Vulpes lagopus (Arctic fox): 121489275
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Entry
121489275 CDS
T07435
Symbol
NOS3
Name
(RefSeq) nitric oxide synthase, endothelial isoform X1
KO
K13242
nitric-oxide synthase, endothelial [EC:
1.14.13.39
]
Organism
vlg
Vulpes lagopus (Arctic fox)
Pathway
vlg00220
Arginine biosynthesis
vlg00330
Arginine and proline metabolism
vlg01100
Metabolic pathways
vlg04020
Calcium signaling pathway
vlg04022
cGMP-PKG signaling pathway
vlg04066
HIF-1 signaling pathway
vlg04071
Sphingolipid signaling pathway
vlg04151
PI3K-Akt signaling pathway
vlg04370
VEGF signaling pathway
vlg04371
Apelin signaling pathway
vlg04611
Platelet activation
vlg04915
Estrogen signaling pathway
vlg04921
Oxytocin signaling pathway
vlg04926
Relaxin signaling pathway
vlg04931
Insulin resistance
vlg04933
AGE-RAGE signaling pathway in diabetic complications
vlg05415
Diabetic cardiomyopathy
vlg05417
Lipid and atherosclerosis
vlg05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
vlg00001
]
09100 Metabolism
09105 Amino acid metabolism
00220 Arginine biosynthesis
121489275 (NOS3)
00330 Arginine and proline metabolism
121489275 (NOS3)
09130 Environmental Information Processing
09132 Signal transduction
04370 VEGF signaling pathway
121489275 (NOS3)
04371 Apelin signaling pathway
121489275 (NOS3)
04066 HIF-1 signaling pathway
121489275 (NOS3)
04020 Calcium signaling pathway
121489275 (NOS3)
04071 Sphingolipid signaling pathway
121489275 (NOS3)
04022 cGMP-PKG signaling pathway
121489275 (NOS3)
04151 PI3K-Akt signaling pathway
121489275 (NOS3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
121489275 (NOS3)
09152 Endocrine system
04915 Estrogen signaling pathway
121489275 (NOS3)
04921 Oxytocin signaling pathway
121489275 (NOS3)
04926 Relaxin signaling pathway
121489275 (NOS3)
09160 Human Diseases
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
121489275 (NOS3)
05418 Fluid shear stress and atherosclerosis
121489275 (NOS3)
05415 Diabetic cardiomyopathy
121489275 (NOS3)
09167 Endocrine and metabolic disease
04931 Insulin resistance
121489275 (NOS3)
04933 AGE-RAGE signaling pathway in diabetic complications
121489275 (NOS3)
Enzymes [BR:
vlg01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
1.14.13.39 nitric-oxide synthase (NADPH)
121489275 (NOS3)
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Motif
Pfam:
NO_synthase
FAD_binding_1
Flavodoxin_1
NAD_binding_1
Motif
Other DBs
NCBI-GeneID:
121489275
NCBI-ProteinID:
XP_041608015
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Position
4:complement(44405355..44423366)
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AA seq
1213 aa
AA seq
DB search
MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPTSEPSRAPALAPPPSPPPAPDHSSPP
LTRPPDGPKFPRVKNWEVGSITYDTLSAQSQQDGPCTPRRCLGSLVFPRKLQSRPSQDPA
PPEQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAW
RNAPRCVGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRASGR
GDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDE
PPELFALPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYM
STEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSYQLAKVTIV
DHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYVLSPAFRYQTD
PWKGSASKGAGVTRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQL
GRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYN
SSPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKQSSNTDSAGALGTLRFCVFGLGSRAYP
HFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQASCETFCVGEDAKA
AARDIFSPKRTWKRQRYRLSAQAEGLQLLPGLIHVHRRKMVQATVLAVENLQSSKSTRAT
ILVRLDTGSQEALQYQPGDHIGICPPNRPGLVEALLSRVEDPPPPGEPVAVEQLEKGSPD
LPCTPSPGGPPPSWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEESSEQQEL
ESLSQDPRRYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSAHP
GEIHLTVAVLAYRTQDGLGPLHYGVCSTWLSQLKAGDPVPCFIRGAPSFRLPPDPSLPCI
LVGPGTGIAPFRGFWQERLHDIDSKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQQRGVF
GRVLTAFSREPDSPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATSVLQTVQRI
LATEGDMELDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERHLRGAVP
WAFDPPGPDTAGP
NT seq
3642 nt
NT seq
+upstream
nt +downstream
nt
atgggcaacttgaagagtgtgggccaggagcccgggcccccttgtggcctggggctgggc
ctgggcctggggctatgtggcaagcagggccctgcctccccgacttcagagcccagccgg
gcaccggccctggcgcccccaccctcacccccaccagcaccagaccacagcagccccccg
ctcacccggcctccagatgggcccaagttccctcgtgtgaagaactgggaggtggggagc
atcacctatgacaccttgagtgcccagtcacagcaggatgggccctgcaccccgagacgc
tgtctgggctctctggtatttccacggaaactgcagagccggccctcccaggaccctgca
ccccctgagcagctgctgagccaggccagggacttcatcaaccagtactacagctccatc
aagaggagtggctcccaggcccatgagcagaggcttcaagaggtggaagctgaggtagca
gccacaggcacctatcagcttcgggaaagcgagctggtgttcggggccaagcaggcctgg
cgaaacgctccccgctgcgtgggccggatccagtgggggaagctgcaggtgtttgatgcc
cgggattgcagttctgcccaggagatgttcacctacatctgcaaccacatcaagtatgcc
accaaccggggcaacctccgctcggccatcacagtgttcccccagcgtgcctcaggccgc
ggagacttccgaatttggaacagccagctggtgcgctatgcgggctacagacagcaggat
ggctcagtgcggggggacccagccaacgtggagatcactgagctctgcatccagcacggc
tggactccaggaaacggccgctttgatgtgctgcccctactgctccaggccccagatgag
cccccagaactctttgctctgccccccgagctggttctcgaggtgcccctggagcacccc
acgctggagtggtttgcggccctgggcctgcgctggtatgccctcccagcggtgagcaac
atgctgctggaaattggggggctggagttccctgcggcccccttcagcggctggtacatg
agcactgagattggcacgcggaacctgtgtgaccctcatcgatacaacatcctggaggat
gtggctgtctgcatggacttggataccaggaccacctcatccctgtggaaagacaaggca
gcagtggaaatcaacttggctgtgctgcacagttaccagctggccaaagtgaccatcgtg
gaccaccatgctgccacagcctccttcatgaagcacctggagaacgagcagaaggccagg
gggggttgccctgctgactgggcctggatcgtgccccccatctctggcagcctcacccct
gttttccatcaggagatggtcaactatgtcctgtccccggccttccgctatcagacagac
ccgtggaaggggagtgcatccaagggtgccggcgtcaccaggaagaaaacctttaaggaa
gtggccaatgcggtgaagatctctgcctcactcatgggcactgtgatggcaaagcgagtg
aaggcgacaatcctctatggctccgagactggccgggcccagagctatgcacagcagctg
gggagactcttccggaaggctttcgacccccgggtcctgtgcatggatgagtatgacgtg
gtgtcccttgagcatgagacgctggtgttggtggtgaccagcacatttgggaatggtgat
cccccagagaatggagagagttttgcggcggccctgatggagatgtcgggtccctacaac
agctcccctcggccagaacagcacaagagttacaaaatccgcttcaacagtgtctcctgc
tcagacccactggtgtcctcctggaggcggaagagaaagcagtccagtaacacagacagt
gctggggcactgggtaccctcaggttctgtgtgttcgggctgggctcccgggcatacccc
cacttttgtgcctttgctcgtgcggtggacacacggctggaagagctgggtggggagcgg
ctgctgcagctgggccaaggagatgagctgtgtggccaggaggaggccttccgaggctgg
gcccaggccgccttccaggcctcctgtgagaccttctgcgtgggagaggatgccaaggct
gccgcccgggacatattcagccccaaacggacctggaagcgccagaggtaccggctgagc
gcccaggctgagggcctccagctgctgccaggactgatccatgtgcacaggaggaagatg
gtccaggctactgtcctcgcggtggaaaacctgcaaagcagcaagtccacccgggccacg
atcctggtgcgcctggacactggaagccaggaggcgctgcagtaccagccaggggaccac
attggcatctgcccgcccaaccggcctggccttgtggaggcgctgctgagccgggtggag
gatccaccgccaccaggagagccagtggcagtggagcagctggagaagggcagccctgat
ctcccctgtacaccatcaccaggtggcccaccccccagctgggttcgggaccctcgcctg
cccccatgcacactgcgccaggctctcaccttcttcctggacatcacttccccgcccagc
cctcaactccttcgactgctcagcaccctggctgaagagtccagtgaacagcaggagctt
gagagcctcagccaggacccccggcgctatgaggaatggaagtggttccgctgccccaca
ctgctggaggtactggaacagttcccatcggtggcactgcccgcccccctgctcctcacc
cagctgcccctgctccagccccggtactactcggtcagctcagcacccagtgcccaccca
ggagagatccacctcacagtagctgtgctggcatacaggacacaggatggactgggcccc
cttcattatggagtctgctccacatggctaagccaacttaaggccggagatcctgtaccc
tgcttcatcaggggggctccctccttccggctgccacctgatcccagtctgccttgcatc
ctagtgggtcctggtacgggtattgccccctttcggggtttctggcaggagcggctgcac
gacattgacagcaaagggctgcagcccgcccccatgactctggtgttcggctgccgatgc
tcccagctcgaccacctttaccgcgacgaggtgcaggatgcccagcagcgcggagttttt
gggcgcgtcctcaccgccttctcccgggagcccgacagccctaagacgtacgtgcaggac
atcctgcggacggagctggctgctgaggtgcaccgcgtgctgtgcctcgagcggggccac
atgtttgtgtgcggcgacgtcaccatggcaaccagcgtcctgcagacggtgcagcgaatc
ctagcgacggagggcgacatggagctggacgaggccggcgacgtcatcggcgtgctgcgg
gatcagcaacgctatcacgaggacattttcgggctcacactgcgcacccaggaggtgacg
agccgcatacgcacccagagcttctccttgcaggagcggcatctgcggggcgcggtgccc
tgggcgttcgacccgcccggcccagacaccgccggcccctga
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