KEGG   Vulpes lagopus (Arctic fox): 121478805
Entry
121478805         CDS       T07435                                 
Symbol
PIK3CB
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
vlg  Vulpes lagopus (Arctic fox)
Pathway
vlg00562  Inositol phosphate metabolism
vlg01100  Metabolic pathways
vlg01521  EGFR tyrosine kinase inhibitor resistance
vlg01522  Endocrine resistance
vlg01524  Platinum drug resistance
vlg04012  ErbB signaling pathway
vlg04014  Ras signaling pathway
vlg04015  Rap1 signaling pathway
vlg04024  cAMP signaling pathway
vlg04062  Chemokine signaling pathway
vlg04066  HIF-1 signaling pathway
vlg04068  FoxO signaling pathway
vlg04070  Phosphatidylinositol signaling system
vlg04071  Sphingolipid signaling pathway
vlg04072  Phospholipase D signaling pathway
vlg04081  Hormone signaling
vlg04140  Autophagy - animal
vlg04150  mTOR signaling pathway
vlg04151  PI3K-Akt signaling pathway
vlg04152  AMPK signaling pathway
vlg04210  Apoptosis
vlg04211  Longevity regulating pathway
vlg04213  Longevity regulating pathway - multiple species
vlg04218  Cellular senescence
vlg04360  Axon guidance
vlg04370  VEGF signaling pathway
vlg04380  Osteoclast differentiation
vlg04510  Focal adhesion
vlg04550  Signaling pathways regulating pluripotency of stem cells
vlg04611  Platelet activation
vlg04613  Neutrophil extracellular trap formation
vlg04620  Toll-like receptor signaling pathway
vlg04625  C-type lectin receptor signaling pathway
vlg04630  JAK-STAT signaling pathway
vlg04650  Natural killer cell mediated cytotoxicity
vlg04660  T cell receptor signaling pathway
vlg04662  B cell receptor signaling pathway
vlg04664  Fc epsilon RI signaling pathway
vlg04666  Fc gamma R-mediated phagocytosis
vlg04668  TNF signaling pathway
vlg04670  Leukocyte transendothelial migration
vlg04722  Neurotrophin signaling pathway
vlg04725  Cholinergic synapse
vlg04750  Inflammatory mediator regulation of TRP channels
vlg04810  Regulation of actin cytoskeleton
vlg04910  Insulin signaling pathway
vlg04914  Progesterone-mediated oocyte maturation
vlg04915  Estrogen signaling pathway
vlg04917  Prolactin signaling pathway
vlg04919  Thyroid hormone signaling pathway
vlg04923  Regulation of lipolysis in adipocytes
vlg04926  Relaxin signaling pathway
vlg04929  GnRH secretion
vlg04930  Type II diabetes mellitus
vlg04931  Insulin resistance
vlg04932  Non-alcoholic fatty liver disease
vlg04933  AGE-RAGE signaling pathway in diabetic complications
vlg04935  Growth hormone synthesis, secretion and action
vlg04960  Aldosterone-regulated sodium reabsorption
vlg04973  Carbohydrate digestion and absorption
vlg05010  Alzheimer disease
vlg05017  Spinocerebellar ataxia
vlg05020  Prion disease
vlg05100  Bacterial invasion of epithelial cells
vlg05132  Salmonella infection
vlg05135  Yersinia infection
vlg05142  Chagas disease
vlg05146  Amoebiasis
vlg05160  Hepatitis C
vlg05161  Hepatitis B
vlg05162  Measles
vlg05163  Human cytomegalovirus infection
vlg05164  Influenza A
vlg05165  Human papillomavirus infection
vlg05166  Human T-cell leukemia virus 1 infection
vlg05167  Kaposi sarcoma-associated herpesvirus infection
vlg05168  Herpes simplex virus 1 infection
vlg05169  Epstein-Barr virus infection
vlg05170  Human immunodeficiency virus 1 infection
vlg05171  Coronavirus disease - COVID-19
vlg05200  Pathways in cancer
vlg05203  Viral carcinogenesis
vlg05205  Proteoglycans in cancer
vlg05206  MicroRNAs in cancer
vlg05207  Chemical carcinogenesis - receptor activation
vlg05208  Chemical carcinogenesis - reactive oxygen species
vlg05210  Colorectal cancer
vlg05211  Renal cell carcinoma
vlg05212  Pancreatic cancer
vlg05213  Endometrial cancer
