Varanus komodoensis (Komodo dragon): 123026483 Help Entry 123026483         CDS       T07701                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism vko  Varanus komodoensis (Komodo dragon) Pathway vko04020   Calcium signaling pathway vko04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:vko00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     123026483 (RYR3)    04020 Calcium signaling pathway     123026483 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:vko04040]     123026483 (RYR3) Ion channels [BR:vko04040]  Voltage-gated cation channels   Ryanodine receptor    123026483 (RYR3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  123026483 NCBI-ProteinID:  XP_044292130 Ensembl:  ENSVKKG00000012172 LinkDB All DBs Position Unknown AA seq 4866 aa AA seqDB search MNLGTLPQGPQDDEVVLQCVANIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVPPDLCIC NFVLEQSLSVRALQEMLANTGDNSSEGAAQGGGHRTLLYGHAILLRHSFSGMYLTCLTTS RSQTDKLAFDVGLQENAAGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLHLSV TYGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVLRLFHGHDECLTIPSTEQNDSPH KRLFYEAGGAGVRARSLWRVEPLRISWSGSNIRWGQPFRLRHITTGQFLALTEDLGLVLL DREKADTKSTSFCFRASKLVKEKLDSAHKRDIEGMGVPEIKYGDSVCFVQHVASALWLTY KAQDAKTTRLGPLKRKVILHQEGHMDDGLTLQRCQHEESQAARIILNTTRLFSQFISGNN RTSTPITLPIEEVLQTLQDLITYFQPPEEELEHEDKQNKLRSLKNRQNLFKEEGMLALVL NCIDRLNVYYSTAHFTGVGREENGTGWKEILNLLYKLLAALIRGNRNNCAQFSNNLDWLI SKLDRLESSSGILEVLHCILIESPEALNLIEEGHIKSIISLLDKHGRNHKVLDVLCSLCL CNGVAVRANQNLICDNLLPRRDLLLQTRLVNNVTSMRPNIFLGTAEGSAQYRKWYFELII DQVDPFLTAEPTHLRVGWASTSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLWSGRIPR AVASVNQHLLASDDVVSCCLDLGAPSISFRINGQPVQGMFENFNTDGFFFPVVSFSAGVK VRFLMGGRHGEFKFLPPTGYAPCYEALLPKEKMKLEPVKEYKRDSDGIRDLLGTTQFLSQ ANFIPFPIDTSQIVLPFHLEKIRDKLAENIHELWGMNKIELGWTYGKVRDDNKRHHPCLV EFSKLPETEKNYNLQMSTETLKTLLALGCHIVHVNPGAEEDLKKIKLPKNYMMSNGYKPA PLDLSEVKLLPSQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQELKNKRNPRLVPYTLLD ERTKKSNRDSLREAVRTFAGYGYNIEPPDQELADQTVEKVSIDKIRFFRVERSYAVKTGK WYFEFEAVTGGDMRVGWARPGCRPDIELGADEQAFVFEGSKGQRWHQGSGFFGRNWQAGD VVGCMINLDDKSIIFTLNGELLITNKGSELAFADFEIDNGFVPICSLGLSQIGRMNFGRD ASTFKYYTMCGLQEGFEPFAVNMNRDVAVWFSKRLPTFVNVPKSHPHIEVTRIDGNIDSP PRLKVTHKTFGTQNSNADMIYCRLSMPIEFHSSFNYSTGLDLIDGFQKRKQSQELLVHAT TVSYFYSVRIFAGQDPSSVWIGWVTPDYHFYTEHFDLNKNCTVTVTLGDERGRVHESVKR SNCYMVWGGETSVNSQRSGRGNVDLEIGCLVELATGMLSFTANGRELGTFYQVEPNTKLF PAVFLQPTSTNLIQFELGKLKNTMPLSAAIFKSEERNPIPQCPPQLDVQTITPVVWSRMP NSFLKVEAERISDRHGWMVQCLEPLQMMALHIPEESRCIDILELCEQEDLMRFHYHTLKL YSSVCALGNNRVAYALCSHVDVSQLFYAIDNQYLPGFLRSGFFDLLISIHLEYSKEAKLM MNNEFIIPITDETRKIKLFPDESKRHGLPGVGLSTCLKPDFKFSTPCFILSHEDHQKPSP