIGRVG CARSLVGTLLRLLALCARVRRCVRVLTRPEARALPVLLHALSLAAADEREMQRAPLVYQL LEIMERILSVAASESLESFLQFSLTFGGPEHVQALLNCTECPGIRNNSVALGHLTRVLAA LVYGNDLKMAMLVDHFKPVLDFNRLDSEQWSDEEFRMELFCVLCANIERNSIGGTLKDYL ISLGIVRDALEYIVKHAPCVKPTLVCTDSDELKEFISRPALKYILRFLTGLAADHEPTQM LVCEKVIPIVHRLEQVSSGEHVGSLAENLLEALRSQPQCAAKVQQVRDFTRQEKKRLAMA VRERQLGALGMRSNERGQVTAQCSLTQQVADLAEEAGAVCCICREGYKYQPTKVLGIYTF TKRCPVEEYEARARKTLGYTTVSHYNIVHVECHMAAVRLARARDEWESAALQNASTRCNG LLPLWGPYVPESAFASCLARHTTYLQECTGHRDIGHSCTVHDLKLLLLRFARGLSFHNDT GGGGPLSNMQLVPALMHMALYVINTTRVAAREVSALEASLAWPPARVLESAQDADGPLYF LTLMLLLYPHAKWRALRLDMIKRMLLLGHVRDVTRGGPAVRALAPEQRAPCAWPEYKPYV VFVALIDQLYNVMFKNVNATTVEQWPIKLAEYIRHNDEANAKAAERVVTTLTDELLPCDS LAEFCDAAGLLEDIPDPDAFLRALLDEQP NT seq 15750 nt NT seq  +upstreamnt  +downstreamnt atggctgcttcgggaggaaatatagaatggtctacagcagttaaaccgattttaacagca ctttacggcccatttttcgataaaaatgatgccgtagaaataattcaagctattattaaa agcgaaaacgaatttgaaaatcatgaggacgtctacgatctcttctacacctgctttgct tgtctttcagcgcattttatcagcatcaatgcaaataacttaccagctgatcagctcagc acagctcatgatgccttcagaattatgctacgacatattctcaagaagatttctcaagcc gtcttgacttatgatgactccattaacatggctgcacccaaagtgacatttaaacagctg cttctgccaattcttggtctgtgcggcattgatggcgggggtctcccacaatcagaactt gcgatattgacttctcttctcaagtcatccaagcttcctgcacatgttaatgcaccagaa actcaaacaacaaagtcatcagtaataccaagccctatcacatctcttgcgtctcaatca gcaacaacagagaagcagcctccatccaatgctcaacgtaggtcagatgcattgctggag caactgaccctgccattaagaaatacaatgacttgtctaacccaaaatcagccagcaaca ggggttgtgtcacccggaagtaaagatagtttggaaagcaccaaagatgggaatgcttct cagcaggcatcagtagatataaagaagtggatgtatgcaacttgtgcatcccttttaatg gagctccgagctgggcccatgttactgaaggtttgctcgtcgctgccctgtctttaccgc tacttgactcgttggcgagacgctaaggaaagcgccgtaccaccacaatttaactccgaa gtcaaactcctcaacttcttgatgaatgaagcttacgtgtgtcgaatggcattatctctg ccatgcctcgagcctttgacgccagagcgcattgctctgctcagcgacctcgccacagcc tggctcgtgtgcgcagttaccgctcaggcaactcttcatccaagagatgatgaaaacgag gaaatgacagccactttagttgagagagcccttggtctctacaacacaattggtgaaact ttcaagcagtccactcgggccggtggctatgtttatcaaaaccatctgatgatcggcgct tgggttctgctgtgcggctttcaccacgcgcttggtggagcacctggaacaactgcgccg cgaagtcctgcgaaggcaccctcgcgaccctacaatctcactaaaatgcaacaaagcctc agcgtggtgtgggtggcgctgggggaccgctgcctggcgtggacgggcgcgctgctgtcg gacgcgcggctggaggcgctgagcgcggccagcgcgcccgccgccgacacgcccgcgccg ctgcagatcctggcgcaccacacggcgcaccagagagagctgcggctcgcttccgctgca cccttgcaccagttgctggtatcgctggcagtggtttgttatcgcaaagcgacgaacttg aagcgagcggttgtacagaaacagaaccaagacgccgatcccgacagatccgattctact