Vibrio cholerae O1 M66-2: VCM66_1407 Help Entry VCM66_1407        CDS       T00891                                  Symbol rtxA Name (GenBank) RTX toxin RtxA   KO K10953   RTX toxin RtxA Organism vcm  Vibrio cholerae O1 M66-2 Pathway vcm05110   Vibrio cholerae infection Brite KEGG Orthology (KO) [BR:vcm00001]  09160 Human Diseases   09171 Infectious disease: bacterial    05110 Vibrio cholerae infection     VCM66_1407 (rtxA)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    02042 Bacterial toxins [BR:vcm02042]     VCM66_1407 (rtxA) Bacterial toxins [BR:vcm02042]  Type II toxins: Membrane damaging toxins   Pore-forming toxins, RTX    VCM66_1407 (rtxA) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  ACD RtxA Peptidase_C80 MLD RtxA_C Abhydrolase_1 Hydrolase_4 Abhydrolase_6 Abhydrolase_3 DUF1057 Thioesterase DUF4105 Abhydrolase_11 Motif Other DBs NCBI-ProteinID:  ACP05723 UniProt:  C3LME7 LinkDB All DBs Position I:1507551..1521227 Genome browser AA seq 4558 aa AA seqDB search MVFYLIPKRRVWLMGKPFWRSVEYFFTGNYSADDGNNNIVAIGFGGQIHAYGGDDHVTVG SIGATVYTGSGNDTVVGGSAYLKVEDSTGHLIVKGAAGYADINKSGDGNVSFAGAAGGVS IDHLGNHGDVSYGGAAAYNGITRKGLSGNVTFAGAGGYNALWHETNQGNLSFTGAGAGNK LDRTWSNRYQGSHGDVTFDGAGAANSISSRVETGNITFRGAGADNHLVRKGKVGDITLQG AGASNRIERTHQAEDVYTQTRGNIRFEGVGGYNSLYSDVAHGDIHFSGGGAYNTIIRKGS GNDFAKEGMTNAKADEIVLTKAVMSGSWIGQDHHVTAVKSASEPNTYLFAFADSTYTKIN KVQLRNDPQTGELKYYSTAWYKEVNHLSNLANQDISDNGGFTAVNINGAYTLSDLKVEHQ QSVTVHAVEKSLTEYEWVTYANGAVIDAKEVSLSDAKMGGHAIYADGTKVDVKAVKSNRQ PNTYIYAKVLGPYTKIVVVELANDPETGALKYQARSWYKEGDHTANIANQDISSATGYNP MGKGGYSLSDLHYSVNAVRSTSETVADIEEYTDQTLFKPANDSGESSGDVRFNGAGGGNV IKSNVTRGNVHFNGGGIANVILHSSQFGNTEFNGGGAANVIVKSGEEGDLTFRGAGLANV LVHQSEQGKMDVYAGGAVNVLVRLGDGQYLAHLLAYGNISVQKGSGDSRVVMLGGYNTHT QIGSGNGLWLAAGGFNVMTQVGKGDVAAVLAGGANVLTKMGEGELTSGMLGGANVITHIS NDDQLSNTTAVALGGANILTKKGKGNTLAVMGGGANVLTHVGDGTTTGVMVGGANILTKV GNGDTTGILLGVGNVLTHVGDGQTLGVMGAAGNIFTKVGDGTSIAVMIGAGNIFTHVGEG NAWALMGGLGNVFTKVGNGDALALMVAEANVFTHIGDGMSVALMLAKGNVATKVGNGTTL AAMVGNVNIFTHIGHGSTFAAMIGQANIMTKVGNDLTAALMVGKANIMTHVGDGTSLGLF AGEVNVMTKVGNGTTLAAMFGKANIMTHVGDGLTGVLALGEANIVTKLGDDFMGVVAAAK ANVVTHVGDATTAAVLAGKGNILTKVGEGTTVGLLISDVGNVMTHVGDGTTIGIAKGKAN LITKVGDGLGVNVTWGQANVFTQVGDGDRYNFAKGEANLITKVGDGQEVSVVQGEANIIT HVGNGDDYTGAWGKANVITKVGHGQNVVLAKGEANIVTQVGDGDSFNALWSKGNIVTKVG DGMQVTAAKGQANITTTVGNGLNVTAAYGDANINTKVGDGVSVNVAWGKYNINTKVGDGL NVAVMKGKANANIHVGDGLNINASYAQNNVAIKVGNGDFYSLAVASSNTSSNKLSALFDN IKQTVLGVGGSQAINYLVQGDEASSSGTHKGRGAIATPEITKLDGFQMDAIKEVSSDLGD