Varanus komodoensis (Komodo dragon): 123018034 Help Entry 123018034         CDS       T07701                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism vko  Varanus komodoensis (Komodo dragon) Pathway vko04020   Calcium signaling pathway vko04260   Cardiac muscle contraction vko04261   Adrenergic signaling in cardiomyocytes vko04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:vko00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     123018034 (RYR2)    04020 Calcium signaling pathway     123018034 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     123018034 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     123018034 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:vko04040]     123018034 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:vko04990]     123018034 (RYR2) Ion channels [BR:vko04040]  Voltage-gated cation channels   Ryanodine receptor    123018034 (RYR2) Domain-containing proteins not elsewhere classified [BR:vko04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    123018034 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  123018034 NCBI-ProteinID:  XP_044275707 Ensembl:  ENSVKKG00000005933 LinkDB All DBs Position Unknown AA seq 4998 aa AA seqDB search MAEMGEGEDEIQFLRTRLPQCFGTGFGGCEEEGKWVKMTKDDEVVLQCTATVHKEQQKLC LAAEGFGNRLCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTEEKAEGLVDVE KWKFMMKTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRTSMDKLAFDVGLQEDTTGE ACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNGSLRVDAAFQQTLWSVAP ISSGSEVAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSIHARSLWR LETLRVAWSGSHIRWGQPFRLRHITTGKYLSLMDDKSLLLTEKEKADVKSTAFCFRSSKE KLDVGIRKEVEGMGAPEIKYGDSVCFIQHVDTGLWLTYQAVDAKSVRMGSVQRKAIMHHE GHMDDGLTLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKAKSSTVDLPIESVSLSL QDLIGYFHPPGEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFAD VAGKEAGETWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLH CILVESPEALNIIKEGHIKSIICLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNL LPGRDLLLQTRLVNHVSSMRPNIFLGISEGSAQYRKWYYELVVDYVEPFTTAEATHLRVG WASTEGYSPYPVGGEEWGGNGVGDDLYSYGFDGLHLWSGCVARAVNSPYQHLLRTDDVIS CCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPP PGYAPCFEAILPKEKLKVEHSREYKQDRNCTRDLLGPNISLSQAAFTPVPVDTSQIVLPP HLERIREKLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFAKLPEQERNYNLQMS LETLKTLLALGCHVGIADEHAEEKVKKLKLPKNFLLSSGYKPAPMDLSCIKLTPSQESMV DKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRT LIGYGYNLEAPDQDHATKPDVFCGMMERFRIFRTEKTYAVKNGKWYFEYEAVTAGDMRVG WAKPGCQPEQELGSDEQAFVFDGFKAQRWHQGNEHFGRSWMTGDIVGCMVDLNERTMMFT LNGEILLDDSGSELAFKDFEVGDGFIPACSLGLSQAGRMNFGKDVSTLKYFTICGLQEGY EPFAVNTNRDITIWLSKRLPQFLPVPPSHEHIEVTRIDGTADSSPCLKVTQKSFGSQNSK TEIMFYRLSMPIECAEVFSKLPGGGVPSSSLFGPKNELDEYDADSDFEVLMKTAHGHLIP