Vulpes lagopus (Arctic fox): 121480288
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Entry
121480288 CDS
T07435
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
vlg
Vulpes lagopus (Arctic fox)
Pathway
vlg05012
Parkinson disease
vlg05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
vlg00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
121480288 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
121480288 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
vlg01001
]
121480288 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
vlg04131
]
121480288 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
vlg04147
]
121480288 (LRRK2)
Enzymes [BR:
vlg01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
121480288 (LRRK2)
Protein kinases [BR:
vlg01001
]
Serine/threonine kinases: TKL group
LRRK family
121480288 (LRRK2)
Membrane trafficking [BR:
vlg04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
121480288 (LRRK2)
Exosome [BR:
vlg04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
121480288 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
LRR_8
Roc
COR
LRR_4
Ras
LRR_14
LRR_9
WD40_CDC20-Fz
Arf
Beta-prop_RSE1_2nd
LRR_13
LRR_NXF1-5
Beta-prop_EML_2
AAA_22
T2SSE
Ank_2
nSTAND3
Kdo
PduV-EutP
ABC_tran
MMR_HSR1
GTP_EFTU
WDR55
AAA_7
WD40_WDHD1_1st
G-alpha
AAA_16
SRPRB
TniB
TsaE
LRR_6
cobW
MobB
Septin
AAA_29
NACHT
TrwB_AAD_bind
ARM_LIN_2nd
SRP54
Motif
Other DBs
NCBI-GeneID:
121480288
NCBI-ProteinID:
XP_041592672
LinkDB
All DBs
Position
21:32312463..32456318
Genome browser
AA seq
2527 aa
AA seq
DB search
MASGSCQGCEEEDEETLKKLIVRLNNVQEGKQIETLVQILEDMLVFTYADHASKLFQGKK
VHVPVLIVLDLYMRVASVQQVGWSLLCKLIEICPNTMQSLMGPQDIGHDWEVLGVHQLIL
KMLTVHNASVNLLTVGLRALDLLLTSGKITLLILDEESDIFLLIFDAMRTFSANDEVQKL
GCKALRVLFERVSEEQLIEFVENKDYMILLNALKNFKDEEEIVLHVLHCLHSLAIPCNNV
EVLMSGNVRCYNIVVEAMKAFPVHEKIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAV
RRYSENATLQIAALSCLALLTETIFLNQDLEEKNENQENDDEEEEKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKEVFQASAN
ALSTLLEQNVNFRKILLSKGIYFNVLELMQKHIHSPEVAESGCKLLDHLFEGSDATLDIM
AAVAPKIITVMKSHEASSLVQLEALRAILHFIVPGMPEDSREDTEYQHKLNLVKKQCFKN
DIHKLVLAALNRFIGIPGIQKSGLRVISSLAQSPDALEVLSLEGAIDSVLHTLQMYPDDQ
EIQCLGLSLIGCLITKKNLCIGTGHLLAKILASSLQRFKDMAEVQIKGFQTILTILELSM
SFGKLLVHHSFDSVIFHQMSSSILESKDQQFLNLCCKCFAKLAMDDELKSVMLERACDQN
NSIMVECLLLLGADANRTKEATSLICQVCEKASSPKLVELLLNGGSREQDVRKALTISIG
KGDSQIISLLLRRLALDLANNSICLGGFCIGKIEPSWLGPLFPDKTSNLRKETNIGSTLA
RMVLRYQMKSTVEGGAASGSNGNFPEEVLDKLDEWTFIPDSYVDSVFGQSDDLDSEGSEG
SFLVKRKSNSISVGEFYHDRALQRCSPNLQRHSNSLGPIFDHEDFLRRKRKILSSDDSLW
SSKFQSHMRHSDSISSLPSEREYITSLDLSANELRDIDALSQKCCISGHLEHLEKLELHQ
NALTSFPQQLCETLKCLTHLDLHSNKFASFPSYLLKMNCIVNLDVSRNDISPSVVLDPTV
KCPTLKQFNLSYNQLSSFPENLGEVVEKLEQLILEGNKIPGICSPLSLKELKILNLSKNH
ITSLAEDFFEACPKVESFSARINYLAAMPFLPSSLTSLKLSQNRFTCVPEAILNLPHLRS
LDMSSNEIEYLPSPAHWKSLNLRELLFSFNQISILDLSEKAYVWSRVEKLHLSHNKLKEI
PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELRLNFDFKHIGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLTKTKKSDLGVQSATVGIDVKDWPIQI
RGKGKKDLILNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVSDEKQRKACISKITKELLNKRGFPAIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVKEN
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVEGYPK
HPKGIISRRDVEKFLSKKKRFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI
LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIAEGLKFPNEFDELAIQGKLPDPVKEYG
CAPWPMVEKLIKKCLKENPQERPTSAQVFDILNSAELICLMRHISIPKNFSVECMVATNH
NSKNASIWLGCGHPNKGQLSFLDLSTEKHTSEEVTDSRILCLALVHLPVEKESWIVCGTQ
SGMLLVINTEDGAKRHTLEKMTDSVTCLYCNPFPKQSKQRNFLLVGTADGNLAIFEDKTV
KCKGAAPLKILNIGNVSTPLMCLSESMNSTEKNIMWGGCGTKLFSFSDDFTIQKLIETKT
NQLFSYAAFSDSNIIAVVVDTAVYVAKKNSPFVEVRDKKTEKLCELIDCVHFLKEEMVKV
NAESKHKLSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRIIRIIHNFCDSVRVMMT
AQLGSLKNVMLVLGYIRKNTEGTQPQKEIQSCLSVWDINLPHEVQNLEKHIEVRKELAEK
MRRISVE
NT seq
7584 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggcagctgtcagggctgcgaggaggaggacgaggaaactctgaagaagttg
atagtcaggctgaacaatgtccaggaaggaaaacagatagagaccctggtccaaatcctg
gaggatatgctggtgttcacgtacgccgaccacgcctccaagttatttcaaggcaaaaaa
gtccacgtgcctgtgttgatcgtcttggacttgtatatgagagtcgctagtgtgcagcag
gtgggttggtcgcttctttgcaaattgatagaaatctgtccaaatacaatgcaaagctta
atgggacctcaggacattggacatgattgggaagtccttggggttcaccaactgattctt
aaaatgctaacagttcataatgccagtgtaaacctgttaacagttggactgagagcttta
gatctccttctaacttcaggcaaaatcactttgctgatactggatgaagaaagtgatatt
ttcttgttaatttttgatgccatgcgcacattttcagccaatgatgaagtccagaaactt
ggatgcaaagctttacgtgtgctgtttgaaagagtttcagaggagcagttgattgaattt
gttgagaataaagattatatgatcttgctcaatgcattaaaaaattttaaagatgaagag
gaaattgtgcttcatgtactacactgtttacattccctagcaattccttgcaataatgtt
gaagtactcatgagtggcaacgtcaggtgttacaatattgtggtagaagccatgaaagca
ttccctgttcatgaaaaaattcaagaagtgagttgctgcttgctccataggcttacatta
ggtaatttttttaacattctggtattaaacgaggtacatgagtttgtggtgaaagctgtg
aggcggtattcagagaacgccacattacagattgcagcactcagctgtttagcgctcctc
actgagactattttcttaaatcaagacttagaggaaaagaatgagaatcaggagaatgat
gatgaggaagaagaaaaattgttctggttggaagcctgttacaaagcattaacatggcat
agaaaaaacaagcacgtgcaggaagctgcatgctgggctctaaacaatctccttatgtac
caaaacagtttacatgagaagattggagatgaagatggccagttcccagctcatagggaa
gtgatgctgtccatgctgatgcattcttcatcaaaagaagtcttccaggcatctgcaaat
gcgttgtcgactctattagaacaaaacgttaatttcagaaaaatcctgttgtcaaaagga
atatacttcaatgtattggagttaatgcagaagcatatacattctcctgaagttgctgaa
agtggctgtaaactgctagatcatctctttgaaggaagtgatgctaccctggatataatg
gcagcagtggcccccaaaatcataacagttatgaaaagtcatgaggcatcctcattggtg
cagctggaggcactccgagctattttacattttatagttccaggcatgccagaagattcc
agggaagatactgaatatcaacataagctaaatctggttaagaagcagtgtttcaagaat
gatattcataaactggtcctagcagctttgaacaggttcattggaattcctgggattcaa
aaaagtggattgagagtaatttcttctctagcacaatctcctgatgcattagaagtatta
tccttggaaggtgctattgattcagtgcttcacacactgcagatgtacccagatgaccaa
gaaattcaatgtctggggttaagtcttataggatgcttgattacaaagaagaatttatgc
ataggaactgggcatctgctggcaaaaattctggcttccagtttacaacgatttaaagat