gtttacttccaggacatgatactctgctctgaagactctgagactgacgatgaagacagc gagccgctgttcgggctgtggttcgagtcgacgctggtggcgcccgacgcgctggagagc ggcctcacgcgcgccggcgcgcccgacagcgacgacgtgcccgacgacaacgccgccgcg cagcaggccttcatgctcgacaaggccgagccctactcgtacataacactggcaacagaa atattcaatctattaactgaagaaataatcggcgaaggagtagaacgactgggagcttca tcgcagcaattgcacgaagcacaccaggcattgttggctgcacttgcaaaggatctcgac agagaaactgctaggactgacactgggacgatatcgccatgtttcggagcacgtctcggg gcgctgtacgcctcgttcagctccgcgctcgtgcgttacttgcacaacttacagccgctg ttgcagcaacaactcatctccacgggctccgataggaacaatatgaccccacttcaggtg ggtcccagagtagcgaagctgctcggtggtatggtcctgagtaaagtagcagcggaccgt gagaacagcattcttgtcatatggcacaagatcatcaacactcttcaggagtgtgcttta caaagccaacccagccaagaccacgattatgaagatttgaatgttgaacatgcacagctc ctcgtgtacttattccattctttgacactgatgcagaagaaatctgttttgctaatgacg tcaaatgcgattattaaagtcgtcgaaactctcggtataagtgatagaaaacgagctatg aatctggcgcctcatcagcttatgctgacaactagactgatgcttctattggaatatcta atgaaacacctctatgatgcaccccagaccttgttacagcagatcgaatggaatctcgta atagcgcccggcctagctcagcgttcgtcagatacgactactacgggcgtgaagactacc acagataacggccagcttaaaactcgcatatactgcgaagttccattcattgaactcgct tataggacaccgacgcaagacgatacttccatgagacctaggttctacgcactcactaac gcggagattaataaccaggaaaatccgaaattagacggtctggcgtgcaacttcgtcttg ggaactccccacaaattgaaatatccattgttgttagacgcattgttgtccttgttgaac tctgcctgtctctgtgacaacccgcagtaccacaactcgccggctgcgctcgccgcggcg cattactgcttccaaactgcttggagactggtgatcagcatgccgccggccacgccgcac atggacaagctgcaggccggcatcgcggccgagctgccgtcgccgctgccgctgcacgcg ctggtgtgggcgccgcgcgcggacaacaagaaggtcttcaacccctggctcaaggacgcg ctcgtcaagcagggcatgtacacgcagtatgcggaaaatttactggccggtgtgagtgcg tcgtgtgacaatatcaaatacacagcgtggctcgcttctgagactatgaaacacctgaaa caaaacctaacatctgatggtctgccctcactccttgatgtaatatcatgcgacgcagct ctaatgagattgaaggtctgtctcgtcgattctgcaactgcgtcggaggcacatcagttc atgcctgacttgctggatttgctcgagactattcttgagtgctgccgactgagcgtgggt atcgagatcgaaggctcgtcggagagcgcgagcaacgcgtcggacgcggccgtgtcgtcc gtgcgcctgcaggtgtgcggcgcggcgggcgtggcgcgcgcggcgggcgcggccggcccg cccgcgctcggcacgtggctcaaggcgcagctgccgcccaacgtggccgcggccgtcgag gcctgcgccgtgccgccgccgctggccgtcaacgctaccttgtatgagtcccacatcata ccatccgaaagcgccgttctacaacttgtgtcgtcacacagcgagctaatgattgtcggt gggaaatactccatcggggcgtcgttgacgatgctggcctattccgcggcaaagcttcta gaaatcggatctagcaagctagctgagaatacaaatcttactaaaaagaccttggaatta attgttcctgccttgactgatggcagacttcaattcttagcagaaccattagcagcaaca ttgaatgcattagtcccacaagtcaataaagcggagcagctcattcacgagcatattttg