DRVEKEAVKTEFNNHKDYAQEKPSRLKQRFMLRRTKPDYSTSHSARLTEDVLADERDDYD YLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTSFDLDRVRTVTVTLGDEKGKVHE SIKRSNCYMVCAGESMSPGQGRNNNGLEIGCSVDAGTGILSFTANGKELSTYYQVEPSTK LFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLTHVLWSR VPNHFLKVDISRVSERQGWSVECLEPLQFMTLHIPEENRSVDILELSEQEELLKFHYHTL RLYSAVCALGNNRVAYAMCSHVDESQLLYAIENKYMPGLLRAGYYDLLIDIHLNTYATAR LMMNNEFIVPMTDETKSITLFPNENKKHGLPGIGLSTSLRPRIQFTSPSFVKINSECYQY SPEFPLEILKSKTIEMLTEAVQEGSLHVRDPVGGTTEFLFVPLIKLFYTLLIMGVFHNED LKHILQLIEPSVFKEDASHEDGTQALVKELVTEGLNSETGGDEIRGEKIPEEGLLQMKLP EPVKLQMCHLLQYLCDCQIRHRIEAIVAFSDDFVAKLQENQRFRYNEVMQALNMSAALTA KKTKEFRSPPQEQINMLLNFKDDKNDCPCPEGIRDHLLDFHEDLMAHCGIQLDEDGILDG NSDLTIKGRLLYLLERVTHLKKKQAEKLVDDDAKKPSTLQQLISETMVRWAQESVIEDPE LVRAMFVLLHRQYDGVGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEE KLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRF LCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALRE PDLEKVVRYLAGCGLQSCPLLISKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANV VVRLLIRRPECFGPALRGEGGNGLLAAMEEAINISEDPTRDGPSPSNGSNRTLSEVEEED DTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLEDLVGVISIP FHMPTIAKDGTVVEPDMSEGFCPDHKAAMVLFLDRVYGIEDQDFLLHLLEVGFLPDLRAA ASLDTVALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGC SLTKAQRDSIEECLLSICGQLRPSMMQHLLRRLVFDIPLLNEHAKMPLKLLTNHYERCWK YYCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPD YMESNYVGVMEKQASMDSDGNFNPQPVDTSNITIPEKLDYFLNKYAEHSHDKWCMEKFAN GWIYGETYSESSKVQPLMKQFKLLSEKEKEVYRWPIKESLKTMLAWGWRVERTREGDTMA LYNRPRRISQTSQVSVDTVHGYTPRAIDMSNVTLSRELHAMAEMMAENYHNIWAKKKKME LEAKVGGGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQINGYVVSRGLKDLELDTPSIE KRFAYSFLQQLIRYVDEAHQYILEFDGGSRGKGEQFPYEQEIKFFAKVVLPLIDQYFKNH RLYFLSSASRPLSSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQ TLDARTVMKTGLESVKMALRTFLDNAAEDLEKTMENLKQGQFTHTRSQPKGVTQIINYTT VALLPVLSSLFEHIGQHQFGEDLILEDVQVSCYRILGSLYALGTSKSIYVERQRSALGEC LAAFAGAFPVAFLETHLNHHNIYSIYNTKTAKDRAGISLPNSVEELCPNIPSLEKLMEEI VELAASGIRYTQMPHVMEVVLPMLCSYMSHWWDHGPENNPDKSEMCCTALTSEHMNTLLG NILKIIHNNLGIDEGAWMKRLAVFSQPIISKVKPQLLKTHFLPLMEKLKKKAATVISDEE HLRAEGRGDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEDLFRM VAEVFIYWSKSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDR YSTQTSLIVAALKRLLPVGLNICAPGDQELIALAKNRLSMKDTEDEVRDIIRNNLHLQGK LEDPAIRWQVALYKDLPNRTEVTSDPEKTVERVLDIANVLFHLEQKFSNRGRKFFRMVEH PQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWVETEDHYFED TLIEDLAKPGEEPAEEDEYIKRVDPLHQLILLFSRTALTEKCKLEEDYLYMAYADIMAKS CHDEEDDDGEEEVKSFEVTGSQRSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGE MGPMVAATLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQSCSVLDLNAFER QNKAEGLGMVTEEGSGEKVMQDDEFTCDLFRFLQLLCEGHSSDFQNYLRTQTGNNTTVNI IISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIHVAKQVFNTLTEYIQGPCTG NQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNV VNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTFSDAFKEYDPDGKGVISKRDFHK AMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMP HDTRLQTFLELADSVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKR QFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSANKEESEHEKPEEQD PRMGFFSLVTVKSALVALRYNIMALMKMLSMKSIKKQMKKVKKMTMKDMIMALFSSYWSI LMGLMHFIASVFRGFFQIMYSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGEGEEID RKPMEAALPAEDLTDLKALSDDSDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLLSSPS LLPLPEVQEKIQDQKANEDEKDEREETKFEPEKAEGEDGEKEVKKEDKEKQKHRQRHKHR HGEPEMQESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSAVVE EKEVPLVDNAETSKLSSLESPSHRIITVHYVLEESSGYMEPTLRILAILHTVISFFCIIG YYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFV KRKVMDKYGEFYGKDRISELLGMDKAALDFSDTREKKKPKKDSSLSAVLNSIDVKYQMWK LGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVL TVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDMPDMKCDDMLTCYMFHMYVGVRAGGGIGD EIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCF ICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCW EFFPAGDCFRKQYEDQLN NT seq 14997 nt NT seq  +upstreamnt  +downstreamnt atggccgaaatgggcgaaggcgaggacgagatacagttcctacgaactagactccctcaa tgctttggaacaggttttggaggatgcgaggaggaaggaaaatgggtgaaaatgaccaag gatgatgaagtggttctgcagtgcactgctactgttcacaaagaacagcagaaattgtgc cttgctgcagaaggatttggcaacaggctctgcttcttggaatcaacttcaaattccaag aatgttcctccagatctctccatctgcacgtttgtgctggaacagtccttatccgtccga gctctccaggaaatgctggctaacacagaggagaaagcagaagggctagttgatgtggaa aaatggaaatttatgatgaagactgctcaaggtggtggccatcgaacactcctgtatgga catgcaatattgctgcgccattcttacagtggtatgtatttgtgttgcctttccacctca cgaacatccatggacaaactggcatttgatgtgggcttgcaagaagacaccacaggtgaa gcctgctggtggaccatacatcctgcttctaagcaacgttcagaaggagaaaaagtacgt gttggggatgatctaatccttgtcagtgtttcttcagaaagatacttgcatttatcttat ggcaatggcagcttgcgtgttgatgcagctttccagcaaacactttggagtgttgcccca atcagttctggaagtgaagtagctcaaggctatctcataggaggtgatgtgctgaggtta ttacatggacacatggatgaatgcctaactgttccttcaggagaacatggagaagagcag agaagaactgtccactatgaaggtggtgctgtgtcaattcatgctcgttctctttggcga cttgagaccttaagggttgcgtggagtggaagtcacattagatgggggcagccattcaga ttaagacatataacaacagggaaatatttaagcctcatggatgacaagagtcttcttcta acagagaaagagaaagctgacgtgaaatctacagcattttgttttcggtcttccaaggag aaattggatgtggggataagaaaagaagtggaggggatgggagcacctgagataaagtat ggagattctgtctgtttcatacagcatgttgacacgggtttgtggcttacataccaagca gtggatgcaaagtctgtaagaatgggatctgtgcaacgcaaggctatcatgcaccatgaa ggccatatggatgatgggctaacattgtctagatctcagcatgaagaatcccgtactgca cgtgtaattcgtagtactgtcttccttttcaacaggttcataaggggccttgatgctctc agcaagaaagcaaagtcttccacagttgatttgcccattgaatcagtcagccttagcctc caggacttgattggttactttcatccacctggtgaacatttagagcacgaagacaagcag