SLTGSVTKVDTPDLNKMQHALNVDDSSVQAPNLIVNGDFELGEHGWQSTHGVEASYAGSV YGVEGEGHGARVTELDTYTNTSLYQDLANLAQGEVIAVSFDFAKRAGLSNNEGIEVLWNG EVVFSSSGDESAWQQKNLKLTAQAGSNRIEFKGTGHNDGLGYILDNVVATSESSQQANAI REHATQNPAAQNALSDKERAEADRQRLEQEKQKQLDAVAGSQSQLESTDQQALENNGQAQ RDAVKEESEAVTAELAKLAQGLDVLDGQATHTGESGDQWRNDFAGGLLDGVQSQLDDAKQ LANDKIAAAKQTLSDNNSKVKESVAKSEAGVAQGEQNRAGVEQDIADAQADAEKRKADAL AKGKDAQQAESDAHHAVNNAQSRGDRDVQLAENKANQAQADAQGAKQNEGDRPDRQGVTG SGLAGNAHSVEGAGETDSHVNTDSQTNADGRFSEGLTEQEQEALEGATNAVNRLQINAGI RAKNSVSSMTSMFSETNSKSIVVPTKVSPEPERQEVTRRDVRISGVNLESLSAVQGSQPT GQLASKSVPGFKSHFASTSIGIENELSGLVVVLPKNSAQTFGYVHDSQGNPLFMLTKDMN QGGYSNPVGINDIQGVNNWQTHTIELVTYPSEISDTAAVESRKEAMLWLAKEFTDHINQS NHQSLPHLVSDDGRFTLVISNSKHLIAAGNGTSIDAQGKTIGMTPSGQQATMAISAKEFG TSSSPEVRLLESAPWYQAGLRDEFLANAKNTTLDDPATAQNVYAYLTSVYSKTADLAKEY GIYINDWDPASEGFSPNAQGLTDPKVKNAWSILPRTKPVRMLELLSAEDSRYVRQQIAEK LKGTYSESLAKNVFEYFQYGGEVAGHGINNATTGSVQQPEPAILFEFRSVPSALSDFVPK TASTVKVDVKALDHFDSASRKAIITEVNALVSGSEDFDAWYQEYRASKGQPPVKNPKSSA SANHKAEWLMTQHAEQWAKITAPYTDNHETLTSTKLASNDKEELHALGETSNLENNKQQE NVASIINTMLNDMLPFYALRTERNLLVQEGDEGFEVRAWPGTEDKSKTIILEDPEDAAQH KAIERFILANFDNFEQMPDELFLVDNKVISHHEGRTHVLAQKVDGAWQYNATVELMSVTE LLDAANVTGKIRGESYQQVIDALTDYHASITEHADYEPESVEKLLNLRKKIEGYVLGHPD SGRVEAMNSLLNQVNTRLDEVSLLSVAEQTIQAQNSFSRLYDQLEAANLKESKHLYLDQN GDFVTKGKGNLANIDLLGSREAVLEKVKLTVSNEYGQTVADTIFAGLSAKDLAKDGKGVD IAGLNKVHQAIEQHLSPVSATLYIWKPSDHSALGHAALQIGQGRTQLEGQAAADFNQQNY VSWWPLGSKSSNISNILNVATKDQPDLKLRWSDFSQPAHQNDTLEHDVASEENDGFGLHD GDIKLKRFIEKLNAAKGIDASFKEASEGYASVLLGNPDMLETTGIPAHVFQPFVEQWNDT SYDMMDVAHRFAQELRLQAQRSDDPELLEKRIGNVIRQFAERALEEIETFKASQADQGRV FRINLEGLDVAAMQAEWHRLSNDPDARYQLLTKNCSSTVAKVLKAGGADKLIGHTWLPKF GVWTPTELFNFGQALQEAQLEIAAKKQSHQVTDVLDALSGNEKPKENVAIENDGTPPRDK ESLSPLTRFLNNELYGDKEARRKIGEITQTLLDHAVEKGESQKITLQGEAGRLTGYYHQG TAPSEGETSSPSGKVVLFLHGSGSSAEEQASAIRNHYQKQGIDMLAVNLRGYGESDGGPS EKGLYQDARTMFNYLVNDKGIDPSNIIIHGYSMGGPIAADLARYAAQNGQAVSGLLLDRP MPSMTKAITAHEVANPAGIVGAIAKAVNGQFSVEKNLEGLPKETSILLLTDNEGLGNEGE KLRTKLTASGYNVTGEQTFYGHEASNRLMSQYADQIVSGLSSSASVDEDLDQQGLDTTST KDQGISNKNDHLQVVDSKEALADGKILHNQNVNSWGPITVTPTTDGGETRFDGQIIVQME NDPVVAKAAANLAGKHAESSVVVQLDSDGNYRVVYGDPSKLDGKLRWQLVGHGRDHSETN NTRLSGYSADELAVKLAKFQQSFNQAENINNKPDHISIVGCSLVSDDKQKGFGHQFINAM DANGLRVDVSVRSSELAVDEAGRKHTKDANGDWVQKAENNKVSLSWDAQGEVVAKDERIR NGIAEGDIDLSRIGVNNVDEPARGAIGDNNDVFDAPEKRKPETEVIANSSSSNQFSYSGN IQVNVGEGEFTAVNWGTSNVGIKVGTGGFKSLAFGDNNVMVHIGDGESKHSVDIGGYQAL EGAQMFLGNRNVSFNFGHSNDLILMMDKSIPTPPLVNPFDGAARISGVLQGIATSGEGED