aagacgacatactctgtgcttgttgatcacttacagccttccacagagaatactttaagg cacatggtcatatactgggagaagattctagaccgaccagcaggtagagtcgcttacgag aatgtattcgcggataactctggttactccctcggtaaaatactcctagctgcaccaaat ggaaagagtgcatttactgaaagggtcataaaacttttcatcaagatatttaatggttgt gacaactctgaactgaacagcgctttatgcgtatcagtttgcaagttcatcggtgtcgcg gatcaacaaaaactcctcagcctgctctctcacatatgcttagtcacaccagcccccacg aacggcaacgcgggcaccgcgaacgcgtcaccgacggagacggagctgcccacacccacg tcgtcggcgcccgacggcaaccccgcgtccgtggcgctgcgcaacgcgctgcgctccgtg ttccgcaccgacgacgcgccgcgcagcgacaacgccaaccgcaacgaccaggacctgccc gtctttgacgcccctatacctgcgcctcgacctccgctagagactgtacaacaatctagt aactcagaaaatggaagctggcctgaaggtagcaaggagaattcaaacgctgtagtcgtc agcagcgaagccggcaacccctttgattcctctaatgataatgctacattactttctttg ctttgtaaacacatcgtccatcacggcggcgagaaggtgtgcgagcgcatggtgggcgcg ctcatcagcgtgagcggcacgacgtgcgcgccggtgctgctgcgcgagctgtgccgcctg gccgacgcgcacgcgggcgccgaccaccgacacctgttccccgccgcactcggctggcta tccacctgtgtggagaacctcagcagttctgaggtgttagagaagttggaagaaggccaa acagacgctaatataacgtcgcagatagaatcagcttgtgtcctcctatcttatctgacc gacgcattgcatactattggttcctctcagcctcatacttggcgatctgttagtcccacg tgggaatctccatcagatcttggatttgacttagattacgcagacgaacaacaagacgaa gatgatacgagtgctgatgattccgatgaagatgccatgctgcagtacaaactatgcacg ttcacggtgacgcagcgcgagtttatgaaccagcattggtatcattgccacacgtgcaag atggtggacggcgtgggagtgtgcacggtgtgcgcgcgcgtgtgccatcgcggacatgac gtttcctacgccaagttcggaaactttttctgcgactgtggtgctaaacccgattctagc tgccaagctctagtaaagcggtcggtgacgcttggtggagcccgcggagctaccaccggg atggaagaaaccccacctgcgccttctattagacgtcggccttctagccctactccccct gcgctgctcgcacctccacgtcgaccagtcctcgcccacaacattcaaggttgccgctcg ttcctgctgtcgtacaacggctggcccgggtgcctggagcgcgtgcggcggctgctgggc gcgctggcgggccccgtgcgcgcggcgtgcgagcgcggcgccgcggtgggcgcgcacggc cgcgcgcagcgtgcgctcgcgcagctgcacctcggcgagaagcggttcacgcacaccgac acgctcatgctgcccacgctgggttcgcaagaaggcgcattcgagaacgtgcgcatgtcg tacacgggtgagaacggacaaacgatccgacagctgatgtcggcgcacaagcttcgccgc gtcgcaatgtgctgcctcgcctcgcctcatggacgtcgacagcatctcgctgtatctcac gagaaaggaaagattacagttctacaactgtcagctttattgaaacaagccgactcatct aaacacaagctgactctgactcgtctctcttctgcgcctataccgtttaccgtgctcagt ctcagtggaaacccttggaatgaagacctgttagctgtgtgtggcttaaaagaatgccat gttcttacgtttaacagtgggggtgctgtagctgatcactttgttttgaatacgggattg gaagcaaacaactacgtgatcaaagcgatctggttgccgggatcgcaaacgcagctggcg ctcgtcacctctgacttcgtcaagatatttgacctgagcaaggatttaaataatccgatg catcatttccttgtaccgagcggaaaggtccgcgacgttacctttgtcaatcaagaagac attatgcacatgttgtgtatgagctctgctggccacatttactggcagcccatgagcgaa