aaccgactaagagccctaaagaatcgacagaatctcttccaggaagagggtatgatcaac ttggtgcttgaatgtatcgatcgcttacatgtatacagcagtgcagcgcattttgctgat gtggctgggaaggaggcaggagagacttggaaatccattctaaactcattgtatgaatta ctagcggctttgattagggggaatcgtaaaaactgtgcccagttttcaggatctcttgat tggctcatcagtcgattggagagactggaagcctcttctggaattcttgaggttttacac tgtatattggtggaaagtccagaagctttaaatattattaaagaaggacatattaaatca atcatatgtcttttggacaaacatggaagaaaccataaggtgttagatgttttgtgttct ctgtgtgtatgtcatggagtagctgtgcgatccaatcaacatctcatctgtgacaatctt ctaccgggaagagacctccttctccagacacgccttgttaaccatgtgagcagcatgaga cccaatattttccttggaatcagtgagggctctgctcagtacagaaaatggtattatgag ctagtggttgactatgtggaaccatttacaacagcagaagctactcatcttcgtgtgggt tgggcttcaacagaaggctattcaccttatcctgtgggaggagaagaatggggaggtaat ggtgttggcgatgacctatactcctatggttttgatggacttcatctctggtcaggttgt gtggcaagagctgtgaattctccttaccagcatctactaagaactgatgatgtaatcagc tgctgccttgacttgagcgctccaagcatttcatttcggataaatgggcagccagtccag gggatgtttgagaatttcaacatagatggtctttttttcccagttgtcagcttctctgca gggataaaggtacgctttttacttggaggccgtcatggggaatttaaattccttccacct ccaggatatgctccttgttttgaagctattctgccaaaagaaaagttgaaggtggaacac agcagagaatataaacaagaccgcaactgcacaagagatctactgggtccaaatatctct ttgtcacaagcagctttcactccagtacctgtagataccagtcagattgtcttgcctcca cacctggaacgaattagagaaaagctagctgaaaatatccatgaactgtgggttatgaat aaaattgaacttggatggcagtatggtcctgtcagagatgacaacaagcgtcagcatcca tgtttagtagagtttgcaaagctgccagaacaagaacgaaattacaacctccaaatgtca ttagaaacactgaaaacactgctggcattagggtgtcatgttggaattgctgatgagcat gctgaagaaaaggtgaagaaactaaaacttccaaagaatttcttgttgtccagtggatac aagcctgcacctatggatctgagttgtatcaagctgaccccatctcaggaatccatggtt gataaacttgcggagaatgctcacaatgtatgggcaagggatcgtatcagacagggttgg acatatggaatccagcaggatgtaaagaaccgtcgaaaccctcgccttgtcccctacgct cttctagatgatcgcactaagaaatcaaacaaagatagtctccgagaagctgttcgtacc ctcattggctatggctataaccttgaggctccagatcaagaccatgctacaaaaccagat gtgttctgtggtatgatggaaaggtttagaatcttccgcacagagaagacatatgctgtg aaaaatgggaagtggtactttgagtatgaagcagtgacagcaggagatatgagggttggt tgggccaagccaggttgtcaaccagaacaagaacttgggtcagatgaacaagcatttgtg tttgatggattcaaggcccaacggtggcaccaaggaaatgagcattttggtcggtcttgg atgacgggggatattgtgggatgtatggttgatctgaatgagcgcaccatgatgttcact ctaaatggtgaaatccttcttgatgactcaggctccgaactggcattcaaggattttgag gttggtgatggcttcatacctgcgtgtagcctgggattgtcacaagcgggcagaatgaac tttggcaaagatgttagcaccctgaaatatttcactatttgtggtttacaagaaggctat gaaccttttgcagtgaatacaaaccgggatattaccatatggctgagcaagagattacct cagtttcttccagtaccaccaagtcatgaacatattgaggttacaagaatagatggaaca gcagatagctccccgtgcttgaaggtcacgcagaagtcctttggttctcaaaacagcaaa acagaaattatgttctatcgtcttagcatgcctattgaatgtgcagaagtattctccaaa cttcctggaggaggagtaccaagttccagcctttttggcccaaagaatgaattggatgag tacgatgcagattctgactttgaggtccttatgaagactgcccatggtcatctcatacct gatcgtgtagaaaaagaagcagtaaaaacagagttcaataaccataaagactatgcacag