EIPIDMLKSRAISMLTESVYCSGTHIRDPVGGKVEFQFVPVLKLIGTLLIMGVFDDNDVK QILLLIDPYVFGEPKEEAMEKTKKEDVTQVEEKSVEAGEKAIKETKTPVKGLLQTRLPES VKLQMCELLNYFCDCELKHRVEAIVSFADTYVSKLQYNQKYRYNELMQALNMSAALTARK TKEFRSPPQEQINMLLNFQLGEDCPCPEEIREELYEFHDDLLIHCGIPLDEEEEEEEDIS WTGKLRSLIHKLKGPPKTKKREPTEEEEKYPTTLKELISQTMVRWAQENQIQDPELVRIM FNLLRRQYDSIGELLQALRKSYTISAASVQDTINLLAALGQIRSLLSVRMGKEEELLMIN GLGEIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSQIAFPKMVASCCRFLCYFCR ISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALEEPDLEKV VTYLAGCGLQSCPMLLAAGYPDIGWNPIEGERYLSFLRFAVFVNGESVEENASVVVKLLI RRPECFGPALRGEGGNGLLAAMQGAIKISENPTLDLPSQGYKREFLEEDEEEIVHMGNAI MSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPIVNKD GTVTEPDMSASFCPDHKAPMVLFLDRVYGIKDQSFLLHLLEVGFLPDLRACASLDTVSLS TTETALALNRYICTAVFPLLTRCASLFSGTEHYVSLIDSTLHTIYRLSKGRSLTKAQRNT IEECLLAICHHLRPSMLQQLLRRLVFDVPLLNEYCKMPLKLLTNHYEQCWKYYCLPSGWG SSGIAAEEELHLTEKLFWGIFDSLSHKKYDPELFRMALPCLSAIAGALPPDYLDTRINSV LEKQTSMDAEGNFDPKPINTANFTLPEKLEYIVNKYAEHTHDKWACDKSNGGWRYAASLD DNMKTHPLIRPFKTLPEKEKEIYRWPARESLKTMLVMGWSLERTKEGESVVQQRENEKLR SISQSSQGNGYNPAPLDLSNVVLSRDLQGMVEIVAENYHNIWAKKKKIELESKGGGSHPL LVPYDTLTAKEKSRDREKAQDLFKFLLVNGITISRGLNDMDLDASSMEKRFAYKFLKKIL KYVDSAQEFIAHLEATVTSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHCLYFLSSPTKL LSSSGYASNKEKEMVASLFCKLAALVRHRISLFGSDATTMVSCLHILAQTLDTRTVMKSG SELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPILTSIF EHVAQHHFGTDLLLGDVQVSCYRILSSLYSLGTGKNIYVERQRPALGECLASLAAAIPVA FLEPSLNLYNPLSVFNTKTARERAILGMPETVEEMCPEIPHLDGLMKEINSLAESGARYT EMPHVIEVILPMLCNYLSYWWERGPENISESAGPCCTMVTSQHLSIILGNILKIINNNLG IDEATWMKRIAVYAQPIISKARPDLLKSHFIPTLEKLKKKAIKIVMEEEQLKADSKTDTQ EAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKKPDADSDELFRMVAEVFILWCKS HNFKREEQNFVIQNEINNLAFLTGDNKSKISKAMQVKSGGHDQERKKSKRRGDLYSIQTS LIVAALKKMLPIGLNMCTPGDQELISLAKSRYSCKDTEEEVKEHLRNNLHLQEKSDDPAV KWQLNLYKDVLKTDEPADPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQRKR AVVACFRMAPLYNLPRHRSINLFLHGYQKYWIETEEYSFEEKLVQDLATPPQKSEEEEEE TEKHPDPLHQIILHFSRNALTERSKLENDPLYTAYSAMMAKSCQSGDDDEVEEKEDEEKE KTFEEKEMEKQKTLYQQSRLHERGAAEMVLQMISASKGEMGPMVVETLKLGIAILNGGNS VVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRER GEKVLQNDEFTKDLFRFLQLLCEGHNNDFQNYLRTQMGNTTTVNIIISTVDYLLRLQESI SDFYWYYSGKDIIDESGQCNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVV GFLHVFANMQMKLSQDSSQIDLLKELLDLLKDMVVMLLSLLEGNVVNGTIGKQMVDTLVE SSSNVEMILKFFDMFLKLKDLTSSEAFKEYDPEGKGIISKKEFQKAMEGQKQYTQSEIEF LLSCAETDENDMFNYVDFVERFHEPAKDIGFNVAVLLTNLSEHMPNDSRLQTLLDPAESV LNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEK MELFVNFCEDTIFEMQLASQISESDTVDRLDEEEDEPCYVREVGDDKKEEQSLESSSAFA