KEGG   Vulpes lagopus (Arctic fox): 121478236
Entry
121478236         CDS       T07435                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
vlg  Vulpes lagopus (Arctic fox)
Pathway
vlg00562  Inositol phosphate metabolism
vlg01100  Metabolic pathways
vlg04015  Rap1 signaling pathway
vlg04020  Calcium signaling pathway
vlg04022  cGMP-PKG signaling pathway
vlg04062  Chemokine signaling pathway
vlg04070  Phosphatidylinositol signaling system
vlg04071  Sphingolipid signaling pathway
vlg04072  Phospholipase D signaling pathway
vlg04081  Hormone signaling
vlg04082  Neuroactive ligand signaling
vlg04261  Adrenergic signaling in cardiomyocytes
vlg04270  Vascular smooth muscle contraction
vlg04310  Wnt signaling pathway
vlg04371  Apelin signaling pathway
vlg04540  Gap junction
vlg04611  Platelet activation
vlg04613  Neutrophil extracellular trap formation
vlg04621  NOD-like receptor signaling pathway
vlg04713  Circadian entrainment
vlg04720  Long-term potentiation
vlg04723  Retrograde endocannabinoid signaling
vlg04724  Glutamatergic synapse
vlg04725  Cholinergic synapse
vlg04726  Serotonergic synapse
vlg04728  Dopaminergic synapse
vlg04730  Long-term depression
vlg04742  Taste transduction
vlg04750  Inflammatory mediator regulation of TRP channels
vlg04911  Insulin secretion
vlg04912  GnRH signaling pathway
vlg04915  Estrogen signaling pathway
vlg04916  Melanogenesis
vlg04918  Thyroid hormone synthesis
vlg04919  Thyroid hormone signaling pathway
vlg04921  Oxytocin signaling pathway
vlg04922  Glucagon signaling pathway
vlg04924  Renin secretion
vlg04925  Aldosterone synthesis and secretion
vlg04926  Relaxin signaling pathway
vlg04927  Cortisol synthesis and secretion
vlg04928  Parathyroid hormone synthesis, secretion and action
vlg04929  GnRH secretion
vlg04933  AGE-RAGE signaling pathway in diabetic complications
vlg04934  Cushing syndrome
vlg04935  Growth hormone synthesis, secretion and action
vlg04961  Endocrine and other factor-regulated calcium reabsorption
vlg04970  Salivary secretion
vlg04971  Gastric acid secretion
vlg04972  Pancreatic secretion
vlg04973  Carbohydrate digestion and absorption
vlg05010  Alzheimer disease
vlg05016  Huntington disease
vlg05017  Spinocerebellar ataxia
vlg05022  Pathways of neurodegeneration - multiple diseases
vlg05142  Chagas disease
vlg05143  African trypanosomiasis
vlg05146  Amoebiasis
vlg05163  Human cytomegalovirus infection
vlg05200  Pathways in cancer
vlg05415  Diabetic cardiomyopathy
vlg05417  Lipid and atherosclerosis
Module
vlg_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:vlg00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    121478236 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    121478236 (PLCB4)
   04310 Wnt signaling pathway
    121478236 (PLCB4)
   04371 Apelin signaling pathway
    121478236 (PLCB4)
   04020 Calcium signaling pathway
    121478236 (PLCB4)
   04070 Phosphatidylinositol signaling system
    121478236 (PLCB4)
   04072 Phospholipase D signaling pathway
    121478236 (PLCB4)
   04071 Sphingolipid signaling pathway
    121478236 (PLCB4)
   04022 cGMP-PKG signaling pathway
    121478236 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    121478236 (PLCB4)
   04081 Hormone signaling
    121478236 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    121478236 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    121478236 (PLCB4)
   04613 Neutrophil extracellular trap formation
    121478236 (PLCB4)
   04621 NOD-like receptor signaling pathway
    121478236 (PLCB4)
   04062 Chemokine signaling pathway
    121478236 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    121478236 (PLCB4)