WLAAQEQQWTLSGAKKFVKDMSGLDQSSSVDYTTLVELDSQNERDSRGLKHDAEATLNKQ YNQWLSGNGNSGTSQLSRADKLRQANEKLAFNFAVGGQGADIQVTTGNWNFMFGDNIQSI LDTNLGSLFGLMTQQFTATGQAKTTFTYTPQDLPRQLKNKLLGQLAGVGAETTLADIFGV DYTASGQIVSRNGQAVDGVAILKEMLEVIGEFSGDQLQAFVDPAKLLDSLKAGIDMGADG IKSFAETHGLKEKAPEEEKDNSSVSVNGANVNSAQGATVADGNTETAETQDRAFGFNSLN LPNLFATIFSQDKQKEMKSLVENLKQNLTADLLNMKEKTFDFLRNSGHLQGDGDINISLG NYNFNWGGDGKDLGAYLGDNNNFWGGRGDDVFYATGKSNIFTGGEGNDMGVLMGRENMMF GGDGNDTAVVAGRINHVFLGAGDDQSFVFGEGGEIDTGSGRDYVVTSGNFNRVDTGDDQD YSVTIGNNNQVELGAGNDFANIFGNYNRINAGAGNDVVKLMGYHAVLNGGDGDDHLIATA ISKFSQFNGGEGRDLMVLGGYQNTFKGGTDVDSFVVSGDVIDNLVEDIRSEDNIVFNGID WQKLWFERSGYDLKLSILRDPSNDSDQSKFEHIGSVTFSDYFNGNRAQVVIGMSEKDLSG EREYTMLSDSAIDALVQAMSGFEPQAGDNGFIDSLESKSQAAISMAWSDVVHKKGLMV NT seq 13677 nt NT seq  +upstreamnt  +downstreamnt gtggttttctatttaatccctaaaagaagagtttggcttatgggaaaaccattttggaga agtgttgaatacttcttcacaggaaactattccgccgacgatggaaacaacaacattgta gccattggttttgggggacaaattcatgcctacggcggtgacgaccacgtcactgttgga tcgattggtgcaacggtgtacaccggtagcggcaacgatacggtcgtgggcggctctgcc tatctcaaagtggaagattccactggccacctaattgtaaaaggcgcggctgggtatgca gacattaataaaagtggcgatggcaatgtgtcattcgctggtgccgccggtggtgtgtcg attgaccacttaggcaatcatggtgatgtcagttacggcggtgccgcggcttataatggc attacccgtaaagggttgagcggcaatgtcacctttgcaggcgcggggggatacaatgcc ctctggcatgaaaccaaccaagggaacctgtcttttacaggagcaggcgcaggtaataaa ttagaccgtacttggtctaaccgttatcaaggctcgcatggcgatgtgacctttgatggt gctggtgccgcgaacagcatcagttcacgcgttgagacaggtaacatcaccttccgtggc gcaggtgcggataaccatttagtccgtaaaggcaaagtgggcgatattactctgcaaggt gctggggcttcaaaccgcattgagcggacacatcaggccgaagatgtctacacgcaaacc cgcggcaatattcgttttgaaggtgtgggtggttacaacagtctttactctgatgtggct catggtgacattcatttctcgggtggcggtgcgtacaacaccattattcgtaaaggttct ggaaatgactttgcgaaagaaggcatgaccaatgctaaggctgatgagattgtattaact aaggccgtgatgagtggctcatggatagggcaagatcatcatgtcacagcggtgaaatcg gctagcgagcctaatacatatctttttgctttcgcagactctacgtataccaaaattaac aaagtacagttacgcaatgatcctcaaactggagaactgaaatattactctacggcttgg tataaagaggttaaccatctaagcaacttagcgaatcaagacatttccgacaacggtggt ttcacagccgttaatatcaatggcgcctacacgctatctgacctcaaagttgaacatcag caatccgtcaccgttcatgcggttgaaaaaagcctgactgaatatgagtgggtgacttac gccaatggtgcggtgattgatgcgaaagaggtgtcattgtcggatgccaaaatgggcggt catgcgatttatgctgatggcactaaggtggatgtcaaagcggtaaaatccaaccgccaa cccaacacttacatttatgccaaagtgcttgggccttacacaaaaattgtggtggtggaa ctggcaaacgatcccgaaaccggggcactgaaatatcaagctcgctcttggtataaagaa ggtgatcacacggccaatatagccaaccaagatatttcatctgcaactgggtataaccca atgggcaaaggtggctactcgctcagtgacttgcactacagcgtaaacgccgttagaagt