MACVAVKKNSATILKMIKLKNLRKQYRKLRKMTVKELVKVSFSFFWVLFVGFFQMFITLV WGIFQILWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDVLEIEKVEVTEHGITAE IVQFVKTEKGESDILSDIFGTHTQKETGSKHGHDVGLGDIADIIGAESPPLLESTTRKKK KGQIPEIARDDESETRTESEKADMEDGEKQDKIKDDAYSEPLEVEEPRKRKRRHGQKVEK PDAVMANFFKALEIYQTKMLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPFEELEE DSDLWHSLDEDEDEEGVVFFVLQESTGYMAPTLRALAVIHTIISFVCVIGYYCLKVPLVV FKREKDIARKLEFDGLYITEQPSEDDIKGQWDRLVINTLSFPNNYWDKFVKRKVINKYGD LYGAERIAELLGLDKNALDFSPVEHTELEEASLVSWLSSIDAKYHIWKLGVVFTDNSFLY LAWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLY TVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEM YRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTT PHGFEMHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQ YEDQLG NT seq 14601 nt NT seq  +upstreamnt  +downstreamnt atgaacctggggacactgccccagggaccacaggatgatgaagtagtgcttcagtgtgtt gccaacattcacaaagaacagcgcaagttctgcttggcagctgaggggcttgggaatcgc ctttgctttttggaaccgacttcagaagctaaatatgtcccacctgacctttgcatctgc aactttgtactggagcagtctttatcagttcgagccctccaggaaatgcttgccaataca ggagacaattccagtgaaggggcagctcaaggtggtggtcatagaacactgttgtacggc catgctatactgcttcgtcattcattcagtggaatgtatttgacatgcttgactacatca agatctcagacagataagcttgcatttgatgtgggactacaagaaaatgcagcaggtgag gcttgctggtggaccatacatcctgcttctaaacaaaggtctgaaggagaaaaggtacgg attggagatgatcttatcctggttagtgtgtcctctgaaagatacctgcatctttctgta acatatggaaacatacaggtggatgcttcctttatgcaaacactatggaatgttcaccct acttgttcaggaagcagcattgaagaagggtacctacttggagggcatgtattgcgttta tttcatggccatgatgaatgtttgacaattccatctacggaacagaatgattcaccgcac aagcgactgttttatgaagcagggggtgctggtgtccgtgcaaggtcgttgtggagagta gaaccccttcgaataagctggagtgggagtaacatccgctggggacagccctttcgtctt cgccacattacaacagggcagtttttggccctaactgaagatttggggcttgtcttgtta gacagagaaaaggcagacacaaaatcaacttccttttgttttagagcatccaagctggtg aaagaaaaactggattcagctcacaaacgtgatatagaaggcatgggagttcctgaaata aagtatggcgattctgtttgttttgtacagcatgtagccagcgctttatggctaacttat aaggcacaagatgctaaaacaacacgcttaggaccactgaaaagaaaggtcatattacac caagaagggcacatggatgatgggctcacattgcaaagatgtcagcatgaagaatcccag gctgctagaatcattctcaacacaacaagactatttagtcagtttataagtggaaacaat agaacctcaactcccatcaccctgcccattgaagaagtacttcagaccctgcaagattta attacatactttcagcctccagaagaagaactagaacatgaagataagcaaaacaaactt cgttcactcaaaaacagacaaaatttattcaaagaagaggggatgctggcactagttttg aactgcattgatcgcttaaatgtctattatagtactgctcattttactggggttggtaga gaagaaaatggtacaggatggaaagaaattctgaatcttctttacaaattgctagctgct ctcattcgtggtaacagaaacaattgtgcccagttttctaataatcttgattggctaatt agtaaattggacagactagaatcttcttcaggtattttggaagtgttgcactgcatcctg attgaaagcccagaggctttaaatttgatagaagaaggccatatcaaatctatcatctca ctgctggataaacatggacggaaccacaaggtccttgatgtgctttgttctctctgttta