Vulpes lagopus (Arctic fox): 121473215
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Entry
121473215 CDS
T07435
Symbol
FPGS
Name
(RefSeq) folylpolyglutamate synthase, mitochondrial isoform X1
KO
K01930
folylpolyglutamate synthase [EC:
6.3.2.17
]
Organism
vlg
Vulpes lagopus (Arctic fox)
Pathway
vlg00790
Folate biosynthesis
vlg01100
Metabolic pathways
vlg01240
Biosynthesis of cofactors
vlg01523
Antifolate resistance
vlg04981
Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:
vlg00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
121473215 (FPGS)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
121473215 (FPGS)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
121473215 (FPGS)
Enzymes [BR:
vlg01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.17 tetrahydrofolate synthase
121473215 (FPGS)
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
bpX5
Motif
Other DBs
NCBI-GeneID:
121473215
NCBI-ProteinID:
XP_041581198
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Position
12:5645392..5665689
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AA seq
588 aa
AA seq
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MSQARRHLRVALFLAAVSPRGATTGVKARRGLSAWPAPQEPGMEYQDAVRTLNTLQTNAG
YLEQVKRQRGDPQTQLEAMKLYLARSGLQVEDLDQLNIIHVTGTKGKGSTCAFTERILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKHFWHLYHRLEETKDSNSCVSMPAYFR
FLTLMAFHIFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGISSLGLDHTSLLGDTVEEI
AWQKGGIFKHGVPAFTVLQPDGPLAVLQDRAQKISCPLYLCPPLEALEEGGPPLTLGLEG
EHQRSNAALALQLARCWLQQKDHQGLGELKVSQPSVLWQMPLAPVFQPTSHMRHGLRDTE
WLGRTQVLRRGPLTWYLDGAHTASSVQACVRWFRQALRRSRVPRRGPEVRVLLFNSTGDR
DPVALLKLLQPCQFDYAVFCPNLTEVSSAGNADQQNFMVTLDQVLLRCLAHQQHWSHLNE
EHASPNLWSPTSLEPGEPTSLLLASHQPHTHSTSSLVFSCISHALQWISQGRDPVFQPPS
PPQGLLAHPVAGSGASLLRDAVAIHVLVTGSLHLVGGVLKLLEPALSQ
NT seq
1767 nt
NT seq
+upstream
nt +downstream
nt
atgtcgcaggcacgccgccacctgcgcgtggctctcttcctggcagcagtttccccgcgc
ggtgcaacgaccggggtcaaggcgcggcgagggttgagcgcgtggcccgcgccgcaggag
cccggcatggagtatcaggatgcagtgcgcacactgaataccctgcagaccaatgctggc
tacctggagcaggtaaagcgccagcggggtgatcctcagacacagctggaagcaatgaag
ctgtacttggcacggagtggtctgcaggtggaagacttggaccagctgaacatcattcac
gtcactgggaccaaggggaagggctccacttgtgccttcacggaacgtattctccgaagc
tacggcctgaagacaggattctttagctctccccacctggtgcaggtgcgggagcggatc
cgcatcaatgggcagcccataagccctgagctcttcaccaagcatttctggcacctctac
caccggctggaggagaccaaggacagcaatagctgtgtctccatgccggcctacttccgc
ttcctcacactcatggccttccacatcttcctccaggagaaggtagacctggcagtagtg
gaagtgggcattggtggtgcttatgactgcaccaacatcatcaggaagcctgtggtgtgt
ggtatctcctctcttggccttgaccacaccagccttctgggggacacagtggaggagatc
gcatggcagaaagggggcatcttcaagcatggcgtccctgccttcacggtgctccagcct
gatggtcccctggcagtgctgcaggaccgtgcccagaagatctcatgtcctctctacctg
tgtccaccactggaagccctggaggaaggggggccgccactgaccctgggcctagaggga
gagcaccagcggtccaatgctgccttagccttgcagctggctcgctgctggctgcagcaa
aaggaccaccaaggccttggggagctgaaggtgtctcagcccagtgtcctgtggcagatg
cccctggcacccgtgttccagcccacgtcccacatgcggcatgggcttcgggacacggag
tggttgggccggacgcaggtgctgcggcgcgggcccctcacctggtacttggacggtgcg
cacaccgccagcagcgtgcaggcctgcgtgcgctggttccgccaggcgctgcgccgcagc
cgggtgccgaggcgcggccctgaggtgcgcgtcttgcttttcaactctacgggggaccgg
gatcccgtggccctgctcaagctgctgcagccctgtcagtttgactatgctgttttctgc
cctaacctgacagaggtgtcatctgctggcaatgcagaccagcagaacttcatggtgacc
ctggaccaggtgttgctccgctgccttgcacaccaacagcactggagccacctgaatgag
gagcatgccagccccaacctctggagccccaccagcctggagcctggtgagcccacctcc
ttgctgttggcttcccaccaaccccacacccatagcaccagctccctcgtcttcagctgc
atctcccacgccctgcagtggatcagccaaggccgggaccctgtctttcagccacccagt
cccccacagggcctccttgcccaccctgtggcaggcagtggggccagcctgctccgcgac
gctgtagccatccacgtactggtcacaggcagcctgcatctagtgggcggtgtcctcaag
ctgctggagcctgccctgtcccagtag
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