   04922 Glucagon signaling pathway
    121478236 (PLCB4)
   04929 GnRH secretion
    121478236 (PLCB4)
   04912 GnRH signaling pathway
    121478236 (PLCB4)
   04915 Estrogen signaling pathway
    121478236 (PLCB4)
   04921 Oxytocin signaling pathway
    121478236 (PLCB4)
   04926 Relaxin signaling pathway
    121478236 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    121478236 (PLCB4)
   04918 Thyroid hormone synthesis
    121478236 (PLCB4)
   04919 Thyroid hormone signaling pathway
    121478236 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    121478236 (PLCB4)
   04916 Melanogenesis
    121478236 (PLCB4)
   04924 Renin secretion
    121478236 (PLCB4)
   04925 Aldosterone synthesis and secretion
    121478236 (PLCB4)
   04927 Cortisol synthesis and secretion
    121478236 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    121478236 (PLCB4)
   04270 Vascular smooth muscle contraction
    121478236 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    121478236 (PLCB4)
   04971 Gastric acid secretion
    121478236 (PLCB4)
   04972 Pancreatic secretion
    121478236 (PLCB4)
   04973 Carbohydrate digestion and absorption
    121478236 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    121478236 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    121478236 (PLCB4)
   04725 Cholinergic synapse
    121478236 (PLCB4)
   04728 Dopaminergic synapse
    121478236 (PLCB4)
   04726 Serotonergic synapse
    121478236 (PLCB4)
   04720 Long-term potentiation
    121478236 (PLCB4)
   04730 Long-term depression
    121478236 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    121478236 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    121478236 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    121478236 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    121478236 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    121478236 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    121478236 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    121478236 (PLCB4)
   05142 Chagas disease
    121478236 (PLCB4)
   05143 African trypanosomiasis
    121478236 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    121478236 (PLCB4)
   05016 Huntington disease
    121478236 (PLCB4)
   05017 Spinocerebellar ataxia
    121478236 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    121478236 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    121478236 (PLCB4)
   05415 Diabetic cardiomyopathy
    121478236 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    121478236 (PLCB4)
   04934 Cushing syndrome
    121478236 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:vlg04131]
    121478236 (PLCB4)
Enzymes [BR:vlg01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     121478236 (PLCB4)
Membrane trafficking [BR:vlg04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    121478236 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    121478236 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 121478236
NCBI-ProteinID: XP_041589094
LinkDB
Position
18:34627373..35044614
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAIFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
ECSLINSIRLGATPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPVSILEDDNEEEIESADQEEEAHPEYKFGNELSADDLGHKEAVANSVKKASD
DLEHEINKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNRLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQ
SSSELRPTTTAAMGSGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLISAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSSV
KLQNAN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaattggcagaaggaagttccttcctttttgcaagaagga
gccatttttgacagatatgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgaatttggcttctttctgacctggaggagtgaaggcaaggaaggacaagtgcta
gaatgctccctcatcaacagtattcgattgggagccaccccaaaggatcccaaaatcttg
gccgctcttgaggctgttggaaagtcagagaatgatctggaagggcggatagtttgtgtc
tgcagtggcacagatctggtgaacatcagtttcacatacatggtggctgagaatccagaa
gtaactaagcaatgggtagaaggattgagatcaatcatacataacttcagagccaacaat
gttagtccaatgacctgcctcaagaaacactggatgaaattggcatttatgaccaacaca
aatggtaaaattccagtcaggagtattactagaacgtttgcatcggggaaaacagaaaaa
gtgatctttcaagcactcaaggagttaggtcttcccagtggaaagaatgatgaaattgag
cctgcagcatttacttatgagaagttctacgaactgacacaaaagatttgtcctcggaca
gatatagaggatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcagcgagaccctcgactgaatgaaattttattc
ccattttatgatgcaaaaagggcaatgcagatcatcgagatgtatgagcctgatgaagat
ttgaagaaaaaaggcctcatatcaagtgatgggttttgcagatatctgatgtcagatgaa
aatgccccagtcttcctggatcgtttagaactttaccaagaaatggaccaccctctggcc
cactacttcatcagttcttcacataacacctatctcactggccgacagtttggtgggaaa
tcttcagtagaaatgtacagacaggttctcctggctggttgcagatgtgttgaacttgac
tgttgggacggaaaaggtgaagaccaagaaccaataataactcatggaaaagctatgtgt
acagatatcctttttaaggatgttattcaagccatcaaggaaactgcatttgtcacatcc
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgtgaagatctatttggggatctcctgttgaaacaagcacttgaatcacat
ccacttgaaccaggcaggcccttaccatcccccaatgacctcaaaagaaaaatactcatc
aaaaataaacggctgaaacctgaggttgaaaaaaaacagctcgaggctttgaaaagcatg
atggaagctggagaatctgctgctccagttagcatcctagaggatgataatgaagaggaa
atagaaagtgctgaccaagaggaggaagctcaccctgaatacaaatttggaaatgaactt
tctgctgatgacttgggtcacaaggaggctgttgcaaatagtgtcaagaaggcgtcggat
gaccttgaacatgaaatcaacaaaaagggcctggttactgtagaagatgagcaggcatgg
atggcatcatataagtatgtaggtgctaccactaatatccatccatatttgtctacaatg
atcaactatgcacagcctgtaaagtttcaaggtttccatgtggctgaagagcgcaatatt
cattataacatgtcttcttttaatgagtccgttggtctaggctacttgaagacacatgca
attgaatttgtgaattataacaaacggcaaatgagtcgcatttaccccaagggaggccgg
gttgattccagtaattacatgcctcaaattttctggaatgctggctgccagatggtttcg
ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat
ggatcatgtgggtacctcctcaaaccagatttcatgagacggcccgatcgaacctttgat
ccgttttctgaaacgcctgtcgatggggttattgcagccacttgctcagtgcaggtcata
tcaggtcagtttttatcagataagaagattggtacgtacgtagaagtggatatgtatggg
ttgcccaccgacactatccgtaaggaattccgaactcgcatggtgatgaacaatggactc
aatccagtttacaacgaagaatcatttgtgtttcggaaggttatcctccctgacctggca
gtcttgagaatagcagtttatgacgacaacaataggctgataggccagaggattcttccg
ctggatggcctccaagcaggctatcgacacatttcccttcgaaacgagggaaataaacca
ttatcactgccaacaattttctgcaatattgttcttaaaacatatgtgcctgatggattt
ggagatattgtggatgctttatcagatccaaagaaatttctttccattacagaaaagaga
gcagaccaaatgagagctatgggcattgaaactagtgacatagcagatgtgcccagcgat
acttctaagaatgacaagaaaggaaaagccaacactgccaaagcaaatgtgaccccacag
agcagctccgagctcagaccaaccaccacagcagccatggggtctggtgtggaagccaag
aaaggtatcgaacttatccctcaagtgaggatagaagatttaaagcagatgaaggcttac
ctgaagcacttaaagaagcaacagaaggagctaaattctttaaagaagaaacatgcgaag
gaacacagcaccatgcagaagttgcactgcacacaagttgacaaaattgtggcacagtat
gacaaagagaagtcgacacatgagaaaatcctagagaaggcgatgaagaagaagggggga
agtaattgtctcgaaatgaaaaaagaaacagaaattaaaattcagacactgacatcagat
cacaaatctaaggtcaaagagatagtggcccagcacacaaaggagtggtcagaaatgatc
aacacccacagtgctgaggagcaagaaatccgggacctgcaccttagccagcagtgtgag
ctcctgagaaagctactgatcagtgcccatgagcagcagacccagcagctgaaactgtcc
catgacagggaaagcaaggaaatgcgagcacaccaggctaagatttctatggaaaacagc
aaagccatcagccaagataaatctatcaagaacaaagcagaacgggaaaggcgagtcagg
gagttaaatagcagcaacaccaaaaagtttctggaagaaagaaagagacttgcaatgaaa
cagtccaaagaaatggatcagttgaaaaaagtccagcttgaacacctagagttcctagag
aaacagaatgagcagctattgaaatcctgccatgcagtgtcccaaacacaaggcgaagga
gatgcagcagatggtgaaattggaagccgagatggaccgcagaccagcaacagtagtgtg
aaacttcaaaatgcaaactga

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