tgtaatggagtagcagtgcgtgctaatcagaacttaatctgtgacaatctccttcctcga agagatctgcttttgcaaacacggctggtgaataatgtgacaagtatgaggccaaacata tttcttggaactgctgagggttcagcacaatataggaaatggtactttgaattaataatt gatcaagtagatccatttttgacggcagaacctacacatctaagggttggctgggcttca acatcaggctatgctccttatcctggaggtggagaaggatggggaggcaatggtgttggt gatgacctatactcatacggttttgatggacttcatctatggtctggtcgaatacccaga gcagttgcatctgtcaatcagcatttgctagcatctgatgatgttgtcagctgttgcttg gatttaggggcacccagcatttccttccgcattaatgggcaacctgtgcaagggatgttt gagaacttcaacactgatggattttttttccctgtggtgagcttctcagcaggtgtcaaa gtgcgtttcttaatgggtggccgccatggagagttcaagtttctccctcctactggctat gcaccttgctatgaagctttgcttcctaaagaaaagatgaaactagagccagtaaaagaa tataagagagattcagatggaattcgagatttgcttggtactacacaatttctctcccaa gctaattttattccttttccaattgacaccagccagattgttttgcctttccatcttgag aagatcagagacaagcttgcagaaaatatccatgaactctggggaatgaataaaatagaa cttggttggacttatggcaaggtacgagatgataacaaaaggcatcacccttgtctggtg gaattttcaaagctacctgaaacagagaaaaactataatctacaaatgtcaacagaaact ttgaagacccttttggcccttgggtgccatattgttcatgtaaatccaggagcagaggaa gatctcaagaaaatcaaactgccaaaaaattatatgatgtcaaatggctataagccagct cctctagatctttctgaagtgaaattgttaccatcacaagaagtattggttgataaactt gcagagaatgcacataatgtctgggcaaaagacagaataaaacaaggctggacctacggc attcagcaggaactcaaaaacaaacgaaatcctcgactggtgccctatacgttattagat gaacgtactaagaaatcaaatagagacagccttcgtgaagctgttcgtacctttgcaggc tatggatataatattgaaccaccagatcaagaactagctgaccaaacagtggaaaaagtg agcattgacaagatacgtttcttcagagtagagcgatcttatgcagttaagactggaaag tggtattttgaatttgaagctgtaacaggaggagatatgcgtgttgggtgggcaagacca ggctgtcggcctgacatagaactgggagctgatgaacaagcatttgtgtttgaaggcagc aaaggccaacgttggcaccaggggagtggattctttggacgaaattggcaagcaggagat gtggtgggctgtatgataaatctagatgacaaatcgataatatttaccctgaatggagag ttacttataaccaataaagggtcagagcttgcttttgcggactttgaaatagataatggt tttgtccctatttgctcattgggtctgtctcagattggccgaatgaactttggaagggat gccagcaccttcaagtactatacaatgtgtggtcttcaagaaggttttgaaccttttgct gtcaatatgaatagagatgtggctgtgtggtttagcaaacgcttaccaacttttgtcaat gtaccaaaaagccacccacatattgaggtaacaagaattgatggaaatattgacagccca ccacgcttaaaagttacgcataagacatttggaacacaaaatagtaatgcagacatgata tattgtcgcttgagcatgccaattgaattccattcatcttttaactacagcactggtttg gacctcattgatggtttccagaaaagaaaacaaagccaagaactacttgttcatgccaca acagtaagttacttctattcagtacggatctttgctggtcaagacccatcttcagtctgg attggttgggtaactcctgactaccacttttacactgaacattttgacctaaataagaac tgcacagtaacggttacattgggagatgagagaggcagagttcatgaaagtgtaaaacgt agtaattgttacatggtctggggaggagaaacatctgttaattcacaaagatcaggccgt ggcaacgttgatttagaaatcggatgtcttgttgaattggctactggaatgttgtcattc acagccaatggaagagaactgggaactttctatcaggttgaaccaaacaccaaattattt ccagcagtttttttacagcctacaagcacaaacctgatacagttcgaacttggtaaatta