Vidua macroura (Pin-tailed whydah): 128805452 Help Entry 128805452         CDS       T11570                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism vmc  Vidua macroura (Pin-tailed whydah) Pathway vmc04020   Calcium signaling pathway vmc04260   Cardiac muscle contraction vmc04261   Adrenergic signaling in cardiomyocytes vmc04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:vmc00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     128805452 (RYR2)    04020 Calcium signaling pathway     128805452 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     128805452 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     128805452 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:vmc04040]     128805452 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:vmc04990]     128805452 (RYR2) Ion channels [BR:vmc04040]  Voltage-gated cation channels   Ryanodine receptor    128805452 (RYR2) Domain-containing proteins not elsewhere classified [BR:vmc04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    128805452 (RYR2) SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  128805452 NCBI-ProteinID:  XP_053830138 LinkDB All DBs Position 3:46310530..46696815 Genome browser AA seq 4968 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCTATVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEENAEGLVDVEKWGFYMKSAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSMDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPVSSGSEVAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQPFRLRHI TTGKYLSLLDDKSLLLTDKEKADIKSTAFCFRSSKEKLDIGTRKEVDGMGAPEIKYGDSI CFIQHVDTGLWLTYQSADAKSVRMGSVQRKAIMHHEGHMDDGLTLSRSQNEESRTARVIR STVFLFNRFIRGLDALSKKVKSSTIDLPIESVSLSLQDLIGYFHPPDEHLEHENKQNRLR ALKNRQNLFQEEGMINLVLECIDRLNVYSSAAHFADVAGKEAGEAWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIICL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGISEGSAQYRKWYYELMVDHLEPFVTAESTHLRVGWASTEGYSPYPGGGAEWGGNGVGD DLYSYGFDGLHLWSGCVARTVNSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCFEAVLPKEKLKVENSREY KQDRSYTRDLLGPTVSLSQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADERAEEK VKKMKLPKNYQLLSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHATRLDVCSG IMEKFRIFRTEKTYAVKAGKWYFEFETVTAGDMRVGWTRPGCLPDQELGSDEEAFVFDGF KAQRWHQGNEHFGRSWLAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFEVADG FLPVCSLGPSQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITIWLSKRLPQFLP VPQNHEHIEVMRIDGTIDSCPCLKVMQKSFGSQNSKTDVMFFRLSMPIECAEVFSRSAAG GLPGSGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRTEREKDATKPELNNHKDYVQEK PSRLKQRFMLRRTKPDYSMSHSARLTEDVLADDRDDYDYLMQTSTYFYSVRIFPGQEPAN VWVGWITSDFHQYDTSFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESLSPGQGR NNNGLEIGCLVDAASGLLTFTANGKELGTYYQVEPSTKLFPAVFAQATSPNVFQFELGRI KNVMPLSAGLFKSEHKNPVSQCPPRLHVQFLTHVLWSRVPNHFLKVDVSRISERQGWMIQ CLNPLQFMALHIPEENRTIDILELTEQEELLKFHYHTLRLYSAVCALGNNRVAHALCSHV DESQLLYAIENKYMPGLLRAGYYDLLIDIHLNTYATARLMMNNEFIVPMTDETKSITLFP DENKKHGLPGIGLSTSLRPRMQFSSPSFVSISSECFQFSPEFPLEILKAKTIEMLTEAVQ EGSLHVRDPVGGSTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPRVFKEAMSQEDE IDFSEKEFSSDELKSEEGEEETRGEQMPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVRHR IEAIVAFSDDFVAKLQENQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKD DKNDCPCPEEIRDQLLDFHEDLMTHCGIELDEDGILDGSSDSTIRGRLLYLMEKVTYLKK KQDEKTVDEDDKTSSTLQQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRA LPKTYTINSVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNL MRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYL LENSSVGLASPSMRGSTPLDVAAASVMDNNELALALKEPDLEKVVRYLAGCGLQSCPLLI CKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGN GLLAAMEEAIQISEDRTRDGPSPSNGSSKTLEIEEQEDDTIHMGNAIMTFYAALIDLLGR CAPEMHLIHAGKGEAIRIRSILRSLIPLEDLVGVISIAFHMPTIAKDGTVVEPDMSAGFC PDHKAAMVLFLDRVYGIEDQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLC TAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEECLLSICGQLR PSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPSGWGNFGAASEEELHLS RKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVNMMEKQSSMDSDGNF NPQPVDTSNITIPEKLEYFINKYAEHAHDKWSMEKFANGWTYGETFSESAKVQPLMKQYK LLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQISVDTAHGY TPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELEAKGGGNHPLLVPYDTLTAKE KAKDREKAQDILKFLQINGYVVSRGLKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYIL EFDGGSRGKGEQFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSSASRPLSSGGHASNKEK EMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVRMALRAFL DNAAEDLEKTMENLKQGQFTHSRNQPKGVTQIINYTTVALLPVLSSLFEHIGQHQFGEDL ILEDVQVSCYRILASLYALGTSKSIYVERQRSALGECLAAFSGAFPVAFLETHLNKHNIY SIYNTKNARDRAVLNLPTSVEEVCPNIPSLMKLMEEIVELAESGIRYTQMPHIMEVILPM LCSYMSHWWEHGPENNPDKAEMCCTALTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAV FSQPIISKAKPELLKTHFLPLMDKLKKKAAVVVSDEEHLRAEGRGDMSEAELLILDEFTT LARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVV QNEINNMSFLISDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNIC APGDQELIALAKNRFSMKDTEDEVRDVIRSNLHLQGKLEDPAIRWQMALYKDLPNRTEDS SDPEKTVERVLDIANVLFHLEQKSACVGRGYFFWEKHPQRSKKAVWHKLLSKQRKRAVVA CFRMAPLYNLPRHRAVNLFLQGYDKSWIETEEHYFEDKLIEDLAKPGEEPPEEDESLKRV DPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEMEK QKLLYQQARLHDRGAAEMVLQTISASKGEMGPMVAATLKLGIAVLNGGNSTVQQKMLDYL KDKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVMQDDEFTCDLFR FLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQ GQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQD SSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFL KLKDLTSSDAFKEYDPDGKGIISKRDFHRAMESHKHYTQSETEFLLSCAETDENETLDYE EFVKRFHEPAKDIGFNVAVLLTNLSEHMPHDTRLQTFLELSESVLNYFQPFLGRIEIMGS AKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQ LAAQISESDLNERSANKEENEKDNPEEEDPRMGFFSLMTMKSALLTLKYNLMTLMKMLSM KSLKKQMKKVKKMTMKDMVLALFSSYWSILVGLLHFACSVVRGFFRIICTLLLGGSLVEG AKKIKVAELLANMPDPTQDEVRGEEEEGERKPTEAALPAEDLTDLRTLTEESDLLSDIFG LDLKREGGQYKLIPHNPNAGLSDLLSTPSLAPVPEVQEKIQVIKVKEEEKEEKEETKSEP EKAEGEDGEKEEKTKEDKGKQKLRQLHTHRYGEPEVQESVFWKNIIAYQQKLLNYFARNF YNMRMLALFVAFAINFILLFYKVSTSAVTEEKELPVVSDGESTTLNILESDDERVIAVHY VLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITE QPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDF SDAREKKKPKKDSSFSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFF AAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDG DMPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILL AIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYL FFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14907 nt NT seq  +upstreamnt  +downstreamnt atggccgaggggggcgagggcgaggacgagatccagttcctgcgaactgatgatgaagtg gttctgcagtgcactgcaactgttcacaaggagcaacagaaattgtgtcttgctgcagaa ggatttggcaacaggctttgctttttggaatccacatctaattctaagaatgttccacct gatttgtccatctgcacctttgtgctggagcagtctctgtcagtacgggccctccaggaa atgctggccaacacagaagaaaatgcagaagggctagttgatgtggaaaaatggggtttc tatatgaaatctgcacaaggtggtggacatcgaacactgctctacgggcatgcaatcttg ctgcgccattcctacagtggcatgtacctatgctgtctctctacatctcgatcgtcaatg gataagctggcatttgatgtaggattgcaagaggacacaacaggtgaggcttgctggtgg accatacatcctgcttctaaacaacgatcagaaggagaaaaagtgcgcgttggagatgat ctgattttagtcagtgtctcttcagaaagatacttgcatctctcttatggcaatggtagc ttacatgttgatgcagccttccagcagacgctctggagtgtagcaccagtcagttcagga agtgaagttgcccaaggatacctgataggaggggatgttctgaggttattgcatggtcac atggatgaatgtttgacagtcccttcgggtgaacatggagaagaacaaagaagaactgtc cattatgaaggtggtgctgtgtccattcatgctcgttccctttggcgactagagactcta agagttgcgtggagtggcagccacattagatggggacagccattcagactaagacatata acaacaggaaaatatttaagtctcctggatgacaagagtcttcttcttacagacaaagag aaggcagatataaaatctacagcattctgttttcggtcttccaaggaaaagttggatata gggacgagaaaggaggtggatggaatgggagcacctgaaataaagtatggggattcaata tgcttcatacaacatgtagatacaggcttgtggctcacatatcagtctgctgatgcaaag tctgtaaggatgggctctgtgcagcgaaaggcaataatgcaccatgaagggcatatggat gatggtttaacactgtccagatctcagaatgaagaatcccgcacagcacgtgtcatccgt agtacagtcttccttttcaacaggttcataaggggccttgatgctctcagcaagaaagtg aagtcttccaccatcgatttgcctatcgagtcagtcagtctgagcctgcaggacttgatt ggctactttcacccccctgatgaacatttggagcatgaaaacaaacaaaacaggctccga gcactgaagaatcgccagaacctcttccaagaagagggtatgatcaaccttgttcttgaa tgtattgatcgcttgaatgtatacagcagcgcagctcactttgcagatgtagctgggaag gaggctggagaagcatggaaatctattctgaattctttgtatgaattactcgcggctctg