vlg05214  Glioma
vlg05215  Prostate cancer
vlg05218  Melanoma
vlg05220  Chronic myeloid leukemia
vlg05221  Acute myeloid leukemia
vlg05222  Small cell lung cancer
vlg05223  Non-small cell lung cancer
vlg05224  Breast cancer
vlg05225  Hepatocellular carcinoma
vlg05226  Gastric cancer
vlg05230  Central carbon metabolism in cancer
vlg05231  Choline metabolism in cancer
vlg05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
vlg05415  Diabetic cardiomyopathy
vlg05417  Lipid and atherosclerosis
vlg05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:vlg00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    121478805 (PIK3CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    121478805 (PIK3CB)
   04015 Rap1 signaling pathway
    121478805 (PIK3CB)
   04630 JAK-STAT signaling pathway
    121478805 (PIK3CB)
   04668 TNF signaling pathway
    121478805 (PIK3CB)
   04066 HIF-1 signaling pathway
    121478805 (PIK3CB)
   04068 FoxO signaling pathway
    121478805 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    121478805 (PIK3CB)
   04072 Phospholipase D signaling pathway
    121478805 (PIK3CB)
   04071 Sphingolipid signaling pathway
    121478805 (PIK3CB)
   04024 cAMP signaling pathway
    121478805 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    121478805 (PIK3CB)
   04152 AMPK signaling pathway
    121478805 (PIK3CB)
   04150 mTOR signaling pathway
    121478805 (PIK3CB)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    121478805 (PIK3CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    121478805 (PIK3CB)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    121478805 (PIK3CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    121478805 (PIK3CB)
   04613 Neutrophil extracellular trap formation
    121478805 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    121478805 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    121478805 (PIK3CB)
   04660 T cell receptor signaling pathway
    121478805 (PIK3CB)
   04662 B cell receptor signaling pathway
    121478805 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    121478805 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    121478805 (PIK3CB)
   04670 Leukocyte transendothelial migration
    121478805 (PIK3CB)
   04062 Chemokine signaling pathway
    121478805 (PIK3CB)
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    121478805 (PIK3CB)
   04929 GnRH secretion
    121478805 (PIK3CB)
   04915 Estrogen signaling pathway
    121478805 (PIK3CB)
   04917 Prolactin signaling pathway
    121478805 (PIK3CB)
   04926 Relaxin signaling pathway
    121478805 (PIK3CB)
   04935 Growth hormone synthesis, secretion and action
    121478805 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    121478805 (PIK3CB)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    121478805 (PIK3CB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    121478805 (PIK3CB)
  09156 Nervous system
   04725 Cholinergic synapse
    121478805 (PIK3CB)
   04722 Neurotrophin signaling pathway
    121478805 (PIK3CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    121478805 (PIK3CB)
  09158 Development and regeneration
   04360 Axon guidance
    121478805 (PIK3CB)
   04380 Osteoclast differentiation
    121478805 (PIK3CB)
  09149 Aging
   04211 Longevity regulating pathway
    121478805 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    121478805 (PIK3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    121478805 (PIK3CB)
   05206 MicroRNAs in cancer
    121478805 (PIK3CB)
   05205 Proteoglycans in cancer
    121478805 (PIK3CB)
   05207 Chemical carcinogenesis - receptor activation
    121478805 (PIK3CB)