gagtctcgggccactctgggaacattctatgttactaacacccttgaagtattacatcct gaaattcaggatgttgccggattggttggaggtggtggtgtgtcgatatactactcgcac atactgaagatgcttttcttctcatacgctcaaggaaagagcttccttgcaccactaaac accgtcgaagacagcgttaaaggaacggcgatgataacgctgtcgtcgtcgtcggcgcag aaggagggcgggcgcggcaagcagggcggcgtgcagtcgctgtgccagtgggccgaggtg cccggacaccccggcctcgtgtccgccgtcatgcaggcctccaacaaccccgtcgtgctc atgctcactccttccaacatatacgtccaggagatcaaggtggtaccggcaaaagcaaag ataacagatatggtagccgtccgccattggtgcggaggcggtggagaacaaaagagcacg cttatattgctgtgcgaggacggtagtttgcggatgtacgcggcaaacaacgaacaaact ggttattggttgtcacctgctatacaacccgtgcacgcacccagacgaagaccgagactg cttacgcatcacaccaagggaaaaacgcaacaggttgtgacaaaatcgaacataaatgga agtccacaatttccgattgactttttcgagcattgtgtcgctatgagcgacatcgaattc ggcggcaatgatctgcttcaggtgtacaacacagctcaaattaaacatcgtctaaacact acaggtctatatgtagtatcaacaaaaatgagcggcttcgtaatggaagttgtcaattct gatcccaacatggtcatttgtggaatacgagtgttgcttggcaatcaagacgttgccagg acccccgcatatgtcgagatacatgggaggtcgatacaaacaatagtagtcagaaaccgt tggtttgatattcctttgactcgtgaggagtctttgcagtctgataagaaacttgtcata aactttggtccctctcaagaccctgatggtgttacaatggtcgattctgtaaaggtctac ggcaaaaataaagaacaatttggttggccagaggaaaacgaagacccatctacttgtgct tcgtcaagtaaggttgcacaggaatcagaaagcaatagcggctcatggaagccgagttcc ttggagcgcttagcgtgcgcggctctcgaagcgctggagctcggcgccggcgcgcccgcc agcagcggagcagccgcaggggcggaggccggcgctgaagctgctcgcaagctgctgtgt gctccggcctctgcccatttacacgcaagagcgcaatgcctgctgcgagccgttcatcag tcgcagtatcatcaattcaaggaccaagccatactcaagtacatatcggtgtcgctgcgg gagctgcgcgacacggcggacgcgcgcaacatcgaccccgaggcgtacttccgcctcgtg ctgctggcgcgcggcgtggccgtggcgcgcccgcagcacctcgtcaagtacagcgcgccc acgccgcccaagccccaagacggtgactggtcagtgctctggaaatccgaagcgcaagat gaaccggatcgagagccgcatctatgcgcacttctgagtagtgtgctgtggaagctaact gcttgtcgcagccagaccacgggcccgcccggcatcctgtcgtacggcctgcggcacgcc gagcacacgctacacgcgctcgctgacaccatacacgcattccagctgcatggcgattct gattgcattgacttcggaaatcaaatctacttatctttgctgttagccgaagatcaaagt ataagcttcggtgccaaggctgctctcatgcgggtgcttcgtccacgtgttaaaagacgt agagtctatataccgtcacctccaaatactccaggtgctggttcttcggtcacaacagct cagccagccagctcaattactgaagcggcggtgtccgagtcagaattgagcgcaaaccgc gatgatcaacaggaaaatcaatatatggatgtagatgactcactggaacccatggtgctg ctcgcacctgatggaggtctcgaggcattgctggatatccccacggacgcggacgacgag acgatggtggagctcgccatcgctctgtcgctgcaggagcagggccggcgcgcgccgccg cccgcgcccgcgcagccgcccgccgcctccgcgtccgccgcgccgcacgcgcccgcctac agcgacgccaccgcgtctcccaacggatctgacgacgagggcagtacggccgcaacagat