aagaacaccatgcctttatcagcagcaatctttaaaagtgaagagagaaatcctattccc cagtgtcctcctcaactagatgttcagacaatcacacctgttgtgtggagcagaatgcca aatagtttcttaaaagtagaggcagagcgcatcagtgaccgtcatgggtggatggtgcag tgcctggaacctttgcagatgatggcacttcatattccagaagaaagcaggtgtatcgat attttggagctatgtgaacaagaagatttgatgaggttccactaccatactttaaaacta tatagttctgtttgtgcactgggtaataacagagtagcttatgcactttgcagccatgtg gatgtttcccaattattttatgcaatagataatcaatacttgcctggatttttacgttct ggattctttgacttactaatcagcattcatttagaatactccaaggaagctaagctcatg atgaacaatgaatttataattcctattacagatgaaaccagaaaaataaaattatttcca gatgaatccaagagacatggtttgcctggagttgggcttagcacctgcttgaaacccgat tttaagttctctaccccttgtttcattttgtctcatgaggatcatcagaaacctagtcca gagataccgatagacatgcttaagtccagggcgataagcatgctaacagaatcagtctac tgcagtggaactcacatacgagaccctgttggaggaaaagttgagttccagtttgttcct gttcttaaacttataggaactttgctcataatgggagtttttgatgataatgatgttaag cagattttactcctcattgatccatatgtgtttggcgagcccaaggaagaagcaatggag aaaacaaagaaggaggatgttacacaggtagaagaaaaatctgtagaggctggggaaaag gcaatcaaggaaactaaaactccagtaaaaggcttgctgcaaacaagattgcctgaatct gttaaactccagatgtgtgagctgctaaattatttctgcgactgtgaactgaaacacaga gtggaagccattgtatcattcgcagatacttacgtctcaaagttacagtataatcagaaa tacagatataatgaactcatgcaagctttgaatatgtctgctgctttaactgccaggaag acaaaggaatttcgctctcctcctcaagagcagattaatatgttgctgaactttcaactg ggtgaggattgtccttgtccagaagagattcgggaagaactatatgagtttcatgatgat ctcctaatccactgtggtattccattagatgaggaagaggaggaggaggaagatatctca tggactggcaaactacgttcattgatacataaactaaaagggccccccaaaacaaaaaag agagagcctacagaagaagaagaaaaatatcctactacattgaaggagctgatatctcaa acaatggttcgttgggctcaggaaaatcagatccaggatccagaattagttcgtattatg tttaaccttcttcgaagacagtatgatagcattggtgaactgctgcaggctctgaggaag tcttacactataagtgctgcctctgtgcaagatacaatcaacttactagcagcactgggt caaatccggtcacttctcagtgtcagaatgggaaaagaagaagaactgcttatgattaat ggcctaggagagataatgaacaacaaagtattttatcagcatcctaacttaatgagagtc ctgggtatgcatgaaacagttatggaagtaatggtaaatgtgcttggaggagacaaatct cagattgcttttcctaaaatggtggcaagttgctgtcgcttcctctgttacttctgtcga atcagtcgccaaaatcaaaaagccatgtttgaacacctaagttatttacttgaaaatagc agtgttggacttgcctctccttctatgaggggttccactccactagacgtagcagctgcc tctgtaatggacaataatgagcttgcacttgcgttggaggagccagacctagaaaaagtt gtgacctacttggcaggttgtggtcttcagagctgtccaatgcttttagcagcaggatat cctgatattggttggaatccaatagaaggtgaacgatacctatcattcttaaggtttgct gtttttgttaatggcgaaagtgttgaggagaatgccagtgtagttgtcaaacttcttatt cgacggccagaatgttttggtccagctcttagaggcgaaggaggaaatggtttgttggct gccatgcaaggagcaattaaaatatctgagaacccgactctagatcttccctctcagggg tataagagggaattccttgaagaagatgaagaagagatagtgcacatgggcaatgcaatt atgtccttctattcagctcttatagatttgcttgggcgctgtgcaccagaaatgcatctt