accagcgaaaccgtagcggatatcgaagaatacacagatcaaaccttgtttaaacccgca aacgatagcggtgaaagctcaggtgatgttcgtttcaacggtgccggtggcggtaacgtc atcaaatcaaacgtgacgcgtggtaatgtgcatttcaacggtggcggtattgccaacgtg attttgcatagctcccaatttggtaataccgaatttaacggtggtggtgcggcgaacgtc attgtcaaaagtggcgaagaaggggatctcaccttccgcggcgcaggtttggcgaacgtc ttggtacaccaaagcgaacaaggcaagatggatgtgtacgcgggcggtgcggtaaacgtg ttggttcgccttggcgatgggcaatatctcgcgcatttactggcttacggtaacatttca gtccaaaaaggcagtggtgatagtcgcgtcgtgatgctcggtggctacaacacccatacc caaatcggctctggcaacggattatggttggccgcgggcggtttcaacgtgatgacgcaa gtcggcaaaggtgatgttgctgcggtactcgctggcggtgcaaacgtactgaccaaaatg ggtgagggtgaactcacgtcgggtatgctgggtggcgcgaacgtaataacccacatcagc aatgatgatcaattatcgaataccacggctgtggcacttggcggtgcaaatattctcacc aaaaaaggcaaagggaatacccttgcggtgatgggtggtggcgcaaacgtgcttacccat gttggtgatggcaccacaacgggtgtcatggtcggcggtgcgaacattctcaccaaagta ggtaacggcgacacgaccggcattctgcttggcgttggcaacgtgctgacgcatgtgggt gatggccaaacccttggcgtaatgggcgcggcgggtaacatcttcaccaaagtgggtgat ggaacctctattgcggtcatgattggtgctggcaacatttttacccatgtgggggaaggg aatgcttgggcgctgatgggcggcttgggtaacgtctttaccaaagtaggcaacggtgat gctctcgcgttaatggtagcagaagccaacgtcttcactcacattggtgatggcatgtcg gtggcactgatgttagccaaaggcaacgttgcgacaaaagtgggtaatggaaccacactc gcggcgatggtggggaacgtcaacatctttacccatattggtcatggcagcacgtttgcg gcgatgatcggccaagccaatatcatgaccaaagtgggcaatgatctcacggcggcgctg atggtcggcaaagcgaacatcatgacccatgttggcgatggtaccagcctagggctgttt gctggcgaagtgaacgtgatgactaaggttggtaacggcaccacgttagcggcgatgttc ggtaaagcgaacatcatgacccatgtcggtgatggcttaaccggtgtactcgcactgggt gaagccaatatcgtgaccaaattgggtgatgatttcatgggggtggtggccgcggctaaa gccaacgtcgtgactcatgttggtgatgctaccaccgcagccgtattggcgggtaaaggc aatatcctcaccaaggtgggtgaaggcaccacggtagggttgttgatttccgatgtcggc aacgtgatgacccacgttggtgacggcaccaccattggtattgccaaaggtaaggccaac ctcattaccaaagtcggtgatggtttaggtgttaatgtcacttgggggcaagccaacgtg tttacccaagtgggcgacggtgatcgctataactttgccaaaggtgaagccaacctcatc accaaagtgggtgatggccaagaagtctccgtggtgcaaggtgaagccaacatcattact catgtgggcaatggcgacgactacactggcgcttggggtaaagcgaacgtcattactaaa gtcggtcatggccaaaacgtggtactggcaaaaggtgaagccaacattgttactcaagtg ggtgatggcgacagctttaacgcactttggagcaaaggcaacatagttaccaaagtgggc gatggtatgcaggtgacggcggcaaaaggccaagccaatatcaccaccaccgtgggtaac ggtttaaatgtcactgctgcctacggcgatgccaatatcaacaccaaggtcggtgatggg gtatccgtcaacgtcgcttggggcaaatataacatcaacacgaaagtgggtgatgggctc aatgtcgctgtgatgaagggcaaagctaacgccaatattcacgttggggacggcctcaac atcaatgcctcctacgcacaaaacaacgtcgccatcaaagtcggtaacggcgatttctat