ggcagtacattacgtacatcgccagctgaagctggcggttccgctgcttctgatagcggt ggttccgcagctgatagcatcggtggcgtctccggtcgaagcagcgcatatggcgaaatg tcggcgccctccggacagccgtgctctactgtcgttgaagtgccggcggcggtcgcagca ggtccatcgagttcgtctcaaccaatggcttcaacgtcccgcgcggtagaagttgagaac gaaacgagaaaattgcacgcactacgtctgtcgctgctgtctgctgctttagatgcttta ccaaccctcagaactctacctggagtgcgcgccataccttttgtacaggtggttttaatg ctggctggtgacttagactcgagcgcggaaggtgaccgagtagtccttgaacgtttactc gaggtgctcgttggtgaacttgatattcaacccgaagagcccacaagtggggaagatcgc acggagaaacgggagctccaactagctatcatgaggctcgagttgctcgtctcagagttg gacgcacaggcgatcgaacattcaccacctgtacacgagcgtactaataggagggaactg cagctcatcataatgagactgctcagtgtgctaatggctcgctggaagacgtgcggcgcg ggcggcggcggcagcgtgtcgcgcggcgaggtgtcgggcgccgcgtgcgccgcgcacgtg tcgcgcctggccgccgcggcgctggtgcgcgcgggcgcgcccaagcactgctacaacgtg ctcgccgcgctgctgccctactggaaggaaaagacgtccgcttctggcacgactactact gttcaacagttactcaaaccacaaccaccacaacctctaccggacatgcaaccatttttt gtcaaagagtatgttaagagccacgcattggaggtgtttgacaactatcctcaactggtg atggagatggctctgcggctcccgtgccaaattcataagcattgtgatccgaagcacttc gatgcacgttggcgcacattactctgcgagtatatgatgaaccagcagacaccgcttaga aaacaagtccgtaagctgctgctcttgctgtgcggaacacgcgagcgttaccggcagctt cgcgacgtacacgcgctcgacacgcaccttaatgcggcgcgtgctctgctcgccactgat gcggcctacgataagctagtgcggttgatggatcacttgaaggcctgtgcggaaatcgtg tcggcgcgcacgggcaactggcagcacacgtgctcgacggagaggcgcgagacgctgggc tggctggtggggatcgcgcggcgcctgcacccgcacgtggcgcccaccgtgctgcagctg ctgcaggcggcgctgtgcgcgcccgcgccgcccgcgcccgccacgccgcccggcccgccg cccaccgcgccgcgccctggacaagacaagaatgcatccgagtggccggatcgcgagcga agcaccgagagtgatgcctttgtgtctgacggatctaaattccaggaacagagagttcca caactagtgcagcaaatattgaaacaggttaatcaagacgaactcaaactctttgtaaaa gcattccttttggaaactaattcgacagcggtccgttggcaagctcacgctttacttctc gctatttacaacaattgctcgccaactgaacaagcttcgcttgtttctttgctgtggggc ttgtggccgacattaccccaatacggacgaaaagctgtccaattcgtcgatctacttggt tacttcacactgaaaactcccaacgtggataatgagaaatacatcggtagtgccgtagaa ctactccgcaaccagaaccagctgctgtcgtcccacggcaactcggctctgtacgcggcg ctgggcgcgtacgtggagctcgacgggtactacctggagtccgagccttgcctcgtctgc aacaacccggaggtgcctatggcgaccatcaaactgccaaccattaagatcgactcgaag ttcacgacaacgacgcagatcgtgaagctggtcaacagccacatgataagtcgcatcagc ctgcgcatcggcgacatcaaacgcagcaagatggtgcgcgtcatcaacttctactacaac aaccgcaccgtgcaggccgtgcaggagctcaagaacaagcccagcatgtggcacaaagcg aagcgtgttcagcttcagtctggtcagtcggaagtgcgtgttgacttccccctgccgatc gtggcctgtaatctcatgatggagtatgctgacttctatgaaaatcaacaagcgactggc gaatccctgcaatgcccgcgttgttctcaatcggtaccggcgaatcccggagtatgtgct