attcgaggaaatcgtaaaaactgcgctcaattttctggatctcttgattggttgatcagc agattagaaagactggaagcctcttctggaattctagaggttttacattgtgtgttggta gaaagcccagaagctctaaacattattaaggaaggacatattaaatcaatcatctgtctt ttggacaagcatggaagaaatcataaggttttggatgttttgtgttctctctgtgtttgt catggagtagctgtgcggtctaatcaacatctaatctgtgataatctcctgccaggaaga gatctgctcttacagacacgccttgtcaaccatgtgagcagcatgcgacccaacatcttc ttggggattagtgaaggctcggctcaatacagaaaatggtactatgaacttatggtggac catctagagccctttgtgactgcagaatcaactcacctacgagtgggctgggcttcaaca gaaggctactcaccctacccagggggaggagcagaatggggaggaaatggtgttggtgat gacctatattcctatggctttgatggtctacatctgtggtcaggttgtgtagcacgaaca gtaaattctcccaaccaacatctattaagaactgatgatgttattagctgctgtttggac ctgagtgcccccagcatctctttccgaataaatggtcagccagttcaaggaatgtttgaa aacttcaacatagatggcctcttcttcccagttgtcagcttctctgcaggaataaaggtt cgtttcttgcttggaggtcgccatggagagttcaagttccttcctccacctggatatgct ccatgttttgaagctgtcctaccaaaagagaagctgaaagtggagaacagccgagagtac aaacaagatcgtagctacacaagagacctactgggtcctactgtctctctgtcacaagca gctttcactccagttcctgtagatactagccagattgttttgcctccccacctggaaaga attagagaaaaattagcagagaacatccatgaactttgggttatgaataagattgaactt ggctggcagtatggaccagttagagatgacaataaaagacaacacccatgcttagtggag ttctcaaaattgccggagcaggaaagaaattataacttgcaaatgtcacttgaaacactg aaaaccctgctggcattaggctgtcatgttggaattgctgatgaacgtgctgaagaaaaa gtgaaaaaaatgaaacttccaaagaactatcagttgttgagtggatataagccagcaccc atggatctgagttttatcaaattgaccccctctcaagaggctatggtggataaactagca gagaatgctcacaatgtgtgggcaagggaccgtataaggcaaggctggacatatggcatc cagcaggatgtgaaaaaccgacgaaatcctcgccttgtaccgtacgctcttttggatgat cgaacaaagaagtccaacaaagacagtcttcgggaagcagtccgcacccttctaggctat ggttacaatctggaagctcctgatcaagatcatgcaacaagactggacgtgtgcagtggg ataatggaaaagttcaggatcttccgcacagaaaagacttatgcagtgaaagctgggaag tggtactttgagtttgagacagttactgcaggagacatgagagttggctggaccaggcca ggttgtctgccagatcaggaacttggctcagatgaagaagcttttgtttttgatggcttt aaggcacagcggtggcatcaaggtaatgagcattttggccgctcttggttggcaggagat gttgttggatgtatggttgacatgaatgagcacactatgatgttcaccttaaatggtgaa atcctgcttgatgactcaggctcagaacttgcattcaaggacttcgaggttgctgacgga tttctacctgtgtgcagcctgggcccatctcaagtgggaagaatgaactttggaaaagat gtcagcactctgaaatatttcactatatgtggcttacaggaagggtatgaaccctttgct gttaatacaaacagagacatcaccatttggctgagtaaaaggcttcctcagtttctacca gtgccacaaaaccatgaacatattgaggtgatgagaattgatggcaccatagacagctgc ccctgcctgaaggtcatgcagaagtcctttggttcacagaacagtaaaacagatgtcatg ttttttcgattaagtatgcccattgaatgtgctgaggtgttctccagatcagctgcagga gggttaccaggctctggtctttttggcccaaaaaatgacttggaagattatgatgctgat tctgattttgaggttctaatgaaaactgctcatggtcatctagttcctgaccggacagaa agagaaaaagatgccacaaaaccagagctgaataaccacaaagattatgttcaagaaaag ccctcacgtcttaagcaaagatttatgctcaggaggacaaagccggattatagcatgagt cactctgcacggcttactgaggatgtgctagcagatgatagggatgactatgattatttg atgcaaacttccacgtacttctattctgtgagaatatttcctggtcaagaacctgctaat