KEGG   Vulpes lagopus (Arctic fox): 121484067
Entry
121484067         CDS       T07435                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
vlg  Vulpes lagopus (Arctic fox)
Pathway
vlg01521  EGFR tyrosine kinase inhibitor resistance
vlg01522  Endocrine resistance
vlg04010  MAPK signaling pathway
vlg04012  ErbB signaling pathway
vlg04014  Ras signaling pathway
vlg04015  Rap1 signaling pathway
vlg04022  cGMP-PKG signaling pathway
vlg04024  cAMP signaling pathway
vlg04062  Chemokine signaling pathway
vlg04066  HIF-1 signaling pathway
vlg04068  FoxO signaling pathway
vlg04071  Sphingolipid signaling pathway
vlg04072  Phospholipase D signaling pathway
vlg04114  Oocyte meiosis
vlg04140  Autophagy - animal
vlg04148  Efferocytosis
vlg04150  mTOR signaling pathway
vlg04151  PI3K-Akt signaling pathway
vlg04210  Apoptosis
vlg04218  Cellular senescence
vlg04270  Vascular smooth muscle contraction
vlg04370  VEGF signaling pathway
vlg04371  Apelin signaling pathway
vlg04380  Osteoclast differentiation
vlg04510  Focal adhesion
vlg04540  Gap junction
vlg04550  Signaling pathways regulating pluripotency of stem cells
vlg04613  Neutrophil extracellular trap formation
vlg04620  Toll-like receptor signaling pathway
vlg04650  Natural killer cell mediated cytotoxicity
vlg04660  T cell receptor signaling pathway
vlg04662  B cell receptor signaling pathway
vlg04664  Fc epsilon RI signaling pathway
vlg04666  Fc gamma R-mediated phagocytosis
vlg04668  TNF signaling pathway
vlg04720  Long-term potentiation
vlg04722  Neurotrophin signaling pathway
vlg04725  Cholinergic synapse
vlg04726  Serotonergic synapse
vlg04730  Long-term depression
vlg04810  Regulation of actin cytoskeleton
vlg04910  Insulin signaling pathway
vlg04912  GnRH signaling pathway
vlg04914  Progesterone-mediated oocyte maturation
vlg04915  Estrogen signaling pathway
vlg04916  Melanogenesis
vlg04917  Prolactin signaling pathway
vlg04919  Thyroid hormone signaling pathway
vlg04921  Oxytocin signaling pathway
vlg04926  Relaxin signaling pathway
vlg04928  Parathyroid hormone synthesis, secretion and action
vlg04929  GnRH secretion
vlg04934  Cushing syndrome
vlg04935  Growth hormone synthesis, secretion and action
vlg05010  Alzheimer disease
vlg05022  Pathways of neurodegeneration - multiple diseases
vlg05034  Alcoholism
vlg05132  Salmonella infection
vlg05135  Yersinia infection
vlg05160  Hepatitis C
vlg05161  Hepatitis B
vlg05163  Human cytomegalovirus infection
vlg05164  Influenza A
vlg05165  Human papillomavirus infection
vlg05166  Human T-cell leukemia virus 1 infection
vlg05167  Kaposi sarcoma-associated herpesvirus infection
vlg05170  Human immunodeficiency virus 1 infection
vlg05200  Pathways in cancer
vlg05205  Proteoglycans in cancer
vlg05206  MicroRNAs in cancer
vlg05207  Chemical carcinogenesis - receptor activation
vlg05208  Chemical carcinogenesis - reactive oxygen species
vlg05210  Colorectal cancer
vlg05211  Renal cell carcinoma
vlg05212  Pancreatic cancer
vlg05213  Endometrial cancer
vlg05214  Glioma
vlg05215  Prostate cancer
vlg05216  Thyroid cancer
vlg05218  Melanoma
vlg05219  Bladder cancer
vlg05220  Chronic myeloid leukemia
vlg05221  Acute myeloid leukemia
vlg05223  Non-small cell lung cancer
vlg05224  Breast cancer
vlg05225  Hepatocellular carcinoma
vlg05226  Gastric cancer
vlg05230  Central carbon metabolism in cancer
vlg05231  Choline metabolism in cancer
vlg05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:vlg00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    121484067 (MAP2K1)
   04012 ErbB signaling pathway
    121484067 (MAP2K1)
   04014 Ras signaling pathway
    121484067 (MAP2K1)
   04015 Rap1 signaling pathway
    121484067 (MAP2K1)
   04370 VEGF signaling pathway
    121484067 (MAP2K1)
   04371 Apelin signaling pathway
    121484067 (MAP2K1)
   04668 TNF signaling pathway
    121484067 (MAP2K1)
   04066 HIF-1 signaling pathway
    121484067 (MAP2K1)
   04068 FoxO signaling pathway
    121484067 (MAP2K1)
   04072 Phospholipase D signaling pathway
    121484067 (MAP2K1)
   04071 Sphingolipid signaling pathway
    121484067 (MAP2K1)
   04024 cAMP signaling pathway
    121484067 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    121484067 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    121484067 (MAP2K1)
   04150 mTOR signaling pathway
    121484067 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    121484067 (MAP2K1)
   04148 Efferocytosis
    121484067 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    121484067 (MAP2K1)
   04210 Apoptosis
    121484067 (MAP2K1)
   04218 Cellular senescence
    121484067 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    121484067 (MAP2K1)
   04540 Gap junction
    121484067 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    121484067 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    121484067 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    121484067 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    121484067 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    121484067 (MAP2K1)
   04660 T cell receptor signaling pathway
    121484067 (MAP2K1)
   04662 B cell receptor signaling pathway
    121484067 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    121484067 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    121484067 (MAP2K1)