atccaaactggaaaaggtgaagctattagaattcggtcaatcctgcgctctctggtacca acagaagatttggttgggattataagcataccactaaaattaccaattgtaaacaaagat ggaactgtcactgagccagacatgtctgcaagtttctgtcctgaccataaggcacccatg gtacttttcctagaccgtgtctatggtataaaggatcaaagcttccttctccatctcctg gaggttggatttttaccagatttaagggcatgtgcctcattggatacagtttctttgagt actacagagacagctcttgctctgaacagatatatttgcacagctgtgtttccattactc actcgatgtgcttctctcttttcgggaactgagcattatgtctctctaattgattccaca cttcatacgatatatcgactatccaaagggcgctcccttacaaaagcacaaagaaacaca atagaagaatgcttgcttgctatttgccatcatttacggccttctatgctgcagcagctt ttgcgacgactagtttttgatgtacctttacttaatgagtactgtaaaatgccacttaag cttctaacaaatcactatgagcaatgctggaaatattactgtttgccttctggatgggga agctctggaattgcagctgaagaagaactacatttaactgaaaaacttttctggggaata tttgattccctctctcacaagaagtatgatccagagcttttccgaatggccttgccttgt ttaagtgcaatagctggggctttgccaccagattatttagacacccgaattaactcagtt ttagaaaagcagacgtcaatggatgctgaaggaaactttgatcccaaacctatcaacaca gccaattttacactacctgaaaagttggagtatattgtcaacaagtatgctgaacataca catgacaaatgggcctgtgacaagagtaatggtggatggaggtatgctgcttcacttgat gacaatatgaagacacatcctttaataagaccttttaaaacattgccagaaaaggaaaag gaaatctatcgatggcctgccagagaatctcttaaaaccatgttagtgatgggatggagt ctagagaggaccaaagaaggagaatcagttgtacaacaacgtgaaaatgaaaagcttcgc agcatttcacagtcaagccaaggaaatggatataacccagcacctctagatctttccaat gttgtactctccagggacctccagggaatggttgaaatagtggcagaaaactatcataat atttgggctaagaagaagaaaattgaattagagagtaaaggtggaggtagtcatccttta ttggtaccatatgacactttgacagccaaagaaaagtctcgggatagagaaaaagcacaa gacttgttcaaatttcttctagttaatggaattaccatatctagaggcttaaatgacatg gatttggatgcttcatcaatggaaaagaggtttgcctataaatttttgaaaaagattctc aagtatgttgactctgctcaagaattcattgcacatttagaagccactgttaccagtgga aaaactgagaaatccccacatgaccaagaaatcaaattctttgcgaaagtcctgctacca ttagttgaccaatactttaccaatcattgtctatacttcctctcatccccaactaagcta ctcagcagtagtggatatgcttcaaataaagaaaaagaaatggtagcaagccttttctgc aaacttgctgctcttgttagacataggatttcactttttggtagtgatgctactacaatg gttagctgcctacatatcttagctcagacgctagatacaagaactgtcatgaaatctggt tcagagctggttaaagcaggactgcgtgccttctttgaaaatgcagctgaggatctggag aagacatcagaaaatcttaaacttggaaaatttactcattctcgaacacaaattaaaggg gtctcacagaatatcaactacacaacagtggcattgttacctattttaacttcaattttt gaacacgttgctcagcatcatttcggcaccgatttgcttttaggtgatgtccaagtttca tgttaccgaattctgagtagcctctactctcttggaactgggaagaacatttatgttgaa aggcaacgaccagctcttggtgaatgcttagcttctcttgcagcagcgattccagtagcc tttcttgaaccttccctcaatctttataatcccctgtctgtcttcaacacaaaaactgcc agagagagagctattttaggtatgcctgaaacagtagaagaaatgtgtccagaaatccct cacttggatggcttaatgaaagaaataaacagcttggcagaatctggagccagatacact gaaatgccacatgtgattgaggttatcttgccgatgctgtgcaactatttatcatactgg tgggaaagggggccagaaaacatttctgaaagtgctgggccctgctgtacaatggtaacc