   05208 Chemical carcinogenesis - reactive oxygen species
    121478805 (PIK3CB)
   05203 Viral carcinogenesis
    121478805 (PIK3CB)
   05230 Central carbon metabolism in cancer
    121478805 (PIK3CB)
   05231 Choline metabolism in cancer
    121478805 (PIK3CB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    121478805 (PIK3CB)
  09162 Cancer: specific types
   05210 Colorectal cancer
    121478805 (PIK3CB)
   05212 Pancreatic cancer
    121478805 (PIK3CB)
   05225 Hepatocellular carcinoma
    121478805 (PIK3CB)
   05226 Gastric cancer
    121478805 (PIK3CB)
   05214 Glioma
    121478805 (PIK3CB)
   05221 Acute myeloid leukemia
    121478805 (PIK3CB)
   05220 Chronic myeloid leukemia
    121478805 (PIK3CB)
   05218 Melanoma
    121478805 (PIK3CB)
   05211 Renal cell carcinoma
    121478805 (PIK3CB)
   05215 Prostate cancer
    121478805 (PIK3CB)
   05213 Endometrial cancer
    121478805 (PIK3CB)
   05224 Breast cancer
    121478805 (PIK3CB)
   05222 Small cell lung cancer
    121478805 (PIK3CB)
   05223 Non-small cell lung cancer
    121478805 (PIK3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    121478805 (PIK3CB)
   05170 Human immunodeficiency virus 1 infection
    121478805 (PIK3CB)
   05161 Hepatitis B
    121478805 (PIK3CB)
   05160 Hepatitis C
    121478805 (PIK3CB)
   05171 Coronavirus disease - COVID-19
    121478805 (PIK3CB)
   05164 Influenza A
    121478805 (PIK3CB)
   05162 Measles
    121478805 (PIK3CB)
   05163 Human cytomegalovirus infection
    121478805 (PIK3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    121478805 (PIK3CB)
   05169 Epstein-Barr virus infection
    121478805 (PIK3CB)
   05165 Human papillomavirus infection
    121478805 (PIK3CB)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    121478805 (PIK3CB)
   05100 Bacterial invasion of epithelial cells
    121478805 (PIK3CB)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    121478805 (PIK3CB)
   05142 Chagas disease
    121478805 (PIK3CB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    121478805 (PIK3CB)
   05017 Spinocerebellar ataxia
    121478805 (PIK3CB)
   05020 Prion disease
    121478805 (PIK3CB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    121478805 (PIK3CB)
   05418 Fluid shear stress and atherosclerosis
    121478805 (PIK3CB)
   05415 Diabetic cardiomyopathy
    121478805 (PIK3CB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    121478805 (PIK3CB)
   04932 Non-alcoholic fatty liver disease
    121478805 (PIK3CB)
   04931 Insulin resistance
    121478805 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    121478805 (PIK3CB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    121478805 (PIK3CB)
   01524 Platinum drug resistance
    121478805 (PIK3CB)
   01522 Endocrine resistance
    121478805 (PIK3CB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:vlg04131]
    121478805 (PIK3CB)
Enzymes [BR:vlg01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     121478805 (PIK3CB)
Membrane trafficking [BR:vlg04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    121478805 (PIK3CB)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 Tom37_C DUF4381
Other DBs
NCBI-GeneID: 121478805
NCBI-ProteinID: XP_041590073
LinkDB
Position
19:complement(35550849..35756605)
AA seq 1070 aa
MCFNFIMPPAMADILDIWAVDSQLASDGSIPVDFLLPTGIYIQLEVPREATISYIKQILW
KQVHNYPMFNLLMEIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDALKDPEVNDFRIKMRKFSEEKIQSLVGLSWMDWLKQTYPPEH
EPSILENLEDKLYGGKLIVAVHFENCQDVFSFQISPNMNPIKINELAIQKRLTIHGKEDE
VSPNDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFMLVECCKIKKMYEQEMIAI
EAAINRNASNLPLPLPPKKMRIISHVWENNNPFQIVLVKGNKLNTEESVKVHVRAGLFHG