gagaaaccttcacgcctcaagcaaaggtttatgttgagaaggacaaaaccagactatagc actagtcactctgcaaggctcactgaagatgtcttagcagatgaacgagatgattatgat tacttgatgcaaacatctacatactattactctgtgcgtatctttcctggacaagagcct gctaatgtctgggtgggctggattacatctgactttcatcaatatgatacaagctttgat ttggacagagtccgtactgttacagtaaccctaggagatgaaaaaggaaaagttcatgag agtatcaaacgaagcaactgctatatggtatgtgcaggagaaagcatgagtccgggacaa ggacgcaataacaatgggctagagattggttgttcggttgatgctggaactggtattctg tccttcacagctaatggcaaagaattaagcacatattatcaggttgaaccaagtactaaa ttatttcctgcagtatttgcacaagctacaagtcccaatgttttccagtttgagttggga agaataaagaatgtaatgccattgtcagctggtttattcaaaagtgaacataaaaaccca gttcctcagtgccctccccgtctccatgtccaatttctgacgcacgtgctttggagcaga gtgccaaaccattttctgaaggtcgatatatcgcgtgtcagtgaacgtcaaggatggtca gtagagtgcctggaacctttgcagttcatgacccttcacatcccagaagaaaacagatct gtggacattttagagctgtcagaacaagaagaattgttaaaatttcactaccatactctc aggttgtactcagctgtttgtgctcttgggaacaatcgagttgcctatgcaatgtgcagc catgttgatgaatcacagcttctatatgcaattgagaacaaatatatgcctggtttgtta cgtgcaggttattatgaccttctcattgacattcaccttaatacctatgccaccgcaagg ctgatgatgaataatgaatttattgttccaatgacagatgagaccaaaagcatcactttg tttcctaatgaaaacaaaaagcatggcttgcctggcattggactcagcacttcgctgcgg cctagaatacagtttacctctcccagttttgtaaaaattaacagtgaatgttaccaatac agtcctgaatttcctttggaaattttaaagtctaaaacaatagagatgctgacagaggcc gttcaagagggcagccttcatgtcagagatcctgtaggtggtactaccgagtttctattt gttcctttgatcaagcttttttacactttactaataatgggagtcttccacaatgaagat ctgaagcacatcttacagctgattgaacctagtgtttttaaggaggatgcaagccatgaa gatgggactcaagcactagtgaaggaactagttacagagggactaaattcagagacagga ggggatgaaataagaggagaaaagatcccagaagaaggccttcttcaaatgaaacttcca gagcctgtgaaactacagatgtgtcatttgctccagtacctttgcgactgtcagatacgc caccgaatagaagccattgtagcattttcagatgactttgtagcaaagcttcaagagaat cagcgtttccggtataatgaagttatgcaggccttaaatatgtctgcagcactgacagcc aagaaaacaaaggagtttcggtctccaccacaggaacaaatcaatatgctgctgaatttt aaggatgataaaaatgattgcccttgtccagaaggaataagagatcacctcttggatttc catgaggatttgatggcacattgtggaattcagctggatgaagatgggattctggatgga aacagtgacctaactattaaaggtcggttgttgtacctcctggaaagagtcacacatctg aaaaagaaacaagcagagaaactagttgatgatgatgcaaagaaaccatcaactctccaa cagttgatatcagagactatggtacggtgggctcaagaatcagtaatagaagatccagag ttggtgagggccatgtttgttttgctacaccgacagtatgatggagttggtggcctagtt cgagctttgccaaagacatacactataaatggtgtttctgtggaagatacaatcaacttg cttgcatctcttggccagatacgttctctcctcagtgtcagaatgggcaaggaagaagag aagcttatgattcgtggattaggggatattatgaataacaaggttttttatcaacatcct aatctgatgagggcactggggatgcacgaaactgtaatggaagtaatggtgaatgtactt ggaggaggggagtcaaaggaaatcacctttcctaagatggtggcaaattgctgtcgtttt ctatgttatttttgccgcatcagtagacagaatcaaaaggctatgtttgatcatcttagc tatcttttggaaaacagtagtgttgggcttgcatccccttctatgcgtggatcaacacct ttagatgttgcagcagcatctgtaatggataataatgaacttgcactagcattgcgggag cctgatttagagaaggtagttcgctacctggctggatgtggtttgcaaagctgccctttg