tctcagcatctcagtataatactgggaaacattttgaaaatcatcaacaacaacctgggg atagatgaagcaacttggatgaagagaattgcagtgtatgctcagccaattattagcaaa gccaggccggatctgttgaaaagtcattttattccaacactggaaaaactaaagaagaaa gccatcaagatagtaatggaggaggagcaactgaaagcagacagtaaaactgatactcaa gaagcagaactgctcattttagatgaatttgcagtactttgccgagacctttatgctttt tatcctatgttgatccgttacgtagacaacaacagatcaaactggcttaaaaaaccagat gcagattctgatgaacttttccgaatggtagctgaagttttcatcctctggtgtaaatca cataatttcaagagagaagaacaaaattttgtaattcagaatgaaatcaacaatttggca tttttaacaggagacaacaagagtaagatttcaaaagccatgcaagtaaagtctggaggc catgatcaagaacgaaagaaatcaaaacggagaggggatttatactcaatacagacttct ttgattgtagcggcacttaaaaagatgcttcccattggactgaatatgtgtactcctgga gatcaagaactgatttctcttgctaagtctagatacagctgtaaagatacagaagaagag gtcaaagaacatttacgcaataacttgcacttgcaagagaagtcagatgatccagctgtg aaatggcagctgaatctgtacaaagatgtcttgaaaactgatgaacctgctgatcctgag aaaactgtggaacgtgtgcaaaggatctcagcagctgtctttcatctggaacaggttgag caaccattaagatcaaagaaagctgtttggcacaagcttttgtcaaaacaacgtaagagg gctgttgttgcttgtttcaggatggcaccattgtataatctaccaaggcaccgttctatt aacctgttcctccatggttatcagaaatattggatagaaacagaggaatattcctttgag gagaaactagttcaggatttggctactcccccacaaaaaagtgaggaggaggaggaagag actgaaaaacatccagatcctcttcatcagattattcttcatttcagtcggaatgctctc actgaaagaagcaaattggaaaatgaccctctatacacagcatattcagcaatgatggca aagagctgtcagagcggagatgatgatgaagtagaagaaaaggaagacgaagaaaaggaa aaaacatttgaggaaaaagaaatggaaaagcagaaaacactttatcagcaatctcgactc catgaacgtggtgctgctgagatggtattacagatgattagtgccagtaaaggtgaaatg ggccccatggtagttgaaactttgaaacttggaattgccattttaaatggaggtaactca gttgttcaacagaaaatgttggattatctgaaggagaaaaaagatgctggattttttcaa tctctctcgggcttaatgcaatcttgcagtgtccttgacttgaatgcctttgagagacaa aataaagctgaaggccttggaatggttacagaagaaggaacactcatcgtacgtgagcgt ggtgagaaagtactacagaatgatgagtttactaaagatctgtttagatttttgcaactg ctgtgtgaaggtcataacaatgattttcagaactatctacgcactcagatgggtaatact acaacagtgaatattattattagcacagttgattatctgttgcgtcttcaggaatctatc agtgacttctattggtactactctggaaaagatataattgatgaatctggacaatgtaac ttctctaaagcactcgctgtgaccaagcagatttttaattcacttactgaatatatccaa ggtccatgtattggaaaccagcagagtctggctcacagtagactatgggatgctgttgtc ggctttcttcatgtttttgctaacatgcaaatgaaactttcccaggattccagtcagatt gacctactgaaagaactactagaccttttgaaggatatggtggtgatgctcttgtcacta cttgaaggtaatgttgtaaatggcacaattgggaaacaaatggtggacactctggttgaa tcttctagcaatgttgaaatgatcttaaagttcttcgacatgtttctcaaactgaaagat ctaacaagttcagaagctttcaaagaatatgacccagaaggcaaaggcataatctcaaag aaggaattccagaaagccatggaaggtcagaagcaatatacacaatcagagattgagttt ctgttgtcctgtgcagaaactgatgaaaatgatatgtttaactatgttgattttgttgaa agatttcatgagcctgccaaagatattggatttaatgtggcagtgctcttaaccaatctt tcagagcatatgccaaacgattcacgacttcagaccttattagatccagcagaaagtgtc