aattgcggtgaaaatgtattccagtgtcacaaatgccgtgccataaattacgacgagaaa gatccgttcctctgccatgcctgtgggttctgcaagtacgcaaagttcgactacacactg acagcgcgcccctgctgtgccgtggacaccatagagaatgacgaggaacgcaagaaaatg gtacagaccattggcgctctgctcgacaaggctgacagagtataccgacaacttattgcg aacaaacccatactagagtcactggttcataaaataagcgagcaccgcgtggagggccgc gccgacgagaactgcaacggcggcggcggctccttcggcggcgcgcagatcaaccgcgtc atccagacgctggcgcacaagtactgcgtcgagagcaagggacacttcgaggacctctcc aagatcatacagaaagtgctcgcctgcagaaaagaattggtagcctacgacagatcacaa agtgaacaacttgaaggagatactctgccagtgtacgccggtttggtacaaaactacgac ggtgatgtcacaaaagagtgcggcggcggcggctgctacggctgctcgctggcgtgcgcc gagcagtgcctcacgctgctgcgcgcgctggcctcgcagcgcgagcaccgcgcgcgcctc gtgcgcttcggcctcgtgcacgagctcgtgcaccacaacctgcaccgcggcacgccgcag tgtcaagacgaagttcgctcgctcatctgtctagtgactcgggataatctccctgccacg aagcagttatgctatttgctttcgcaaagaattactctgtcattgatgggtcatgctgcc tcgcaagatcacaacaattccgtacggcctttggtactattgctgggtgcattggttaaa gttcaagactctgtggagtgttgggaagtaagattgcgttgtatagtcaagctatgggtt tggtgctgtcctcaactgacggaagttgtaggcatcccaccggcagctacagccatatta aaatctgaggcactatctggaataccaggaattaacacgtcttcacctaactcgcaccag ttcgcgctgcagcaggtggcgctgccgtgcctgcgctacatgcaggagctcatggtgccc gccgcgcccgcgccgcccgcgcccgcgccgcccgccgacgaccagcccaaggacgataag gaatcaagccagccaacagcgcctccacctatagtcctccaggcgaatactggcaactta gtcgtagatttatctgcatggctggctggaagagtgccgcacaaccaatggaggaaactg gttgctaagaacgaaataccgcccgccgataccactctaccgacgcgcgacctacacctc gctcacaagtatctcggcaaatggaaagaaaagatgctgttgtcgcatggcatgcgtacc atatcgctggatgagggcggctggctgagaccagtcatgttcgaccccagttcacgtatc gcacgtgacactgcttgccagatggtcaagtcgctgtgtgactcttacgacaggacgaag gcggtgcttatattattgacgagcttcttaccagaagtaggatcagctggtgaagcgagc gaacaatttctgcttctataccaaagcctagcgtcggaagctccgtggaaacagttcctg gcactgcggggtgtgctgcaacagatagccgatctgatgaccaaagagatcgaacaatta caccgtctcgaagaaacaactcttacatctgatctggctcaaggctacgcgctgaagcgg ctgacggagctgctggccatgttcctggaggaggcgggcgcgcggcgcgcctacaagacg cggctggtgggcgccgtgctgggcggctacctgtcgctgcggcgcctcgtcgtgcagcgc acgcgcctcaccgacgacacgcaggagaagctgctcgagctgctggaggagatgaccact ggcacggaagcggagacggcagagttcatgactgtttgtattgagacggtgcagaagtac ccgctacacgattaccgaacacccgtcttcatattcgagcgactctgttctatcatctac cccgaagagaacgacgtcggagaattcttcctcacgttagagaaagatccacagcaggaa gactttttgcagggccgaatgttaggcaatccatactcatctctggaaccaggcatgggc ccacttatgcgagatgtaaagaacaagatctgtacggattgtgagctggttgcgttgctg gaggacgacaatggtatggagctgctcgtgtgtaacaagatcatgtcgctcgatttgccg