Vulpes lagopus (Arctic fox): 121486536 Help Entry 121486536         CDS       T07435                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism vlg  Vulpes lagopus (Arctic fox) Pathway vlg04020   Calcium signaling pathway vlg04024   cAMP signaling pathway vlg04260   Cardiac muscle contraction vlg04261   Adrenergic signaling in cardiomyocytes vlg04371   Apelin signaling pathway vlg04713   Circadian entrainment vlg04911   Insulin secretion vlg04921   Oxytocin signaling pathway vlg04972   Pancreatic secretion vlg05020   Prion disease vlg05022   Pathways of neurodegeneration - multiple diseases vlg05410   Hypertrophic cardiomyopathy vlg05412   Arrhythmogenic right ventricular cardiomyopathy vlg05414   Dilated cardiomyopathy vlg05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:vlg00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     121486536 (RYR2)    04020 Calcium signaling pathway     121486536 (RYR2)    04024 cAMP signaling pathway     121486536 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     121486536 (RYR2)    04921 Oxytocin signaling pathway     121486536 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     121486536 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     121486536 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     121486536 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     121486536 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     121486536 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     121486536 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     121486536 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     121486536 (RYR2)    05414 Dilated cardiomyopathy     121486536 (RYR2)    05415 Diabetic cardiomyopathy     121486536 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:vlg04040]     121486536 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:vlg04990]     121486536 (RYR2) Ion channels [BR:vlg04040]  Voltage-gated cation channels   Ryanodine receptor    121486536 (RYR2) Domain-containing proteins not elsewhere classified [BR:vlg04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    121486536 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  121486536 NCBI-ProteinID:  XP_041603412 LinkDB All DBs Position 3:85654397..86381370 Genome browser AA seq 4975 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV TTGKYLSLMEDKSLLLMDKENADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSV CYIQHINTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKVRASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD DLFSYGFDGLHLWSGCIARTVSSPNQHLLKTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREY KQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEEK VKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSG TGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGSDEHAFAFDGF KAQRWHQGNEHYGRSWQAGDVVGCMVDMTERTMMFTLNGEVLLDDSGSELAFKDFDVGDG FIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSSTDIMFYRLSMPIECAEVFSKTVAG GLPGTGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEK PSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPAN VWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR NNNGLEIGCVVDAASGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRI KNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQ CLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHV DEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNSEFIVPMTEETKSITLFP DENKKHGLPGIGLSTSLRPRIQFSSPSFVSINNECYQYSPEFPLDILKAKTIQMLTEAVK EGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPDEE TEALEKEPCPEDSKSEGAGEEEAKGVKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRH RIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFK DDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLK KKQAEKPIESDSKKSSTLQQLISETMVRWAQESVIEDPDLVRAMFVLLHRQYDGIGGLVR ALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPN LMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSY LLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQML VSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGG NGLLAAMEEAIKIAEDPSRDGPSPTSGSSKTLDTEEEEDDTIHMGNAIMTFYSALIDLLG RCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGF CPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYL CTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQL RPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHL SRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGN FNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPY KLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHG YSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAK EKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYI LEFDGGGRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKE KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAF LDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGED LILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPIAFLETHLDKHNI YSIYNTKSSRERAALNLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILP MLCSYMSRWWEHGPENNPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLA VFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEFT TLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEDLFRMVAEVFIYWSKSHNFKREEQNFV VQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNI CAPGDQELIALAKNRFSMKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTED TSDPEKTVERVLDIANVLFHLEQKSTCMRRRYYSLVEHPQRSKKAVWHKLLSKQRKRAVV ACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGADPPEEEESTKR VDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQ RSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGDTGPMVAATLKLGIAILNGGNST VQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQD DEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYY SGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFA HMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEM ILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAET DENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPF LGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNF CEDTIFEMQLAAQISESDLNERSVSKEESEKEKPEEQGPRMGFFSILTVKSALLALRYNV LTLMRMLSLKSLKKQMKRVKKMTVKDMVMAAFSSYWNIFMSLLHFVASVSRGFFRIICSL LLGGSLVEGAKKIRVAELLANMPDPTQDEVRGDSEEGDRKPMEASLPSEDLTDLKELTEE SDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPIPDVQEKFQEQKAKEEEKEEK EENKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLL NYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELSTRSSSENAKVSSLDSGSP RIITVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEF DGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGM DKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSILG HYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKF YNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFF FVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQE HNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14928 nt NT seq  +upstreamnt  +downstreamnt atggccgacgggggcgagggcgaggacgagatccagttcctgcgaactgatgatgaagtg gttctgcagtgtaccgcaaccatccacaaagaacaacagaagctgtgtttggcagcagaa ggctttggcaacagactttgtttcttggagtccacttcaaattccaagaatgttcctcca gacctctccatctgcacctttgtgctggaacagtctctctctgtccgggctctgcaagag atgctggctaacacggtggagaagtcagaagggcaagttgatgtggaaaaatggaaattc atgatgaagactgctcaaggtggtggtcatcgaacacttctctatggacatgccatattg ctacgccattcctacagtggtatgtatctgtgctgcctctccacctcccggtcttcaact gataaactggcctttgatgttggcttgcaagaggacacaacaggtgaggcttgctggtgg actattcaccctgcctctaagcagcggtcggaaggagaaaaggttcgagttggagatgac ctcatcttagtcagtgtgtcctctgagaggtacctgcacttgtcttatggcaacggcagc ttacacgtggatgctgctttccagcagactctttggagcgtggccccaatcagctcagga agcgaagcagcccaagggtatctaattggtggtgacgtcctcaggttgctgcatggacac atggatgaatgcctcactgtcccttcgggagagcacggtgaagagcagcggagaactgtt cactatgaaggtggtgctgtatctgttcatgcacgttccctgtggaggctagagacacta agagttgcgtggagtggaagccacataagatggggccagcctttccgactacgccatgtc acaacaggaaaatacttgagtctcatggaagacaaaagccttctactcatggacaaagaa aacgcagatgtaaaatcaacagcatttaccttccgatcttccaaggaaaaattggatgtg ggtgtgagaaaagaagtagatggcatggggacatctgaaataaaatatggagactcagta tgctatatacaacatataaatacaggcctatggcttacctaccagtctgtggatgtaaaa tcagtgagaatgggatccatacaacgtaaggctattatgcatcatgaaggtcacatggat gatggcttaaatttatccagatctcagcatgaagaatcacggactgcacgagtcattcgg agcacagttttccttttcaatagatttataaggggcctcgatgcgctcagcaagaaagtg agggcctccactgtggacctccctatagagtctgtgagtctaagtctgcaagacttgatt ggctacttccaccccccggatgagcacttggagcatgaagacaagcagaacagattgcga gctctcaagaaccggcaaaacctcttccaggaagagggaatgatcaacctcgtgctcgag tgtatagacaggctgcatgtgtacagcagcgcggcacactttgctgatgttgctgggaga gaagcaggcgagtcctggaagtcgattttgaattctctctatgagttgctagcggcttta attagaggaaatcgtaaaaactgtgctcaattttctggctcccttgattggttgatcagc cgactagaaagactggaagcttcttctgggattcttgaagttttacactgtgtgttagta gaaagtccggaagctctaaatattatcaaggaaggacacattaaatccataatctcactt ttagacaagcatggaagaaaccacaaggttctggatgtcttgtgctctctctgtgtctgc catggagtagcagtgcgttctaaccagcacctcatctgtgacaatctgctgccaggaaga gatctcctattacagacgcgccttgtaaaccacgtcagcagcatgagacccaatattttt ctgggcgtcagtgaagggtccgctcagtataagaagtggtactatgagctgatggtggac cacacggagccatttgtgactgctgaagccacgcacctgcgggtgggctgggcttccacc gaagggtactctccctaccccggaggcggtgaggagtggggtggaaatggagtcggagat gatctcttttcctacggattcgatggccttcacctctggtcaggttgcattgctcgtact gtaagctcaccaaaccagcacttgctgaaaactgatgacgtcatcagttgctgtttagat ctgagtgccccaagcatctcattccgaattaacggacaacctgttcaaggaatgtttgag aatttcaacattgatggcctcttctttccagttgttagtttctctgcaggaataaaggta cgctttctgcttggggggagacatggagaatttaaattcctccctccacctgggtacgct ccttgttatgaagccgttctgccgaaagaaaagttgaaagtggagcacagccgagagtac aagcaggaaaggacctacacacgggatctgctgggccccacggtttccctgactcaggct