gtctgggtgggctggattacatcagactttcaccagtatgatacaagctttgacttggac agagtgcgtactgtcacagttacactgggagacgaaaaagggaaggttcatgagagtata aaacgcagcaactgctatatggtgtgcgcaggagagagcttgagccctggacaaggacgt aataataatggtctggagattggttgcttggttgatgctgccagtggcctgctgaccttc acagctaatggcaaggaactaggcacgtactatcaggttgaaccaagtacaaagttgttt cctgctgtatttgctcaagctacaagccccaatgttttccagtttgaattgggaagaata aagaatgtaatgccgttatctgctggattattcaaaagtgaacacaaaaacccagtctct cagtgccccccacgcctccatgtccagtttctgactcatgtgctttggagcagagtgcca aaccacttcttgaaggtggatgtgtctcggatcagtgaacgtcaaggctggatgatacag tgcctgaatcctttgcagttcatggcccttcatattcctgaggaaaacagaacaattgat attttagagctgacagaacaagaggaattgctgaaatttcactaccacaccctccgattg tattcagctgtttgtgctttaggcaacaaccgagtggcccatgctctgtgtagccacgta gatgaatctcagcttctctatgctattgagaataaatacatgccaggattattacgtgca ggatattatgacttactcattgacatccatctcaatacctatgcaactgccaggctgatg atgaataatgaatttatagttccaatgacagatgagaccaagagtattactttgtttcct gatgaaaacaaaaaacatggccttcctggtataggacttagcacttcattaaggccaaga atgcagttttcctctccaagttttgtgagcattagcagtgaatgctttcagttcagtcct gaattccctctggaaattttgaaggccaaaaccatagagatgctgactgaagctgttcag gagggaagcctccatgtcagagatccagttggaggttctacagaatttctgtttgttcct ctcatcaagctcttttataccctcctaattatgggaatcttccacaatgaggatctgaaa cacatcctgcagttgattgagccccgagttttcaaagaagcaatgagccaggaggatgaa attgatttctcagagaaggagttcagttcagatgagctcaagtcagaagagggagaggaa gaaaccagaggagagcaaatgccaaaggaaggactccttcagatgaaacttccagaacct gttaagttacagatgtgtcacctactccagtacctgtgtgattgccaagtgcgacaccga atagaagccattgtagcattttctgatgattttgtggccaagcttcaagagaatcagcgc ttccggtacaatgaagtgatgcaggccttgaacatgtctgctgccctgacagctaggaaa acaaaagaatttcgatcccctcctcaagaacagattaacatgctgctgaactttaaagat gataaaaatgattgtccttgccctgaagaaattcgggatcaactcttggatttccatgaa gacttaatgacacactgtggaattgaactagatgaagatggaatcttggatggcagcagt gattcaaccattaggggtcgcctcctataccttatggaaaaagttacttatctgaagaag aaacaagatgagaagacagttgatgaggatgataagacatcctctactctccagcagttg atttcagacacgatggtgcgttgggcccaggagtcagtgatagaagacccggagttagtg agggccatgtttgtgctgctgcatcgccagtatgatggtattggtggtctggttcgagcc ctaccaaagacctacaccataaatagtgtgtctgtggaagacaccatcaatcttctggca tcccttggccaaatccgttccttgcttagtgtcagaatggggaaggaagaggagaagctt atgattcgtggattaggagacatcatgaataataaagtattttaccagcatccaaatctc atgagagccttaggcatgcatgaaactgtcatggaagtgatggtgaatgtgcttggtgga ggagaatccaaggaaatcactttcccaaagatggtggcaaactgctgtcgttttctatgt tatttttgccgcatcagcaggcagaatcaaaaagctatgtttgatcatcttagctattta ttggaaaacagcagtgttggccttgcctctccttctatgcgagggtcaactcctttagat gttgctgcagcatctgtaatggataacaatgaacttgctctggcgttaaaggagcctgat ctggagaaggtggttcgctacttggctggatgtgggttgcagagttgtcctttgttgatt tgtaaaggctacccagacattggatggaatccagttgaaggagaaagatatttggatttt cttcgttttgctgttttttgcaatggagagagtgtggaggagaatgctaatgttgtagtc