TELLCKTIVSSEISGKNDHIWNEPLEFDINTCDLPRMARLCFAVYAVLDKVKTKKSTKNI
NPCKYQTIRKSGKVHYPVAWVNTMVFDFKGQLRSGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLAVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALANRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAVKLNKAKGKEAMHTCLKQNAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgcttcaatttcataatgcctcctgctatggcagacatccttgacatctgggcagtg
gattcacagttagcatctgatggctccatacctgtggatttccttttgcccactgggatt
tatattcagttggaggttcctcgggaagctaccatttcctatattaagcagattttatgg
aaacaagttcacaattatccaatgtttaacctccttatggaaattgactcctatatgttt
gcatgtgtgaatcaaactgctgtatatgaggagcttgaagatgaaacaagaagactctgt
gatgtcagaccttttcttccagttctcaaattagtgacaagaagttgtgacccaggggaa
aaattagactcaaaaattggagtccttataggaaaaggtctacatgaatttgatgcactg
aaggatcctgaagtgaatgatttccgaataaaaatgcgcaaattcagtgaggaaaagatt
cagtcacttgtgggattgtcttggatggattggctgaagcagacatatccaccagaacat
gaaccatcgatccttgaaaacttagaagataaactttatggaggaaagctcattgtggct
gttcattttgaaaattgtcaggacgtgtttagctttcaaatatctcctaatatgaatcct
atcaaaataaatgaactggcaatccaaaaacgtttaactattcatgggaaagaagatgaa
gttagccccaatgattatgtgttgcaagtcagtgggagagtagaatatgtatttggtgat
cacccactaattcaattccagtatatccggaactgtgtaatgaacaggactttgccccat
tttatgcttgtggaatgttgcaagattaagaagatgtatgaacaggaaatgattgccata
gaggctgccataaatcgaaatgcatcaaaccttcctcttcctttacccccaaagaaaatg
cgaattatttctcatgtttgggaaaataacaatcctttccaaattgtcttggttaaggga
aataaacttaacacagaagaaagtgtaaaagttcatgtcagggctggcctttttcatggt
actgaactcctctgtaaaaccatcgtaagctcagagatatcagggaaaaatgatcacatt
tggaatgaaccactggaatttgatataaatacttgtgacctgccacgaatggctcgatta
tgttttgctgtttatgccgttttagataaagtgaaaacaaaaaagtcaactaaaaatatt
aatccctgtaaatatcagaccatccggaaatctgggaaagtgcattatcctgtggcatgg
gtaaatacgatggtttttgactttaaaggacagttgagatctggagacataatactgcac
agctggtcttcatttcctgatgaacttgaagaaatgttgaatccaatgggaactgttcaa
acaaatccatatactgaaaatgcaacagctttgcatatcaaattcccagagaataaaaaa
caaccttattattatcctccctttgataagataatcgagaaggcagctgagattgcaagc
agtgacagcgctaatgtatcaagtcgaggtggaaaaaagtttcttgctgtactgaaagaa
atcttggacagggatcctttgtctcaactttgtgagaatgaaatggatcttatatggact
ttgagacaagattgcagagagaattttccacagtcactgccaaaattactgctgtcgatc
aagtggaataagcttgaggatgttgctcagcttcaggcactacttcagatttggcctaaa
ctgcccccccgggaggccttagagcttctagatttcaactatccagatcagtacgtgcga
gaatatgctgtgggctgcctgcgacagatgagtgatgaagaactctctcagtatctttta
caactggtgcaagttttaaaatatgagccttttcttgattgtgccctgtctagattcctc
ttagaaagagcgcttgctaatcggaggatagggcagtttctattttggcaccttaggtca
gaagtgcatatccctgctgtctcagtacagtttggtgtcatccttgaagcatactgccgg
ggaagcgtagggcacatgaaagtgctttccaagcaggttgaagcactcaataagttaaaa
actttaaatagtttaatcaaactgaatgcagtgaagctaaacaaagccaaagggaaggag
gccatgcatacttgtttaaaacagaatgcttaccgggaagccctctctgacctgcagtcg
cctctgaatccatgtgttatactttcagaactctatgttgaaaagtgtaaatacatggat
tccaaaatgaagcctttgtggctcgtgtacaacaacaaagtgtttggtgaggattcagtt
ggagtgatttttaaaaatggtgatgatttacgacaagatatgttgacactccagatgctg
cgcttgatggatttactttggaaagaagctggtctggatcttcggatgctgccttatggc
tgtttagcgacaggagaccgctctggcctcattgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgtggctgccgcagcagccttcaacaaagatgcc
cttctgaactggcttaaagaatacaattctggggatgacctagaccgagccattgaagag
tttaccttgtcctgtgccggctactgtgtagcttcttatgtccttgggattggtgataga
catagtgacaacatcatggtcaaaaaaactggccagctcttccacattgactttggacat
attcttggaaatttcaagtctaaatttggcattaaaagggaacgggtgccttttattctt
acctatgatttcattcatgtgattcaacaaggaaaaacaggaaacacagaaaagtttggc
cgcttccgccagtgttgtgaggatgcatatctgatattacgacggcacgggaatctcttc
atcaccctttttgcactgatgttgactgcagggcttcctgagctcacatcagtcaaggat
atacagtatcttaaggactctcttgccttagggaagagtgaagaagaagcactcaagcaa
tttaagcaaaaatttgatgaggcactcagggaaagctggactactaaagtgaactggatg
gcgcacacagttcggaaagactacagatcttaa

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