Vibrio cholerae O1 M66-2: VCM66_2287
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Entry
VCM66_2287 CDS
T00891
Symbol
thrA
Name
(GenBank) threonine-sensitive aspartokinase I/homoserine dehydrogenase
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
vcm
Vibrio cholerae O1 M66-2
Pathway
vcm00260
Glycine, serine and threonine metabolism
vcm00261
Monobactam biosynthesis
vcm00270
Cysteine and methionine metabolism
vcm00300
Lysine biosynthesis
vcm01100
Metabolic pathways
vcm01110
Biosynthesis of secondary metabolites
vcm01120
Microbial metabolism in diverse environments
vcm01230
Biosynthesis of amino acids
Module
vcm_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
vcm_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
vcm_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
vcm00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
VCM66_2287 (thrA)
00270 Cysteine and methionine metabolism
VCM66_2287 (thrA)
00300 Lysine biosynthesis
VCM66_2287 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
VCM66_2287 (thrA)
Enzymes [BR:
vcm01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
VCM66_2287 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
VCM66_2287 (thrA)
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GFIT
Motif
Pfam:
AA_kinase
Homoserine_dh
ACT_9
NAD_binding_3
ACT_7
ACT
Motif
Other DBs
NCBI-ProteinID:
ACP06588
UniProt:
C3LQD6
LinkDB
All DBs
Position
I:complement(2456867..2459344)
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AA seq
825 aa
AA seq
DB search
MHLEEGMRVLKFGGSSLADPERFLRAADIIANNAQQEEVAVVLSAPGKTTNKLVAVIESA
LRQGEVEAQIVELESSFYALLDGIKAQLPNLDDSAYQQQVHSSMTQLRQFVHGITLLGMC
PDNVNARIISKGERVSIQLMKAVMEAKGLPANLVDPVKYLLAKGDHLEAMVDVEISTQRF
RQAPLPQQHVNIMPGFTAGNAQGELVCLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYN
CDPRLVDDARLLKSLSYQEAMELSYFGASVLHPKTIAPIAQFQIPCLIKNSFNPQGAGTL
IGQDTGEDKLAIKGITTLSNLTMVNVSGPGMKGMVGMASRVFGAMSAADVSIVLITQSSS
EYSISFCIEAQHKALAQQALADAFELELKDGLLEPVEFVDNVAIITLVGDGMRTSRGVAS
QFFSSLAEVHVNVIAIAQGSSERAISAVIPDDKISEAIKACHENLFNSKHFLDVFVVGVG
GVGGELVDQIQRQQAKLAEKGIMMRVCGLANSKGMLLDSQGLPLEQWRDRMINADQAFSL
ENLVALVQRNHIINPVLVDCTSSDEIANQYADFLAAGFHVVTPNKKANTASMSYYHQLRN
VARHSRRKLMYETTVGAGLPVIENLQNLIAAGDELEKFSGILSGSLSFIFGKLDEGMTLS
QATQLAKEKGFTEPDPRDDLSGMDVARKLLILAREAGYELELSDVDVEQALPAGFDASGS
VEEFMARLAQADAAFAERVAQAKAEGKVLRYVAQIVDGQCQVRIVAVDENDPMFKVKEGE
NALAFYSRYYQPIPLVLRGYGAGSEVTAAGVFSDVMRTLGWKLGV
NT seq
2478 nt
NT seq
+upstream
nt +downstream
nt
atgcatttggaggaagggatgcgagtattaaagtttggaggttcatcgctggcggatccg
gagcgttttctacgcgctgccgatatcatcgcgaataacgcacagcaggaagaggtggcc
gttgtcctctctgctccgggaaaaaccaccaataaattggtggcagtgattgaaagtgct
ttacgtcagggagaggtggaagcgcaaatcgtagagctagagagctcattctatgccttg
cttgatggcattaaagcgcagctcccgaatttggatgacagtgcttatcaacagcaagtg
cactcttccatgactcagttacgccagtttgtgcatggcattacgttgctcggtatgtgt
ccagacaatgtgaatgcacgcattatcagtaaaggtgaacgcgtttccattcaattgatg
aaagcggtgatggaagccaaaggtctgccagcgaatttggttgaccccgttaaatacctg
cttgccaaaggggatcatcttgaagctatggtcgatgtggaaatctcgactcagcgtttc
agacaagcaccattgccacaacagcacgtcaatatcatgccgggctttactgcgggtaat
gcacagggtgagttggtctgtttagggcgtaacggttcggattactcagccgcagtactg
gctgcctgtttacgtgcggattgttgtgaaatctggacggatgtggatggagtttataac
tgcgatccgcgtttggtcgatgatgcgcgtcttttgaaatcccttagctatcaagaggcg
atggagctttcttacttcggagcatctgtgttgcatccgaagaccattgcaccgattgct
caatttcaaatcccttgcctgatcaaaaacagcttcaatccacaaggtgcgggcaccttg
attggccaagacactggcgaagataaactcgcgatcaaaggcattaccactctgagcaat
ctgaccatggtcaacgtttctggtccaggaatgaaaggcatggtggggatggcgagccgc
gtgtttggcgcgatgtcagcggcagatgtgtcgatcgtgctcattactcaatcttcttcg
gaatacagcatcagtttctgtatcgaagcacaacataaagctttggcacagcaagcgctg
gcggatgcatttgaactggaactcaaagatggcctgcttgagccggttgagtttgtcgat
aacgtcgccatcatcacgctggttggtgatggtatgcgtacctctcgcggtgtcgcgtcg
caatttttctcatctctggccgaagtacacgtcaacgtgattgcgattgcccaaggctct
tctgagcgtgcgatttcagcggtgatccccgatgataagatttcagaagcgatcaaggcc
tgtcacgaaaacctcttcaactctaaacactttttagatgtgtttgtggtcggtgttggt
ggcgtgggcggtgagttggtggatcaaattcagcgtcaacaagccaagcttgcggaaaaa
ggcatcatgatgcgcgtttgtggcctcgctaacagtaaaggcatgctgcttgatagccaa
ggcttgccgttagagcagtggcgcgatcgtatgatcaatgcggatcaagcgttcagttta
gagaatctggtggctttggtgcagcgtaatcacatcattaacccagtattggtggattgc
acgtccagtgatgagattgctaaccagtatgcggatttcctcgccgcgggtttccatgtg
gtgaccccgaacaagaaagccaataccgctagcatgagttattaccatcagctacgtaat
gtggctcgtcattcgcgtcgcaaactgatgtatgaaactacagttggcgcgggtctaccc
gttatcgaaaacttgcaaaacctaattgcagcaggggatgagctggaaaaattcagcggt
attctctcaggttctctctcctttatcttcggtaaattggatgaaggcatgaccttgagc
caagcaacgcagcttgctaaagagaaaggctttacagagccagatccgcgcgatgatctc
tctggtatggatgtggcgcgcaagttactgattttggcgcgtgaagcagggtacgaattg
gagctgagcgatgtggatgttgaacaagcactgcccgctggctttgatgcttcaggcagt
gttgaggagttcatggctcgtttagcgcaagccgatgccgcgtttgccgagcgagtggcg
caagccaaagccgaaggcaaagtgcttcgctatgtggcgcaaatcgtcgatggccagtgc
caagtgcggattgtcgcggttgatgaaaacgatcctatgttcaaagtcaaagaaggtgaa
aacgcgctggctttctacagccgttactatcagccaatcccattggtattacgtggttac
ggcgcgggttctgaagtgactgctgcaggcgtgttctcagatgtgatgcgtacactcggt
tggaaattaggggtttaa
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