gccttcacaccaattcctgtggataccagccagattgtgttgcctcctcatctagagaga ataagagaaaaactggcagagaatatccatgaactttgggttatgaataaaatagagctt ggctggcagtatggtccggttagagatgacaataagagacaacacccctgtctggttgag ttctccaagctgcctgaacaagagcgcaattacaacttgcagatgtctctggagaccctg aagactttgctggcattaggatgtcatgtgggcatttcagatgaacatgctgaagaaaag gtgaaaaaaatgaagctgcccaagaattaccagctgacaagtgggtataagcctgcccca atggacctgagctttatcaaactcaccccatctcaggaagcaatggtggacaagttggca gaaaatgctcataatgtatgggcccgagatcgaatccggcagggctggacttacggcatc caacaggatgtaaagaacagaagaaaccctcgcctggttccctacactcttctagatgac cgcaccaagaaatccaataaagacagcctccgtgaagctgttcgcacgctgctggggtat ggctacaatctggaagcaccagatcaggatcatgccgccagagctgaagtgtgcagcggc acaggtgagagattcagaatcttccgtgctgagaaaacctacgctgtcaaggcaggaagg tggtattttgaatttgaggctgtcactgcaggcgacatgagagttggctggagcaggcca ggttgtcaacctgatcaagagcttggctccgacgaacatgcctttgcttttgatggcttc aaggctcagcggtggcaccagggcaacgagcattatgggcggtcatggcaagcgggagat gtcgtggggtgtatggtggacatgacagagcgtaccatgatgttcacgctcaatggcgaa gtccttctggacgattcgggctcagaactggcgttcaaggactttgatgttggtgatgga ttcattcctgtctgtagccttggagtggctcaagtgggcaggatgaactttggaaaggat gtcagcaccttgaaatatttcaccatctgtggcttacaagagggctatgaaccatttgcg gttaacacaaacagggatattaccatgtggctaagcaagaggcttcctcagtttctccag gtcccatcaaatcatgagcatatcgaggtgaccagaatagatggcaccatagacagttct ccatgtttaaaggtcactcagaagtcctttggttctcagaacagcagcaccgatatcatg ttctatcgcctgagcatgcccattgagtgcgcagaagttttttccaagacggtagcagga ggactcccaggcactggcctctttgggcccaagaatgatctggaggactatgatgcagat tctgactttgaggttctaatgaagaccgctcatggccatctcgtgccagatcgagttgac aaagacaaggaagccacaaaaccagagtttaataaccacaaagattatgctcaagaaaag ccttctcgtctgaaacaaagatttttgcttagaagaaccaagccagattacagcacgagc cattctgcaagactcactgaagatgtccttgcagacgatagggatgattacgattacttg atgcaaacgtccacgtactattactcagtgagaatctttcctggccaagaacctgcaaac gtctgggtaggctggattacatcagattttcatcaatatgatacaggctttgacttggac agagttcgtacagtaaccgttaccctaggagatgaaaagggaaaagtgcatgaaagcatc aaacgcagcaactgctatatggtatgtgcaggcgagagcatgagccctgggcaaggacgc aacaacaatggcctggagatcgggtgtgtggtggacgccgccagtgggctgctcacattc accgccaatggcaaggagctgagcacttactaccaggtggagccaagtacaaaattattt cctgcagtgtttgcacaagctacaagtcccaatgttttccagtttgagttgggaagaata aagaacgtgatgcctctgtcagcgggattgttcaagagtgagcacaaaaaccctgtgcca cagtgtcccccacgtctccacgtgcaatttctatcccacgtcctgtggagcagaatgccc aaccagttcttgaaggtagatgtctctcgaataagtgagcgccaaggctggctggtgcag tgtttggatcccctgcagttcatgtctcttcatatcccagaggagaacaggtcagtggac atactggaattgacagagcaggaggagctgctgaagttccactatcacactctcaggctt tactccgctgtgtgcgcccttgggaaccaccgggtggcccatgccttgtgcagccacgtg gatgaacctcagctgctctacgccatcgagaacaaatacatgcctggcttgctgcgtgct ggctactacgacttgctcattgacatccacctcagctcctatgccactgccaggctcatg atgaacagtgagttcatcgtgcccatgacagaggagaccaagagcatcacccttttccct gatgagaacaaaaaacatggcctcccgggaattggcctcagcacttccctcaggccacgg atacaattttcctcccccagttttgtaagcattaataatgaatgttaccagtacagtcca gagttcccactggacatcctcaaggccaaaaccattcagatgctgacagaagctgtgaaa gagggcagccttcatgcccgggacccagttggggggacaactgagttcttgtttgtacct ctcatcaagcttttctatactttactcatcatggggatcttccacaatgaggacttgaaa cacatcttgcagttgatagagcccagcgtattcaaggaagctgccactccagatgaggag actgaggccctggagaaggaaccctgcccagaagactccaagtcagaaggagctggagaa gaagaagccaaaggggttaagaggcccaaggaaggcctgctccaaatgaaactgcctgag