agactgcttattcgccgacctgagtgttttggtcctgctctaagaggagaaggaggcaat gggttgcttgctgccatggaggaggcaatacaaatatcagaagatcgaacaagagatgga ccttccccaagtaatggatctagtaaaacccttgaaatagaagaacaagaagatgacact attcacatgggaaatgcaatcatgaccttttatgctgccttgattgatctcttaggacgt tgtgcccctgaaatgcatctaatccatgctggtaaaggggaggccattagaatcagatca attttacggtctttgattccacttgaagatttggtgggagtaatcagtattgctttccac atgccaaccatagcaaaagatggtactgtggtggaacctgacatgtctgcgggattttgc ccagatcacaaggcagccatggttttgttccttgacagggtctatggaattgaggaccag gattttcttctacaccttcttgaagttggctttctgccagaccttcgtgctgctgcctca ttagatacggctgctttaagtgctacagatatggctttggctctgaatcgatacctttgc acagcagtcttgcctctcttgaccagatgtgctcctctgtttgctggcacggagcaccat gcttctctcatcgattccttattacacactgtgtacagactctcaaagggatgctctctt accaaagctcagcgagattctattgaagagtgtttgctgtccatctgtgggcagttgcgg ccttccatgatgcagcatttgctgaggagattagtatttgatgtacctctgttaaatgaa catgcaaagatgcctctcaagttgctgacaaatcattatgaaagatgctggaagtattat tgtttgccaagtggatggggtaactttggtgctgcctcagaagaagaacttcatttatcc agaaagttgttctggggtatttttgatgctttatctcaaaagaagtatgaacaagaactg ttcaaattggccttgccttgtctgagtgcagttgcaggagccttacctccagattatatg gaatcaaattatgtcaatatgatggaaaagcagtcctcaatggattcagatgggaacttt aatcctcaacctgttgatacctcaaacattacaatccctgaaaagctagaatatttcatt aacaaatatgcagaacatgctcatgacaaatggtcaatggaaaagtttgccaatggatgg acctatggtgaaacattttctgaatctgcaaaggtgcaaccattaatgaaacaatataag ttgctgtctgaaaaggagaaagaaatttatcgatggccaatcaaagaatcactcaaaacc atgctggcatggggatggcgaattgaaagaacacgggaaggagattccatggcactatat aatcggacacgtcgtatatctcaaaccagtcaaatctctgtagatacagcccatggttac actcctcgagcaattgacatgagcaatgtcaccctctccagagacctacatgctatggct gagatgatggctgaaaactaccataacatatgggcaaagaaaaagaaactggagcttgaa gcaaaaggaggaggcaaccatccccttcttgttccttatgatacactcacagccaaagaa aaagccaaggacagagaaaaagcacaggatattctgaaatttctacagattaatggatat gttgtctccagaggacttaaggacctggaattagacacgccttccattgagaaacgcttt gcctatagtttccttcaacagcttataagatacgtggatgaagcccatcagtacattttg gagtttgatggtggcagcagaggcaaaggagagcaattcccatatgaacaagaaatcaag ttttttgccaaagttgtgctccctttgattgatcagtattttaaaaatcatcgcctgtat ttcttatcttcagcaagtaggcctctcagcagtgggggccatgcctctaataaagagaaa gaaatggtgacaagcctgttctgcaaacttggagttcttgtcaggcataggatttcactg tttggaaacgatgcaacatcaatagtcaactgtcttcacatactgggacagaccttggat gcgaggactgtgatgaaaactggtctggaatctgttaggatggcattgagagcatttttg gacaatgctgctgaggatctagagaaaacaatggaaaatcttaagcaaggccagtttaca cacagcagaaaccagccaaaaggagttacacaaatcattaattataccacagttgctctc ctgccagtgttatcttcactgtttgagcatattggacagcaccagtttggggaagatttg atattggaagatgttcaggtctcttgttacagaatattggccagtttatatgctctggga accagcaagagtatctatgtagagaggcaacgatcagcactaggagagtgcttggctgct ttctcaggggcctttccagtggcttttttggaaactcatttgaacaaacataatatctac tcaatctacaataccaagaatgcaagagatagagcagttctcaatttgccaactagtgta