agtttagcggtggcatcgagcaataccagcagcaacaagctctctgccttgtttgataac atcaaacaaaccgtactcggtgtcggtggcagccaagccatcaactacttagtgcaaggc gatgaagcctcctcatccggcacgcataaaggtcgtggtgcgattgctacacctgaaatc accaaactggatggtttccaaatggatgccattaaggaagtcagttctgacctcggtgat agtctcacgggcagcgtgactaaggttgatactcctgatctcaacaagatgcagcatgcg ctcaatgttgatgattcttccgttcaagctccgaatctgattgtgaatggggattttgag ctgggcgaacatggctggcaatctactcatggggttgaagcctcttatgcaggcagtgtg tatggcgtagagggtgaaggtcacggcgcacgtgtgaccgagctcgatacttataccaac accagtctctatcaagatctggctaatctagcgcaaggtgaagttattgcggtgagcttt gattttgcaaaacgcgcgggcctttctaataacgaaggcatcgaagttctttggaacggt gaagtggtattctcatcgtcgggtgacgagtctgcttggcagcaaaaaaacttaaagctg accgcgcaggctggcagtaaccgtatcgaattcaaaggcacaggccacaatgatggactg ggctacatcctagataatgtggtggcgacctcagagtcatcgcaacaagccaatgcaatc cgtgagcacgcaacgcaaaacccagcagcgcagaatgctctatccgataaagagcgtgca gaagcggatcgccaacgtcttgaacaagaaaagcagaaacagcttgatgctgtcgcaggg tcacaaagtcagttggagtcgaccgaccaacaagcgctagaaaataatggtcaagctcaa cgtgatgcggtgaaagaagagtcggaagccgtgaccgccgagttggcaaaactggcgcaa ggtctcgatgtgcttgatggccaagcaacgcatactggcgagtccggcgaccaatggcgc aatgattttgccggtggtctgctcgatggcgttcaaagccagctcgacgatgccaagcaa ctcgcgaatgacaagattgctgcagcgaagcagaccctgtctgacaataacagcaaagtc aaagaatccgttgcgaaatctgaagcgggtgtggcacaaggcgagcaaaatcgagcggga gtagagcaagacattgctgatgctcaagccgatgctgaaaaacgtaaagccgatgcttta gcaaaaggtaaggatgcacaacaagcggaatctgatgcacatcatgcggtaaataatgct caatcacgcggcgatcgtgatgtgcaattggcggaaaacaaagccaaccaagcacaagcc gatgctcaaggtgctaaacaaaacgaaggtgatcgtcctgatcgtcaaggcgtgactggt agtggccttgcgggtaatgctcatagtgtggaaggcgctggcgaaacagacagtcatgtc aacaccgacagccaaaccaacgccgatggccgattcagtgaaggtttaaccgaacaagag caagaagcgctagaaggtgcgaccaacgcagtgaaccgtttgcaaattaacgcaggtatt cgagcgaaaaacagcgttagcagtatgacttctatgttctctgaaacaaatagcaagagc attgttgttcctaccaaagtctcgcctgaaccagagcgccaagaagtgactcgtagagac gtccgtatctcaggggtgaacctcgaaagtctaagtgcggtacagggaagtcaaccaacg ggtcaactggcttcgaaaagtgtccccggatttaaaagccatttcgcatcgacatccatt ggtatagaaaatgagttatccggtctggtggtggttttaccgaaaaactcagcgcagact tttggctatgtgcatgattcacaaggtaacccattgttcatgctaaccaaggatatgaat caaggtggttatagcaacccagtgggtatcaatgatattcaaggggtgaacaactggcag acgcatacgattgaactggttacatatcctagtgaaatcagtgatacagcagcggttgaa agtcgtaaagaggcaatgctatggcttgcgaaagagtttaccgatcatatcaatcagtct aaccaccaaagcttacctcatttagtgagtgatgacggtcgtttcactctggttatatcg aactctaagcatcttattgcggcgggtaacggaacctctattgatgcacaaggcaagacc ataggaatgacccctagtggccaacaagcaacaatggcgatcagtgcgaaagaatttggt