atggctgaagtacagattaaaggatttcagacaatcttgacaatactagaattgtcaatg
tcttttggaaagctgctggtgcatcattcctttgattctgtgatattccatcagatgtct
tccagtatccttgaatcaaaggatcaacagtttctaaacctttgttgcaagtgctttgcg
aaattagctatggatgatgagttaaaaagtgtgatgctggagagagcatgcgatcagaat
aacagtatcatggttgaatgcttgcttctgttgggagcggacgccaatcgaacaaaggaa
gcaacatctttaatttgtcaggtatgtgagaaagcgagcagtcccaaattggtggaactg
ttattgaatggtggttcccgtgaacaagatgttcggaaagccttgacaataagcattgga
aaaggtgacagccaaatcatcagcttactcttaaggagacttgccctggatctggccaat
aatagcatttgccttggaggattttgtataggaaaaatcgaaccttcgtggcttggtcct
ttatttccggataagacatctaatttaagaaaagaaacaaatataggatccaccctagca
agaatggtgctcaggtatcagatgaaaagtactgtggaaggaggggcagcctcaggcagc
aatggaaattttcctgaagaagtacttgataaattggatgaatggaccttcattccagac
tcttacgtggacagtgtgtttggtcaaagtgatgacctggatagtgaaggaagtgaaggt
tcatttcttgtgaaaagaaaatccaattcaattagtgtaggagaattttaccatgatcgt
gccttgcagcgttgctcaccaaatttgcaaaggcattccaattcattgggacccattttc
gatcatgaagatttcctgaggcgaaaaagaaaaatattgtcttcagatgactcactctgg
tcatcaaaatttcaatcccatatgagacattcagacagcatttcttccttgccttctgag
agagaatatattacatcattggacctttcagcaaatgaactaagagatattgatgcccta
agccagaaatgctgtataagtggtcatttggagcatcttgaaaagctggagcttcaccag
aatgcacttacaagctttccacaacaactgtgtgaaacgctgaagtgtttgacacatttg
gacttgcacagtaataaatttgcatcatttccctcttacctgttgaaaatgaattgtatt
gtcaaccttgatgtctctcgaaacgacatcagcccctcagtagttctggatcctacagtg
aagtgcccaaccttgaaacagtttaacttgtcatataatcagctgtcttcttttcctgag
aaccttggcgaagtggtagagaaattggaacagctcattttagaaggaaataagatacca
ggaatatgttcccccttaagcctgaaggaactgaagattttaaaccttagtaaaaaccac
attacatccctagcagaggacttctttgaggcatgtcctaaagtggagagtttcagtgcc
agaattaattatcttgctgctatgccttttttgccttcttctctgacaagcctaaaatta
tctcaaaacagatttacatgtgttccagaagcaattttaaatcttccacacttgcgatcc
ttagatatgagcagcaatgaaattgagtatctaccgagtcctgcacactggaaatctttg
aacttaagggaactcttgttcagttttaatcagatcagcatcttggacttgagtgaaaaa
gcttatgtgtggtcaagagtagagaaactacatctttctcataataaactgaaggagatt
cctccagagattggctgtcttgaaaacctgacctcccttgatgtcagttacaatttggaa
ctgagatcctttcctaatgaaatggggaaattaagcaaaatatgggaccttcctttggat
gaactacggcttaattttgattttaaacatataggatgtaaagccaaagacatcataagg
tttcttcaacagcggttaaaaaaggctgtgccctataaccgaatgaagcttatgattgtg
ggaaatactgggagtggtaaaactaccttattgcagcaattaacaaaaaccaagaaatca
gatcttggggtgcagagtgccacagttggtatagatgtgaaagactggcctatccaaata
agaggcaaagggaagaaagacctcattttaaatgtgtgggattttgcaggtcgtgaggaa
ttctacagcacgcatccccacttcatgacccaacgagccctttaccttgctgtttatgac
ctcagcaaagggcaggctgaagtggatgccatgaagccttggctcttcaatataaaggct
cgtgcttcttcttcccctgtgatcctcgttggcacgcatttggatgtttctgatgaaaag
cagcgtaaagcctgcataagtaaaatcaccaaggaactcttgaacaagcgagggtttcct
gcaataagggattaccactttgtgaatgccactgaggaatctgatgctttggcaaaactt
cggaaaaccatcataaatgagagtcttaattttaagatccgagatcagcctgttgttggg
cagctgattccagactgttatgtagaacttgagaaaatcattttatcagagcgtaaaaat
gtgccaattgaatttcctgtaatcgaccggaaacgattattacaacttgtaaaggaaaat
cagctgcagttggatgaaaatgagctccctcatgcagttcacttcctaaatgaatcaggg