gttaaggaagtatataaaaaggtgtggtgcacttcgggagagggcgttgacgcgatgcgt gtagtttaccggatgcgcggtttgctcggagatgcgaccgaagagttcgtggagaccctc agccaaaccaacgcggaaacagtcgacgacgagcaggtctatcgcatggcgaacgtactc gccgactgcggagggctggaagtgatgctgcagcggctggcggccatcgggcgcgtgggc tgcgcgcgctcgctggtgggcacgctgctgcggctgctggcgctgtgcgcgcgcgtgcgg cgctgcgtgcgcgtgctgacgcggcccgaggcgcgcgcgctgcccgtgctgctgcacgcg ctcagcctggccgccgccgacgagcgcgagatgcagcgcgcgcccctcgtctaccagctg ctcgagataatggaacgcattctctccgtcgcagctagcgaaagtctcgaatcgtttttg caattctcactcactttcggtggaccggagcacgtccaagctctactcaattgcactgaa tgtccaggaattcgaaacaattcagttgcactcggacatctcacacgggtactcgccgcc ctcgtttacggcaacgatctcaagatggcaatgttagtggatcacttcaaacctgtgctg gactttaaccgacttgattctgagcaatggagcgatgaagagttccgcatggagttgttc tgtgttctgtgcgcgaatatagaacgcaattccatcggtggcactctcaaagattacttg atttcgctgggcatagttcgtgatgccttggagtatattgtgaaacatgcgccgtgtgtg aaaccgactctcgtgtgcacggactcggatgagctgaaagagttcatcagtcggccagca ctgaaatacatcctgcgcttcctcaccgggctcgccgcggatcatgaacctacccagatg ctagtgtgcgagaaagttattccaatcgtgcatcgcctagagcaagtctcgtccggagaa cacgtgggttctctcgcagagaacttactggaagcgctacgttctcagccgcaatgcgcc gccaaagtccaacaagtccgagacttcactagacaggagaagaaacgtctagcgatggcg gtgcgcgagcggcagctgggcgcgctgggcatgcgcagtaacgagcgcggccaggtcacg gcgcagtgcagcctcacgcagcaggtggccgacctggccgaggaggcgggcgccgtgtgc tgcatctgccgcgagggctacaagtaccagcccaccaaggtgctcggtatctacacgttc acgaagcgctgcccggtggaggagtacgaggcgcgcgcgcggaagacgctcggctacacc acggtctcgcactacaacatcgtgcacgtcgagtgccacatggccgccgtcaggcttgca cgtgctagagatgagtgggagagcgcggcgttgcaaaacgcttcgacgagatgcaacggc ctcctgcctctatgggggccgtacgtacccgagtcggcgtttgcctcttgcctcgctaga catactacatatttacaggagtgcaccggacatcgcgacattggacacagctgcacagtt cacgacttgaagttgctcctgctgcgtttcgcgcgcggcctcagcttccacaacgacaca ggaggcggcggcccgctctccaacatgcagctggtgccggcgctcatgcacatggcactc tacgtcatcaacacgacccgcgtggccgctcgtgaggtgtccgcgttggaggcgagcctg gcgtggccgccggcgcgcgtgctggagtcggcgcaggacgcagacggcccgctgtacttc ctcacactcatgctgctgctgtatccgcatgccaaatggcgcgcgctgcggctggacatg atcaagcgcatgctgctgctgggccacgtgcgcgacgtgacgcgcggcgggccggccgtg cgcgcgctggcgcccgagcagcgcgcgccgtgcgcgtggcccgagtacaagccctacgtc gtgttcgtcgcgctcattgaccagctctacaacgtcatgttcaagaacgtgaacgcgacg acggtggagcagtggccgataaagctggccgagtacatccggcacaacgacgaggccaac gccaaggcggcggagcgcgtggtgacgacgctgacggacgagctgctgccgtgcgactcg ctcgccgagttctgcgacgcggccggcctgctcgaggacatccccgacccggacgccttc ctgcgcgcgctgctggacgagcagccgtga

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