gaagaggtttgcccaaatattccttccttgatgaagctaatggaagaaatagtggaactg gcagaatctggtattcgttacacacaaatgccacatatcatggaagtcatactgcctatg ctgtgtagttacatgtcacactggtgggagcatgggccagagaacaatcctgacaaggct gaaatgtgctgcacagccttgacgtcagagcacatgaacactctcttgggtaacatattg aaaatcatctataacaaccttggtattgatgaaggagcctggatgaagagattagcagtg ttttcccagcccatcataagtaaagcgaagccagagctcttaaagacacacttccttcca ctgatggataaactaaagaaaaaggcagcagtggttgtatcggatgaagaacatctaaga gcagaaggcagaggtgacatgtcggaggctgaactgctcatcctagatgagttcaccact ttggcacgggacctctatgccttctaccctttgttgattagatttgtggactataacagg gcaaaatggctgaaagagcccaatcctgaagcagaagagttgttccgcatggtggctgag gttttcatttactggtcaaagtctcataatttcaaaagggaagagcagaacttcgtggta caaaatgaaatcaacaacatgtctttccttatcagtgacaccaaatctaagatgtctaag gcagcagtttctgaccaggaaaggaagaagatgaagcgaaaaggtgaccgctactctatg cagacctctctcattgtggcagcactgaagagattgcttccaataggcctaaacatttgt gctcctggagaccaagagctaattgcactggccaaaaatcgttttagcatgaaagacact gaagatgaagtacgagatgtcatccgcagtaatcttcaccttcagggcaagcttgaggat cccgccattagatggcagatggcactttacaaagatttgccaaacaggacagaagattcc tcagatccagagaagactgtggaaagggtccttgatatagctaatgtgctatttcacctg gaacagaaatctgcttgcgtaggccgaggctatttcttttgggaaaaacatccacagcgg tccaaaaaagcagtgtggcataagctgctgtctaaacagaggaaaagagcagtagtggcc tgctttagaatggcaccgttgtataatctgccaagacaccgagccgtcaatctctttctt caaggctatgataaatcttggattgaaacagaagaacactattttgaagacaaactgata gaagacttagcaaaacctggagaggaaccaccagaagaagatgaaagccttaaaagagtt gatcctttacatcaacttattctgctattcagtcgaacagccttgactgaaaaatgcaaa ttggaagaagatttcctttatatggcttatgctgacattatggcaaagagctgccatgat gaagaagatgatgatggtgaagaagaagtgaaaagttttgaagaaaaagaaatggaaaag caaaaacttctgtatcaacaagccagactgcatgatcggggtgctgctgagatggttctg cagacaatcagtgcaagtaaaggtgagatggggccaatggttgcagcaaccctaaagcta ggaattgccgtcctaaatggaggaaattctactgttcaacagaaaatgcttgactacctc aaggataaaaaggatgtggggttctttcagagccttgctggtcttatgcagtcttgtagc gttcttgacctaaatgcgtttgaacgtcagaacaaagcagaaggccttggcatggtgact gaagagggatcaggagaaaaggtgatgcaggatgatgagttcacctgtgacctcttccgc ttccttcagttgctttgtgaaggacacaattcagattttcagaattacctgagaactcaa actggtaacaacacaactgttaatattataatttctactgtggattacttattgagagtt caggaatccatcagtgatttctattggtattattctgggaaggatgttattgatgaacaa ggacaacgaaatttttccaaagccatccaggttgcaaagcaggttttcaatactctcaca gaatatatccaggggccatgtactggtaatcagcaaagtctggcacacagcaggctgtgg gatgctgtagttggttttcttcatgtgtttgcccacatgcagatgaagctctctcaggat tccagtcaaattgaactattgaaggaattaatggatcttcagaaagatatggttgtcatg ttgctgtctatgctggaaggtaatgttgtgaatggaactattggaaagcagatggtcgat atgcttgtggaatcatcaaacaatgtggagatgattctgaaattttttgatatgttccta aaattgaaagatttgacttcctctgatgcattcaaagaatatgaccctgatggtaaaggg ataatttcgaagagggattttcacagggcaatggaaagccataagcactacactcagtct gaaacggagtttctgctgtcatgtgctgaaacagatgagaatgagactttggactatgag gagtttgtaaaacgatttcatgagcctgcaaaagacattggtttcaatgtcgctgttctc