gtccttcttcattttcaagatccagctctgcagttaagtgacttatattttgtggaaccc
aagtggctttgtaaagtcatggcacagattttgacagtgaaagtggaaggctatccaaaa
catcctaagggaatcatttcacgtagagatgtggaaaaatttctttcaaagaaaaagaga
tttccaaagaactacatgtcacagtattttaaactgctagaaaaattccagattgccttg
ccaataggagaagaatatttgctggttccaagcagtttgtctgatcacaggcctgtgata
gagcttccccattgtgagaactctgaaattatcattcgactatacgaaatgccttatttt
ccaatgggattttggtcgaggttaatcaatcgattacttgaaatttcaccttacatgctt
tcaggaagagaacgagcacttcgcccaaacagaatgtattggcgacaaggcatctacttg
aattggtctcctgaagcttattgtctggtaggatctgaagtcttagacaatcacccagag
agtttcttaaaaattacagttccttcttgtagaaaaggctgtattcttttgggccaagtt
gtggatcacattgattctctgatggaagaatggtttcctggattgctggagattgatatc
tgtggtgaaggagaaactctgttgaagaaatgggcattatatagttttaatgatggtgaa
gagcatcaaaaaatcttacttgacgacttgatgaagaaagcagaagaaggagaccttcta
gtaaatccagatcaaccaaggctcaccattccaatatctcaaattgctcctgacttaatt
ttggctgacttacctagaaatattatgctgaataatgatgaattggaatttgaacaagct
ccagagtttctcttaggtgatggcagttttggatctgtttatcgagcagcctatgaagga
gaagaggtggctgtgaagattttcaataaacatacatcacttagactgttaagacaagag
ctggtggtcctttgccacctccaccaccccagcttaatatctttgctggcggctgggatt
cgtcctcgcatgttggtgatggagttggcctccaagggttcgctggaccgcttgcttcag
caggacaaagccagtctcaccagaactctgcagcacagaattgcactacacgtggctgat
ggcttgagatacctccactcagccatgattatataccgtgacttgaagccccacaatgtg
ttgctcttcaccctgtaccccaatgctgccatcatcgcaaagattgctgactatgggatt
gctcagtactgctgtagaatggggataaagacgtcagagggcacaccaggatttcgtgca
cctgaagttgctagaggaaacgttatttataaccaacaggctgatgtttattcatttggt
ttactcctctatgacattttgacaactggaggtagaatagcagagggtttgaagtttcca
aatgagtttgatgaactggcaatacaaggaaaattacctgatccagttaaagaatatggc
tgtgccccctggcccatggttgagaagttaattaaaaagtgtttgaaagaaaatcctcaa
gaaaggcctacttctgcccaggtctttgacattttgaattcagctgagttaatctgtctg
atgagacatatatcaatacctaaaaactttagtgttgaatgcatggtcgctacaaatcat
aacagcaagaatgcaagcatctggctgggctgtgggcacccgaacaaaggacagctctca
tttcttgacttaagtacagaaaagcacacttctgaggaagttactgatagtagaatactg
tgcctggctttggtgcatcttcctgttgaaaaggaaagttggattgtgtgtgggacacag
tctggcatgctcctggtcatcaataccgaagatggggcaaagagacatacccttgaaaag
atgactgattctgtgacttgcttgtattgcaatccctttcccaagcaaagcaagcaaaga
aattttcttctggtggggactgctgatggcaatttagcaatttttgaagataaaactgtt
aagtgtaaaggagccgctcctttgaagatactaaatataggaaatgtcagtactccactg
atgtgtttgagtgaatccatgaattcaactgaaaaaaacattatgtggggaggatgtggt
acaaaacttttctcattttctgatgatttcaccattcagaaactcattgagacaaagaca
aatcagctgttttcttatgcagcattcagtgattccaacatcatagcagtggtggtagac
acggctgtctacgtagctaagaaaaatagcccatttgtggaagtacgggataagaaaact
gaaaaactctgtgaactaatagactgtgtgcactttttaaaggaggaaatggtaaaagta
aatgcagagtcaaaacacaagctctcttactctgggagagtgaaaaccctctgcctccag
aagaacactgctctctggataggaactggaggaggccatattttactccttgatctctcg
actcgtcgaattatacgtataattcacaatttttgtgattctgtcagagtcatgatgaca
gcacaattaggaagccttaaaaatgtcatgctggttttggggtatatccggaaaaatact
gaaggtacacaaccccaaaaagagatacaatcttgtttgtctgtttgggacatcaatctt
ccacatgaagtgcaaaatttagaaaaacatattgaagtgagaaaagaattagctgaaaaa
atgagaagaatatcggttgaataa
DBGET
integrated database retrieval system