acaagctcgtcgccggaagtcagactgcttgaatctgcgccttggtatcaagcagggttg agagatgagtttttagcaaacgcgaaaaacaccacgttggatgatcccgctacagcacaa aatgtgtatgcctatctcacgtctgtctattcaaaaacagcagatttggccaaagagtat gggatctacatcaatgattgggatcctgcctctgaaggtttttcaccgaatgctcaaggg ttaacggatccgaaagtcaaaaatgcttggagcatattgccaagaactaaacccgttaga atgctggaacttctgagtgcggaagactcacgctacgtaaggcaacaaattgcggaaaag ctgaaaggcacctattcagaaagccttgctaagaacgtgtttgaatacttccaatatggt ggagaagtcgctggacatggaatcaataatgcgacgacaggaagtgtgcaacagcctgaa ccagcgatcttatttgagtttcgcagtgtaccgagtgcattaagtgactttgtacccaaa acagcgtcaacggtgaaagtggatgttaaggcactcgatcattttgactcggcaagccgt aaagccatcattactgaagtaaatgctttggttagcggtagtgaggatttcgatgcttgg tatcaggagtatcgagcaagcaaaggacagccgccagtcaaaaatcctaagtccagtgca tccgccaatcacaaagctgaatggttgatgacgcagcatgctgaacaatgggcgaaaatt accgctccttatactgataaccatgagacgctcacatctaccaagcttgcttctaacgat aaagaagaattacacgctttaggtgaaacgtcgaatctagagaataacaagcagcaagaa aacgtcgcttccataattaacaccatgttaaatgacatgctgccattctatgcacttcgt accgaacgaaatctactggtacaagaaggagatgaaggcttcgaagtgcgtgcttggcca ggaaccgaagacaagagtaaaaccattattcttgaggatcctgaagacgcggctcagcac aaagccatcgaacgcttcattctggccaacttcgataatttcgaacaaatgccagacgag ctcttcttggtggataacaaagtgatttcacaccatgaaggtcgtacacatgtgttggcg caaaaagtcgatggtgcatggcaatacaacgccacagtcgagctgatgtcagtcactgaa ctactggatgcggcgaatgtaacgggtaagatccgcggtgaaagctatcagcaagtgatc gacgcattgactgattaccacgccagcatcactgagcacgcagattatgaaccggagtcc gtggaaaaactgctcaacttgcgtaaaaaaattgaaggttatgtactcggacacccagac tcaggccgtgttgaagcgatgaattcactgttaaatcaggtgaatacgcgtttagatgaa gtttcactgctgtcagttgctgagcaaactatccaagcgcaaaacagtttcagccgacta tatgaccagctagaagccgctaacttgaaagagagtaagcacctttatctggatcaaaat ggtgactttgttaccaaaggcaaaggtaatcttgccaatatcgatctgctaggtagccgc gaagctgtgcttgaaaaagtgaagttaacagtaagtaacgagtacggtcaaaccgttgcg gatacaatttttgctggattatcagccaaagatcttgccaaagacggtaaaggggttgat atcgcgggtttgaataaagtacatcaagcgattgaacagcatctgtcacctgtcagcgcc acgttgtacatttggaaaccgagtgatcatagcgcgctaggtcatgccgcattgcaaata ggccaaggtcgcacgcaacttgaaggtcaagctgcagctgattttaaccagcaaaattac gtaagctggtggccactaggcagcaagtcatccaatatcagcaatatcttgaatgtggcc acaaaagaccaacctgatcttaagctgcgctggagcgacttcagtcaacctgcacatcaa aatgacacgcttgagcatgatgttgcttcggaagaaaacgatggctttggtttgcatgat ggcgacattaagctgaaacgctttatcgagaagctcaatgccgcgaaaggaattgacgct tcatttaaagaggcttctgaaggttacgcgagcgtactactgggtaacccagatatgctc gaaacgacaggtattcctgcacatgttttccaaccatttgtcgaacaatggaatgacacc agttatgacatgatggacgtggcacaccgttttgcgcaagagctcagactacaggctcaa