ctgaccaacctgtcagagcacatgccccatgatacacgattgcaaactttcctggagctc tcagagagtgtgctgaattactttcagcctttcctcggacgtatagaaatcatgggcagc gcaaagcgcattgaacgagtttattttgaaataagtgagtcaagtcggactcagtgggaa aaacctcaggtaaaagagtcaaagagacaatttatatttgatgtcgttaatgagggtggg gagaaagaaaagatggagctttttgttaacttctgtgaggacaccatctttgaaatgcaa ctggctgcccagatctctgaatcagatctgaatgaaaggtcagctaataaagaggagaat gagaaagataatcctgaggaagaagatcctagaatgggtttcttctctctcatgaccatg aagtcagctttactaactctcaagtataatttaatgactcttatgaaaatgctcagcatg aagagtctaaagaaacaaatgaaaaaagtgaagaaaatgaccatgaaggacatggtcttg gctttgttttcttcctactggagcattttggtgggcttactacatttcgcttgtagcgtt gtccggggcttttttcgcatcatatgcactttgctgctcggaggaagcctagtagaagga gccaagaaaatcaaggtggctgaactgttggctaatatgccagatcccactcaggatgaa gtgcgtggggaagaagaagaaggggagaggaaaccaacagaagctgcattgcctgcagaa gacttgacagatctgcggactttaacagaagagagtgatctactctcagatatatttggt ttggatttgaaacgagaaggtggacagtataaattgatcccccacaatccaaatgctggt ttgagtgatttactgagcactccctccttagccccagtgcccgaggtacaggaaaaaatc caggtaattaaggtgaaagaagaggaaaaggaggagaaagaagaaacaaaatcagaacct gaaaaagccgaaggagaagatggagaaaaagaagagaaaaccaaggaagacaaagggaaa cagaaattaagacaactgcacacacacagatatggagaaccagaagttcaggaatcagtt ttctggaagaatatcattgcataccagcagaagcttcttaattattttgcacgaaacttt tacaacatgaggatgttggcgttatttgttgcttttgccatcaacttcatccttcttttc tataaggtctccacatctgctgtgacagaagaaaaggagcttcctgtggtatctgatggt gaaagtaccacgttgaacatcctggaaagtgatgatgagagggtcattgcagtgcattat gtactggaagaaagcagtggctacatggagcccacactgaggattttggccatcctacac acagtcatctcattcttctgcatcatagggtattattgtttgaaagttccactggttatt tttaagagagaaaaggaagtagcaaggaaattggaatttgatgggctatatataactgag cagccatcagaggatgatattaagggacagtgggatagacttgtaatcaacacacagtct tttccaaataactattgggacaagtttgtgaaaagaaaggtaatggataaatatggtgag ttctatggccgtgacaggatcagtgaattactaggaatggacaaagctgctcttgatttt agtgatgctcgagaaaagaaaaaaccaaagaaggatagctccttttctgctgtgctaaat tccattgatgttaagtatcagatgtggaaattaggagttgttttcaccgataattctttc ctttacctagcatggtacatgaccatgtcagtccttggccattacaacaattttttcttt gctgctcatctccttgacattgcaatgggattcaagacattgcgaactatcctgtcatca gtcacccacaatggcaaacagcttgtcctaacagtgggattactggcagtagtggtatac ttgtatacagtagtggcattcaattttttccgcaagttctacaacaagagtgaagatggt gacatgccagacatgaaatgtgatgatatgctaacatgctatatgtttcatatgtatgtt ggagtacgtgcaggaggaggcattggtgatgaaatagaagatccagcaggagatgaatat gaaatctatcggattatctttgacatcactttcttcttctttgtgattgttatcctgctt gcaattatccaaggtttaattattgatgcttttggtgagttaagagatcagcaagagcaa gttaaggaagacatggagacgaagtgctttatctgtggaataggaaatgactactttgat acagtgcctcatggctttgaaacacacacactacaggagcacaacttggccaattatttg ttttttctgatgtatcttattaacaaagatgaaaccgagcatacaggacaggaatcatat gtatggaaaatgtatcaagaacggtgctgggagtttttccctgctggtgattgcttccga aaacaatatgaagaccagctcaactaa

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