ctgatttctaaaggctacccagatattggatggaatccagtagaaggagagcgttatttg gattttcttcgttttgctgttttttgcaatggggagagcgttgaagagaatgctaatgtg gtggtcagactgctcatacggcgtcctgagtgttttgggccagcactgagaggagaaggt ggtaatggcttgcttgctgccatggaagaagccataaacatatcagaagaccctacaaga gatggaccttcaccaagtaatggttccaatagaacactaagtgaagtggaagaagaagat gatactattcacatgggaaatgccatcatgaccttttatgctgctttgatcgatctccta ggacgctgtgctccagaaatgcatctaattcatgctggtaaaggagaagccattagaatc agatctattctgcggtctttgatacctttggaagatttggtgggcgtaattagcattcct ttccacatgccaactattgcaaaagatggtactgtggtggaacctgatatgtcagagggg ttttgcccagaccacaaggcagcaatggtattgttccttgacagggtctatggaattgaa gatcaggattttcttctacaccttctagaagttggctttcttcccgatcttcgtgctgct gcttcactagatacggttgctctgagtgctacagatatggccctggctctcaatcggtac ctctgcactgctgttttgcctttattaactagatgtgctcctctttttgctggcacagaa caccatgcttcccttatagattccttgctacacactgtataccgactctccaagggctgc tctcttaccaaagctcagcgggactctattgaagagtgcctactctccatttgtggtcaa ctgaggccttcaatgatgcaacatttgttgagaagattagtgtttgatattcctctacta aatgaacatgcaaagatgccgcttaaattgctgacaaatcattatgaaagatgctggaag tattactgtttgccaggaggatggggtaactttggtgcagcttcagaagaggaactccat ttatcccgaaagttgttctggggtatttttgatgccttatctcaaaagaaatatgaacag gaactattcaagctagctttgccctgcttgagtgccgttgcaggggctttaccacctgat tatatggaatctaattatgttggtgtgatggaaaaacaggcctccatggattcagatgga aactttaatccacaacctgttgatacttcaaacattacaattcctgaaaagctagactac tttcttaacaaatatgctgaacattcccatgataaatggtgcatggaaaagtttgcaaat gggtggatatatggtgaaacatactcagaatcttccaaagtgcagccattaatgaaacaa tttaaactgttatcagaaaaggaaaaagaagtttacagatggccaatcaaagaatctctg aagaccatgcttgcttggggatggcgggttgaaagaacaagggaaggagatactatggct ttgtataataggccacgtcgaatatcacaaacaagtcaggtttctgtagatactgtccat ggatatactccccgtgcaattgacatgagtaatgttactctctccagagagctgcatgct atggctgagatgatggctgaaaactatcataatatatgggcaaagaaaaagaaaatggaa cttgaagcaaaagtgggaggaggaaaccatcccttacttgttccctatgatacactgaca gccaaagaaaaggccaaggacagagagaaagctcaagatattttgaagtttctacagatc aatggatatgtcgtctccagaggtctaaaggatctagagttagacacaccttccattgag aaacggtttgcgtacagttttcttcagcaactgataagatatgtagatgaagcccatcag tatattctggagtttgatggtggcagtagaggcaaaggagaacaatttccttatgaacaa gaaatcaagttctttgctaaggttgtacttccattaattgatcagtatttcaaaaatcat cgcctgtatttcctgtcttcagcaagcaggcctctcagcagtggggggcatgcctctaac aaggagaaagaaatggtaaccagcctattctgcaaacttggagttcttgtcaggcatagg atttcactgtttggaaatgatgcaacttcaatagtcaattgtcttcatatcttgggccag actttggatgcaaggacagtgatgaaaacaggtttggagtctgttaagatggccttgagg acatttttggataatgctgcagaggacctggaaaagacaatggagaaccttaagcaaggg cagttcacacataccaggagtcaaccaaaaggggtgacacaaataattaactacaccact gtggccctcctgccagtgctgtcttccttatttgaacacattggacagcatcagtttgga gaagacctgatattggaagatgtacaagtttcttgttacagaatattgggcagtttatat gctctggggaccagcaagagtatctatgtggaacggcagcgctcagctttaggtgaatgc ctagctgcatttgctggtgcctttcctgtggcatttttagaaactcacctgaaccatcac