   04062 Chemokine signaling pathway
    121484067 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    121484067 (MAP2K1)
   04929 GnRH secretion
    121484067 (MAP2K1)
   04912 GnRH signaling pathway
    121484067 (MAP2K1)
   04915 Estrogen signaling pathway
    121484067 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    121484067 (MAP2K1)
   04917 Prolactin signaling pathway
    121484067 (MAP2K1)
   04921 Oxytocin signaling pathway
    121484067 (MAP2K1)
   04926 Relaxin signaling pathway
    121484067 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    121484067 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    121484067 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    121484067 (MAP2K1)
   04916 Melanogenesis
    121484067 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    121484067 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    121484067 (MAP2K1)
   04726 Serotonergic synapse
    121484067 (MAP2K1)
   04720 Long-term potentiation
    121484067 (MAP2K1)
   04730 Long-term depression
    121484067 (MAP2K1)
   04722 Neurotrophin signaling pathway
    121484067 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    121484067 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    121484067 (MAP2K1)
   05206 MicroRNAs in cancer
    121484067 (MAP2K1)
   05205 Proteoglycans in cancer
    121484067 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    121484067 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    121484067 (MAP2K1)
   05230 Central carbon metabolism in cancer
    121484067 (MAP2K1)
   05231 Choline metabolism in cancer
    121484067 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    121484067 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    121484067 (MAP2K1)
   05212 Pancreatic cancer
    121484067 (MAP2K1)
   05225 Hepatocellular carcinoma
    121484067 (MAP2K1)
   05226 Gastric cancer
    121484067 (MAP2K1)
   05214 Glioma
    121484067 (MAP2K1)
   05216 Thyroid cancer
    121484067 (MAP2K1)
   05221 Acute myeloid leukemia
    121484067 (MAP2K1)
   05220 Chronic myeloid leukemia
    121484067 (MAP2K1)
   05218 Melanoma
    121484067 (MAP2K1)
   05211 Renal cell carcinoma
    121484067 (MAP2K1)
   05219 Bladder cancer
    121484067 (MAP2K1)
   05215 Prostate cancer
    121484067 (MAP2K1)
   05213 Endometrial cancer
    121484067 (MAP2K1)
   05224 Breast cancer
    121484067 (MAP2K1)
   05223 Non-small cell lung cancer
    121484067 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    121484067 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    121484067 (MAP2K1)
   05161 Hepatitis B
    121484067 (MAP2K1)
   05160 Hepatitis C
    121484067 (MAP2K1)
   05164 Influenza A
    121484067 (MAP2K1)
   05163 Human cytomegalovirus infection
    121484067 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    121484067 (MAP2K1)
   05165 Human papillomavirus infection
    121484067 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    121484067 (MAP2K1)
   05135 Yersinia infection
    121484067 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    121484067 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    121484067 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    121484067 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    121484067 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    121484067 (MAP2K1)
   01522 Endocrine resistance
    121484067 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:vlg01001]
    121484067 (MAP2K1)
Enzymes [BR:vlg01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     121484067 (MAP2K1)
Protein kinases [BR:vlg01001]
 Serine/threonine kinases: STE group
  STE7 family
   121484067 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 121484067
NCBI-ProteinID: XP_041598661
LinkDB
Position
2:complement(50964196..51042865)
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDVAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDGEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctcggcggtg
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagcttgatgagcagcagcggaagcgccttgaggcctttctcacccagaagcagaaggtc
ggggaactgaaggatgatgacttcgagaagatcagtgagctgggtgctggcaacggtggc
gtggtgttcaaggtctcccacaagccgtccggcctagtcatggccagaaagctaattcac
ctggagatcaaacctgcaatccggaaccagatcataagggagctacaggttctacatgag
tgcaactccccgtacatcgtgggcttctatggtgcattctacagcgatggcgagatcagt
atctgcatggagcacatggatgggggttccttggatcaagtcctgaagaaagctggaaga
attcctgaacaaattctaggaaaagttagcatcgctgtaataaaaggtctgacatacctg
agggagaagcacaagattatgcacagagatgtcaagccttccaacatccttgtgaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcattgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tccgtgcagtcggacatctggagcatggggctctctctggtggagatggcggttgggagg
tatcccatccctcctccggatgccaaggagctggagctgatgtttgggtgccaagtggag
ggagacgtggctgagaccccacccagaccaaggaccccgggaagaccccttagctcttat
ggaatggacagccgaccgcccatggcaatttttgagctgttggattacatagtcaatgag
cctcctccaaaactgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaacccagcagagagagcagatctgaagcaactcatggttcatgccttc
atcaagagatctgacggtgaagaagtggattttgcaggttggctctgctccaccattggc
cttaaccagcccagcacgccgacccacgcagctggcgtctaa

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