agaagtgacgatcccgaactgcttgaaaagcgcatcggcaatgtgattcgccaatttgca gaaagagcactggaagagatcgaaaccttcaaagcaagccaagccgatcaaggtcgagta ttccgaattaaccttgaaggcctcgatgtggcggcaatgcaagcagaatggcatcgtcta agcaacgatccggatgctcgttatcaattactgaccaaaaactgctccagcacagtggct aaagtgttgaaagccggcggggcggataaactgattggccatacatggctgcctaagttt ggtgtttggacgccgaccgagcttttcaactttggtcaggcactgcaggaagctcagctg gaaattgccgcgaagaagcaaagtcatcaagtcactgatgtccttgatgccttgtcaggc aatgagaagcctaaagaaaacgtggcgattgaaaatgatggtacgccaccgcgcgataaa gaatctctgagcccattgactcgattcctcaataacgagttgtatggtgataaagaggct cgccgtaagattggcgaaatcacgcaaaccctacttgatcacgcggtggaaaaaggtgaa tcgcagaaaatcactctgcaaggagaagcgggccgtctaacggggtattaccatcaggga acagccccaagcgaaggtgaaacgagctcgccaagcggcaaagtcgtattgttcctgcac ggttctggttcttctgctgaagagcaagcgagcgcgattcgaaatcactaccagaagcaa ggtatcgatatgctcgcagtcaacctgcgtggctatggtgaaagcgacggtggaccaagc gaaaaaggcttgtaccaagatgctcgcaccatgttcaactacctagtgaatgataagggt attgacccaagcaacatcatcattcacggctactcaatgggcggtccaattgccgcagat ttagcacgttatgccgcgcaaaacggccaagcggtgtctggcttattgcttgaccgtcct atgccaagcatgaccaaagcaatcaccgctcacgaagtggcgaatccagcgggcattgtg ggggctatcgcgaaagcggttaacggccagttctctgtagagaaaaatctcgaaggtttg ccaaaagagacatccattctgctgttgaccgataacgaaggtttgggtaacgaaggtgag aaacttcgtaccaaactcactgcctctggttacaacgtcactggcgagcagacattctat ggtcacgaagcaagcaaccgtttgatgagtcaatatgcggatcaaattgtctccggtttg tccagcagtgcaagtgtagatgaagacctagatcaacaagggttggataccacatcaacc aaggatcaaggtatctcaaataagaatgatcatctgcaagtggtggatagtaaagaagca ttagcggatggaaaaatactccataatcaaaatgttaatagctggggcccgattacggtt acaccaacgacagatggtggtgaaacccgcttcgacggtcaaatcatcgttcaaatggaa aacgacccggtagtagcaaaagcggcagccaatttagcaggtaaacatgctgaaagcagt gtggtggtgcagctcgattcagacggcaactatcgcgtggtgtatggcgatccgtcaaaa ctggatggaaagctacgttggcagttggtggggcatggtcgcgaccactcagaaactaac aatactcgcttaagtggttacagtgccgatgagttggccgtgaaattggccaagttccaa cagtcgtttaatcaagccgaaaacatcaacaacaaaccggatcacatcagtattgttggt tgttctttggtgagtgacgacaagcaaaaaggctttggtcatcagtttattaacgcgatg gatgcgaatggtcttcgtgtcgatgtctctgttcgtagttctgaactggccgtagacgag gcgggacgtaagcataccaaggacgcgaatggcgattgggttcaaaaggcagaaaacaac aaagtttcgctaagctgggacgcgcaaggtgaagttgttgccaaggatgaacgtattcgc aatggtattgcggaaggcgacatcgatctctctcgtattggtgtcaacaatgtcgatgaa cctgctcgtggcgcgatcggtgacaataatgacgtgtttgatgcgccagaaaaacgcaaa ccagaaacggaagtgattgccaattctagcagcagtaatcaattcagctactcaggtaac attcaagttaacgtgggcgaaggggagtttacggcggtgaactgggggacatcgaatgtg ggcattaaagtcggtactggtggctttaaatcgctggcctttggtgacaataacgttatg gttcatatcggtgacggtgaaagcaaacacagtgttgatatcggtggctatcaagcactg