aacatatattctatttacaataccaagactgcgaaagacagagcaggtatcagtttgcca aacagtgtagaagagctttgtccaaacattccttctttggagaagctaatggaagaaatt gtggaattagctgcatctggcattcgctatacacaaatgcctcatgtaatggaggttgtg ttgcccatgctttgtagttacatgtcacattggtgggaccatggacctgaaaataatcct gacaagagtgaaatgtgctgcacagctttgacttcagagcatatgaatacccttctgggg aatatactgaaaatcatacataataacttgggcatagatgagggagcctggatgaagaga ttggcagtgttttctcagcctatcataagcaaagtgaagccccagcttctgaaaacacat tttctgccactgatggagaaactgaagaaaaaagctgcaaccgttatatctgatgaggaa cacttaagagcagaaggcagaggagacatgtcggaggcagaactcctcatcctagatgag ttcactacgctagcacgggacctttatgccttctacccattgttgattagatttgtggac tacaacagagcaaagtggctaaaagaacctaacccagaggctgaagacttatttcgtatg gttgctgaagtattcatttactggtcaaaatctcataattttaaaagagaagaacagaat tttgttgtgcagaatgaaatcaacaatatgtcttttcttattactgataccaagtccaag atgtccaaggcagctgtttcagatcaggaaaggaaaaaaatgaagcggaaaggagaccgt tattctacacagacctctcttattgtggcagctttaaaaagattgctacctgttgggcta aatatttgtgctcctggtgaccaagaattaattgcacttgcgaaaaacagattaagtatg aaagacactgaggatgaagttcgagatattattcgtaacaaccttcatttacagggaaag cttgaagatcctgccattaggtggcaagtggccctgtacaaagatctaccaaacaggact gaagttacttcagatccagaaaagacagtggaacgggtccttgatatagctaatgtgctt tttcatctggaacagaaattctctaatcggggccggaaatttttcagaatggttgaacat ccccagaggtcaaaaaaagctgtatggcataaactgctatccaaacagagaaaaagagct gtggtagcttgcttcagaatggcaccactatataatcttccacgccatcgagctgtcaat ctttttcttcagggatatgaaaaatcctgggtagaaacagaagaccactattttgaagat acactgatagaagatctagcaaaaccaggagaagagccagcagaggaagatgaatatatt aagagagttgatcctctgcatcagcttattttattgttcagtcgaacagcattaacagaa aaatgcaaactggaagaagattacctttatatggcgtatgctgatattatggcaaagagc tgtcatgatgaagaagatgatgatggtgaagaagaggtgaagagctttgaagtcacagga tcccaacgcagcaaggaaaaagaaatggaaaaacaaaaacttctgtaccaacaagcaaga ctacatgatcggggagctgctgagatggttcttcagacaattagtgccagcaaaggtgag atggggccaatggttgcagccaccctgaaacttggaattgcgatcttgaatggaggaaat tctactgttcaacagaaaatgcttgactacctcaaggacaaaaaggatgtaggcttcttt cagagtcttgctggacttatgcagtcttgtagtgttcttgacctaaatgcttttgaacgt caaaacaaagcagagggccttggcatggtaacagaagaaggatcaggagaaaaagtgatg caggatgatgaatttacttgtgatctcttccggttccttcagttgctttgtgaagggcac agctcagattttcagaattacttgaggactcaaactggtaacaatacaactgtcaatatt atcatatctactgtggattacttattgcgagttcaggaatcaattagtgatttctattgg tattattctggaaaggatgttattgatgaacaaggacaacgtaatttctcaaaagcaatt cacgttgcaaagcaggtcttcaatacacttacagaatatattcagggaccatgtacaggc aaccagcagagtctagcacatagcaggctatgggatgctgtggttggttttcttcatgtg tttgcccacatgcagatgaagctatctcaggactctagccagattgaattactgaaagaa ttaatggatctccagaaggatatggtggttatgttgctatctatgttagaaggcaatgtt gtgaatggaacaattggcaagcagatggttgacatgctagtggaatcttccaacaatgta gaaatgattttaaagttttttgatatgtttctaaaactaaaggatttgactttctcggat gcatttaaagaatatgatcctgatggtaagggtgtcatttcaaaaagagatttccacaaa gcaatggagagccataagcactacactcaatcagaaactgagtttctgctctcctgtgct gaaacggatgagaacgagactcttgactatgaggaatttgtgaaacggtttcatgagcca