cttaactattttgaaccttatctgggacgcattgagataatgggtggtgccaagaagatt gaaagggtttattttgagatcagtgaatccagtaggacacaatgggaaaagccacaagtg aaagaatcaaaaagacagtttatttttgatgttgtaaatgaaggtggagaacaagagaaa atggagctttttgtaaacttctgtgaggacacaatttttgaaatgcaattggcatctcag atctctgaatcagacacagttgacagacttgatgaggaagaggacgaaccttgctatgtg agggaagttggagatgataagaaagaagaacaatctcttgaatcatcttcagcttttgca atggcatgtgttgctgtgaagaaaaattctgcaaccatcttaaaaatgattaaactgaaa aacttaaggaaacagtacagaaaactaagaaagatgaccgtaaaagaattggtaaaggtg tctttttcatttttctgggtgctgtttgttggatttttccaaatgtttatcactttagtt tggggtatttttcaaattctttggagtacagtgtttgggggtggtctagtggaaggagcc aaaaatataagagttaccaaaatactaggagacatgcctgatccaacacagtttggaatc catgatgatgtcctcgagatagagaaagttgaagttacagaacatggcattacagctgaa attgtgcagtttgtaaaaactgaaaagggagaaagtgacatcttgtcagatatttttggc actcatacacagaaagaaactggatcaaaacatggccatgatgttggcctaggggatatt gctgatattattggagcagaaagccctcctcttttggaaagcacaactcgcaagaagaaa aaagggcagatacctgaaattgcaagggatgatgaatcggaaacaagaacagaatctgag aaggctgacatggaagatggtgagaaacaagataaaataaaagatgatgcatattctgaa cctctggaagttgaagaacctaggaaaaggaagcgaaggcatgggcaaaaagtagagaaa ccagatgcagttatggctaacttttttaaagcattggaaatttaccagacaaaaatgctg cactatttggccagaaatttctacaatttaagatttcttgcactttttgtggccttcgct atcaacttcattctcctcttctacaaggtgacagaagagccatttgaagaactagaagaa gattctgatttatggcattctttggatgaggatgaggacgaagagggagttgtattcttc gtattacaagagagtacaggctacatggcaccaacgctcagagctctagctgttattcat acaatcatttcttttgtatgtgttattggatactactgtttgaaggttcccctggttgta ttcaagagggaaaaagatattgcaaggaaactggaatttgatggtctgtacattactgaa cagccctctgaagatgacattaaaggacaatgggaccgtctggtcataaacactctatct ttcccaaataattattgggacaagtttgtaaaacgaaaggtaatcaacaagtatggtgat ttatatggagcagaacgcattgcagaactcttaggtctggacaaaaacgctctggatttc agtccggtggaacatacggaactagaggaagcatctcttgtttcatggttaagttctatt gatgccaagtaccatatctggaagcttggtgtagttttcacagataattctttcctgtac ttagcttggtacacaactatgtccatccttggccactacaacaacttcttctttgctgct cacttactggatattgctatgggttttaagaccttacgtactatcttgtcttctgtaacc cacaatggcaaacagcttgtattgaccgttggactcttagcagtagtggtatacctttac actgttgtagcattcaactttttccgcaaattttataacaagagtgaagatgaggatgag cctgacatgaagtgtgatgacatgatgacttgttatctcttccatatgtatgttggggta agagcaggtggaggcattggggatgaaattgaagatcctgcaggtgacccttatgaaatg tatcgaattatttttgacatcacatttttcttcttcgtcattgtcatccttctggctatc attcaaggtctgattattgatgcctttggtgaattaagggaccaacaggagcaagttaaa gaagacatggagaccaaatgttttatttgtggaattggtaatgactattttgacacaaca ccccatgggtttgaaatgcatactttacaagagcacaacttggccaactatttgttcttt ctgatgtatctcattaataaggatgaaactgaacacactggacaagagtcatatgtgtgg aaaatgtatcaagaaagatgctgggatttcttcccagctggagattgctttcgtaaacag tatgaagatcaacttggataa

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