ccagttaaattgcagatgtgcctgctgcttcagtatctctgtgactgtcaggtccggcac cggatagaagccattgtggccttttcagatgactttgtagctaagctccaagataatcag cgcttccgatacaatgaagttatgcaagccttaaacatgtcagctgcactcactgccagg aaaacgaaggaatttagatcaccacctcaagaacagatcaatatgcttctcaattttaag gatgacaaaagtgaatgtccatgtcctgaggaaatccgtgaccaactcttagattttcat gaagatttgatgacacactgtggaattgagcttgatgaagatgggtctttggatggaaac agtgacttaacaattagaggacgcctgctgtccctggtagaaaaggtgacatacctgaag aagaaacaagctgaaaaaccaattgagagtgactccaagaagtcctccactcttcaacag ttgatttctgagaccatggtccgatgggcacaagagtctgtcattgaagaccctgacttg gtgagggccatgtttgtgttgctccatcgacagtatgatggcattgggggtctggtccgg gctctgccaaagacctacactataaatggtgtctccgtggaggataccatcaacctgctg gcatctcttggtcagattcgttctctgctgagtgtaagaatgggcaaagaagaagagaag cttatgattcgtggattaggggatatcatgaataataaagtgttttaccagcaccctaat ctcatgagggcacttgggatgcatgagacagtgatggaggtcatggtgaatgtccttggc ggtggagagtccaaggaaatcacttttcctaagatggtggccaactgttgccgtttcctc tgttacttctgtcgtataagtaggcagaatcaaaaagctatgttcgatcatctcagctat ttattggagaacagcagtgttggtcttgcctcaccagctatgagaggttcgacaccgctg gacgtagcagctgcctcagtgatggataataatgagctggccttagctctgcgtgagcca gatctggaaaaggtagttcgatatttggctgggtgtggactgcagagctgccagatgctg gtgtctaagggttatccagacattggatggaatccagttgaaggagagagatatcttgac tttctcagatttgctgtcttctgtaatggggagagtgtggaagagaatgctaatgttgtg gtgaggttgctcatccggaggcccgagtgttttggtcctgctttgagaggggaaggtggg aatggtctgcttgcagccatggaggaagccataaaaatagctgaagatccttctcgagat ggtccctcaccaactagtggatccagtaaaacacttgatacagaagaggaggaagatgac actatccacatggggaatgccatcatgaccttttactcggctttgattgaccttttggga cgttgtgctcctgaaatgcatttgattcatgctggtaagggggaagccatcagaatccgg tcaattttgagatccctaattcccctgggagatttggtgggagtaatcagcattgctttt cagatgccaacaatagccaaagatgggaatgtggtggagcctgacatgtctgcggggttt tgcccagatcacaaggcagccatggttttgttccttgacagggtctatgggattgaggtt caagatttcctcctccatcttcttgaggttggctttctgccagatctccgggctgctgct tctttagatacggctgctttgagtgctacagatatggccctggccctcaatcggtacctt tgcacagctgtgttgcctttgttaacaagatgtgcccctctttttgctggcacagagcac cacgcttccctcattgactcattacttcacactgtgtacagactttctaagggctgctct cttaccaaagctcagcgggattccatagaagtttgtttactctctatttgtggccaattg agaccttctatgatgcagcacttactccgaagattagtatttgatgttccattattaaat gaacatgcaaagatgccccttaagctgctgacaaatcattatgaaagatgctggaaatat tactgcctgcctggagggtgggggaacttcggagctgcctcagaagaagagcttcattta tcgagaaagttgttttggggcatttttgacgccctatctcaaaagaaatatgagcaagaa cttttcaaactggcactgccttgcctgagtgcagttgcgggagctttgcctccagactac atggagtcaaattatgtcagtatgatggaaaaacagtcatcaatggattctgaagggaac tttaacccacaacctgttgatacctcaaatataacaattcctgagaagttggaatacttc attaacaaatatgcggaacattctcatgacaaatggtcaatggacaagttggcaaatgga tggatttatggagaaatatattcagactcatctaaagttcagccattaatgaagccatat aaactattatctgaaaaggaaaaagaaatttatcgctggccaatcaaagagtctctaaaa accatgcttgcgtggggttggagaattgagagaacacgggaaggagacagcatggccctc tataaccggactcgtcgcatttctcagacaagccaggtttctgtagatgctgcccatggt tatagccccagagccattgacatgagcaatgtcacactgtccagagacctgcatgctatg gcagaaatgatggctgaaaactaccataacatatgggcaaagaaaaagaaaatggaactg gagtccaaaggaggtggaaatcatccccttctggtaccttatgatacgctgacagccaaa gagaaagccaaggacagggaaaaagcacaggacatcctcaagttcttgcaaatcaatggc tatgctgtatccagggggtttaaggacctggaattggacacaccttccattgagaaacga