gaaggtgcgcaaatgttcctcggtaaccgtaatgtgagctttaatttcggacacagtaat gatctgatcctaatgatggataagtcgatcccaactccaccactcgtcaatccattcgac ggtgccgcacgtatttctggtgtgttgcaaggtattgctacgtctggagagggagaagat tggcttgccgctcaagagcagcaatggacactgtctggcgcgaagaagttcgtcaaagat atgtctggtttggatcaaagtagcagtgtggattacaccacattagttgaattggattca caaaatgaacgtgatagccgtggcctgaagcacgatgcagaagcgacactgaataagcaa tacaatcagtggctaagcggtaacggtaatagtggcacgagtcagctcagccgcgctgat aagcttcgtcaagccaatgaaaagctagcatttaactttgccgtaggtggacaaggggcg gatattcaagtcacgacgggtaactggaactttatgttcggcgataacattcagtcgatt ttggataccaacttaggttcactgtttggtctcatgacgcagcagttcaccgcaacggga caagcaaaaaccaccttcacttatacgccacaagatttgccgcgccagctcaagaataag ctactcggccagttagctggagtaggggctgaaacgacattggcggatatttttggtgtg gattacaccgcgtcaggtcaaattgtttcgcgtaatggtcaagccgtcgatggagtggcg attctcaaagagatgctggaagtcatcggtgagttcagcggagatcaactgcaggctttt gtcgacccagctaagttactggatagcttgaaagcgggtatcgacatgggagcggatggc atcaagtcttttgctgaaactcatgggctgaaagagaaagcgcctgaagaggaaaaggac aattcttcggtttctgttaatggtgcgaacgtgaacagtgcgcaaggtgcgactgtggct gatggcaatactgaaacagcagaaacacaagatcgtgcctttggctttaactcgcttaac ctgcctaacttgtttgcgactattttcagccaagataagcagaaggaaatgaagtcactg gtggagaatcttaaacagaatctcaccgccgatctgctgaatatgaaggagaaaacgttt gatttccttcgtaatagtggccatctccaaggagatggtgatatcaacatctccctagga aactacaacttcaactggggtggtgatggtaaagatctcggtgcgtatctcggagataac aacaacttctggggtggacgaggcgatgatgtgttctacgcaacaggcaagtcaaacatc ttcacgggtggagaaggcaacgacatgggcgttctgatggggcgtgaaaacatgatgttt ggtggtgatggcaacgacacggcagtggttgctggacgcattaaccatgtcttccttggt gctggtgacgaccagtcgtttgtctttggcgaaggtggtgaaattgataccggttcaggc cgtgactatgtggtgacttctggcaacttcaaccgtgtggatacgggagatgatcaagac tactccgttacgattggcaacaataaccaagtggaactcggagcaggtaatgactttgcc aatatctttggtaactataaccgtatcaatgccggtgcgggtaacgatgtggtgaaactg atgggttaccatgccgtgctaaacggtggtgatggagatgatcacctgattgcaacggcc atctctaagttcagccagttcaacggtggtgaaggccgtgatctgatggtacttggtggt tatcaaaatactttcaaaggtggcacggatgtggacagctttgtggtgagcggtgatgtt atcgacaaccttgtggaagacattcgcagcgaagataacattgtcttcaatggtatcgat tggcagaaactgtggttcgagcgcagcgggtatgacctgaaactgtcgattttgcgtgat ccgtctaacgacagtgaccaatcgaagtttgagcatattggttcggtgacattcagtgat tactttaatggtaaccgcgctcaagtggttatcggaatgagtgagaaagacctgtcgggt gaacgtgaatacaccatgttatcggatagtgcgattgacgctctggttcaagcgatgagt ggttttgaaccgcaagcgggtgacaatggctttatcgacagcctagagagtaaatctcaa gctgcgatcagcatggcgtggtcagacgtggttcacaaaaaaggattgatggtgtaa

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