gccaaagacattggcttcaatgttgctgtccttctgacaaacttgtccgagcacatgcct catgatactcgactgcaaacttttcttgaactggcagacagtgttctgaactattttcag ccctttttaggccgcatagaaataatgggcagtgcaaagcgcattgaacgagtttatttt gagataagtgaatcaagtcggacacagtgggaaaaacctcaagttaaagaatcaaagaga cagtttatctttgatgtggtaaatgaaggaggggaaaaggaaaaaatggaactttttgtt aatttctgtgaagataccatctttgaaatgcagttggctgctcagatctccgagtcagat ttgaatgagaggtctgcaaataaagaagaaagtgagcatgagaagcctgaggagcaggat cctaggatgggcttcttctccttagtgactgtcaaatcagctttagtggctctcaggtat aacataatggcactcatgaaaatgctaagcatgaaaagcataaagaagcagatgaagaag gtgaaaaaaatgaccatgaaagacatgataatggctttgttttcctcgtactggagcatt ttaatgggcttgatgcactttatagcaagcgttttccgaggcttctttcaaatcatgtac agcttgctgcttggaggaagtctggttgaaggggctaagaaaatcaaggtggctgaacta ttagcaaacatgcctgaccccactcaagatgaggtgcgtggtgaaggggaagaaatagat aggaagccaatggaagctgctttgcctgcagaagatttaacagatctcaaagctttgtca gatgatagtgacctcctatcagacatatttggcttggatttaaaaagagagggaggacaa tataagctaataccacataatcccaacgcaggcctgagtgatttgttgagcagtccttct ttactccctttacctgaagtgcaagaaaaaatacaggaccagaaggcaaatgaagatgaa aaggatgagagagaagaaacaaaatttgaacctgaaaaagcagaaggagaagatggagaa aaggaagtgaaaaaagaagataaagagaaacagaaacacaggcagcgccacaaacataga catggtgaaccagaaatgcaagaatcagccttctggaagaaaatcattgcataccaacag aaacttcttaactattttgctcgaaatttctacaatatgaggatgctagctttatttgtt gcatttgccattaacttcatccttctcttctataaggtttccacatctgcagtagttgaa gaaaaggaggttcctttggttgataatgctgaaacctccaagctaagcagcctggaaagt ccctctcatcgaatcatcacagtgcattatgttcttgaagagagcagtgggtacatggaa cctacactccgtattttagcgattctgcacacagtcatctcctttttctgcatcattgga tattactgtttgaaagttccattggttatatttaaacgagaaaaggaagttgcaagaaaa ttagaatttgatgggctgtatatcacagaacagccttcagaagatgatattaaaggacaa tgggatagacttgtcatcaacactcagtcatttccaaacaactattgggacaagtttgta aaaagaaaggtaatggataaatatggagagttctatggcaaggacagaatcagtgaattg cttggaatggataaagccgctctggatttcagtgataccagagaaaaaaagaaacccaaa aaagacagctctttatcagctgtgctgaattctattgatgtaaagtatcagatgtggaaa ttaggagttgttttcaccgataattcttttctttacttggcctggtatatgaccatgtca gtccttggtcattacaacaactttttctttgctgctcatctccttgacatagcaatggga ttcaaaacactgcgaactattctgtcatcagtgacccacaatgggaaacagcttgtgctg acagtggggttactggctgtggtagtttacctatacacagtggttgccttcaattttttc cgcaaattctacaataagagtgaagatggagatatgccagatatgaaatgtgatgatatg ttaacgtgctacatgtttcacatgtatgtgggagtgcgtgcaggtggtggaattggtgat gaaatcgaagatccagcaggcgatgagtatgaaatctatcgaatcatctttgacattact tttttcttctttgtaatagttattctactagctattatacaaggtttaattattgatgca tttggagaattacgagatcagcaagaacaagttaaagaagacatggagaccaaatgcttt atctgtgggataggtaatgattactttgatacagttccacatggttttgaaacacacact ctacaggagcacaacttggccaattatctatttttcctgatgtatctcattaataaggat gaaacagaacatactggacaggaatcttatgtatggaaaatgtaccaggaaagatgctgg gaatttttccctgctggtgattgctttcgaaagcagtatgaagaccaactcaactaa

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