tttgcctacagcttccttcagcaactcattcgctatgtggatgaagcccatcagtatatc ctggagtttgatggtggcggcagaagcaaaggagaacatttcccttatgaacaagaaatc aagttctttgctaaagtggttcttcctttaattgatcaatatttcaaaaaccatcgctta tacttcttatctgcagcaagcagacctctctgttctggaggacatgcatcaaacaaggag aaagaaatggtgacgagcctattctgcaaacttggagttcttgtcaggcataggatttca ctatttggaaatgatgccacatcaattgtcaactgtcttcatattttgggtcagactttg gatgccaggacagtgatgaagactggtctggaaagcgttaaaagcgccctccgagctttt ctagacaatgctgcggaggatctggagaagaccatggagaatctcaagcaaggccagttc acccacacccgaaaccaacccaaaggtgttactcagattatcaattataccacggtggct ctgttgccgatgctgtcatcattatttgagcatattggccagcatcaattcggagaagat ctaatattggaagatgtacaagtgtcatgttatagaattctgactagtttatatgctttg ggaaccagcaaaagtatttatgtggaaaggcaacgttctgcattaggagaatgtctcgct gcttttgctggtgcctttcccatagcatttttggaaactcatctggacaaacataacatt tactctatctacaatactaagtcctcacgagaaagagcagctcttaatttgccaactaat gtggaagatgtttgcccaaatataccatctttggagaaactcatggaagaaattgtggaa ttagctgagtctggcattcgctacacacaaatgccacatgtaatggaagtcatactgccc atgctttgcagctacatgtctcgttggtgggagcatggacccgaaaacaatccggaaagg gctgaaatgtgctgtacagccctgaactccgagcacatgaacacacttctgggaaatata ttgaaaatcatatataataacttgggaatcgatgagggcgcctggatgaagaggttagca gttttttcacagcccattataaataaagtgaaacctcagctcctgaaaactcatttcttg ccactaatggagaaactcaagaaaaaagcagcaatggtggtgtctgaggaggaccatctg aaggctgaggccaggggggatatgtctgaggcagaacttctcattcttgatgagtttacc acactggctagagatctctatgccttctacccactcttgattagatttgtggactataac agggcaaagtggctaaaagagcctaacccagaagcagaggaccttttccgcatggtggcc gaagtatttatctactggtcaaaatctcacaatttcaaaagagaagagcagaacttcgtg gtacagaatgaaatcaacaacatgtctttccttatcactgacaccaagtcaaagatgtca aaggcagctgtttctgatcaggaaaggaagaaaatgaagcgcaaaggagatcgatattcc atgcagacttctcttattgtggcagctctgaagcgcttgctgcccattgggttgaacatc tgtgcccctggggaccaggagctcatcgctctggccaaaaaccgattcagtatgaaagac actgaggatgaagtacgagatataattcgcagtaatattcatttacaaggcaagttggag gatcctgctatcagatggcaaatggctctttacaaagacttaccaaacaggactgaagat acatcagatccggaaaagaccgtagaaagagtattagatatagcaaatgtgctttttcat cttgagcagaagtctacatgtatgcgccggagatattacagtctggtggagcacccacag agatccaagaaggctgtatggcacaaactgttatccaagcagaggaaaagagcagtggta gcctgttttcgaatggctcctttatacaacctgccaaggcatcgggctgtcaatctcttt cttcagggatatgaaaagtcttggattgaaacagaagaacactactttgaagataaatta atagaagatttagcaaagcctggagccgaccctccagaagaagaggaaagcacgaagaga gttgatcccctccatcaactcatccttctgtttagtcgaacagctttaacagaaaaatgc aaactggaagaagactttttatatatggcttatgcagatattatggcaaagagttgtcat gatgaggaagatgatgatggtgaagaagaagtgaagagttttgaagtcacaggatcccaa cgcagcaaggaaaaagaaatggaaaagcaaaagcttctataccaacaagccaggcttcat gaccgaggggctgcggagatggtgctgcagaccatcagtgccagcaaaggtgatactgga ccaatggtagctgcgactttgaaacttggcatcgctatcttaaatggcgggaactctaca gtacagcagaaaatgcttgactacctcaaggagaaaaaggatgtgggcttctttcagagc cttgctggcctgatgcagtcatgtagtgtcctcgacctaaatgcatttgagcgacaaaac aaagctgaaggacttggaatggtgaccgaggaaggatcaggagaaaaggttcttcaggat gacgagttcacttgtgacctcttccgcttcctacaactgctttgtgagggacacaactca gattttcaaaattatctgagaacccagactggcaataacacaactgttaacatcatcatc tctactgtagactacctcctgagagtccaggaatccattagcgatttctattggtactac tctgggaaagatgttattgatgaacaaggacaacggaatttttccaaagcaattcaagta gcaaagcaagtctttaacactctcacagagtatattcagggtccttgcactgggaatcag cagagcctggcccacagcaggctgtgggacgcagttgtgggctttcttcatgtatttgcc cacatgcagatgaagctatctcaggattccagtcaaattgagctattaaaagaattaatg gatcttcagaaggatatggtggtcatgttgctgtccatgttagaaggtaatgtcgtcaat ggaaccattggcaaacagatggtcgatatgcttgtggaatcttccaacaatgtggagatg attctcaagttttttgacatgtttttaaaactaaaagatttgacgtcctcagacacattt aaggaatacgatcccgatggcaaaggagtcatttccaagagggacttccataaagcgatg gagagtcataagcactatacacagtcagaaaccgagtttcttctgtcctgtgcagagacc gatgaaaacgagactctcgactatgaagagtttgtcaaacgcttccatgagcccgcaaag gacataggcttcaacgttgccgtcctcctgacaaacttgtctgaacacatgcccaatgac acccggctgcagacgtttctggagttggcagagagtgtgctgaattacttccagcccttt ctgggccgcatcgagatcatgggaagtgccaaacgcatcgagagggtctattttgaaatc agtgagtccagccgcacccagtgggagaagccccaggtcaaggagtccaaacggcagttc atatttgacgttgtcaatgaagggggagaaaaggagaagatggaactttttgtgaacttc tgtgaggacaccatatttgaaatgcagttggcggcacagatctcggagtcggatttgaat gagaggtcagtgagtaaggaagagagtgagaaggagaagcctgaagagcaggggcccagg atgggtttcttttccattctgacagtcaagtcagccctgttggctctcaggtacaatgtc ttgaccctcatgcgaatgctcagcctgaagagcctgaagaagcagatgaaaagagtgaag aagatgactgtgaaggatatggttatggctgccttttcatcctattggaatattttcatg agcctcctgcacttcgtggccagcgtttccagaggctttttccgtatcatttgcagcctg ctgctggggggcagcctagtagaaggggcaaagaagatcagggtggcagagctcttagcc aacatgccggaccccacacaggatgaagtgaggggggatagcgaggagggggacaggaaa cccatggaagcttccctgccctcagaagacttgacagacctaaaggagctgacagaggaa agtgaccttctttcggatatattcggcttggacctgaagagagaaggaggacagtacaaa ctcattcctcataatcccaatgctggcctcagcgacctcatgagcaacccggtccccatc cctgacgtgcaggaaaaatttcaggaacagaaggccaaagaggaagaaaaggaggaaaaa gaagaaaacaagtctgaacctgaaaaggctgagggagaagatggagaaaaagaagaaaaa gccaaggaagataagggtaaacagaagctgaggcaactccacacacatagatatggagag ccagaagttcccgagtcagcgttctggaagaaaatcatagcatatcaacagaaacttcta aactattttgctcgcaacttttacaacatgagaatgttagccttatttgtcgcatttgca atcaatttcatcttgctgttttataaggtctccacttcttctgtggttgaaggaaaggag ctctccactcgcagttcaagtgaaaatgccaaagttagcagcctagacagtgggtcaccc agaatcatcacggttcactacgtcctggaggagagcagcggctacatggagcccacactg aggatcttagctattctccacacggtcatttctttcttctgcatcatcggatactactgc ttgaaagtcccattggttatttttaagcgagaaaaggaagttgctcgaaaattggaattt gatgggctttatattacagaacagccttcagaagatgatattaaaggccagtgggataga cttgtaatcaacacacagtcatttcccaacaactattgggacaaatttgttaaaagaaag gttatggataaatatggagagttctatggccgggacagaatcagtgagctccttggtatg gacaaagcagctctggacttcagcgatgccagggaaaagaagaagccaaaaaaagacagc tccctgtcggctgtactgaactctatcgacgtgaagtatcagatgtggaaattaggagtc gtctttactgacaattcttttctctacctggcctggtatatgactatgtccattcttgga cactataacaactttttttttgctgctcatctccttgacattgctatggggttcaaaaca ctaagaaccatcttgtcatcggtaacgcacaatggcaaacagcttgtattaaccgttggc ttattagctgttgttgtatacctatatactgttgtggcattcaattttttccgaaaattc tacaataaaagtgaagatggtgatacaccagatatgaaatgtgatgatatgctaacgtgc tatatgttccacatgtatgttggggtacgtgctggagggggtattggtgatgaaattgaa gacccagcaggcgatgaatatgagatctatcgaatcatctttgacatcaccttcttcttc ttcgtgatcgtcatcctcttggctataatacaaggtttaattattgatgcttttggagaa ctaagagaccaacaggagcaagtcaaagaagacatggagactaaatgcttcatctgtggg ataggcaatgattacttcgacacagtgccacatggctttgaaacccacactttacaggaa cacaacttggctaattacctgttttttctgatgtatctcataaacaaggatgaaacagag cacacaggacaggaatcttatgtctggaagatgtatcaagaaaggtgctgggaattcttc ccagcaggggactgtttccggaaacagtatgaggaccagctaaattaa

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